MargaretLippincottMD

Endocrinology • Boston, MA

Diabetes, Lipid Metabolism

Physician

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Office
55 Fruit St
Bartlett Ext 5th Floor
Boston, MA 02114
Phone+1 617-726-8434

Fax+1 617-726-5357
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Education & Training

Massachusetts General HospitalFellowship, Endocrinology, Diabetes, and Metabolism, 2012
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 2007 - 2010
Duke University School of MedicineClass of 2007

Certifications & Licensure

MA State Medical License 2010 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Clinical Trials

Kisspeptin Administration in the Adult Start of enrollment: 2009 Jun 23
Recruiting
Phase 1
Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling Start of enrollment: 2011 Sep 01
Completed
Phase 1
Kisspeptin Influence on Glucose Homeostasis Start of enrollment: 2017 Jul 18
Recruiting
Phase 1
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance Start of enrollment: 2019 Sep 01
Recruiting
Phase 1
Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism Start of enrollment: 2021 Jan 20
Recruiting
Phase 2
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance Test Start of enrollment: 2021 Oct 28
Recruiting
Phase 1
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Publications & Presentations

PubMed

Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum.
Samvida S Venkatesh, Laura B L Wittemans, Duncan S Palmer, Nikolas A Baya, Teresa Ferreira, Barney Hill, Frederik Heymann Lassen, Melody J Parker, Saskia Reibe, Ahmed ...> ;Medrxiv. 2024 Mar 20
How human genetic context can inform pathogenicity classification: FGFR1 variation in idiopathic hypogonadotropic hypogonadism.
Wanxue Xu, Lacey Plummer, Stephanie B Seminara, Ravikumar Balasubramanian, Margaret F Lippincott> ;Human Genetics. 2023 Nov 1
1 citations
The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, a...
Margaret F Lippincott, Wanxue Xu, Abigail A Smith, Xinyu Miao, Agathe Lafont, Omar Shennib, Gordon J Farley, Riwa Sabbagh, Angela Delaney, Maria Stamou, Lacey Plummer,...> ;Genetics in Medicine. 2022 Dec 1
10 citations
Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans.
Katerina Hoskova, Nora Kayton Bryant, Margaret E Chen, Lisa B Nachtigall, Margaret F Lippincott, Ravikumar Balasubramanian, Stephanie B Seminara> ;The Journal of Clinical Endocrinology and Metabolism. 2022 Jul 14
5 citations
Prevalence and Phenotypic Effects of Copy Number Variants in Isolated Hypogonadotropic Hypogonadism.
Maria I Stamou, Harrison Brand, Mei Wang, Isaac Wong, Margaret F Lippincott, Lacey Plummer, William F Crowley, Michael Talkowski, Stephanie Seminara, Ravikumar Balasub...> ;The Journal of Clinical Endocrinology and Metabolism. 2022 Jul 14
38 citations
The genetic architecture of sporadic and multiple consecutive miscarriage.
Triin Laisk, Ana Luiza Gonçalves Soares, Teresa Ferreira, Jodie N. Painter, Jenny C Censin, Samantha Laber, Jonas Bacelis, Chia-Yen Chen, Maarja Lepamets, Kuang Lin, S...> ;Nature Communications. 2020 Nov 25
15 citations
Evaluating co‐created patient‐facing materials to increase understanding of genetic test results
Andrew A. Dwyer, Margaret G. Au, Neil Smith, Lacey Plummer, Margaret F. Lippincott, Ravikumar Balasubramanian, Stephanie B. Seminara> ;Journal of Genetic Counseling. 2021 Apr 1
18 citations
Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay
Yee-Ming Chan, Margaret F. Lippincott, Priscila Sales Barroso, Cielo Alleyn, Jill L. Brodsky, Hector Granados, Stephanie A. Roberts, Courtney Sandler, Abhinash Srivats...> ;The Journal of Clinical Endocrinology and Metabolism. 2020 Aug 1
1 citations
Polycystic ovary syndrome in patients with hair thinning.
Sonya Prasad, Brianna De Souza, Laura J. Burns, Margaret F. Lippincott, Maryanne M. Senna> ;Journal of the American Academy of Dermatology. 2020 Jul 1
22 citations
Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling
Margaret F. Lippincott, S. Leon, Yee-Ming Chan, Chrysanthi Fergani, Rajae Talbi, I. S. Farooqi, Christopher M. Jones, Wiebke Arlt, Susan E. Stewart, Trevor Cole, E. Te...> ;The Journal of Clinical Endocrinology and Metabolism. 2019 Oct 1
16 citations
Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length.
Triin Laisk, Viktorija Kukuškina, Duncan S. Palmer, Samantha Laber, Chen C-Y., Teresa Ferreira, Nilufer Rahmioglu, Krina T. Zondervan, Christian M. Becker, Jordan W. S...> ;Human Molecular Genetics. 2018 Dec 15
1 citations
Assessing Sex Steroid Influence on Kisspeptin Responsiveness in Idiopathic Hypogonadotropic Hypogonadism
Margaret F. Lippincott, Kiana Nguyen, Angela Delaney, Yee-Ming Chan, Stephanie B. Seminara> ;Journal of the Endocrine Society. 2018 Sep 20
96 citations
Burden Testing of Rare Variants Identified through Exome Sequencing via Publicly Available Control Data
Michael H. Guo, Lacey Plummer, Yee-Ming Chan, Joel N. Hirschhorn, Margaret F. Lippincott> ;American Journal of Human Genetics. 2018 Oct 4
13 citations
Divergent responses to kisspeptin in children with delayed puberty.
Yee-Ming Chan, Margaret F. Lippincott, Temitope O. Kusa, Stephanie B. Seminara> ;JCI Insight. 2018 Apr 19
7 citations
Discordance in the Dependence on Kisspeptin Signaling in Mini Puberty vs Adolescent Puberty: Human Genetic Evidence.
Muhammad Shahab, Margaret F. Lippincott, Yee-Ming Chan, Addie Davies, Paulina M. Merino, Lacey Plummer, Verónica Mericq, Stephanie B. Seminara> ;The Journal of Clinical Endocrinology and Metabolism. 2018 Apr 1
6 citations
Continuous Kisspeptin Administration in Postmenopausal Women: Impact of Estradiol on Luteinizing Hormone Secretion.
Margaret F. Lippincott, Yee-Ming Chan, Dianali Rivera Morales, Stephanie B. Seminara> ;The Journal of Clinical Endocrinology and Metabolism. 2017 Jun 1
13 citations
Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome.
Natalie D Shaw, Harrison Brand, Zachary A Kupchinsky, Hemant Bengani, Lacey Plummer, Takako I Jones, Serkan Erdin, Kathleen A Williamson, Joe Rainger, Alexei Stortchev...> ;Nature Genetics. 2017 May 26
32 citations
Phenotypic spectrum of POLR3B mutations: isolated hypogonadotropic hypogonadism without neurological or dental anomalies
Mary R Richards, Lacey Plummer, Yee-Ming Chan, Margaret F. Lippincott, Richard Quinton, Philip Kumanov, Stephanie B. Seminara> ;Journal of Medical Genetics. 2017 Jan 1
32 citations
SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome.
Natalie D Shaw, Harrison Brand, Zachary A Kupchinsky, Hemant Bengani, Lacey Plummer, Takako I Jones, Serkan Erdin, Kathleen A Williamson, Joe Rainger, Alexei Stortchev...> ;Nature Genetics. 2017 Feb 1
29 citations
Determinants of Power in Gene-Based Burden Testing for Monogenic Disorders
Michael H. Guo, Andrew Dauber, Margaret F. Lippincott, Yee-Ming Chan, Rany M. Salem, Joel N. Hirschhorn> ;American Journal of Human Genetics. 2016 Sep 1
18 citations
Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty.
Margaret F. Lippincott, Yee-Ming Chan, Angela Delaney, Dianali Rivera-Morales, James P. Butler, Stephanie B. Seminara> ;The Journal of Clinical Endocrinology and Metabolism. 2016 May 23
20 citations
Exogenous kisspeptin administration as a probe of GnRH neuronal function in patients with idiopathic hypogonadotropic hypogonadism.
Yee-Ming Chan, Margaret F. Lippincott, James P. Butler, Valerie F. Sidhoum, Cindy X. Li, Lacey Plummer, Stephanie B. Seminara> ;The Journal of Clinical Endocrinology and Metabolism. 2014 Sep 16
103 citations
Reversal and relapse of hypogonadotropic hypogonadism: resilience and fragility of the reproductive neuroendocrine system.
Valerie F. Sidhoum, Yee-Ming Chan, Margaret F. Lippincott, Ravikumar Balasubramanian, Richard Quinton, Lacey Plummer, Andrew A. Dwyer, Nelly Pitteloud, Frances J. Haye...> ;The Journal of Clinical Endocrinology and Metabolism. 2014 Mar 1
8 citations
Use of genetic models of idiopathic hypogonadotrophic hypogonadism in mice and men to understand the mechanisms of disease
Margaret F. Lippincott, Cadence True, Stephanie B. Seminara> ;Experimental Physiology. 2013 Nov 1
75 citations
Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae
Ryuichi Nishihama, Jennifer H. Schreiter, Masayuki Onishi, Elizabeth A. Vallen, Julia Hanna, Katarina Moravcevic, Margaret F. Lippincott, Haesun Han, Mark A. Lemmon, J...> ;The Journal of Cell Biology. 2009 Jun 15
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