LeonaWAyersMD

PubMed

• Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma.
  Liu, Z., Luo, Y., Kirimunda, S., Verboom, M., Onabajo, O., Gouveia, M., Ogwang, M., Kerchan, P., Reynolds, S., Tenge, C., Were, P., Kuremu, R., Wekesa, W., Masalu, N.,...> ;Communications Biology. 2024 Jan 5
• Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa.
  Zhou, W., Fischer, A., Ogwang, M., Luo, W., Kerchan, P., Reynolds, S., Tenge, C., Were, P., Kuremu, R., Wekesa, W., Masalu, N., Kawira, E., Kinyera, T., Otim, I., Lega...> ;Nature Communications. 2023 Dec 6
• Sickle cell allele HBB-rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa.
  Hyokyoung G Hong, Mateus H Gouveia, Martin D Ogwang, Patrick Kerchan, Steven J Reynolds, Constance N Tenge, Pamela A Were, Robert T Kuremu, Walter N Wekesa, Nestory Ma...> ;American Journal of Hematology. 2024 Jan 1
• 1 citations
  The emergence of SARS-CoV-2 lineages and associated saliva antibody responses among asymptomatic individuals in a large university community.
  Marlena R Merling, Amanda Williams, Najmus S Mahfooz, Marisa Ruane-Foster, Jacob Smith, Jeff Jahnes, Leona W Ayers, Jose A Bazan, Alison Norris, Abigail Norris Turner,...> ;Plos Pathogens. 2023 Aug 1
• 4 citations
  Burkitt lymphoma risk shows geographic and temporal associations withinfections in Uganda, Tanzania, and Kenya.
  Kelly Broen, Joey Dickens, Rob Trangucci, Martin D Ogwang, Constance N Tenge, Nestory Masalu, Steven J Reynolds, Esther Kawira, Patrick Kerchan, Pamela A Were, Robert ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Jan 10
• 4 citations
  Accuracy of whole slide image based image analysis is adversely affected by preanalytical factors such as stained tissue slide and paraffin block age.
  Nada Shaker, Ruhani Sardana, Satoshi Hamasaki, David G Nohle, Leona W Ayers, Anil V Parwani> ;Journal of Pathology Informatics. 2022 Jan 1
• 7 citations
  Epstein-Barr Virus in Burkitt Lymphoma in Africa Reveals a Limited Set of Whole Genome andSequence Patterns: Analysis of Archival Datasets and Field Samples From Ugand...
  Hsiao-Mei Liao, Hebing Liu, Pei-Ju Chin, Bingjie Li, Guo-Chiuan Hung, Shien Tsai, Isaac Otim, Ismail D Legason, Martin D Ogwang, Steven J Reynolds, Patrick Kerchan, Co...> ;Frontiers in Oncology. 2022 Jan 1
• COVID-19 Pandemic Impact on Cooperative Human Tissue Network Midwestern Division Service to Investigators.
  Randal L. Mandt, David G. Nohle, Ruhani Sardana, Marta Couce, Leona W. Ayers, Anil V. Parwani> ;Biopreservation and Biobanking. 2021 Oct 18
• 2 citations
  Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study
  Sally Peprah, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira...> ;Infectious Agents and Cancer. 2021 Jun 7
• Author Correction to: Endemic Burkitt lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility
  Mateus H. Gouveia, Isaac Otim, Martin D. Ogwang, Mingyi Wang, Bin Zhu, Nathan Cole, Wen Luo, Belynda Hicks, Kristine Jones, Kathrin Oehl-Huber, Leona W. Ayers, Stefani...> ;Leukemia. 2021 Feb 1
• 3 citations
  Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility.
  Mateus H. Gouveia, Isaac Otim, Martin D. Ogwang, Mingyi Wang, Bin Zhu, Nathan Cole, Wen Luo, Belynda Hicks, Kristine Jones, Kathrin Oehl-Huber, Leona W. Ayers, Stefani...> ;Leukemia. 2021 Apr 1
• 14 citations
  Endemic Burkitt lymphoma: A complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya
  Lawrence S. Redmond, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance Tenge, Pamela A. Were, Robert T. Kuremu, Nestory Masalu, Esther Kawira, Isaac Oti...> ;Malaria Journal. 2020 Jul 28
• 5 citations
  Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya.
  Sally Peprah, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira...> ;British Journal of Haematology. 2020 May 12
• 5 citations
  Variation in the Human Leukocyte Antigen system and risk for endemic Burkitt lymphoma in northern Uganda.
  Samuel Kirimunda, Murielle Verboom, Isaac Otim, Mark Ssennono, Ismail D. Legason, Hadijah Nabalende, Martin D. Ogwang, Patrick Kerchan, Tobias Kinyera, Ivan Mwebaza, M...> ;British Journal of Haematology. 2020 Feb 18
• 19 citations
  Risk factors for Burkitt lymphoma in East African children and minors: A case–control study in malaria‐endemic regions in Uganda, Tanzania and Kenya
  Sally Peprah, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Peter Odada Sumba, Nestory Ma...> ;International Journal of Cancer. 2020 Feb 15
• 128 citations
  Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma.
  Bruno M. Grande, Daniela S. Gerhard, Aixiang Jiang, Nicholas B. Griner, Jeremy S. Abramson, Thomas B. Alexander, Hilary Allen, Leona W. Ayers, Jeffrey M. Bethony, Kish...> ;Blood. 2019 Mar 21
• 16 citations
  Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control stu...
  Andriy Derkach, Isaac Otim, Ruth M. Pfeiffer, Olusegun O. Onabajo, Ismail D. Legason, Hadijah Nabalende, Martin D. Ogwang, Patrick Kerchan, Ambrose Talisuna, Leona W. ...> ;Ebiomedicine. 2019 Jan 1
• 2 citations
  Acceptable Weight Ranges for Research Tissue Procurement and Biorepositories, 2015-2017.
  David G. Nohle, Randal L. Mandt, Marta Couce, Anil V. Parwani, Leona W. Ayers> ;Biopreservation and Biobanking. 2018 Dec 17
• 14 citations
  Mast Cell Activation and KSHV Infection in Kaposi Sarcoma.
  Leona W. Ayers, Arturo Barbachano-Guerrero, Shane C McAllister, Julie A. Ritchie, Elizabeth Asiago-Reddy, Linda C. Bartlett, Ethel Cesarman, Dongliang Wang, Rosemary R...> ;Clinical Cancer Research. 2018 Oct 15
• 33 citations
  Evaluating the Causal Link Between Malaria Infection and Endemic Burkitt Lymphoma in Northern Uganda: A Mendelian Randomization Study.
  Ismail D. Legason, Ruth M. Pfeiffer, Krizia Ivana Udquim, Andrew W. Bergen, Mateus H. Gouveia, Samuel Kirimunda, Isaac Otim, Eric Karlins, Patrick Kerchan, Hadijah Nab...> ;Ebiomedicine. 2017 Nov 1
• 13 citations
  Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration
  Mette Ø. Agerbæk, Marina Ayres Pereira, Thomas Mandel Clausen, Caroline Pehrson, Htoo Zarni Oo, Charlotte B. Spliid, Jamie R. Rich, Fung Vincent K C, Francis K. Nkruma...> ;International Journal of Cancer. 2017 Apr 1
• 22 citations
  A review of the pattern of AIDS defining, HIV associated neoplasms and premalignant lesions diagnosed from 2000-2011 at Kenyatta National Hospital, Kenya.
  Emily A Rogena, Kenneth O Simbiri, G De Falco, Lorenzo Leoncini, Leona W. Ayers, Joshua Nyagol> ;Infectious Agents and Cancer. 2015 Aug 24
• 107 citations
  Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.
  Lapo Alinari, Kiran V. Mahasenan, Fengting Yan, Vrajesh Karkhanis, Jihyun Chung, Emily Smith, Carl Quinion, Porsha Smith, Lisa Kim, John T. Patton, Rosa Lapalombella, ...> ;Blood. 2015 Apr 16
• 2 citations
  EBV-Positive Grey Zone Lymphoma in an HIV Infected Man from Kampala, Uganda: Case Report.
  Lynette K Tumwine, Jackson Orem, Leona W. Ayers> ;International Journal of Medical and Pharmaceutical Case Reports. 2015 Jan 10
• 32 citations
  The effects of frozen tissue storage conditions on the integrity of RNA and protein
  H Auer, James A. Mobley, LW Ayers, Jay Bowen, Rodrigo F. Chuaqui, LA Johnson, Virginia A. LiVolsi, IA Lubensky, D McGarvey, LC Monovich, Christopher A. Moskaluk, CA Ru...> ;Biotechnic & Histochemistry. 2014 Sep 15
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Journal Articles

• Mast Cell Activation and KSHV Infection in Kaposi Sarcoma  
  Leona W Ayers, Shane C McAllister, Jeffrey N Martin, Clinical Cancer Research

Books/Book Chapters

• Burkitt’s Lymphoma. 
  Chapter: Diagnosis of Burkitt Lymphoma 
  Page 35 - 52Ayers LW, Tumwine LKEditors: Robertson, E.Springer / CM: Current Medicine Group, LLC, Philadelphia2013
• Methods in Biobanking, Methods in Molecular Biology. 
  Chapter: The AIDS and Cancer Specimen Resource (chapter 8). 
  Page 193 - 203Ayers LW, Silver S, Orenstein JM, McGrath MS, Garcia DLEditors: Diller J.Humana Press, New YorkEdition 1,2011
• Textbook of Diagnostic Microbiology. 
  Chapter: Microscopic examination of infected materials (Chapter 7). 
  Ayers LWEditors: Mahon C, Lehman D, Manuselis G.Saunders Elsevier, St. LouisEdition 4,2011
• Textbook of Diagnostic Microbiology. 
  Chapter: Microscopic examination of infected materials (Chapter 7). 
  Ayers LWEditors: Mahon C, Manuselis G.W.B. Saunders, St. LouisEdition 3,2006
• Textbook of Diagnostic Microbiology. 
  Chapter: Microscopic examination of infected materials (Chapter 8). 
  Page 262 - 309Ayers LWEditors: Mahon C, Manuselis G.W.B. Saunders, PhiladelphiaEdition 2,2000
• Clinical Diagnosis and Management by Laboratory Methods. 
  Chapter: Medical bacteriology (Chapter 48). 
  Washington J, Ayers LW, Woods GEditors: Henry, JB.W.B. Saunders, Philadelphia1996
• Textbook of Diagnostic Microbiology. 
  Chapter: Identification of microorganisms using chromatographic techniques (Chapter 5-D). 
  Page 168 - 184Ayers LWEditors: Mahon C, Manuselis G.W.B. Saunders, Philadelphia1995
• Laboratory Medicine: Test selection and Interpretation. 
  Chapter: Skin, wound and tissue specimens. 
  Ayers LW, Fritsche JT, Lancz G, Pindur A, Specter SEditors: Howanitz PJ, Howanitz JH.Churchill Livingstone, Inc, New York1991
• Principles and Practice of Surgical Pathology. 
  Chapter: Surgical pathology of infectious diseases. 
  Page 27 - 55Ayers LW, Koneman EW, Merrick TAEditors: Silverberg SG.John Wiley & Sons, Inc, New YorkEdition 1,1983
• APHA Academy of Pharmaceutical Sciences Symposium 
  Chapter: Multiple dose pharmacokinetics of gentamicin in man: evaluation of the Jelliffee nomogram and the adjustment of dosage in patient with renal impairment. (Chapter 12) 
  Michelson PA, Miller WA, Warner JF, Ayers LW, Boxembaum H1983
• The Anatomical Basis of Medical Practice. 
  Chapter: Anatomy of the AV conducting system 
  Page 515 - 516Ayers LWEditors: Federick BR, Wilson JW, Gehweiler JA.Williams and Wilkins Company, Philadelphia1971
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Abstracts/Posters

• Optimal use of rare AIDS associated cancer specimens by the ACSR.
  McGrath M, Bracci, P, Garcia DL, Huysentruyt L. Patel A, Ayers L, Silver S, International Society for Biological and Environmental Repositories (ISBER) Annual Meeting, Sidney, Australia, 5/2013
• Microvascular Density (MVD) quantification using tissue digital image analysis.
  Ping P, Kellough DA, Nohle DG, Hammond SH, Akgul M, Tong M, Mallery SR, Ayers LW, 6th Annual Translational to Clinical (T2C) Regenerative Medicine Wound Care Conference, The Ohio State University, Ohio Union, Columbus, OH, 3/2013
• EBV+ plasmacytoma (PC) and plasmablastic lymphoma (PBL): HIV/AIDS-related extramedullary plasma cell proliferative disorders (PCPD) in Sub-Saharan Africa.
  Perner Y, Stevens W, Ayabomi EA, Adebamowo C, Chumba DK, Illiyasu Y, Naresh KN, NDung’u JR, Tumwine LK, Ayers LW, International Academy of Pathology (IAP) Congress, Westin Hotel, Cape Town, South Africa, 9/2012
• Non-Hodgkin’s lymphomas in Nigeria; report of the West Sub-Saharan Africa Lymphoma Consortium (SSALC).
  Illiyasu Y, Adebamowo C, Ukah CO, Osuagwu CC, Enwere OO, Anyawu SNC, Anyiam DD, Nwofor AE, Adelusola P, Durosinmi MA, Olabode OP, Otu TI, Nnodu O, Yilkudi MG, Osime OC..., International Academy of Pathology (IAP) Congress, Westin Hotel, Cape Town, South Africa, 9/2012
• Non-Hodgkin’s lymphomas in East sub-Saharan Africa report of the Sub-Saharan Africa Lymphoma Consortium (SSALC).
  NDung’u JR, Tumwine LK, Chumba DK, Lukande R, Ayers LW, International Academy of Pathology (IAP) Congress, Westin Hotel, Cape Town, South Africa, 9/2012
• Non-Hodgkin’s lymphomas in South sub-Saharan Africa report of the Sub-Saharan Africa Lymphoma Consortium (SSALC).
  Abayomi EA, Maartens D, Stevens W, Perner Y, Ayers LW, International Academy of Pathology (IAP) Congress, Westin Hotel, Cape Town, South Africa, 9/2012
• Human mast cells: a new target for KSHV infection.
  Ritchie JA, Ayers LW, Rosemary Rochford R, King CA, International Congress on Oncogenic Herpesviruses, Sheraton University City, Phildelphia, PA, 8/2012
• Implementing new technologies and data migration of existing data at a multi-site biobank: The AIDS and Cancer Specimen Resource experience.
  Patel AA, Ayers LW, Bracci PM, Garcia D, Gupta R, Sylvia S, McGrath MS, International Society for Biological and Environmental Repositories (ISBER) Annual Meeting, Westin Bayshore Hotel, Vancouver, BC, Canada, 5/2012
• Facilitated on-line tissue quality assessment for biological repositories.
  Hammond SH, Kellough DA, Plikerd MM, Nohle DG, Ayers LW, International Society for Biological and Environmental Repositories (ISBER) Annual Meeting, Westin Bayshore Hotel, Vancouver, BC, Canada, 5/2012
• Documentation of research tissue quality: application of Definiens Tissue Studio 3.0 to region of interest assessment.
  Kellough DA, Hammond SH, Plikerd MM, Nohle DG, Ayers LW, International Society for Biological and Environmental Repositories (ISBER) Annual Meeting, Westin Bayshore Hotel, Vancouver, BC, Canada, 5/2012
• PRMT5 enzyme expression in malignant lymphomas and high grade plasmacytomas compared to normal tonsil.
  Koehler KA, Baiocchi RA, Ayers, LW, 11th Annual Ohio State University Medical Center Trainee Research Day, Columbus, OH, 4/19/2012
• Advanced morphometric quantification and segmentation of regions of interest (ROI) in research tissues.
  Kellough DA, Hammond SH, Plikerd MM, Nohle DG, Ayers LW, 14th Annual Scientific Meeting, OSU Comprehensive Cancer Center – James, The Ohio State University, Ohio Union, Columbus, OH, 3/8/2012
• On-line biospecimen histology review for facilitated biorepository internal and external quality control (QC) of research tissue quality.
  Ayers LW, Kellough DA, Hammond SH, Plikerd MM, Nohle DG, 5th Annual Biospecimen Research Network Symposium (BRN), Bethesda North Marriott Conference Center, Bethesda, MD, 2/2012
• Informatics solutions for management of unique specimen collections at a multi-site biobank: The AIDS and Cancer specimen Resource experience.
  Patel A, Ayers LW, Bracci PM, Garcia DL, Gupta R, Silver S, McGrath MS, 5th Annual Biospecimen Research Network Symposium (BRN), Bethesda North Marriott Conference Center, Bethesda, MD, 2/2012
• AIDS-related malignant lymphoma subtype characteristics in South, East and West Sub-Saharan Africa: report of the Sub-Saharan Africa Lymphoma Consortium (SSALC/NCI).
  Ayers, LW, AORTIC International Cancer Conference: Entering the 21st Century, Intercontinental City Stars Hotel, Cairo, Egypt, 11/30/2011
• Kenya-WVU-SUNY Upstate-OSU Research Collaboration in AIDS Malignancy: Developing strength-of-evidence clinical approach to define HIV-associated malignancies for tumor...
  Korir A, Gathere S, Mohammed A, Mwanda W, Rochford R, Ayers L, Metheny C, Remick SC, Mutuma G, AORTIC International Cancer Conference: Entering the 21st Century, Intercontinental City Stars Hotel, Cairo, Egypt, 11/30/2011
• HIV/AIDS-related non-Hodgkin’s lymphomas and confounders: preliminary report of the Sub-Saharan Africa Lymphoma Consortium (SSALC).
  Ayers LW, Abayomi EA, Adebamowo C, Chumba DK, Iliyasu Y, Naresh KN, NDung'u JR, Perner Y, Stevens W, Tumwine LK., 13th International Conference on Malignancies in AIDS and Other Aquired Immunodeficiencies, Lister Hill Center Auditorium, National Library of Medicine, NIH, 11/2011
• Multicentric Castlemen’s Disease (MCD) and other related KSHV lymphoproliferations in East Africa plenary.
  Ayers LW, Lukande R, N'Dung'u JR, Chumba DK, Tumwine LK, 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies, National Library of Medicine, NIH, Bethesda, MD, 11/2011
• The Cooperative Human Tissue Network, a successful prospective model of biorepository operations.
  Grizzle WE, Ayers L, Bollinger N, Chauqui R, Johnson L, LiVolsi V, Lubensky IA, McGarvey D, Monovich L, Moskaluk C, Ramirez N, Rumpel C, Sexton KC, Washington K, Wiles K, 4th Annual Biospecimen Research Network Symposium, Advancing Cancer Research Through Biospecimen Science, Bethesda, MD USA, 3/2011
• Research tissue procurement efficiency in a large Comprehensive Cancer Center 2004 – 2010: Enriched investigator service through NCI cooperative tissue procurement con...
  Ramaradjou J, Senecal K, MacLennan GT, Staugaitis S, Ayers LW, 4th Annual Biospecimen Research Network Symposium, Advancing Cancer Research Through Biospecimen Science, Bethesda, MD, USA, 3/2011
• Merkel cell carcinoma (MCC) and cell-cycle inhibitor p27: Down regulation associates with poor outcome biomarkers with an interesting exception.
  Ayers LW, Poster presentation, OSUCCC – James 13th Annual Scientific Meeting, The Ohio State University, Columbus, OH USA, 2/18/2011
• Research tissue procurement efficiency at The Ohio State University Comprehensive Cancer Center, 2004-2010.
  Ramaradjou J, Senecal K, Frankel WL, Ayers LW, Poster presentation, OSUCCC – James 13th Annual Scientific Meeting, The Ohio State University, Columbus, OH USA, 2/18/2011
• Diagnosis of HIV-related malignancies in resource-constrained settings of sub-Saharan Africa, A cautionary tale for non-Hodgkin’s lymphoma.
  Ayers LW, Lukande R, Tumwine LK, 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies, Lister Hill Center Auditorium, NIH, Bethesda, MD, 10/2010
• Castleman disease and HHV-8 related entities in Kenya.
  N’Dung’u J, Zhao WJ, Ayers LW, 10th Biennial Conference, Association of Pathologists of East, Central and Southern Africa (APECSA), Kampala, Uganda, 9/2010
• Sarcomatoid B-cell lymphoma of the scalp; First report of a case in Africa.
  Lukande R, Ayers LW, 10th Biennial Conference, Association of Pathologists of East, Central and Southern Africa (APECSA), Kampala, Uganda, 9/2010
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Lectures

• Tissue micro arrays: A tool for cancer studies in the genomics era. 
  Research Methodologies for study of HIV/AIDS associated Malignancies, Mumbai, India
• Atypical lymphoproliferative disorders in HIV positive patients in the developing world. What can you learn from Africa? 
  International Network for Cancer Treatment & Research (INCTR), Certosa di Pontignano, Siena Italy - 5/2010
• Pathology of AIDS related lymphomas in Africa. 
  8th INCTR Meeting on Cancer in Countries with Limited Resources, Lara, Antalya, Turkey - 3/24/2009
• Cancer diagnosis, surveillance and research. 
  World Health Organization (WHO) Pathology Consensus Workshop, Dar es Salaam, Tanzania - 5/27/2008
• African pathology and cancer diagnosis: focus on lymphoma and distant collaborators. 
  World Health Organization (WHO) Consensus Conference on Pathology, Dar es Saalem, Tanzania - 5/2008
• Immunophenotyping of lymphoma samples from the 1st African HIV/AIDS lymphoma clinical trial with an oral chemotherapy regimen. 
  Uganda Cancer Institute, Clinical Trials Group, Makerere University, Kampala, Uganda - 4/2007
• Navigating ACSR tissue micro array websites. 
  Research Methodologies for study of HIV/AIDS associated Malignancies, Mumbai, India - 1/28/2007
• Tissue micro arrays: a practical experience. 
  Research Methodologies for study of HIV/AIDS associated Malignancies, Mumbai, India - 1/26/2007
• Uncommon morphologies in pathology practice. 
  Resident Lecture, Department Pathology, Cleveland Clinic, Cleveland, Ohio - 4/27/2006
• The National Cancer Institute global repository for HIV infected biological samples: The AIDS Cancer and Specimen Resource (ACSR) at your service. 
  Grand Rounds Lecture, Department Pathology, Cleveland Clinic, Cleveland, Ohio - 4/27/2006
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