LawrenceFongMD

Oncology • San Francisco, CA

Professor, Medicine, UCSF

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Office
1825 4th St
San Francisco, CA 94143
Phone+1 415-476-4616

Fax+1 415-353-7107
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Education & Training

Stanford Health Care-Sponsored Stanford UniversityFellowship, Medical Oncology, 1994 - 1998
University of WashingtonResidency, Internal Medicine, 1991 - 1994
Stanford University School of MedicineClass of 1992

Certifications & Licensure

CA State Medical License 1994 - 2025
American Board of Internal Medicine Medical Oncology
National Board of Physicians and Surgeons Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

GM-CSF Before Surgery in Treating Patients With Localized Prostate Cancer Start of enrollment: 2006 Jul 01
Completed
Phase 1
Phase II PAP Plus GM-CSF Versus GM-CSF Alone for Non-metastatic Prostate Cancer Start of enrollment: 2011 May 23
Completed
Phase 2
Ipilimumab and GMCSF Immunotherapy for Prostate Cancer Start of enrollment: 2015 Jun 01
Withdrawn
Phase 2
Sipuleucel-T With Immediate vs. Delayed Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Blockade for Prostate Cancer Start of enrollment: 2014 Apr 22
Completed
Phase 2
Safety Study of BPX-201 Dendritic Cell Vaccine Plus AP1903 in Metastatic Castrate Resistent Prostate Cancer Start of enrollment: 2013 Apr 01
Completed
Phase 1
CYT107 After Vaccine Treatment (Provenge®) in Patients With Metastatic Castration-Resistant Prostate Cancer Start of enrollment: 2013 Sep 10
Completed
Phase 2
Selinexor in Treating Patients With Abiraterone Acetate and/or Enzalutamide Refractory Metastatic Castration-Resistant Prostate Cancer Start of enrollment: 2014 Sep 02
Terminated
Phase 2
Neoadjuvant Atezolizumab-Based Combination Therapy in Men With Localized Prostate Cancer Prior to Radical Prostatectomy Start of enrollment: 2019 Oct 30
Recruiting
Phase 2
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Publications & Presentations

PubMed

Immune Modulation with RANKL Blockade through Denosumab Treatment in Patients with Cancer.
Hewitt Chang, Jaqueline Marquez, Brandon K Chen, Daniel M Kim, Michael L Cheng, Eric V Liu, Hai Yang, Li Zhang, Meenal Sinha, Alexander Cheung, Serena S Kwek, Eric D C...> ;Cancer Immunology Research. 2024 Apr 2
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.
Jiuling Yang, Li Wang, James R Byrnes, Lisa L Kirkemo, Hannah Driks, Cassandra D Belair, Oscar A Aguilar, Lewis L Lanier, James A Wells, Robert Blelloch, Lawrence Fong> ;Cancer Immunology Research. 2024 Apr 1
Randomized Phase II Study Evaluating the Addition of Pembrolizumab to Radium-223 in Metastatic Castration-resistant Prostate Cancer.
Atish D Choudhury, Lucia Kwak, Alexander Cheung, Kathryn M Allaire, Jaqueline Marquez, David D Yang, Abhishek Tripathi, Jacqueline M Kilar, Meredith Flynn, Brianna May...> ;Cancer Immunology Research. 2024 Mar 29
Outcomes of High-Grade Immune Checkpoint Inhibitor Hepatitis in Hospitalized and Nonhospitalized Patients.
Michael Li, Danny Wong, Jordan S Sack, Alexander S Vogel, F Stephen Hodi, Lawrence Fong, Jennifer C Lai, Stephen D Zucker, Shilpa Grover> ;Clinical Gastroenterology and Hepatology. 2024 Feb 23
Neoadjuvant CD40 Agonism Remodels the Tumor Immune Microenvironment in Locally Advanced Esophageal/Gastroesophageal Junction Cancer.
Soto, M., Filbert, E., Yang, H., Starzinski, S., Starzinski, A., Gin, M., Le, P., Li, T., Bol, B., Cheung, A., Zhang, L., Chen, B., Hsu, F., Ko, A., Fong, L., Keenan, B.> ;Cancer Research Communications. 2024 Jan 25
1 citations
Oral Toxicities of PSMA-Targeted Immunotherapies for The Management of Prostate Cancer.
Chitra Priya Emperumal, Alessandro Villa, Caleb Hwang, David Oh, Lawrence Fong, Rahul Aggarwal, Bridget P Keenan> ;Clinical Genitourinary Cancer. 2024 Apr 1
TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments.
Yuan-Li Tsai, Marcel Arias-Badia, Theresa A Kadlecek, Yee May Lwin, Aahir Srinath, Neel H Shah, Zhi-En Wang, Diane Barber, John Kuriyan, Lawrence Fong, Arthur Weiss> ;Immunity. 2023 Dec 12
2 citations
Single-doseLu-PSMA-617 followed by maintenance pembrolizumab in patients with metastatic castration-resistant prostate cancer: an open-label, dose-expansion, phase 1 t...
Rahul Aggarwal, Stephanie Starzinski, Ivan de Kouchkovsky, Vadim Koshkin, Rohit Bose, Jonathan Chou, Arpita Desai, Daniel Kwon, Samuel Kaushal, Lauren Trihy, Medini Ra...> ;The Lancet. Oncology. 2023 Nov 1
1 citations
The Cancer Moonshot Immuno-Oncology Translational Network at 5: accelerating cancer immunotherapies.
Ananth Annapragada, Andrew G Sikora, Himangi Marathe, Song Liu, Michael Demetriou, Lawrence Fong, Jinming Gao, Donald Kufe, Zachary S Morris, Eduardo Vilar, Elad Sharo...> ;Journal of the National Cancer Institute. 2023 Nov 8
CD4T cells help myeloid-mediated killing of immune-evasive tumors.
Kai Wu, Lawrence Fong> ;Trends in Cancer. 2023 Oct 1
2 citations
Biomarker-directed, pembrolizumab-based combination therapy in non-small cell lung cancer: phase 2 KEYNOTE-495/KeyImPaCT trial interim results.
Martin Gutierrez, Wei-Sen Lam, Matthew D Hellmann, Matthew A Gubens, Charu Aggarwal, Daniel Shao Weng Tan, Enriqueta Felip, Joanne W Y Chiu, Jong-Seok Lee, James Chih-...> ;Nature Medicine. 2023 Jul 1
Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma.
Miho Tanaka, Lotus Lum, Kenneth Hu, Cecilia Ledezma-Soto, Bushra Samad, Daphne Superville, Kenneth Ng, Zoe Adams, Kelly Kersten, Lawrence Fong, Alexis J Combes, Matthe...> ;Biorxiv. 2023 Jun 21
2 citations
Early Liver Specialist Consultation is Associated With Faster Biochemical Resolution of Severe Immune Checkpoint Inhibitor-Induced Hepatitis.
Michael Li, Danny Wong, Jordan S Sack, Alexander S Vogel, F Stephen Hodi, Lawrence Fong, Jennifer C Lai, Shilpa Grover, Stephen D Zucker> ;Journal of the National Comprehensive Cancer Network. 2023 Jun 1
4 citations
Vaccinating against cancer: getting to prime time.
Ryan Chang, James L Gulley, Lawrence Fong> ;Journal for Immunotherapy of Cancer. 2023 Jun 1
1 citations
Impact of Squamous Histology on Clinical Outcomes and Molecular Profiling in Metastatic Urothelial Carcinoma Patients Treated With Immune Checkpoint Inhibitors or Enfo...
Tanya Jindal, Li Zhang, Prianka Deshmukh, Kevin Reyes, Emily Chan, Vipul Kumar, Xiaolin Zhu, Edward Maldonado, Stephanie Feng, Michelle Johnson, Austin Angelidakis, Da...> ;Clinical Genitourinary Cancer. 2023 Oct 1
57 citations
Dynamic CD8T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes.
Maha K Rahim, Trine Line H Okholm, Kyle B Jones, Elizabeth E McCarthy, Candace C Liu, Jacqueline L Yee, Stanley J Tamaki, Diana M Marquez, Iliana Tenvooren, Katherine ...> ;Cell. 2023 Mar 16
14 citations
Exhausted intratumoral Vδ2γδ T cells in human kidney cancer retain effector function.
Chiara Rancan, Marcel Arias-Badia, Pranay Dogra, Brandon Chen, Dvir Aran, Hai Yang, Diamond Luong, Arielle Ilano, Jacky Li, Hewitt Chang, Serena S Kwek, Li Zhang, Lewi...> ;Nature Immunology. 2023 Apr 1
3 citations
Modulation of myeloid and T cells in vivo by Bruton's tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma.
Sinha, M., Betts, C., Zhang, L., Griffith, M., Solman, I., Chen, B., Liu, E., Tamaki, W., Stultz, J., Marquez, J., Sivagnanam, S., Cheung, A., Pener, D., Fahlman, A., ...> ;Journal for Immunotherapy of Cancer. 2023 Jan 1
1 citations
Somatic alterations ofandassociated with response to enfortumab vedotin in patients with advanced urothelial cancer.
Tanya Jindal, Xiaolin Zhu, Rohit Bose, Vipul Kumar, Edward Maldonado, Prianka Deshmukh, Chase Shipp, Stephanie Feng, Michelle S Johnson, Austin Angelidakis, Daniel Kwo...> ;Frontiers in Oncology. 2023 Jan 1
20 citations
Efficacy and safety of pembrolizumab in metastatic urothelial carcinoma: results from KEYNOTE-045 and KEYNOTE-052 after up to 5 years of follow-up.
A V Balar, D E Castellano, P Grivas, D J Vaughn, T Powles, J Vuky, Y Fradet, J-L Lee, L Fong, N J Vogelzang, M A Climent, A Necchi, D P Petrylak, E R Plimack, J Z Xu, ...> ;Annals of Oncology. 2023 Mar 1
1 citations
Serial stereotactic body radiation therapy for oligometastatic prostate cancer detected by novel PET-based radiotracers.
Daniel H Kwon, Nonna Shakhnazaryan, David Shui, Julian C Hong, Osama Mohamad, Ivan de Kouchkovsky, Hala T Borno, Rohit Bose, Jonathan Chou, Arpita Desai, Lawrence Fong...> ;Urologic Oncology. 2023 Mar 1
13 citations
The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.
Martin Sjöström, Shuang G Zhao, Samuel Levy, Meng Zhang, Yuhong Ning, Raunak Shrestha, Arian Lundberg, Cameron Herberts, Adam Foye, Rahul Aggarwal, Junjie T Hua, Haolo...> ;Cancer Research. 2022 Nov 2
5 citations
Circulating monocytes associated with anti-PD-1 resistance in human biliary cancer induce T cell paralysis.
Bridget P Keenan, Elizabeth E McCarthy, Arielle Ilano, Hai Yang, Li Zhang, Kathryn Allaire, Zenghua Fan, Tony Li, David S Lee, Yang Sun, Alexander Cheung, Diamond Luon...> ;Cell Reports. 2022 Sep 20
3 citations
Agonizing over the Stimulatory Immune Checkpoint ICOS.
Jerry C Lee, Lawrence Fong> ;Clinical Cancer Research. 2022 Sep 1
57 citations
Androgen conspires with the CD8T cell exhaustion program and contributes to sex bias in cancer.
Hyunwoo Kwon, Johanna M Schafer, No-Joon Song, Satoshi Kaneko, Anqi Li, Tong Xiao, Anjun Ma, Carter Allen, Komal Das, Lei Zhou, Brian Riesenberg, Yuzhou Chang, Payton ...> ;Science Immunology. 2022 Jul 1
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Press Mentions

Leaving Lymph Nodes Intact Could Increase Efficacy of Cancer ImmunotherapyApril 12th, 2023
Portage Biotech Hosting Key Opinion Leader Event on Targeting the Adenosine Pathway in CancerFebruary 28th, 2023
Innovent Announces the Establishment of the Scientific Advisory BoardAugust 8th, 2021
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