MarcNWeinMDPhD

Endocrinology • Boston, MA

Diabetes, Lipid Metabolism

Research Fellow in Medicine, Massachusetts General Hospital

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Office
Massachusetts General Hospital
55 Fruit St.
Boston, MA 02114
Phone+1 617-726-2862

Fax+1 617-724-7441
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Education & Training

Massachusetts General HospitalFellowship, Endocrinology, Diabetes, and Metabolism, 2011 - 2014
Massachusetts General HospitalResidency, Internal Medicine, 2009 - 2011
Harvard Medical SchoolClass of 2009

Certifications & Licensure

MA State Medical License 2011 - 2024

Publications & Presentations

PubMed

A homozygousmutation causes osteogenesis and dentinogenesis imperfecta with craniofacial anomalies.
Dalal A Al-Mutairi, Ali A Jarragh, Basel H Alsabah, Wasif Mohammed, Lateefa Alkharafi, Marc N Wein> ;JBMR Plus. 2024 May 1
Blood and bones: Mechanical cues and Hippo signaling drive vascular invasion during limb formation.
Wein, M.> ;Developmental Cell. 2024 Jan 22
The performance of artificial intelligence chatbot large language models to address skeletal biology and bone health queries.
Michelle Cung, Branden Sosa, He S Yang, Michelle M McDonald, Brya G Matthews, Annegreet G Vlug, Erik A Imel, Marc N Wein, Emily Margaret Stein, Matthew B Greenblatt> ;Journal of Bone and Mineral Research. 2024 Jan 4
Selective reduction of visceral adipose tissue with injectable ice slurry.
Sara Moradi Tuchayi, Yeva Khachatryan, Ying Wang, R Rox Anderson, Jialiang S Wang, Marc N Wein, Lilit Garibyan> ;Scientific Reports. 2023 Sep 28
4 citations
SP7: from Bone Development to Skeletal Disease.
Jialiang S Wang, Nicha Tokavanich, Marc N Wein> ;Current Osteoporosis Reports. 2023 Apr 1
6 citations
A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis.
Sung-Hee Yoon, Mark B Meyer, Carlos Arevalo, Murat Tekguc, Chengcheng Zhang, Jialiang S Wang, Christian D Castro Andrade, Katelyn Strauss, Tadatoshi Sato, Nancy A Benk...> ;The Journal of Clinical Investigation. 2023 May 1
17 citations
Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis.
Wen Zhou, Petra Simic, Iris Y Zhou, Peter Caravan, Xavier Vela Parada, Donghai Wen, Onica L Washington, Maria Shvedova, Kerry A Pierce, Clary B Clish, Michael Mannstad...> ;The Journal of Clinical Investigation. 2023 Apr 17
2 citations
Supporting Our Physician Parents (SOPPort): A pilot program for parental wellness at the Massachusetts General Hospital.
Li, J., Hanley, L., Powe, C., Seiglie, J., Haines, M., Wein, M., Bregar, A., Miller, K., Dichtel, L.> ;Journal of Clinical and Translational Science. 2023 Jan 1
12 citations
Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice.
Tadatoshi Sato, Christian D Castro Andrade, Sung-Hee Yoon, Yingshe Zhao, William J Greenlee, Patricia C Weber, Usha Viswanathan, John Kulp, Daniel J Brooks, Marie B De...> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Dec 13
7 citations
Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules.
Mark B Meyer, Nancy A Benkusky, Seong Min Lee, Sung-Hee Yoon, Michael Mannstadt, Marc N Wein, J Wesley Pike> ;The Journal of Biological Chemistry. 2022 Nov 1
3 citations
Partial prevention of glucocorticoid-induced osteocyte deterioration in young male mice with osteocrin gene therapy.
Courtney M Mazur, Christian D Castro Andrade, Nicha Tokavanich, Tadatoshi Sato, Michael Bruce, Daniel J Brooks, Mary L Bouxsein, Jialiang S Wang, Marc N Wein> ;Iscience. 2022 Sep 16
3 citations
Pathways Controlling Formation and Maintenance of the Osteocyte Dendrite Network.
Jialiang S Wang, Marc N Wein> ;Current Osteoporosis Reports. 2022 Dec 1
2 citations
Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice.
Eileen J Daley, Sung-Hee Yoon, Monica Reyes, Michael Bruce, Daniel J Brooks, Mary Bouxsein, John T Potts, Henry M Kronenberg, Marc N Wein, Beate Lanske, Harald Jüppner...> ;Endocrinology. 2022 Jul 1
Salt inducible kinases and PTH1R action.
Sung-Hee Yoon, Cheng-Chia Tang, Marc N Wein> ;Vitamins and Hormones. 2022 Jan 1
52 citations
Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis.
Peter Geon Kim, Abhishek Niroula, Veronica Shkolnik, Marie McConkey, Amy E. Lin, Mikolaj Slabicki, John P. Kemp, Alexander G. Bick, Christopher J. Gibson, Gabriel K. G...> ;The Journal of Experimental Medicine. 2021 Dec 6
40 citations
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.
Jialiang S. Wang, Tushar Kamath, Courtney M. Mazur, Fatemeh Mirzamohammadi, Daniel Rotter, Hironori Hojo, Christian D. Castro, Nicha Tokavanich, Rushi Patel, Nicolas G...> ;Nature Communications. 2021 Nov 1
7 citations
Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
Cheng-Chia Tang, Christian D. Castro Andrade, Maureen J O'Meara, Sung-Hee Yoon, Tadatoshi Sato, Daniel J. Brooks, Mary L. Bouxsein, Janaina S. Martins, Jinhua Wang, Na...> ;Elife. 2021 Jun 23
9 citations
Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long-Acting PTH.
Tadatoshi Sato, Shiv K. Verma, Ashok Khatri, Thomas Dean, Olga Göransson, Thomas J. Gardella, Marc N. Wein> ;JBMR Plus. 2021 May 1
44 citations
Sclerostin and Osteocalcin: Candidate Bone-Produced Hormones.
Jialiang S. Wang, Courtney M. Mazur, Marc N. Wein> ;Frontiers in Endocrinology. 2021 Mar 10
9 citations
Role of histone deacetylases in bone development and skeletal disorders.
Jialiang S. Wang, Sung-Hee Yoon, Marc N. Wein> ;Bone. 2021 Feb 1
9 citations
PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate
Shigeki Nishimori, Marc N. Wein, Henry M. Kronenberg> ;Bone. 2021 Jan 1
9 citations
The Role of Wnt Signaling in Postnatal Tooth Root Development.
Nicha Tokavanich, Marc N Wein, Jeryl D English, Noriaki Ono, Wanida Ono> ;Frontiers in Dental Medicine. 2021 Jan 1
49 citations
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction.
Tadatoshi Sato, Shiv K. Verma, Christian D. Castro Andrade, Maureen J O'Meara, Nia Campbell, Jialiang S. Wang, Murat Cetinbas, Audrey Lang, Brandon J. Ausk, Daniel J. ...> ;Nature Communications. 2020 Jul 1
62 citations
Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney.
Petra Simic, Wondong Kim, Wen Zhou, Kerry A. Pierce, Wenhan Chang, David B. Sykes, Najihah Aziz, Sammy Elmariah, Debby Ngo, Paola Divieti Pajevic, Nicolas Govea, Bryan...> ;The Journal of Clinical Investigation. 2020 Mar 2
18 citations
Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling
Shigeki Nishimori, Maureen J O'Meara, Christian D. Castro, Hiroshi Noda, Murat Cetinbas, Janaina S. Martins, Ugur M. Ayturk, Daniel J. Brooks, Michael Bruce, Mizuki Na...> ;The Journal of Clinical Investigation. 2019 Dec 2
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Journal Articles

The Great Opportunity: Cultivating Scientific Inquiry in Medical Residency
Marc N Wein, Michael K Mansour, Jatin M Vyas, Jayaraj Rajagopal, Mark C Fishman, Kathleen E Corey, Caroline L Sokol, Katrina A Armstrong, The Journal of Infectious Diseases

Press Mentions

Dr. Marc Wein: Extra Attention Should Be Paid to Fracture Risk in COPD Patients Receiving High-Dose Inhaled CorticosteroidsNovember 16th, 2020
SMURF2 Regulates Bone Homeostasis by Disrupting SMAD3 Interaction with Vitamin D Receptor in OsteoblastsFebruary 20th, 2017
Signaling Pathway Could Be Key to Improved Osteoporosis TreatmentOctober 19th, 2016