LawrenceHYoungMD

Cardiology • New Haven, CT

Adult Congenital Heart Disease, Interventional Cardiology

Professor, Internal Medicine, Yale University School of Medicine

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Office
789 Howard Ave
Dana Building, 3rd Fl
New Haven, CT 06519
Phone+1 203-785-4629

Fax+1 203-785-3588
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Education & Training

Yale-New Haven Medical CenterResidency, Internal Medicine, 1980 - 1983
Yale School of MedicineClass of 1980

Certifications & Licensure

CT State Medical License 1982 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013-2014
Top MD Consumers Checkbook

Publications & Presentations

PubMed

LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments.
Wenwen Tang, Yi Luan, Qianying Yuan, Ao Li, Song Chen, Stanley Menacherry, Dianqing Wu, Lawrence Young> ;Nature Communications. 2024 Apr 9
1 citations
Intra-Aortic Balloon Pump Exacerbates Left Ventricular Outflow Tract Obstruction in a Patient With Takotsubo and Hypertrophic Cardiomyopathy.
Altin, S., Balan, S., Thompson, J., Odanovic, N., McNamara, R., Young, L., Griffin, M.> ;CASE. 2023 Dec 1
1 citations
An explainable machine learning-based phenomapping strategy for adaptive predictive enrichment in randomized clinical trials.
Evangelos K Oikonomou, Phyllis M Thangaraj, Deepak L Bhatt, Joseph S Ross, Lawrence H Young, Harlan M Krumholz, Marc A Suchard, Rohan Khera> ;NPJ Digital Medicine. 2023 Nov 25
An explainable machine learning-based phenomapping strategy for adaptive predictive enrichment in randomized controlled trials.
Evangelos K Oikonomou, Phyllis M Thangaraj, Deepak L Bhatt, Joseph S Ross, Lawrence H Young, Harlan M Krumholz, Marc A Suchard, Rohan Khera> ;Medrxiv. 2023 Nov 1
A Case of Fulminant Right Heart Failure Owing to Tumoral Pulmonary Hypertension.
Kedong Wang, Anuj Verma, Kaitlin E Fish, Jiun-Ruey Hu, P Elliott Miller, Jon S Morrow, Inderjit Singh, Lawrence H Young> ;JACC. Case Reports. 2023 Mar 15
8 citations
MIF is a common genetic determinant of COVID-19 symptomatic infection and severity.
J J Shin, W Fan, J Par-Young, M Piecychna, L Leng, K Israni-Winger, H Qing, J Gu, H Zhao, W L Schulz, S Unlu, J Kuster, G Young, J Liu, A I Ko, A Baeza Garcia, M Saule...> ;QJM. 2023 Mar 27
10 citations
Efficacy of lower doses of pioglitazone after stroke or transient ischaemic attack in patients with insulin resistance.
J David Spence, Catherine Viscoli, Walter N Kernan, Lawrence H Young, Karen Furie, Ralph DeFronzo, Muhammad Abdul-Ghani, Paresh Dandona, Silvio E Inzucchi> ;Diabetes, Obesity & Metabolism. 2022 Jun 1
16 citations
Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy.
Muhammad Riaz, Jinkyu Park, Lorenzo R Sewanan, Yongming Ren, Jonas Schwan, Subhash K Das, Pawel T Pomianowski, Yan Huang, Matthew W Ellis, Jiesi Luo, Juli Liu, Loujin ...> ;Circulation. 2022 Apr 19
8 citations
Distinct Roles of Type I and Type III Interferons During a Native Murine β Coronavirus Lung Infection.
Lokesh Sharma, Xiaohua Peng, Hua Qing, Brandon K. Hilliard, Joo-Young Kim, Anush Swaminathan, Justin Tian, Kavita Israni-Winger, Cuiling Zhang, Victoria Habet, Lin Wan...> ;Journal of Virology. 2021 Oct 27
1 citations
NAD Repletion Therapy: A Silver Bullet for HFpEF?
Fadi G. Akar, Lawrence H. Young> ;Circulation Research. 2021 May 28
1 citations
Right Ventricular Fatty Infiltration With an Abnormal ECG.
Natalija Odanovic, Hamid Mojibian, Lawrence H. Young> ;JACC. Case Reports. 2021 Feb 1
19 citations
Dual Angiotensin Receptor-Neprilysin Inhibition With Sacubitril/Valsartan Attenuates Systolic Dysfunction in Experimental Doxorubicin-Induced Cardiotoxicity
Nabil E. Boutagy, Attila Feher, Daniel Pfau, Zhao Liu, Nicole Guerrera, Lisa A. Freeburg, Sydney J. Womack, Abigail C. Hoenes, Caroline J. Zeiss, Lawrence H. Young, Fr...> ;JACC. Cardiooncology. 2020 Dec 1
1 citations
Subaortic Membranes in Patients With Hereditary Hemorrhagic Telangiectasia and Liver Vascular Malformations
Agnes S Kim, Katharine J. Henderson, Sumeet Pawar, Min Jung Kim, Shahnaz Punjani, Jeffrey Pollak, John T. Fahey, Guadalupe Garcia-Tsao, Lissa Sugeng, Lawrence H. Young> ;Journal of the American Heart Association. 2020 Oct 20
4 citations
Diabetes prevention and cardiovascular complications
Silvio E. Inzucchi, Catherine M. Viscoli, Lawrence H. Young, Walter N. Kernan> ;Diabetologia. 2019 Sep 14
16 citations
Cardiomyocyte d-dopachrome tautomerase protects against heart failure.
Yina Ma, Kevin N. Su, Daniel Pfau, Veena S. Rao, Xiaohong Wu, Xiaoyue Hu, Lin Leng, Xin Du, Marta Piecychna, Kenneth Bedi, Stuart G. Campbell, Anne Eichmann, Jeffrey M...> ;JCI Insight. 2019 Sep 5
265 citations
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.
Harding H. Luan, Andrew Wang, Brandon K. Hilliard, Fernando Carvalho, Connor E. Rosen, Amy M. Ahasic, Erica L. Herzog, Insoo Kang, Margaret A. Pisani, Shuang Yu, Cuili...> ;Cell. 2019 Aug 22
4 citations
Metabolic syndrome identifies normal weight insulin-resistant stroke patients at risk for recurrent vascular disease:
Jennifer L. Dearborn, Catherine M. Viscoli, Silvio E. Inzucchi, Lawrence H. Young, Walter N. Kernan> ;International Journal of Stroke. 2019 Aug 1
1 citations
Presentation of Liver Failure From a Pericardial Mass.
Vinh Q. Nguyen, Virginia Workman, Kristin Stendahl, Lawrence Young, Jeffrey Sklar, Lauren A. Baldassarre> ;Circulation. Cardiovascular Imaging. 2019 Jun 1
68 citations
Pioglitazone Therapy in Patients With Stroke and Prediabetes: A Post Hoc Analysis of the IRIS Randomized Clinical Trial.
J. D. Spence, Catherine M. Viscoli, Silvio E. Inzucchi, Jennifer Dearborn-Tomazos, Gary A. Ford, Mark Gorman, Karen L. Furie, Anne M. Lovejoy, Lawrence H. Young, Walte...> ;JAMA Neurology. 2019 May 1
40 citations
Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure.
Daniel Pfau, Stephanie Thorn, Jiasheng Zhang, Nicole Mikush, Jennifer M. Renaud, Ran Klein, Robert A. deKemp, Xiaohong Wu, Xiaoyue Hu, Albert J. Sinusas, Lawrence H. Y...> ;Scientific Reports. 2019 Apr 8
7 citations
Achievement of Guideline-Recommended Weight Loss Among Patients With Ischemic Stroke and Obesity.
Jennifer L. Dearborn, Catherine M. Viscoli, Lawrence H. Young, Mark Gorman, Karen L. Furie, Walter N. Kernan> ;Stroke. 2019 Mar 1
9 citations
Scoring System to Optimize Pioglitazone Therapy After Stroke Based on Fracture Risk.
Catherine M. Viscoli, David M. Kent, Robin Conwit, Jennifer L. Dearborn, Karen L. Furie, Mark Gorman, Peter D. Guarino, Silvio E. Inzucchi, Amber Stuart, Lawrence H. Y...> ;Stroke. 2019 Jan 1
1 citations
Evolution of Intrahepatic Shunts in a Patient With Hereditary Hemorrhagic Telangiectasia
Leila Haghighat, Eric J. Brandt, Deborah D. Proctor, Guadalupe Garcia-Tsao, Jeffrey Pollak, Lawrence H. Young> ;Annals of Internal Medicine. 2018 Oct 2
38 citations
Heart Failure After Ischemic Stroke or Transient Ischemic Attack in Insulin-Resistant Patients Without Diabetes Mellitus Treated With Pioglitazone
Lawrence H. Young, Catherine M. Viscoli, Gregory G. Schwartz, Silvio E. Inzucchi, Jeptha P. Curtis, Mark Gorman, Karen L. Furie, Robin Conwit, Erica S. Spatz, Anne M. ...> ;Circulation. 2018 Sep 18
Effects of Preparatory Coaching and Home Practice for Deep Inspiration Breath Hold on Cardiac Dose for Left Breast Radiation Therapy.
Kim, A.,Kalet, A. M.,Cao, N.,Hippe, D. S.,Fang, L. C.,Young, L.,Meyer, J.,Lang, E. V.,Mayr, N. A.> ;Clin Oncol (R Coll Radiol). 2018 May 19
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Journal Articles

Macrophage Migration Inhibitory Factor Mediates Metabolic Dysfunction Induced by Atypical Antipsychotic Therapy
Jia Li, Lawrence Young, Richard Bucala, The Journal of Clinical Investigation

Grant Support

AMP-ACTIVATED Protein Kinase In The Ischemic HeartNational Heart, Lung, And Blood Institute2009–2011
Regulation Of Glucose Transport In The Ischemic HeartNational Heart, Lung, And Blood Institute2000–2008
Visualsonics Vevo 770 Imaging SystemNational Center For Research Resources2007
Effects Of Exercise During Insulin Induced Hypoglycemia On Heart Function In IDDMNational Center For Research Resources2000–2001
Insulin Induced Hypoglycemia On Cardiac Function In Patients With IDDMNational Center For Research Resources1997–2001
Prospective Evaluation Of GI Manifestations Of Hereditary HemorrhageNational Center For Research Resources1996–1997
Double Blind Placebo Controlled Multicenter Study Of ZopolrestatNational Center For Research Resources1996–1997
In Vivo Heart Protein Metabolism In Diabetes &IschemiaNational Heart, Lung, And Blood Institute1986–1990
Regulation Of Amino Acid Transport In Sarcolemma MembranNational Heart, Lung, And Blood Institute1985

Professional Memberships

American Heart Association - AHA
Fellow

Hospital Affiliations

Yale-New Haven HospitalNew Haven, Connecticut