LMichaelThompsonMD

PubMed

• Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes.
  Conforti, P.,Besusso, D.,Bocchi, V. D.,Faedo, A.,Cesana, E.,Rossetti, G.,Ranzani, V.,Svendsen, C. N.,Thompson, L. M.,Toselli, M.,Biella, G.,Pagani, M.,Cattaneo, E.> ;Proc. Natl. Acad. Sci. U.S.A.. 2018 Jan 10
• TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.
  Zhao X, Chen X, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC> ;Proc. Natl. Acad. Sci. U.S.A.. 2016-09-20
• PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo.
  Ochaba J, Monteys AM, O'Rourke JG, Reidling JC, Steffan JS, Davidson BL, Thompson LM> ;Neuron. 2016-05-04
• Potential function for the Huntingtin protein as a scaffold for selective autophagy.
  Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky DJ, Finkbeiner S, Zeitlin SO, Marsh JL, Housm...> ;Proc. Natl. Acad. Sci. U.S.A.. 2014-11-25
• 40 citations
  ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion
  Roy S. Song, Ben Massenburg, Wendy C. Wenderski, Vino Jayaraman, Lauren Thompson, Susana R. Neves> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Sep 17
• Targeting H3K4 trimethylation in Huntington disease.
  Vashishtha M, Ng CW, Yildirim F, Gipson TA, Kratter IH, Bodai L, Song W, Lau A, Labadorf A, Vogel-Ciernia A, Troncosco J, Ross CA, Bates GP, Krainc D, Sadri-Vakili G, ...> ;Proc. Natl. Acad. Sci. U.S.A.. 2013-08-06
• SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.
  O'Rourke JG, Gareau JR, Ochaba J, Song W, Raskó T, Reverter D, Lee J, Monteys AM, Pallos J, Mee L, Vashishtha M, Apostol BL, Nicholson TP, Illes K, Zhu Y, Dasso M, Bat...> ;Cell Rep. 2013-07-25
• Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.
  Sontag EM, Joachimiak LA, Tan Z, Tomlinson A, Housman DE, Glabe CG, Potkin SG, Frydman J, Thompson LM> ;Proc. Natl. Acad. Sci. U.S.A.. 2013-02-19
• A transgenic minipig model of Huntington's Disease.
  Baxa M, Hruska-Plochan M, Juhas S, Vodicka P, Pavlok A, Juhasova J, Miyanohara A, Nejime T, Klima J, Macakova M, Marsala S, Weiss A, Kubickova S, Musilova P, Vrtel R, ...> ;J Huntingtons Dis. 2013-01-01
• Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.
  Sontag EM, Lotz GP, Agrawal N, Tran A, Aron R, Yang G, Necula M, Lau A, Finkbeiner S, Glabe C, Marsh JL, Muchowski PJ, Thompson LM> ;J. Neurosci.. 2012-08-08
• Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease.
  Jia H, Pallos J, Jacques V, Lau A, Tang B, Cooper A, Syed A, Purcell J, Chen Y, Sharma S, Sangrey GR, Darnell SB, Plasterer H, Sadri-Vakili G, Gottesfeld JM, Thompson ...> ;Neurobiol. Dis.. 2012-05-01
• Psychrobacter sanguinis sp. nov., recovered from four clinical specimens over a 4-year period.
  Wirth SE, Ayala-del-Río HL, Cole JA, Kohlerschmidt DJ, Musser KA, Sepúlveda-Torres LdC, Thompson LM, Wolfgang WJ> ;Int. J. Syst. Evol. Microbiol.. 2012-01-01
• SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.
  Luthi-Carter R, Taylor DM, Pallos J, Lambert E, Amore A, Parker A, Moffitt H, Smith DL, Runne H, Gokce O, Kuhn A, Xiang Z, Maxwell MM, Reeves SA, Bates GP, Neri C, Tho...> ;Proc. Natl. Acad. Sci. U.S.A.. 2010-04-27
• Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons.
  Sinadinos, C., Burbidge-King, T., Soh, D., Thompson, L.M., Marsh, J.L., Wyttenbach, A., Mudher, A.K.> ;Neurobiol Dis. 2009 May
• Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging.
  Meulener MC, Xu K, Thomson L, Thompson L, Ischiropoulos H, Bonini NM> ;Proc. Natl. Acad. Sci. U.S.A.. 2006-08-15
• Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies.
  Wolfgang WJ, Miller TW, Webster JM, Huston JS, Thompson LM, Marsh JL, Messer A> ;Proc. Natl. Acad. Sci. U.S.A.. 2005-08-09
• Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset.
  Wexler NS, Lorimer J, Porter J, Gomez F, Moskowitz C, Shackell E, Marder K, Penchaszadeh G, Roberts SA, Gayán J, Brocklebank D, Cherny SS, Cardon LR, Gray J, Dlouhy SR...> ;Proc. Natl. Acad. Sci. U.S.A.. 2004-03-09
• Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting ...
  Luthi-Carter R, Apostol BL, Dunah AW, DeJohn MM, Farrell LA, Bates GP, Young AB, Standaert DG, Thompson LM, Cha JHJ> ;Neurobiol. Dis.. 2003-12-01
• Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.
  Hockly E, Richon VM, Woodman B, Smith DL, Zhou X, Rosa E, Sathasivam K, Ghazi-Noori S, Mahal A, Lowden PAS, Steffan JS, Marsh JL, Thompson LM, Lewis CM, Marks PA, Bate...> ;Proc. Natl. Acad. Sci. U.S.A.. 2003-02-18
• A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.
  Kazantsev A, Walker HA, Slepko N, Bear JE, Preisinger E, Steffan JS, Zhu Y, Gertler FB, Housman DE, Marsh JL, Thompson LM> ;Nat. Genet.. 2002-04-01
• Arfaptin 2 regulates the aggregation of mutant huntingtin protein.
  Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C> ;Nat. Cell Biol.. 2002-03-01
• Antisense-mediated down-regulation of the human huntingtin gene.
  Boado, R.J., Kazantsev, A., Apostol, B.L., Thompson, L.M., Pardridge, W.M.> ;J Pharmacol Exp Ther. 2000 Oct
• The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
  Steffan, J.S., Kazantsev, A., Spasic-Boskovic, O., Greenwald, M., Zhu, Y.Z., Gohler, H., Wanker, E.E., Bates, G.P., Housman, D.E., Thompson, L.M.> ;Proc Natl Acad Sci U S A. 2000 Jun 6
• 42 citations
  Bacterial counts associated with sawdust and recycled manure bedding treated with commercial conditioners.
  J.S. Hogan, V.L. Bogacz, L. Thompson, S. Romig, P.S. Schoenberger, William P. Weiss, K.L. Smith> ;Journal of Dairy Science. 1999 Aug 1
• Comparison of the intracellular signaling responses by three chimeric fibroblast growth factor receptors in PC12 cells.
  Raffioni, S., Thomas, D., Foehr, E.D., Thompson, L.M., Bradshaw, R.A.> ;Proc Natl Acad Sci U S A. 1999 Jun 22
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