ManalFAbdelmalekMDMD, MPH

Gastroenterology • Rochester, MN

Hepatology & Liver Transplantation

Professor of Medicine, Mayo Clinic, Rochester, MN

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Office
200 1st Street SW
Rochester, MN 55905
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Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Gastroenterology, 1996 - 1998
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 1992 - 1995
University of Missouri Kansas City School of MedicineClass of 1992

Certifications & Licensure

AZ State Medical License 1996 - Present
MN State Medical License 2022 - 2024
NC State Medical License 2006 - 2023
FL State Medical License 1998 - 2011
American Board of Internal Medicine Gastroenterology
American Board of Internal Medicine Transplant Hepatology

Awards, Honors, & Recognition

Most Compassionate Doctor American Registry
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013

Clinical Trials

Insulin Resistance in Nonalcoholic Fatty Liver Disease: A Case Control Study Start of enrollment: 2007 Jul 01
Terminated
Metformin for the Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) Start of enrollment: 2009 Apr 01
Terminated
Phase 4
Pharmacokinetics of NRL972 in Patients With Nonalcoholic Steatohepatitis (NASH) and Non-Alcoholic Fatty Liver Disease (NAFLD) Start of enrollment: 2008 Jun 01
Completed
Phase 2
Nonalcoholic Fatty Liver Disease (NAFLD) Adult Database 2 Start of enrollment: 2009 Dec 02
Completed
Impact of Fructose on Metabolism, Energy Homeostasis and Magnetic Resonance Biomarkers in Nonalcoholic Fatty Liver Disease Start of enrollment: 2013 Oct 01
Terminated
Phase 2
JKB-121 for the Treatment of Nonalcoholic Steatohepatitis Start of enrollment: 2015 Aug 01
Completed
Phase 2
Clinical Trial to Evaluation the Safety and Efficacy of GR-MD-02 for the Treatment of Liver Fibrosis and Resultant Portal Hypertension in Patients With Nash Cirrhosis Start of enrollment: 2015 Jun 01
Completed
Phase 2
Statins for the Treatment of NASH Start of enrollment: 2023 Jan 25
Recruiting
Phase 2
Roles: Principal Investigator, Contact
Role of Lisinopril in Preventing the Progression of Non-Alcoholic Fatty Liver Disease, RELIEF-NAFLD Study Start of enrollment: 2021 May 11
Recruiting
Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

The role of glucagon-like peptide-1 receptor agonists in metabolic dysfunction-associated steatohepatitis.
Stephen A Harrison, Manal F Abdelmalek, Arun J Sanyal> ;Diabetes, Obesity & Metabolism. 2024 Mar 21
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD.
William A Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D Guy, Manal F Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Hon...> ;Hepatology Communications. 2024 Mar 1
Phase 2, open-label, rollover study of cenicriviroc for liver fibrosis associated with metabolic dysfunction-associated steatohepatitis.
Francque, S., Hodge, A., Boursier, J., Rodriguez-Araujo, G., Park, G., Younes, Z., Alkhouri, N., Abdelmalek, M.> ;Hepatology Communications. 2024 Feb 1
Steatotic liver disease, a useful construct in primary care that doesn't upset the apple cart.
Abdelmalek, M., Rinella, M.> ;Hepatology. 2023 Dec 15
AHRR Hypomethylation mediates the association between maternal smoking and metabolic profiles in children.
Adriana C Vidal, Shivram A Chandramouli, Joddy Marchesoni, Nia Brown, Yukun Liu, Susan K Murphy, Rachel Maguire, Yaxu Wang, Manal F Abdelmalek, Alisha M Mavis, Mustafa...> ;Hepatology Communications. 2023 Oct 1
A randomized, double-blind, placebo-controlled trial of aldafermin in patients with NASH and compensated cirrhosis.
Mary E Rinella, Hsiao D Lieu, Kris V Kowdley, Zachary D Goodman, Naim Alkhouri, Eric Lawitz, Vlad Ratziu, Manal F Abdelmalek, Vincent Wai-Sun Wong, Ziad H Younes, Aasi...> ;Hepatology. 2024 Mar 1
9 citations
AGA Clinical Practice Update on the Role of Noninvasive Biomarkers in the Evaluation and Management of Nonalcoholic Fatty Liver Disease: Expert Review.
Julia J Wattacheril, Manal F Abdelmalek, Joseph K Lim, Arun J Sanyal> ;Gastroenterology. 2023 Oct 1
8 citations
Results from a new efficacy and safety analysis of the REGENERATE trial of obeticholic acid for treatment of pre-cirrhotic fibrosis due to non-alcoholic steatohepatitis.
Arun J Sanyal, Vlad Ratziu, Rohit Loomba, Quentin M Anstee, Kris V Kowdley, Mary E Rinella, Muhammad Y Sheikh, James F Trotter, Whitfield Knapple, Eric J Lawitz, Manal...> ;Journal of Hepatology. 2023 Nov 1
Serum Metabolites Are Associated With HFpEF in Biopsy-Proven Nonalcoholic Fatty Liver Disease.
Kara Wegermann, Marat Fudim, Ricardo Henao, Catherine F Howe, Robert McGarrah, Cynthia Guy, Manal F Abdelmalek, Anna Mae Diehl, Cynthia A Moylan> ;Journal of the American Heart Association. 2023 Jul 18
158 citations
A multisociety Delphi consensus statement on new fatty liver disease nomenclature.
Mary E Rinella, Jeffrey V Lazarus, Vlad Ratziu, Sven M Francque, Arun J Sanyal, Fasiha Kanwal, Diana Romero, Manal F Abdelmalek, Quentin M Anstee, Juan Pablo Arab, Mar...> ;Hepatology. 2023 Dec 1
91 citations
A multisociety Delphi consensus statement on new fatty liver disease nomenclature.
Mary E Rinella, Jeffrey V Lazarus, Vlad Ratziu, Sven M Francque, Arun J Sanyal, Fasiha Kanwal, Diana Romero, Manal F Abdelmalek, Quentin M Anstee, Juan Pablo Arab, Mar...> ;Annals of Hepatology. 2023 Jun 24
465 citations
A multisociety Delphi consensus statement on new fatty liver disease nomenclature.
Mary E Rinella, Jeffrey V Lazarus, Vlad Ratziu, Sven M Francque, Arun J Sanyal, Fasiha Kanwal, Diana Romero, Manal F Abdelmalek, Quentin M Anstee, Juan Pablo Arab, Mar...> ;Journal of Hepatology. 2023 Dec 1
1 citations
Longer Breastfeeding Duration Is Associated With Decreased Risk of Hepatic Fibrosis Among Young Women With Nonalcoholic Fatty Liver Disease.
Georgia Sofia Karachaliou, Ayako Suzuki, Vaishali A Patel, Lori A Bastian, Anna Mae Diehl, Manal F Abdelmalek> ;Clinical Gastroenterology and Hepatology. 2024 Feb 1
Reply: ELF in the risk stratification of NAFLD-Are the ELF thresholds suggested by the AASLD guidelines appropriate?
Mary E Rinella, Norah Terrault, Brent Neuschwander-Tetri, Rohit Loomba, Manal Abdelmalek> ;Hepatology. 2023 Dec 1
11 citations
Tropifexor plus cenicriviroc combination versus monotherapy in nonalcoholic steatohepatitis: Results from the phase 2b TANDEM study.
Quentin M Anstee, Kathryn J Lucas, Sven Francque, Manal F Abdelmalek, Arun J Sanyal, Vlad Ratziu, Adrian C Gadano, Mary Rinella, Michael Charlton, Rohit Loomba, Edward...> ;Hepatology. 2023 Oct 1
Current Treatment Options, Including Diet, Exercise, and Medications: The Impact on Histology.
Mazen Noureddin, Manal F Abdelmalek> ;Clinics in Liver Disease. 2023 May 1
10 citations
Pegbelfermin in Patients With Nonalcoholic Steatohepatitis and Stage 3 Fibrosis (FALCON 1): A Randomized Phase 2b Study.
Rohit Loomba, Arun J Sanyal, Atsushi Nakajima, Brent A Neuschwander-Tetri, Zachary D Goodman, Stephen A Harrison, Eric J Lawitz, Nadege Gunn, Kento Imajo, Natarajan Ra...> ;Clinical Gastroenterology and Hepatology. 2024 Jan 1
11 citations
Pegbelfermin in Patients With Nonalcoholic Steatohepatitis and Compensated Cirrhosis (FALCON 2): A Randomized Phase 2b Study.
Manal F Abdelmalek, Arun J Sanyal, Atsushi Nakajima, Brent A Neuschwander-Tetri, Zachary D Goodman, Eric J Lawitz, Stephen A Harrison, Ira M Jacobson, Kento Imajo, Nad...> ;Clinical Gastroenterology and Hepatology. 2024 Jan 1
21 citations
Cenicriviroc Lacked Efficacy to Treat Liver Fibrosis in Nonalcoholic Steatohepatitis: AURORA Phase III Randomized Study.
Quentin M Anstee, Brent A Neuschwander-Tetri, Vincent Wai-Sun Wong, Manal F Abdelmalek, Gerardo Rodriguez-Araujo, Henrik Landgren, Grace S Park, Pierre Bedossa, Naim A...> ;Clinical Gastroenterology and Hepatology. 2024 Jan 1
2 citations
Targeting senescent hepatocytes using the thrombomodulin-PAR1 inhibitor vorapaxar ameliorates NAFLD progression.
Raquel Maeso-Díaz, Kuo Du, Christopher Pan, Cynthia D Guy, Seh Hoon Oh, Tianyi Chen, Liuyang Wang, Dennis C Ko, Linda Tang, Rajesh K Dutta, Ji Hye Jun, Ayako Suzuki, M...> ;Hepatology. 2023 Oct 1
6 citations
A phase 2, adaptive randomized, double-blind, placebo-controlled, multicenter, 52-week study of HM15211 in patients with biopsy-confirmed non-alcoholic steatohepatitis...
Manal F Abdelmalek, Ayako Suzuki, Willian Sanchez, Eric Lawitz, Claudia Filozof, Hyungjin Cho, Eunhye Baek, JaeDuk Choi, Seungjae Baek> ;Contemporary Clinical Trials. 2023 Jul 1
4 citations
A proposal from the liver forum for the management of comorbidities in non-alcoholic steatohepatitis therapeutic trials.
Raluca Pais, Bertrand Cariou, Mazen Noureddin, Sven Francque, Jörn M Schattenberg, Manal F Abdelmalek, Gadi Lalazar, Sharat Varma, Julie Dietrich, Veronica Miller, Aru...> ;Journal of Hepatology. 2023 Sep 1
64 citations
Semaglutide 2·4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial.
Rohit Loomba, Manal F Abdelmalek, Matthew J Armstrong, Maximilian Jara, Mette Skalshøi Kjær, Niels Krarup, Eric Lawitz, Vlad Ratziu, Arun J Sanyal, Jörn M Schattenberg...> ;The Lancet. Gastroenterology & Hepatology. 2023 Jun 1
8 citations
The use of current knowledge and non-invasive testing modalities for predicting at-risk non-alcoholic steatohepatitis and assessing fibrosis.
Marcelo Kugelmas, Mazen Noureddin, Nadege Gunn, Kimberly Brown, Zobair Younossi, Manal Abdelmalek, Naim Alkhouri> ;Liver International. 2023 May 1
2 citations
MRI Quantification of Placebo Effect in Nonalcoholic Steatohepatitis Clinical Trials.
Marybeth A Nedrud, Michael S Middleton, Cynthia A Moylan, Reginald Lerebours, Sheng Luo, Alfredo Farjat, Cynthia Guy, Rohit Loomba, Manal F Abdelmalek, Claude B Sirlin...> ;Radiology. 2023 Mar 1
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Journal Articles

The Lancet Child & Adolescent Health
Arun Sanyal, Stephen A Harrison, Edgar D Charles, Stephanie Noviello, Manal F Abdelmalek, Eric J Lawitz, Rohit Loomba, The Lancet

Press Mentions

5 Surprising Things to Know About Fatty Liver DiseaseMay 6th, 2022
Global Liver Institute’s International NASH Day 2021 Attracts Broad SupportJune 18th, 2021
Inventiva Achieves a Major Milestone by Completing Patient Recruitment for Its Phase IIb Clinical Study with Lanifibranor in NASHSeptember 4th, 2019
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Grant Support

Impact Of Fructose On Metabolism, Energy Homeostasis And MR Biomarkers In NafldNational Institute Of Diabetes And Digestive And Kidney Diseases2012
Hyperinsulinemia And Insulin Resistance In Fatty LiverNational Institute Of Diabetes And Digestive And Kidney Diseases2006–2009
Insulin Resistance In Nonalcoholic Fatty Liver Disease A Case Control StudyNational Center For Research Resources2006–2007
Trial Of Betaine In PTS With Nonalcoholic SteatohepatisNational Center For Research Resources2005–2007
Hyperinsulinemia And Insulin Resistance In Fatty LiverNational Institute Of Diabetes And Digestive And Kidney Diseases2005
Trial Of Betaine In PTS With Nonalcoholic SteatohepatitisNational Center For Research Resources2004