MagedMCostantineMD

Obstetrics & Gynecology • Columbus, OH

Maternal & Fetal Medicine/High Risk

Professor, Maternal Fetal Medicine, Department of Obstetrics & Gynecology, The Ohio State University

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Office
1800 Zollinger Rd
4th Floor
Columbus, OH 43221
Phone+1 614-293-2222

Fax+1 614-293-2200
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Education & Training

University of Texas Medical Branch HospitalsFellowship, Maternal-Fetal Medicine, 2010
University of Cincinnati Medical Center/College of MedicineResidency, Obstetrics and Gynecology, 2004 - 2007
American University of Beirut Faculty of MedicineClass of 2001

Certifications & Licensure

TX State Medical License 2007 - 2025
OH State Medical License 2004 - 2025
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Maternal-Fetal Medicine

Clinical Trials

Pravastatin for Prevention of Preeclampsia Start of enrollment: 2012 Aug 01
Active, not recruiting
Phase 1
A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix Start of enrollment: 2015 Nov 13
Recruiting
Phase 3
Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity? Start of enrollment: 2016 Nov 01
Terminated
Phase 2, Phase 3
Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean Start of enrollment: 2018 Mar 15
Completed
Phase 3
Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy Start of enrollment: 2018 Aug 03
Recruiting
Not Applicable
Pravastatin to Prevent Preeclampsia Start of enrollment: 2019 Jul 17
Active, not recruiting
Phase 3
Use of Cheetah® Cardiac Monitoring System to Guide Discontinuation of Magnesium Sulfate in Women With Severe Preeclampsia Start of enrollment: 2021 Feb 22
Completed
Not Applicable
Roles: Contact, Principal Investigator
EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE) Start of enrollment: 2024 Jun 01
Not yet recruiting
Roles: Principal Investigator
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Publications & Presentations

PubMed

Sonographic Predictors of Antepartum Bleeding in Placenta Previa.
Russo, J., Frey, H., Smith, D., Gonzalez-Brown, V., Costanstine, M., Adesomo, A., Shellhaas, C.> ;American Journal of Perinatology. 2024 Mar 1
Concentrations of Fluoxetine Enantiomers Decline During Pregnancy and Increase After Birth.
Katherine L Wisner, Michael J Avram, Alfred L George Jr, Tatiana V Abramova, Amy Yang, Steve N Caritis, Maged M Costantine, Catherine S Stika> ;Journal of Clinical Psychopharmacology. 2024 Feb 29
Use of non-invasive cardiac monitoring to guide discontinuation of postpartum magnesium sulfate in individuals with preeclampsia with severe features.
Joe Eid, Marwan M Ma'ayeh, Sara Post, Christina Darin, Sydney Rentsch, Michael Cackovic, Kara M Rood, Maged M Costantine> ;Pregnancy Hypertension. 2024 Feb 23
Postpartum pharmacologic thromboprophylaxis and complications in a US cohort.
Bruno, A., Sandoval, G., Hughes, B., Grobman, W., Saade, G., Manuck, T., Longo, M., Metz, T., Simhan, H., Rouse, D., Mendez-Figueroa, H., Gyamfi-Bannerman, C., Bailit,...> ;American Journal of Obstetrics and Gynecology. 2024 Feb 8
Association of Mild Iodine Insufficiency during Pregnancy with Child Neurodevelopment in Patients with Subclinical Hypothyroidism or Hypothyroxinemia.
Casey, B., Mele, L., Varner, M., Reddy, U., Wapner, R., Thorp, J., Saade, G., Tita, A., Rouse, D., Mercer, B., , Peaceman, A., Sibai, B., Costantine, M., Caritis, S.> ;American Journal of Perinatology. 2024 Jan 16
Patient Priorities, Decisional Comfort, and Satisfaction with Metformin versus Insulin for the Treatment of Gestational Diabetes Mellitus.
Wu, J., Trinh, A., Cross, S., Rice, D., Powe, C., Brindle, S., Andreatta, S., Bartholomew, A., MacPherson, C., Saade, G., McAlearney, A., Venkatesh, K., Costantine, M....> ;American Journal of Perinatology. 2023 Dec 4
Challenges in Conducting Clinical Trials for Preeclampsia.
T Caroline Bank, Diana Kline, Maged M Costantine> ;Current Hypertension Reports. 2024 Feb 1
Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection - 2-Year Outcomes.
Brenna L Hughes, Rebecca G Clifton, Dwight J Rouse, George R Saade, Mara J Dinsmoor, Uma M Reddy, Robert Pass, Donna Allard, Gail Mallett, Cora MacPherson, Ronald Wapn...> ;The New England Journal of Medicine. 2023 Nov 9
Noninvasive Bioelectronic Treatment of Postcesarean Pain: A Randomized Clinical Trial.
Jennifer L Grasch, Maged M Costantine, Devra D Doan Mast, Baylee Klopfenstein, Jessica R Russo, Taryn L Summerfield, Kara M Rood> ;JAMA Network Open. 2023 Oct 2
Association between glycemic control and group B streptococcus colonization among pregnant individuals with pregestational diabetes.
Christine Field, T Caroline Bank, Colleen K Spees, Katherine Germann, Mark B Landon, Steven Gabbe, William A Grobman, Maged M Costantine, Kartik K Venkatesh, Venkatesh...> ;American Journal of Reproductive Immunology. 2023 Oct 1
1 citations
Desirability of outcome ranking for obstetrical trials: illustration and application to the ARRIVE trial.
Grecio J Sandoval, William A Grobman, Scott R Evans, Madeline M Rice, Rebecca G Clifton, Suneet P Chauhan, Maged M Costantine, Kelly S Gibson, Monica Longo, Torri D Me...> ;American Journal of Obstetrics and Gynecology. 2024 Mar 1
Genetic Predisposition to Adverse Neurodevelopmental Outcome of Extremely Low Birth Weight Infants.
Michael W Varner, Elizabeth A Thom, C Michael Cotten, Susan R Hintz, Grier P Page, Dwight J Rouse, Brian M Mercer, Maged M Costantine, Yoram Sorokin, John M Thorp Jr, ...> ;American Journal of Perinatology. 2023 Sep 19
Increasing rates of sars-cov-2 infection in newborns during the omicron variant epoch.
Sara Post, Heather Guhde, Rakhi Gupta Basuray, Pablo J Sanchez, Maged M Costantine, Kara M Rood, Joe Eid> ;American Journal of Reproductive Immunology. 2023 Aug 1
Predictive performance of the American College of Surgeons risk calculator for postoperative complications in nonobstetrical individuals undergoing nonobstetric surgery.
Ayush Peddireddi, Lauren C Roby, Courtney D Lynch, Jiqiang Wu, Ade Adesomo, Joseph DeMari, Timothy M Pawlik, William A Grobman, Maged M Costantine, J Eric Jelovsek, Ka...> ;American Journal of Obstetrics & Gynecology MFM. 2023 Sep 1
136 citations
Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection.
Kumar, A. D., Carrithers, M. D., Carrithers, M. D., Elias, M., Altman, N. J., Chu, H. Y., Krieger, A., Radosta, J. M., Sabati, A. A., Tanayott Thaweethai, Sarah E Joll...> ;JAMA. 2023 Jun 13
1 citations
Challenges in Conducting Therapeutic Trials in Pregnancy: Emphasizing Recent Lessons Learned.
Tracy Caroline Bank, Catherine S Stika, Raman Venkataramanan, Christine Field, Maged M Costantine> ;Journal of Clinical Pharmacology. 2023 Jun 1
Association between community-level political affiliation and peripartum vaccination.
Sara Post, Courtney D Lynch, Maged M Costantine, Brandon Fox, Jiqiang Wu, Miranda K Kiefer, Kara M Rood, Mark B Landon, William A Grobman, Kartik K Venkatesh> ;American Journal of Obstetrics & Gynecology MFM. 2023 Aug 1
5 citations
The MPRINT Hub Data, Model, Knowledge and Research Coordination Center: Bridging the gap in maternal-pediatric therapeutics research through data integration and pharm...
Quinney, S., Bies, R., Grannis, S., Bartlett, C., Mendonca, E., Rogerson, C., Backes, C., Shah, D., Tillman, E., Costantine, M., Aruldhas, B., Allam, R., Grant, A., Ab...> ;Pharmacotherapy. 2023 May 1
2 citations
Researching COVID to enhance recovery (RECOVER) pregnancy study: Rationale, objectives and design.
Torri D Metz, Rebecca G Clifton, Richard Gallagher, Rachel S Gross, Leora I Horwitz, Vanessa L Jacoby, Susanne P Martin-Herz, Myriam Peralta-Carcelen, Harrison T Reede...> ;Medrxiv. 2023 Apr 24
Relationship between plasma concentration of 17-hydroxyprogesterone caproate and gestational age at preterm delivery.
Steve N Caritis, Maged M Costantine, Shannon Clark, Catherine S Stika, Jessica W Kiley, Torri D Metz, Suneet P Chauhan, Raman Venkataramanan> ;American Journal of Obstetrics & Gynecology MFM. 2023 Jul 1
Reply: Investigations of pravastatin for the prevention of preeclampsia.
Maged M Costantine, Rebecca G Clifton, George R Saade> ;American Journal of Obstetrics and Gynecology. 2023 Aug 1
Prediction of vaginal birth after cesarean using information at admission for delivery: a calculator without race or ethnicity.
Grobman, W., Sandoval, G., Rice, M., Chauhan, S., Clifton, R., Costantine, M., Gibson, K., Metz, T., Parry, S., Reddy, U., Rouse, D., Saade, G., Simhan, H., Thorp, J.,...> ;American Journal of Obstetrics and Gynecology. 2024 Mar 1
2 citations
Aspirin and Pravastatin for Preeclampsia Prevention in High-Risk Pregnancy.
Kara M Rood, Maged M Costantine, Joe Eid> ;Obstetrics and Gynecology Clinics of North America. 2023 Mar 1
1 citations
Association between Diabetes in Pregnancy and Shoulder Dystocia by Infant Birth Weight in an Era of Cesarean Delivery for Suspected Macrosomia.
Mahmoud Abdelwahab, Heather A Frey, Courtney D Lynch, Mark A Klebanoff, Stephen F Thung, Maged M Costantine, Mark B Landon, Kartik K Venkatesh> ;American Journal of Perinatology. 2023 Jul 1
1 citations
Long-term neurodevelopmental follow-up of children exposed to pravastatin in utero.
Maged M Costantine, Rebecca G Clifton, Trisha M Boekhoudt, Kirsten Lawrence, Katherine L Wisner, William Grobman, Steve N Caritis, Hyagriv N Simhan, Mary F Hebert, Mon...> ;American Journal of Obstetrics and Gynecology. 2023 Aug 1
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Press Mentions

Prescribing Without Data: Doctors Advocate for the Inclusion of Pregnant People in Clinical ResearchMarch 22nd, 2022
Ohio State Medical Center Awarded Money to Study Aspirin Therapy in PregnancyNovember 30th, 2023
College Faculty to Oversee $14 Million Study Evaluating Optimal Aspirin Doses in PregnancyDecember 13th, 2023
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