LeonFreedmanMD

PubMed

• 8 citations
  What's in a sample? Increasing transparency in biospecimen procurement methods
  Joshua LaBaer, Joseph F. Miceli, Leonard P. Freedman> ;Nature Methods. 2018 Apr 27
• 3 citations
  Matched preclinical designs for improved translatability
  Tero Aittokallio, Andreas Scherer, Matti Poutanen, Leonard P. Freedman> ;Science Translational Medicine. 2017 May 10
• 54 citations
  Reproducibility2020: Progress and priorities.
  Leonard P. Freedman, Gautham Venugopalan, Rosann Wisman> ;F1000research. 2017 May 2
• 2 citations
  On rigor and replication
  Leonard P. Freedman> ;Science. 2017 Apr 7
• 24 citations
  [Letter to the Editor] The need for improved education and training in research antibody usage and validation practices
  Leonard P. Freedman, Mark C Gibson, Andrew Bradbury, Arthur M. Buchberg, Darryl Davis, Marisa Dolled-Filhart, Fridtjof Lund-Johansen, David L. Rimm> ;Biotechniques. 2016 Jul 1
• 18 citations
  The culture of cell culture practices and authentication--Results from a 2015 Survey.
  Leonard P. Freedman, Mark C Gibson, Rosann Wisman, Stephen P. Ethier, Howard R. Soule, Yvonne Reid, Richard M. Neve> ;Biotechniques. 2015 Oct 1
• 7 citations
  Know Thy Cells: Improving Biomedical Research Reproducibility.
  Leonard P. Freedman> ;Science Translational Medicine. 2015 Jul 1
• 525 citations
  The Economics of Reproducibility in Preclinical Research
  Leonard P. Freedman, Iain M. Cockburn, Timothy Simcoe> ;Plos Biology. 2015 Jun 9
• 83 citations
  Reproducibility: changing the policies and culture of cell line authentication
  Leonard P. Freedman, Mark C Gibson, Stephen P. Ethier, Howard R. Soule, Richard M. Neve, Yvonne Reid> ;Nature Methods. 2015 May 28
• 16 citations
  Antibodies: Validate recombinants too
  Leonard P. Freedman> ;Nature. 2015 Feb 26
• 32 citations
  The impact of preclinical irreproducibility on drug development.
  Leonard P. Freedman, Mark C Gibson> ;Clinical Pharmacology and Therapeutics. 2015 Jan 1
• 51 citations
  The Increasing Urgency for Standards in Basic Biologic Research
  Leonard P. Freedman, James Inglese> ;Cancer Research. 2014 Aug 1
• 3 citations
  Retraction for Kitagawa et al., A Regulatory Circuit Mediating Convergence between Nurr1 Transcriptional Regulation and Wnt Signaling
  Hirochika Kitagawa, William J. Ray, Helmut Glantschnig, Pascale V. Nantermet, Yuanjiang Yu, Chih-Tai Leu, Shun-ichi Harada, Shigeaki Kato, Leonard P. Freedman> ;Molecular and Cellular Biology. 2014 Mar 1
• 3 citations
  Reproducibility: Life sciences lag in stringent standards.
  Leonard P. Freedman> ;Nature. 2013 Dec 19
• 37 citations
  Liver X Receptor-Retinoid X Receptor (LXR-RXR) Heterodimer Cistrome Reveals Coordination of LXR and AP1 Signaling in Keratinocytes
  Qi Shen, Yuchen Bai, Ken C. N. Chang, Yongjun Wang, Thomas P. Burris, Leonard P. Freedman, Catherine C. Thompson, Sunil Nagpal> ;The Journal of Biological Chemistry. 2011 Apr 22
• 53 citations
  Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity.
  Thomas J. Berrodin, Qi Shen, Elaine Quinet, Matthew R. Yudt, Leonard P. Freedman, Sunil Nagpal> ;Molecular Pharmacology. 2010 Dec 1
• Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic ...
  Schmidt, A., Kimmel, D. B., Bai, C., Scafonas, A., Rutledge, S., Vogel, R. L., McElwee-Witmer, S., Chen, F., Nantermet, P. V., Kasparcova, V., Leu, C. T., Zhang, H. Z....> ;J Biol Chem. 2010 May 28
• Estrogen receptor beta is a novel therapeutic target for photoaging.
  Chang, K. C., Wang, Y., Oh, I. G., Jenkins, S., Freedman, L. P., Thompson, C. C., Chung, J. H., Nagpal, S.> ;Mol Pharmacol. 2010 May
• Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase. Retraction.
  James G. Greger, Natalie Fursov, Neil Cooch, Sean McLarney, Leonard P. Freedman, Dean P. Edwards, Boris J. Cheskis> ;Molecular and Cellular Biology. 2010 Mar 1
• Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin.
  Wolf I, Laitman Y, Rubinek T, Abramovitz L, Novikov I, Beeri R, Kuro-O M, Koeffler HP, Catane R, Freedman LS, Levy-Lahad E, Karlan BY, Friedman E, Kaufman B> ;Oncogene. 2010-01-07
• 55 citations
  Androgen-mediated improvement of body composition and muscle function involves a novel early transcriptional program including IGF1, mechano growth factor, and inducti...
  Michael A. Gentile, Pascale V. Nantermet, Robert L. Vogel, Robert A. Phillips, Daniel J. Holder, Paul Hodor, Chun Cheng, Hongyue Dai, Leonard P. Freedman, William J. Ray> ;Journal of Molecular Endocrinology. 2010 Jan 1
• 56 citations
  Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination.
  Thomas J. Berrodin, Ken C. N. Chang, Barry S. Komm, Leonard P. Freedman, Sunil Nagpal> ;Molecular Endocrinology. 2009 Jan 1
• 1 citations
  The skinny on fat: how oxysterols may regulate functional glucocorticoids in adipose tissue.
  Matthew R. Yudt, Leonard P. Freedman> ;Endocrinology. 2008 Dec 1
• 36 citations
  Liver X receptor is a therapeutic target for photoaging and chronological skin aging.
  Ken C. N. Chang, Qi Shen, Inn Gyung Oh, Scott A. Jelinsky, Susan F. Jenkins, Wei Wang, Yihe Wang, Margaret LaCava, Matthew R. Yudt, Catherine C. Thompson, Leonard P. F...> ;Molecular Endocrinology. 2008 Nov 1
• 78 citations
  MNAR plays an important role in ERa activation of Src/MAPK and PI3K/Akt signaling pathways.
  Boris J. Cheskis, James G. Greger, Neil Cooch, Christopher McNally, Sean McLarney, Ho-Sun Lam, Su Jane Rutledge, Belew Mekonnen, Diane Hauze, Sunil Nagpal, Leonard P. ...> ;Steroids. 2008 Oct 1
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