Leonard I Zon MD

Hematologic Oncology

Professor, Pediatrics, Children's Hospital, Harvard Medical School

300 Longwood AveResearch Building floor 7Boston, MA 02115
Phone+1 617-919-2069

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Education & Training

Mass General Brigham/Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 1986 - 1988
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 1983 - 1986
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1983

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Certifications & Licensure

MA State Medical License 1986 - 2027
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Elected Member Institute of Medicine, 2005
Elected Member The American Society for Clinical Investigation, 1996
Whos Who in Medicine and Healthcare Marquis Whos Who

Publications & Presentations

PubMed

Functional characterization of the 9q34.13 locus identifies RAPGEF1 as a candidate gene modulating risk for melanoma and nevi via RAS activation.
Rohit Thakur, Mai Xu, Alexandra M Thornock, Joshuah Yon, Samuel Anyaso-Samuel
American Journal of Human Genetics. 2026-10-01
Melatonin, circadian metabolism, mitochondrial remodeling, and cell size dynamics in primitive hematopoietic stem cells.
Priyasmita Chakrabarti, Abhishek K Singh, Nicola K Wilson, Iwo Kucinski, Orit Kollet
Blood. 2026-09-21
Author Correction: Specific oncogene activation of the cell of origin in mucosal melanoma.
Swathy Babu, Jiajia Chen, Chloé S Baron, Kaiwen Sun, Emily Robitschek
Nature Communications. 2026-08-20

Journal Articles

Human Tumor Genomics and Zebrafish Modeling Identify SPRED1 Loss as a Driver of Mucosal Melanoma
Hong Wu, Richard C Jordan, Boris C Bastian, Leonard I Zon, Iwei Yeh, Science Magazine
Protection from UV Light Is an Evolutionarily Conserved Feature of the Haematopoietic Niche
David E Fisher, John M Gansner, Leonard I Zon, Nature

Abstracts/Posters

Transcriptional Regulation of Coenzyme Q Biosynthesis By TIF1_ Drives Erythropoiesis
Leonard I. Zon, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Transcription Factor Induction of Ectopic Vascular Blood Stem Cell Niches In Vivo
Leonard I. Zon, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Ing4 Regulates Stress Hematopoiesis and Represses Self-Renewal in Multipotent Progenitor Cells
Leonard I. Zon, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

Transcriptional Signaling Centers Govern Human Erythropoiesis and Harbor Genetic Variations of Red Blood Cell Traits
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Friday Scientific Workshop on Myeloid Development: Transcription Factors
60th American Society of Hematology Annual Meeting - 11/30/2018

Press Mentions

“Craters” on Melanoma Tumors Unveil Biomarker of Immunotherapy SuccessOctober 17th, 2025
Craters on Melanoma Cell Surfaces Identified as Key Sites for Tumor DestructionOctober 17th, 2025
CRATERs Identified as Key Sites for T Cell-Mediated Tumor DestructionOctober 16th, 2025

Grant Support

Stress Granules in Red Blood Cell DevelopmentBOSTON CHILDREN'S HOSPITAL2025–2030
Evaluating Pathways Involved in Melanoma InitiationBOSTON CHILDREN'S HOSPITAL2025–2030
Functional characterization of the endothelial cell niche for hematopoietic stem cellsBOSTON CHILDREN'S HOSPITAL2024–2028
A community resource for germline and somatic genetic disease modeling in zebrafishBRIGHAM AND WOMEN'S HOSPITAL2023–2027
Molecular Circuits in the Hematopoietic Stem Cell NicheBOSTON CHILDREN'S HOSPITAL2020–2025

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Doximity / States / Massachusetts / Boston / Leonard Zon, MD

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