LauraGravesSchuettpelzMD

Pediatric Hematology & Oncology • Saint Louis, MO

Instructor, Pediatrics, Washington University in St. Louis School of Medicine

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Office
1 Childrens Pl
Ste 9S
Saint Louis, MO 63110
Phone+1 314-454-6018

Fax+1 314-454-2780
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Education & Training

Washington University/B-JH/SLCH ConsortiumFellowship, Pediatric Hematology/Oncology, 2008 - 2011
Washington University/B-JH/SLCH ConsortiumResidency, Pediatrics, 2005 - 2008
Northwestern University The Feinberg School of MedicineClass of 2005

Certifications & Licensure

MO State Medical License 2009 - 2025
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Publications & Presentations

PubMed

Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells.
Mousumi Chakraborty, Zev J Greenberg, Qian Dong, Nate Roundy, Jeffrey J Bednarski, Luana Chiquetto Paracatu, Eric Duncavage, Weikai Li, Laura G Schuettpelz> ;Journal of Immunology. 2024 Apr 1
5 citations
A human STAT3 gain-of-function variant confers T cell dysregulation without predominant Treg dysfunction in mice.
Erica G Schmitt, Kelsey A Toth, Samuel I Risma, Ana Kolicheski, Nermina Saucier, Rafael J Feliciano Berríos, Zev J Greenberg, Jennifer W Leiding, Jack J Bleesing, Akal...> ;JCI Insight. 2022 Nov 8
7 citations
Toll-like receptor and cytokine expression throughout the bone marrow differs between patients with low- and high-risk myelodysplastic syndromes.
Luana Chiquetto Paracatu, Darlene A Monlish, Zev J Greenberg, Daniel A C Fisher, Matthew J Walter, Stephen T Oh, Laura G Schuettpelz> ;Experimental Hematology. 2022 Jun 1
4 citations
Microbiota Signals Suppress B Lymphopoiesis With Aging in Mice.
Joseph R. Krambs, Darlene Monlish, Feng Gao, Laura G. Schuettpelz, Daniel C. Link> ;Frontiers in Immunology. 2021 Oct 19
Clonal hematopoiesis in CIN
Laura G. Schuettpelz> ;Blood. 2021 Oct 7
191 citations
Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders.
Simone Brioschi, Wei Le Wang, Vincent Peng, Meng Wang, Irina Shchukina, Zev J. Greenberg, Jennifer K. Bando, Natalia Jaeger, Rafael S. Czepielewski, Amanda Swain, Deni...> ;Science. 2021 Jul 23
247 citations
Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma.
Andrea Cugurra, Tornike Mamuladze, Justin Rustenhoven, Taitea Dykstra, Giorgi Beroshvili, Zev J. Greenberg, Wendy Baker, Zach Papadopoulos, Antoine Drieu, Susan M. Bla...> ;Science. 2021 Jun 3
43 citations
Toll-Like Receptor Signaling in the Establishment and Function of the Immune System.
Jahnavi Aluri, Megan A. Cooper, Laura G. Schuettpelz> ;Cells. 2021 Jun 2
37 citations
Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain of function
Jahnavi Aluri, Alicia Bach, Saara Kaviany, Luana Chiquetto Paracatu, Maleewan Kitcharoensakkul, Magdalena Walkiewicz, Christopher D. Putnam, Marwan Shinawi, Nermina Sa...> ;Blood. 2021 May 6
23 citations
Open conformation of tetraspanins shapes interaction partner networks on cell membranes.
Yihu Yang, Xiaoran Roger Liu, Zev J. Greenberg, Fengbo Zhou, Peng He, Lingling Fan, Shixuan Liu, Guomin Shen, Takeshi Egawa, Michael L. Gross, Laura G. Schuettpelz, We...> ;The EMBO Journal. 2020 Sep 15
8 citations
TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.
Darlene Monlish, Zev J. Greenberg, Sima T. Bhatt, Kathryn M. Leonard, Molly Romine, Qian Dong, Lauren Bendesky, Eric J. Duncavage, Jeffrey A. Magee, Laura G. Schuettpelz> ;Experimental Hematology. 2020 Aug 1
26 citations
Contribution of Aberrant Toll Like Receptor Signaling to the Pathogenesis of Myelodysplastic Syndromes
Luana Chiquetto Paracatu, Laura G. Schuettpelz> ;Frontiers in Immunology. 2020 Jun 17
87 citations
Pediatric acute lymphoblastic leukemia, version 2.2020
Patrick A. Brown, Hiroto Inaba, Colleen Annesley, Jill C. Beck, Susan Colace, Mari Dallas, Kenneth B. DeSantes, Kara M. Kelly, Carrie L. Kitko, Norman J. Lacayo, Nicol...> ;Journal of the National Comprehensive Cancer Network. 2020 Jan 1
16 citations
The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling
Zev J. Greenberg, Darlene Monlish, Rachel L. Bartnett, Yihu Yang, Guomin Shen, Weikai Li, Jeffrey J. Bednarski, Laura G. Schuettpelz> ;Journal of Immunology. 2020 Jan 1
22 citations
Trauma Induces Emergency Hematopoiesis through IL-1/MyD88-Dependent Production of G-CSF.
Anja Fuchs, Darlene Monlish, Sarbani Ghosh, Shin-Wen Chang, Grant V. Bochicchio, Laura G. Schuettpelz, Isaiah R. Turnbull> ;Journal of Immunology. 2019 Apr 15
2 citations
Rapid development of pulmonary hypertension during treatment of paediatric cancer
Manish Aggarwal, Laura G. Schuettpelz, Julie Kolodziej, R. Mark Grady> ;Cardiology in the Young. 2019 Jan 25
41 citations
NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages
Juhi Bagaitkar, Jing Huang, Melody Y. Zeng, Nancy Pech, Darlene Monlish, Lizet J. Perez-Zapata, Irina Miralda, Laura G. Schuettpelz, Mary C. Dinauer> ;Blood. 2018 May 24
11 citations
Loss of Toll-like receptor 2 results in accelerated leukemogenesis in the NUP98-HOXD13 mouse model of MDS.
Darlene Monlish, Sima T. Bhatt, Eric J. Duncavage, Zev J. Greenberg, John L. Keller, Molly Romine, Wei Yang, Peter D. Aplan, Matthew J. Walter, Laura G. Schuettpelz> ;Blood. 2018 Mar 1
4 citations
Editorial: Inflammatory Signaling in Bone Marrow Failure and Hematopoietic Malignancy
Eirini Trompouki, Lisa Mullen, Delmiro Fernandez-Reyes, Junji Yodoi, Soohyun Kim, Laura G. Schuettpelz> ;Frontiers in Immunology. 2017 Jun 2
35 citations
Continuous blockade of CXCR4 results in dramatic mobilization and expansion of hematopoietic stem and progenitor cells.
Darja Karpova, Julie Ritchey, Matthew Holt, Grazia Abou-Ezzi, Darlene Monlish, Lena Batoon, Susan M. Millard, Gabriele Spohn, Eliza Wiercinska, Ezhil Chendamarai, Wei ...> ;Blood. 2017 May 25
67 citations
The Role of Toll-Like Receptors in Hematopoietic Malignancies.
Darlene Monlish, Sima T. Bhatt, Laura G. Schuettpelz> ;Frontiers in Immunology. 2016 Sep 28
40 citations
Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms.
Angela Herman, Darlene Monlish, Molly Romine, Sima T. Bhatt, Sabrina Zippel, Laura G. Schuettpelz> ;Blood Cancer Journal. 2016 Jun 17
17 citations
Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines
Shaina N. Porter, Andrew Cluster, Robert A.J. Signer, Jenna Voigtmann, Darlene Monlish, Laura G. Schuettpelz, Jeffrey A. Magee> ;Stem Cell Reports. 2016 Jun 14
102 citations
G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling.
Laura G. Schuettpelz, Joshua N. Borgerding, Matthew J. Christopher, Priya K. Gopalan, Molly Romine, Angela Herman, Jill R. Woloszynek, Adam M. Greenbaum, Daniel C. Link> ;Leukemia. 2014 Feb 12
107 citations
Regulation of hematopoietic stem cell activity by inflammation.
Laura G. Schuettpelz, Daniel C. Link> ;Frontiers in Immunology. 2013 Jul 19
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Abstracts/Posters

The Tetraspanin CD53 Regulates Early B Cell Development By Promoting IL-7R Signaling
Laura G. Schuettpelz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Hospital Affiliations

St. Louis Children's HospitalSaint Louis, Missouri
Barnes-Jewish HospitalSaint Louis, Missouri