LawrenceDavidSherMD

Allergy & Immunology • Palos Verdes Estates, CA

Asthma & Allergic Conditions, Pediatric Asthma & Allergic Conditions

Palos Vedes Medical Group

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Office
550 Deep Valley Dr
Suite 317
Palos Verdes Estates, CA 90274
Phone+1 310-544-6858

Fax+1 310-544-6855
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Education & Training

UCLA David Geffen School of Medicine/UCLA Medical CenterFellowship, Allergy and Immunology, 1986 - 1989
UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Pediatrics, 1983 - 1986
University of Utah School of MedicineClass of 1983

Certifications & Licensure

CA State Medical License 1984 - 2025
American Board of Allergy and Immunology Allergy & Immunology
American Board of Pediatrics Pediatrics

Awards, Honors, & Recognition

Fellow (FAAAAI) American Academy of Allergy Asthma and Immunology

Clinical Trials

Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy Start of enrollment: 2004 Oct 01
Completed
Phase 3
Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome Start of enrollment: 2004 Oct 01
Completed
Phase 3
Study Evaluating 13 Valent Pneumococcal Conjugate Vaccine With Trivalent Inactivated Influenza Vaccine Start of enrollment: 2007 Sep 01
Completed
Phase 3
Dose-optimization in Adolescents Aged 13-17 Diagnosed With Attention-deficit/Hyperactivity Disorder (ADHD) Using Extended-release Guanfacine HCl Start of enrollment: 2011 Sep 19
Completed
Phase 3
Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder Start of enrollment: 2012 Apr 03
Completed
Phase 4
A Study of ARRY-502 in Patients With Persistent Asthma Start of enrollment: 2012 Apr 02
Completed
Phase 2
A Safety and Efficacy Study of Inhaled R940343 in Patients With Mild to Moderate Asthma Start of enrollment: 2012 Jul 01
Completed
Phase 2
An Evaluation Of PF-03715455 In Moderate To Severe Uncontrolled Asthma Start of enrollment: 2014 Nov 01
Terminated
Phase 2
Longer-term Study of AR101 in Subjects Who Participated in a Prior AR101 Study (ARC008) Start of enrollment: 2017 Oct 11
Completed
Phase 3
AR101 Real-World Open-Label Extension Study Start of enrollment: 2017 Oct 18
Completed
Phase 3
A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Non-Hospitalized Participants With Influenza A Infection Who Are at Risk of Developing Complications Start of enrollment: 2018 Jan 21
Terminated
Phase 3
Oral Immunotherapy for Desensitization in Children, Adolescents, and Young Adults With Hen Egg Allergy Start of enrollment: 2019 Aug 20
Terminated
Phase 2
A Study to Evaluate the Effect of Dupilumab on Exercise Capacity in Adult Patients With Asthma Start of enrollment: 2020 Jul 16
Completed
Phase 4
Roles: Contact
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Publications & Presentations

PubMed

The long-term effect of dupilumab on dyspnea, sleep, and activity in oral corticosteroid-dependent severe asthma.
Lawrence D Sher, Giovanni Passalacqua, Camille Taillé, Lauren Cohn, Nadia Daizadeh, Nami Pandit-Abid, Xavier Soler, Angela Khodzhayev, Juby A Jacob-Nara, Yamo Deniz, P...> ;Annals of Allergy, Asthma & Immunology. 2023 Mar 1
18 citations
Safety of Epicutaneous Immunotherapy in Peanut-Allergic Children: REALISE Randomized Clinical Trial Results.
Jacqueline A. Pongracic, Remi Gagnon, Gordon Sussman, Dareen Siri, Roxanne C. Oriel, Terri F. Brown-Whitehorn, Todd D. Green, Dianne E. Campbell, Sara Anvari, William ...> ;The Journal of Allergy and Clinical Immunology. in Practice. 2021 Nov 27
27 citations
Dupilumab Improves Asthma and Sinonasal Outcomes in Adults with Moderate-to-Severe Atopic Dermatitis.
Mark Boguniewicz, Lisa A. Beck, Lawrence Sher, Emma Guttman-Yassky, Diamant Thaçi, Andrew Blauvelt, Margitta Worm, Jonathan Corren, Weily Soong, Peter A. Lio, Ana B. R...> ;The Journal of Allergy and Clinical Immunology. in Practice. 2021 Mar 1
Long-term safety and effectiveness of lisdexamfetamine dimesylate in adults with attention-deficit/ hyperactivity disorder.
Weisler R, Young J, Mattingly G, Gao J, Squires L, Adler L, 304 Study Group> ;CNS spectrums.
208 citations
Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis: A Phase 3 Randomized Clinical Trial.
Eric L. Simpson, Amy S. Paller, Elaine C. Siegfried, Mark Boguniewicz, Lawrence Sher, Melinda Gooderham, Lisa A. Beck, Emma Guttman-Yassky, David M. Pariser, Andrew Bl...> ;JAMA Dermatology. 2020 Jan 1
82 citations
Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma
David A. Stempel, Stanley J. Szefler, Søren Pedersen, Robert S. Zeiger, Anne Yeakey, Laurie A. Lee, Andrew H. Liu, Herman Mitchell, Kenneth M. Kral, Ibrahim Raphiou, B...> ;The New England Journal of Medicine. 2016 Aug 31
6 citations
American Academy of Allergy, Asthma & Immunology membership experience with allergen immunotherapy safety in patients with specific medical conditions.
Désirée E S Larenas-Linnemann, David W Hauswirth, Christopher W Calabria, Lawrence D Sher, Matthew A Rank> ;Allergy and Asthma Proceedings. 2016 Sep 1
974 citations
Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
Mario Castro, Jonathan Corren, Ian D. Pavord, Jorge Maspero, Sally E. Wenzel, Klaus F. Rabe, William W. Busse, Linda B. Ford, Lawrence Sher, J. Mark FitzGerald, Consta...> ;The New England Journal of Medicine. 2018 May 21
8 citations
Fluticasone propionate and fluticasone propionate/salmeterol multidose dry powder inhalers compared with placebo for persistent asthma.
Lawrence Sher, Gloria Yiu, Anat Sakov, Siyu Liu, Cynthia F. Caracta> ;Allergy and Asthma Proceedings. 2017 Sep 21
79 citations
Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trial.
Gary T Ferguson, J. Mark FitzGerald, Eugene R. Bleecker, Michel Laviolette, David I. Bernstein, Craig LaForce, Lyndon Mansfield, Peter Barker, Yanping Wu, Maria Jison,...> ;The Lancet. Respiratory Medicine. 2017 Jul 1
11 citations
American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children.
Christopher W. Calabria, David W. Hauswirth, Matthew A. Rank, Lawrence D. Sher, Désirée Larenas-Linnemann> ;Allergy and Asthma Proceedings. 2017 Mar 1
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis.
Simpson EL, Bieber T, Guttman-Yassky E, Beck LA, Blauvelt A, Cork MJ, Silverberg JI, Deleuran M, Kataoka Y, Lacour JP, Kingo K, Worm M, Poulin Y, Wollenberg A, Soo Y, ...> ;The New England journal of medicine. 2016-09-30
Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone.
Stempel DA, Raphiou IH, Kral KM, Yeakey AM, Emmett AH, Prazma CM, Buaron KS, Pascoe SJ, AUSTRI Investigators> ;The New England journal of medicine. 2016-03-06
Mepolizumab treatment in patients with severe eosinophilic asthma.
Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, Humbert M, Katz LE, Keene ON, Yancey SW, Chanez P, MENSA Investigators> ;The New England journal of medicine. 2014-09-08
838 citations
Dupilumab in persistent asthma with elevated eosinophil levels.
Sally E. Wenzel, Linda B. Ford, David S. Pearlman, Sheldon L. Spector, Lawrence Sher, Franck Skobieranda, Lin Wang, Stephane C. Kirkesseli, Ross E. Rocklin, Brian Bock...> ;The New England Journal of Medicine. 2013 Jun 26
Twenty-six-week efficacy and safety study of mometasone furoate/formoterol 200/10 microg combination treatment in patients with persistent asthma previously receiving ...
Nathan RA, Nolte H, Pearlman DS, P04334 Study Investigators> ;Allergy and asthma proceedings. 2010-07-30
Immunogenicity and safety of a combined diphtheria, tetanus, 5-component acellular pertussis, inactivated poliomyelitis, Haemophilus type b conjugate vaccine when admi...
Bernstein HH, Noriega F, M5A07 Pentacel Study Group> ;Vaccine. 2010-07-06
138 citations
Pearls and pitfalls of allergy diagnostic testing: report from the American College of Allergy, Asthma and Immunology/American Academy of Allergy, Asthma and Immunolog...
Linda Cox, Brock Williams, Scott H. Sicherer, John Oppenheimer, Larry Sher, Robert G. Hamilton, David B.K. Golden> ;Annals of Allergy, Asthma & Immunology. 2008 Dec 1
Double-blind, placebo-controlled study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder.
Adler LA, Goodman DW, Kollins SH, Weisler RH, Krishnan S, Zhang Y, Biederman J, 303 Study Group> ;The Journal of clinical psychiatry. 2008-09-09
5 citations
Pharmacokinetics and pharmacodynamics of gatifloxacin in children with recurrent otitis media: application of sparse sampling in clinical development
Christopher M. Rubino, Paul G. Ambrose, Brenda Cirincione, Adriano Arguedas, Lawrence Sher, Eduardo López, Xavier Sáez-Llorens, Dennis M. Grasela> ;Diagnostic Microbiology and Infectious Disease. 2007 Sep 1
5 citations
Gatifloxacin Therapy for Children: Turn on the Light
Roger Echols, Kamal Hamed, Adriano Arguedas, Ron Dagan, Larry Sher, Xavier Sáez-Llorens, Michael E. Pichichero> ;Clinical Infectious Diseases. 2005 Dec 15
49 citations
Safety and Efficacy of Gatifloxacin Therapy for Children with Recurrent Acute Otitis Media (AOM) and/or AOM Treatment Failure
Michael E. Pichichero, Adriano Arguedas, Ron Dagan, Larry Sher, Xavier Sáez-Llorens, Kamal Hamed, Roger Echols> ;Clinical Infectious Diseases. 2005 Aug 15
20 citations
Randomized, investigator-blinded, multicenter, comparative study of gatifloxacin versus amoxicillin/clavulanate in recurrent otitis media and acute otitis media treatm...
Lawrence Sher, Adriano Arguedas, Michael Husseman, Michael E. Pichichero, Kamal Hamed, Debjit Biswas, Phillip F. Pierce, Roger Echols> ;The Pediatric Infectious Disease Journal. 2005 Apr 1
48 citations
Open label, multicenter study of gatifloxacin treatment of recurrent otitis media and acute otitis media treatment failure.
Adriano Arguedas, Larry Sher, Eduardo López, Xavier Sáez-Llorens, Kamal Hamed, Karen Skuba, Phillip F. Pierce> ;The Pediatric Infectious Disease Journal. 2003 Nov 1
7 citations
Community-based treatment of acute uncomplicated bacterial rhinosinusitis with gatifloxacin.
Lawrence David Sher, Michael D. Poole, Kristen Von Seggern, Matthew A. Wikler, Susan C. Nicholson, George A. Pankey> ;Otolaryngology--Head and Neck Surgery. 2002 Sep 1
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Press Mentions

OCS-Sparing Effect of Dupilumab for Severe Asthma MaintainedJuly 23rd, 2022
Pandemic-Weary LA County Crestfallen over News of Masks’ Return, Mere Weeks After Restrictions EasedJuly 15th, 2021
Are We Declaring Pandemic over Too Fast? California’s June 15 Deadline for Reopening Splits ExpertsApril 8th, 2021
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