LorenAnthonyLaineMD

Gastroenterology • West Haven, CT

Physician

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Office
950 Campbell Ave
West Haven, CT 06516
Phone+1 203-937-3462
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Education & Training

University of California (San Diego) Medical CenterFellowship, Gastroenterology, 1982 - 1985
UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Internal Medicine, 1979 - 1982
David Geffen School of Medicine at UCLAClass of 1979

Certifications & Licensure

CT State Medical License 2013 - 2024
CA State Medical License 1980 - 2021
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Fellow (AGAF) American Gastroenterological Association, 2009
Super Doctor SuperDoctors.com

Clinical Trials

A Randomized Comparative Pharmacokinetic Study of Oral Ganciclovir After Treatment With Intravenous Ganciclovir for Cytomegalovirus Gastrointestinal Disease in AIDS Patients
Completed
Phase 1
Trial of Oral Versus Intravenous Proton Pump Inhibitor on Intragastric pH in Patients With Bleeding Ulcers Start of enrollment: 2006 Feb 01
Completed
Not Applicable
Trial of Wireless Capsule Endoscopy in the Evaluation of Obscure Gastrointestinal Bleeding Start of enrollment: 2003 Mar 01
Completed
Phase 4
Early Colonoscopy for Lower Gastrointestinal (GI) Bleeding Start of enrollment: 2002 Aug 01
Terminated
Not Applicable
A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors Start of enrollment: 2012 Aug 13
Completed
Phase 3
Time Interval for Endoscopic Variceal Ligation Start of enrollment: 2008 Aug 01
Completed
Phase 4
Randomized Trial of Diphenhydramine Versus Continued Midazolam in "Difficult-to-sedate" Patients Undergoing Colonoscopy Start of enrollment: 2013 Feb 01
Completed
Not Applicable
Randomized Trial of Outpatient vs. Inpatient Management of Low-risk Patients With Upper Gastrointestinal Bleeding. Start of enrollment: 2013 Dec 01
Terminated
Not Applicable
Image-Enhanced Endoscopy (IEE) for Diagnosis of Non-Erosive Reflux Disease Start of enrollment: 2015 Mar 01
Completed
Evaluation of the National Randomized Proton Pump Inhibitor De-prescribing (RaPPID) Program Start of enrollment: 2019 Sep 16
Completed
Not Applicable
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Publications & Presentations

PubMed

Review article: Upper gastrointestinal bleeding - review of current evidence and implications for management.
Dennis L Shung, Loren Laine> ;Alimentary Pharmacology & Therapeutics. 2024 May 1
AGA Clinical Practice Update on High-Quality Upper Endoscopy: Expert Review.
Nagula, S., Parasa, S., Laine, L., Shah, S.> ;Clinical Gastroenterology and Hepatology. 2024 Feb 21
CLINICAL PREDICTIVE VALUE OF RENALASE IN POST-ERCP PANCREATITIS.
Desir, G., Guo, X., Ciarleglio, M., Deng, Y., Muniraj, T., Gorelick, F., Jamidar, P., Farrell, J., Aslanian, H., Laine, L.> ;Gastrointestinal Endoscopy. 2023 Dec 14
Achieving Value by Risk Stratification With Machine Learning Model or Clinical Risk Score in Acute Upper Gastrointestinal Bleeding: A Cost Minimization Analysis.
Dennis L Shung, John K Lin, Loren Laine> ;The American Journal of Gastroenterology. 2024 Feb 1
Letter: factors influencing discontinuation of aspirin in patients after gastrointestinal bleeding - authors' reply.
Darrick K Li, Loren Laine> ;Alimentary Pharmacology & Therapeutics. 2023 Jun 1
Presentation of the Julius M. Friedenwald Medal to Sheila E. Crowe, MD.
Loren Laine, Gail Hecht> ;Gastroenterology. 2023 Jun 1
17 citations
Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial.
Loren Laine, Kenneth DeVault, Philip Katz, Stefan Mitev, John Lowe, Barbara Hunt, Stuart Spechler> ;Gastroenterology. 2023 Jan 1
4 citations
Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding.
Darrick K Li, Shawn Y Ong, Michelle L Hughes, Kenneth W Hung, Ritu Agarwal, Jamil Alexis, Shreyak Sharma, Jacqueline Pires, Michael Nanna, Loren Laine, Damianos, J.> ;Alimentary Pharmacology & Therapeutics. 2023 Jan 1
5 citations
Rebleeding in peptic ulcer bleeding - a nationwide cohort study of 19,537 patients.
Stig B Laursen, Adrian J Stanley, Loren Laine, Ove B Schaffalitzky de Muckadell> ;Scandinavian Journal of Gastroenterology. 2022 Dec 1
7 citations
Trends in characteristics, management, and outcomes of patients presenting with gastrointestinal bleeding to emergency departments in the United States from 2006 to 2019.
Neil S Zheng, Cynthia Tsay, Loren Laine, Dennis L Shung> ;Alimentary Pharmacology & Therapeutics. 2022 Dec 1
Response to Graham.
Loren Laine, Prateek Sharma, Darcy J Mulford, Barbara Hunt, Eckhard Leifke, Neila Smith, Colin W Howden> ;The American Journal of Gastroenterology. 2022 Nov 1
2 citations
Disparities in Access to Endoscopy for Patients With Upper Gastrointestinal Bleeding Presenting to Emergency Departments.
Nicolette J Rodriguez, Neil S Zheng, Catherine Mezzacappa, Maureen Canavan, Loren Laine, Dennis L Shung> ;Gastroenterology. 2023 Jun 1
64 citations
Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial.
William D Chey, Francis Mégraud, Loren Laine, Luis J López, Barbara J Hunt, Colin W Howden> ;Gastroenterology. 2022 Sep 1
18 citations
Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects.
Loren Laine, Prateek Sharma, Darcy J Mulford, Barbara Hunt, Eckhard Leifke, Neila Smith, Colin W Howden> ;The American Journal of Gastroenterology. 2022 Jul 1
1 citations
International multicenter study comparing demographics, therapy and outcomes in bleeding from Mallory Weiss tears and peptic ulcers.
Jennifer E Tham, Lucy Lynch, Stig B Laursen, Loren Laine, Harry R Dalton, Jeffrey Ngu, Eduardo Redondo-Cerezo, Michael Schultz, Iain Murray, Nick Michell, Alan J Morri...> ;Endoscopy International Open. 2022 May 1
33 citations
American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute ...
Neena S Abraham, Alan N Barkun, Bryan G Sauer, James Douketis, Loren Laine, Peter A Noseworthy, Jennifer J Telford, Grigorios I Leontiadis> ;The American Journal of Gastroenterology. 2022 Apr 1
3 citations
American College of Gastroenterology-Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute ...
Neena S Abraham, Alan N Barkun, Bryan G Sauer, James Douketis, Loren Laine, Peter A Noseworthy, Jennifer J Telford, Grigorios I Leontiadis> ;Journal of the Canadian Association of Gastroenterology. 2022 Apr 1
7 citations
Management of Patients on Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Peri-Endoscopic Period: A Clinical Practice Guideline Dissemi...
Alan N Barkun, James Douketis, Peter A Noseworthy, Loren Laine, Jennifer J Telford, Neena S Abraham> ;The American Journal of Gastroenterology. 2022 Apr 1
2 citations
Adapting to the Challenge of Hospital-Based Care: The Evolving Role of Gastroenterology Hospitalists.
Michelle L Hughes, Darrick K Li, Kenneth W Hung, Loren Laine> ;The American Journal of Gastroenterology. 2022 Mar 1
Antiplatelet Monotherapy Is Associated with an Increased Risk of Bleeding After Endoscopic Sphincterotomy.
Alan Zakko, Liam Zakko, Alyssa Grimshaw, Loren Laine> ;Digestive Diseases and Sciences. 2021 Nov 18
2 citations
Correction to: ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding.
Loren Laine, Alan N. Barkun, John R. Saltzman, Myriam Martel, Grigorios I. Leontiadis> ;The American Journal of Gastroenterology. 2021 Nov 1
2 citations
Gastrointestinal Injury Caused by Aspirin or Clopidogrel Monotherapy Versus Dual Antiplatelet Therapy.
John A. Bittl, Loren Laine> ;Journal of the American College of Cardiology. 2021 Oct 15
148 citations
Ozanimod as induction and maintenance therapy for ulcerative colitis.
William J. Sandborn, Brian G. Feagan, Geert R. D'Haens, Douglas C. Wolf, Igor Jovanovic, Stephen B. Hanauer, Subrata Ghosh, AnnKatrin Petersen, Steven Y Hua, Ji Hwan L...> ;The New England Journal of Medicine. 2021 Sep 30
9 citations
Immune Checkpoint Inhibitor-associated Diarrhea and Colitis: A Systematic Review and Meta-analysis of Observational Studies.
Ashley N. Tran, Melinda Wang, Melanie A. Hundt, Rishika Chugh, Jonathan T. Ohm, Alyssa Grimshaw, Maria M. Ciarleglio, Kenneth W. Hung, Deborah D. Proctor, Christina Pr...> ;Journal of Immunotherapy. 2021 Aug 11
5 citations
Acute gastrointestinal bleeding: proposed study outcomes for new randomised controlled trials.
Dennis M. Jensen, Alan N. Barkun, David R. Cave, Ian M. Gralnek, Rome Jutabha, Loren Laine, James Y.W. Lau, John R. Saltzman, Roy Soetikno, Joseph J.Y. Sung> ;Alimentary Pharmacology & Therapeutics. 2021 Jul 20
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Journal Articles

Outcomes with Bloody vs. Coffee-Grounds Hematemesis
Loren Laine, MD, Nature
Analyses of Bloody vs. Coffee-Grounds Hematemesis
Loren Laine, MD, Nature

Press Mentions

Weight Loss Surgery Could Cut Cancer Risk in Half over TimeMay 1st, 2023
Digestive Health Center Provides Care to over 1000 Patients in First Three Weeks of OperationFebruary 23rd, 2023
New Digestive Health Center Combines Research with Clinical PracticeFebruary 13th, 2023
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