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Leonard Milstone, MD, Dermatology, New Haven, CT, Yale-New Haven Hospital

LeonardMMilstoneMD

Dermatology • New Haven, CT

Physician

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Summary

  • Clinical Interests/Research
    Leonard Milstone, MD, a Professor Emeritus of Dermatology at Yale, follows a large group of patients with ichthyosis and other genetic disorders of keratinization. These patients have stimulated a number of collaborative studies of genotype-phenotype correlations, trials of novel treatments for those diseases, and analysis of local and systemic effects of retinoids.

    Laboratory Research
    He studies the structure and function of epidermal keratinocytes and their proteins in vitro, in experimental animals, and in patients with ichthyosis. Past work includes: discovery of interferon gamma; identification and characterization of keratins 4 and 13; identification and characterization of epican, the CD44 proteoglycan unique to stratified squamous epithelia; elucidation of the genetic cause of ichthyosis with confetti; demonstration that epidermal desquamation can be harnessed to remove systemic toxins from the body; delivery of small nucleotides to epidermis for the purpose of gene editing

Education & Training

  • Yale-New Haven Medical Center
    Yale-New Haven Medical CenterResidency, Dermatology, 1975 - 1977
  • Oregon Health & Science University
    Oregon Health & Science UniversityResidency, Dermatology, 1971 - 1972
  • Oregon Health & Science University
    Oregon Health & Science UniversityInternship, Internal Medicine, 1970 - 1971
  • Yale School of Medicine
    Yale School of MedicineClass of 1970

Certifications & Licensure

  • CT State Medical License
    CT State Medical License 1978 - 2024
  • American Board of Dermatology Dermatology

Awards, Honors, & Recognition

  • CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
  • Fellow (FAAD) American Academy of Dermatology

Publications & Presentations

PubMed

Press Mentions

  • Dermatologists Test a Promising Treatment for Skin Diseases That Often Target Children
    Dermatologists Test a Promising Treatment for Skin Diseases That Often Target ChildrenFebruary 10th, 2023
  • Azitra Awarded NIH SBIR Grant to Develop Microbiome-Based Therapeutic for Netherton Syndrome
    Azitra Awarded NIH SBIR Grant to Develop Microbiome-Based Therapeutic for Netherton SyndromeAugust 1st, 2018

Grant Support

  • Frontiers In Ichthyosis ResearchNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2010
  • Dermatoremediation Of Iron OverloadNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2002–2010
  • Delivery Of Biologically Active Nucleic Acids To Epidermal CellsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009
  • Effects Of Retinoids On Calcium Metabolism And Bone MineralizationNational Center For Research Resources1996–1999
  • Homologous Recombination In Skin Cells For Gene TherapyNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1998
  • Gene Targeting In Normal Human KeratinocytesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1996
  • Epican, A Proteoglycan Form Of CD44 On KeratinocytesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1994–1996
  • Parathyroid Hormone-Like Peptide From KeratinocytesNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1986–1991
  • Conference On Newly Described Keratinocyte FunctionsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1988

Professional Memberships

Hospital Affiliations

Dr. Leonard Milstone, Dr. Leonard Milstone, MD, Dr. L Milstone, Dr. Leonard M Milstone