Lee Antoinette Darville MD

PubMed

• Diagnostic-avoiding Chlamydia trachomatis variants detected in cervical and endometrial specimens from women during 16S microbiome profiling.
  Sangmi Jeong, Tammy Tollison, Hayden Brochu, Hsuan Chou, Tammy Yu
  BMC Infectious Diseases. 2025-03-12
• T cell signatures associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort.
  Kacy S Yount, Chi-Jane Chen, Avinash Kollipara, Chuwen Liu, Neha V Mokashi
  JCI Insight. 2025-02-27
• Intranasal immunization with CPAF combined with ADU-S100 induces an effector CD4 T cell response and reduces bacterial burden following intravaginal infection with Chl...
  Taylor B Poston, Jenna Girardi, Marie Kim, Peter Zwarycz, A Grace Polson
  Vaccine. 2025-01-01

Journal Articles

• Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct disease.  
  O’Connell CM, Ingalls RR, Andrews CW Jr, Scurlock AM, Darville T, J Immunol 2007 Sep 15;179(6):4027-34. PMID: 17785841
• Characterization of chlamydial genital infection resulting from sexual transmission from male to female guinea pigs and determination of infectious dose.  
  Rank RJ, Bowlin AK, Reed RL, Darville T, Infect Immun2003; 71(11):6148-6154
• Toll-like receptor-2, but not toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection.  
  Darville T, O’Neill JM, Andrews CW, Jr., Nagarajan UM, Stahl L, and Ojcius DM, J Immunol2003; 171:6187-6197
• Infective endocarditis in Arkansan children from 1990 through 2002.  
  Coward K, Tucker N, Darville T, Pediatr Infect Dis J 2003 Dec;22(12):1048-52
• Management of acute hematogenous osteomyelitis in children.  
  Darville T, Jacobs RF, Pediatr Infect Dis J. 2004 Mar;23(3):255-7
• Protection against Chlamydia trachomatis infection in vitro and modulation of inflammatory response in vivo by membrane-associated glycosaminoglycans.  
  Darville T, Yedgar S, Krimsky M, Andrews CW Jr, Jungas T, and Ojcius DM, Microbes Infect 2004 Apr;6(4):369-76
• Cell Death, BAX activation, and HMGB1 release during infection with Chlamydia.  
  Jungas T, Verbeke P, Darville T, and Ojcius DM, Microbes Infect. 2004 Nov; 6(13):1145-55
• Relationship between intracranial granulomas and cerebrospinal fluid levels of gamma interferon and interleukin-10 in patients with tuberculous meningitis.  
  Mansour AM, Frenck RW Jr, Darville T, Nakhla IA, Wierzba TF, Sultan Y, Bassiouny MI, McCarthy K, Jacobs RF, ClinDiagn Lab Immunol. 2005 Feb;12(2):363-5
• Can Chlamydia be stopped?  
  Ojcius DM, Darville T, Bavoil PM, SciAmer2005 May; 292(5):72-79
• Chlamydia trachomatis induces expression of IP-10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88.  
  Nagarajan UM,Ojcius DM, Stahl T, Rank RG and Darville T, J Immunol, 2005 Jul 1;175(1):450-60
• Coercive Treatment of HIV-Positive Children Is Not Justified: In Reply.  
  Darville T, Wheeler JG, Tucker N, Hackler C, Young K, Maples H, Pediatrics 2005; 116:1606-1608e
• Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival.  
  Verbeke P, Welter-Stahl, Ying S, Hansen J, Hacker G, Darville T,Ojcius D, PLoS Pathog. 2006 May;2(5):e45
• Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum.  
  Welter-Stahl L, Ojcius DM, Viala J, Girardin S, Liu W, Delarbre C, Philpott D, Kelly KA, Darville T, Cell Microbiol, 2006 Jun 8; (6):1047-57.PMID: 16681844
• Lack of an effect of antibiotic treatment on prolonged detection of chlamydial DNA in murine genital tract infection.  
  Reeves DM, Nagarajan U, O'Connell C, Andrews CW, Darville T, Antimicrob Agents Chemother.2007 Jul;51(7):2646-8.PMID: 17502410
• Inhibition of chlamydial infectious activity due to P2X7 receptor-dependent phospholipase D activation.  
  Coutinho-Silva R, Stahl L, Raymond M-N, Jungas T, Burnstock G, Darville T, and Ojcius DM, Immunity 2003; 19(3):403-12
• Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally infected mice.  
  Darville T, Welter-Stahl L, Cruz C, Sater AA, Andrews CW Jr, Ojcius DM, J Immunol. 2007 Sep 15;179(6):3707-3714. PMID: 17785807
• Type I IFN signaling exacerbates Chlamydia muridarum genital infection in a murine model.  
  Nagarajan UM, Prantner D, Sikes JD, Andrews CW Jr, Goodwin AM, Nagarajan S, Darville T, Infect Immun. 2008 Oct;76(10):4642-8. PMID: 18663004
• Chronic granulomatous disease in an adolescent with recurrent impetigo and cholecystectomy.  
  Scholnicoff ET, MacGinnitie AJ, Lin PL, Darville T, Pediatr Infect Dis J. 2009 Mar;28(3):255-7. PMID: 19165129
• The combination of the gastrointestingal integrin (alpha4beta7) and selectin ligand enhances T cell migration to the reproductive tract during infection with Chlamydia...  
  Kelly KA, Wiley D, Wiesmeier E, Briskin M, Butch A, Darville T, Am J Reprod Immunol. 2009 Apr 22; PMID: 19392980
• Two different homing pathways involving integrin beta7 and E-selecting significantly influence trafficking of CD4 cells to the genital tract following Chlamydia murida...  
  Kelly KA, Chan AM, Butch A, Darville T, Am J Reprod Immunol. 2009 Apr 22.PMID: 19392981
• Critical role for interleukin-1beta during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages.  
  Prantner D, Darville T, Sikes JD, Andrews CW Jr, Brade H, Rank RG, Nagarajan UM, Infect Immun. 2009 Dec;77(12):5334-46. PMID: 19805535
• Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection.  
  Prantner D, Darville T, Nagarajan UM, J Immunol. 2010 Mar 1;184(5):2551-60. PMID: 20107183
• Pathogenesis of genital tract disease due to Chlamydia trachomatis.  
  Darville T, Hiltke TJ, J Infect Dis. 2010 Jun 15;201Suppl 2:S114-25. Review. PMID: 20524234
• Infectivity acts as in vivo selection for maintenance of the chlamydial cryptic plasmid.  
  Russell M, Darville T, Chandra-Kuntal K, Smith B, Andrews CW Jr, O'Connell CM, Infect Immun. 2011 Jan;79(1):98-107. Epub 2010 Oct 25. PMID: 20974819
• MyD88 deficiency leads to decreased NK cell gamma interferon production and T cell recruitment during Chlamydia muridarum genital tract infection, but a predominant Th...  
  Nagarajan UM, Sikes J, Prantner D, Andrews CW Jr, Frazer L, Goodwin A, Snowden JN, Darville T, Infect Immun. 2011 Jan;79(1):486-98. Epub 2010 Nov 15. PMID: 21078858
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Books/Book Chapters

• Principles and Practice of Pediatric Infectious Diseases. 
  Chapter: Genesis of fever and the inflammatory response 
  Page 93 - 98Darville TEditors: Long S.Churchill LivingstonEdition 2,
• Infectious Diseases of the Fetus and the Newborn Infants. 
  Chapter: Chlamydia Infections 
  Page 598 - 604Darville TEditors: Remington J, Klein J, Wilson C, Nizet V, and Maldonado Y.W. B. SaundersEdition 7,
• Post-Infectious Sequelae And Long-Term Consequences of Infectious Diseases. 
  Chapter: Chlamydia pneumoniae and Chlamydia trachomatis 
  Hammerschlag MR, Kohlhoff SA, Darville TEditors: Fratamico PM, Smith JL, Brogden KA.American Society for Microbiology, Washington, DC
• Case Studies in Infectious Diseases. 
  Chapter: Chlamydia trachomatis 
  Page 529 - 532Darville TEditors: Holland S.Garland Science, Taylor and Francis Group, Abingdon, Oxon, England
• Principles and Practice of Pediatric Infectious Diseases. 
  Chapter: Chlamydia trachomatis 
  Page 877 - 884Darville TEditors: Long S.Churchill LivingstonEdition 3,
• Nelson’s Textbook of Pediatrics. 
  Chapter: Neisseria gonorrhoeae (Gonococcus) 
  Page 899 - 903Darville TEditors: Behrman RE, Kliegman RM, Jenson HB.W. B. SaundersEdition 18,
• Hot Topics in Infection and Immunity III, Volume 582. 
  Chapter: Chlamydia trachomatis genital infections in adolescents and young adults 
  Page 85 - 97Darville TEditors: Pollard AJ, Finn A.Springer, New York, NY
• Chlamydia: Genomics, Pathogenesis and Implications for Control. 
  Chapter: Innate Immunity 
  Darville TEditors: P Bavoil and P Wyrick.Harcourt Press
• Infectious Diseases of the Fetus and Newborn Infant. 
  Chapter: Chlamydia Infections 
  Page 385 - 390Darville TEditors: Remington J, Klein J, Wilson C, Baker C.Churchill LivingstonEdition 6,
• Nelson’s Textbook of Pediatrics. 
  Chapter: Neisseria gonorrhoeae (Gonococcus) 
  Page 899 - 904Darville TEditors: Behrman RE, Kliegman RM, Jenson HB.W. B. SaundersEdition 17,
• Principles and Practice of Pediatric Infectious Diseases. 
  Chapter: Bacteremia, sepsis, and septic shock 
  Page 902 - 908Darville TEditors: Long S.Churchill LivingstonEdition 2,
• Practice of Pediatric Infectious Diseases. 
  Chapter: Lymphadenopathy, Lymphadenitis, and Lymphangitis 
  Page 751 - 780Darville T, Jacobs RFEditors: Jenson HB, Baltimore RS.Appleton and Lange
• Principles and Practice of Pediatric Infectious Diseases. 
  Chapter: Chlamydia trachomatis 
  Page 90 - 92Darville TEditors: Long S.Churchill LivingstonEdition 2,
• Rudolph's Pediatrics. 
  Chapter: Bacteremia, sepsis, and septic shock 
  Page 896 - 900Jacobs RF, Darville TEditors: Rudolph AM, Hoffman JIE, Rudolph CD.McGraw Hill
• Pediatric Infectious Diseases. 
  Chapter: Lymphadenopathy, Lymphadenitis and Lymphangitis 
  Page 610 - 629Darville T, Jacobs RFEditors: Baltimore RS, Jenson.W. B. Saunders Company
• Current Pediatric Therapy. 
  Chapter: Septic shock 
  Page 229 - 233Darville T, Jacobs RFEditors: Burg FD, Inglefinger J, Polin R, Gershon AA.Harcourt BraceEdition 17,
• Principles and Practice of Pediatric Infectious Diseases. 
  Chapter: Lymphadenopathy, lymphadenitis, and lymphangitis 
  Page 610 - 629Darville T, Jacobs RFEditors: Jenson HB, Baltimore RS.Saunders
• Persistent Bacterial infections. 
  Chapter: Chlamydia spp 
  Page 229 - 261Darville TEditors: Nataro JP, Blaser MJ, Cunningham-Rundles S.American Society for Microbiology
• Conn’s Current Therapy. 
  Chapter: Osteomyelitis 
  Page 1011 - 1014Darville T, Jacobs RJEditors: Rakel RE.WB Saunders Co
• Textbook of Pediatric Infectious Diseases. 
  Chapter: Nocardia species 
  Page 1266 - 1269Darville T, Jacobs RFEditors: Feigin RD, Cherry JD.WB SaundersEdition 4,
• Essentials of Pediatric Intensive Care. 
  Chapter: Systemic inflammatory response syndrome 
  Page 266 - 280Darville T, Fiser TEditors: Levin and Morriss.Quality Medical Publishing
• Rudolph's Pediatrics. 
  Chapter: Bacteremia, sepsis, and septic shock 
  Page 530 - 536Jacobs RF, Darville TEditors: Rudolph AM, Hoffman JIE, Rudolph CD.Appleton and LangeEdition 20,
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Abstracts/Posters

• NK cells inability to produce IFN gamma in MyD88-/- mice contributes to the delayed clearance of Chlamydia muridarum primary genital infection.
  Nagarajan U.M, Sikes JD, Prantner D, Goodwin A, and Darville T, American Association of Immunology Meeting, Seattle, Washington
• Differential dendritic cell responses in strains of mice with different outcomes of chlamydial genital tract infection.
  Johnson J and Darville T, 2nd Annual Chlamydia Basic Research Society Meeting, Indianapolis, Indiana
• The lack of pathology in mice infected with plasmid-deficient strains of Chlamydia muridarum is due to an absence of TLR2-dependent signaling.
  Darville T, R Ingalls, CW Andrews, Jr., CM O’Connell, Society of Leukocyte Biology, San Antonio, Texas
• The resolution of chlamydial genital tract infection is independent of TLR2, and TLR4, but partially dependent on MyD88.
  Nichols J, Sikes JD, Andrews CW Jr, Ojcius DM, and Darville T, 3rd Annual Chlamydia Basic Research Society Meeting, Louisville, Kentucky
• Regulatory CD4+CD25+Foxp3+ GITR+ T lymphocyte kinetics following genital tract infection with Chlamydia muridarum.
  Scurlock AM, Sikes JD, Foote IP, Rank RG, and Darville T, 3rd Annual Chlamydia Basic Research Society Meeting, Louisville, Kentucky
• Prior infection with plasmid-deficient Chlamydia muridarum protects against the development of oviduct disease after challenge with wild-type strain, Nigg.
  Darville T, Sikes JD, Andrews CW Jr, and O’Connell CM, 3rd Annual Chlamydia Basic Research Society Meeting, Louisville, Kentucky
• Prior infection with plasmid-deficient Chlamydia muridarum protect against the development of oviduct disease after challenge with virulent wild-type strain, Nigg and ...
  Darville T, Sikes JD, Andrews CW Jr, and O’Connell CM, Society of Pediatric Research Meeting, Toronto, Canada
• Development of a murine genital tract model of chlamydia and latent HSV co-infection.
  Russell M, Schreiner R, Frazer L, Andrews CW Jr, Hendricks R, Cherpes T, and Darville T, Pediatric Infectious Diseases Society/St. Jude’s Meeting, Memphis, Tennessee
• Lack of oviduct pathology in mice infected with TLR2-signaling deficient chlamydiae is associated with earlier resolution of oviduct inflammation, and a decreased Th17...
  Darville T, Andrews CW Jr, Sikes JD, Frazer L, Scurlock AM, Foote I and O’Connell CM, American Association of Immunologists Meeting, Seattle, Washington
• Chlamydial-induced TLR2 signaling leads to increased neutrophil production of proinflammatory molecules and delayed spontaneous apoptosis.
  Frazer L, O’Connell CM, and Darville T, American Association of Immunology Meeting, Seattle, Washington
• Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis and Chlamydia muridarum.
  Stahl L, Ojcius DM, Viala J, Girardin S, Delarbre C, Philpott D, Kelly KA, and Darville T, 2nd Annual Chlamydia Basic Research Society Meeting, Indianapolis, Indiana
• Rapid tests for Chlamydia based on Loop-mediated isothermal amplification (LAMP).
  Ishwad C S, Dhamne N A, Darville T, O'Connell C, Scurlock A, Vats A N, American Society for Microbiology Meeting, Philadelphia, Pennsylvania
• Successful coinfection of female mice with Neisseria gonorrhoeae and Chlamydia trachomatis.
  Vonck RA, Darville T, O’Connell CM, and Jerse AE, International Society of Sexually Transmitted Diseases Research Meeting, London, England
• Chlamydia trachomatis polymorphic membrane proteins and pelvic inflammatory disease.
  B Taylor, T Darville, C Tan, P Bavoil, R Ness, C Haggerty, Society for Pediatric and Perinatal Epidemiologic Research Meeting, Seattle, Washington
• Infection of Human Neutrophils with Chlamydia trachomatis Serovar D Promotes their Activation and Delays Apoptosis, which is Potentiated by Chlamydia-induced TLR2 Stim...
  L. Frazer, C. O'Connell, T. Darville, American Society for Microbiology, San Diego, California
• Infectivity Acts as In Vivo Selection for Maintenance of The Chlamydial “Cryptic” Plasmid.
  M. Y. Russell, E. R. Green, T. Darville, C. O'Connell, American Society for Microbiology, San Diego, California
• Plasmid-deficient Chlamydia caviae Are Equally Virulent to Wild-type GPIC in the Guinea Pig Model of Genital Tract Disease.
  M. Zurenski, K. Chandra-Kuntal, L. Frazer, C. O'Connell, T. Darville, American Society for Microbiology, San Diego, California
• Evaluation of Chlamydia trachomatis-specific Peripheral Blood CD4 T Cell Responses in High-risk Adolescent Females.
  R. Desai, R. Barral, K. Karunakaran, R. Brunham, T. Darville, American Society for Microbiology, San Diego, California
• A Pre-existing Chlamydial Infection Alters the Host Response to Neisseria gonorrhoeae in a Novel Murine Coinfection Model.
  R. A. Vonck, T. Darville, A. E. Jerse, American Society for Microbiology, San Diego, California
• HIV testing in high-risk adolescent females screened for other STIs.
  Christine Hall, Toni Darville, Romina Barral, Gina Sucato, Society for Adolescent Health and Medicine, Seattle, Washington
• Estrogen’s effects on inflammation, course, and outcome of chlamydial genital tract disease in a guinea pig model.
  Darville T, Laffoon KK, Bowlin A, Rank RG, 95th General Meeting of the American Society of Microbiology, Washington, D.C
• Mouse strain dependent variation in the course of serovar E genital tract infection is associated with differences in host response.
  Darville T, Laffoon K, Reddy L, Shymasani W., Rank RG, Third Meeting of the European Society for Chlamydia Research, Societa Editrice Esculapio, Bologna, Italy
• Transforming growth factor-? is associated with increased pathology in ?-interferon gene knock out mice infected with chlamydiae.
  Darville T, Andrews Jr. CW, Kishen LR, Rank RG, and Williams, DM, Ninth International Symposium on Human Chlamydial Infections, Napa Valley, California
• A role for interleukin-6 in host defense against Chlamydia trachomatis.
  Williams DM, Grubbs B, Darville T, Kelly K, Rank RG, Ninth International Symposium on Human Chlamydial Infections, Napa Valley, California
• Does inhibition of tumor necrosis factor-? affect chlamydial genital tract infection in mice and guinea pigs?
  Darville T, Andrews CW, Jr, Rank RG, Fourth Meeting of the European Society for Chlamydia Research, Helsinki, Finland
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Other

• Intervention strategies for human immunodeficiency virus infected children poorly adherent with antiretroviral therapy; non-adherence as medical neglect. 
  Roberts GM, Wheeler JG, Tucker NC, Hackler C, Young K, Maples HD, and Darville T, Pediatrics 2004;114:e346-e353
  http://www.pediatrics.org/cgi/content/full/114/3/e346