MargaretLMacmillanMDMSc, FRCPC

Pediatric Hematology & Oncology • Minneapolis, MN

Pediatric Hematologic Oncology

Professor of Pediatrics, Director, Blood and Marrow Transplantation & Cellular Therapy Program University of Minnesota Medical School

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Office
MMC 484
420 Delaware St SE
Minneapolis, MN 55455
Phone+1 612-626-2961
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Education & Training

University of Toronto Faculty of MedicineClass of 1991

Certifications & Licensure

MN State Medical License 1999 - 2025

Clinical Trials

Stem Cell Transplantation for Fanconi Anemia Start of enrollment: 2004 Mar 01
Terminated
Phase 1, Phase 2
Stem Cell Transplant for Juvenile Myelomonocytic Leukemia (JMML) Start of enrollment: 1999 Nov 18
Completed
Phase 1, Phase 2
Stem Cell Transplantation for Hematological Malignancies Start of enrollment: 2000 Jun 07
Terminated
Phase 2, Phase 3
Hematopoietic Stem Cell Transplantation in High Risk Patients With Fanconi Anemia Start of enrollment: 2002 Mar 26
Completed
Phase 2
TBI Dose De-escalation for Fanconi Anemia Start of enrollment: 2006 May 18
Completed
Phase 2, Phase 3
HSCT for High Risk Inherited Inborn Errors Start of enrollment: 2006 Sep 01
Completed
Phase 2
Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402) Start of enrollment: 2006 Nov 01
Completed
Phase 3
T-Regulatory Cell Infusion Post Umbilical Cord Blood Transplant in Patients With Advanced Hematologic Cancer Start of enrollment: 2007 Jul 23
Completed
Phase 1
Cytosine Arabinoside and Mitoxantrone for Patients With Juvenile Myelomonocytic Leukemia Receiving Repeat Stem Cell Transplantation Start of enrollment: 1999 Jun 01
Terminated
Phase 1, Phase 2
Cytoxan, Fludara, and Antithymocyte Globulin Conditioning Followed By Stem Cell Transplant in Treating Fanconi Anemia Start of enrollment: 2000 Feb 17
Completed
Phase 1, Phase 2
Donor T Cells in Treating Patients With High-Risk Hematologic Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant Start of enrollment: 2008 Jun 01
Terminated
Phase 1
Inducible Regulatory T Cells (iTregs) in Non-Myeloablative Sibling Donor Peripheral Blood Stem Cell Transplantation Start of enrollment: 2013 Nov 08
Completed
Phase 1
Busulfan and Cyclophosphamide Followed By ALLO BMT Start of enrollment: 2013 Jan 01
Terminated
Not Applicable
Pediatric cGVHD Symptom Scale Start of enrollment: 2019 Oct 02
Recruiting
Roles: Contact
MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies Start of enrollment: 2023 May 11
Recruiting
Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Liquid Chromatography-Mass Spectrometry Screening of Cyclophosphamide DNA Damage In Vitro and in Patients Undergoing Chemotherapy Treatment.
Valeria Guidolin, Foster C Jacobs, Margaret L MacMillan, Peter W Villalta, Silvia Balbo> ;Chemical Research in Toxicology. 2023 Aug 21
3 citations
Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy.
Valeria Guidolin, Yupeng Li, Foster C Jacobs, Margaret L MacMillan, Peter W Villalta, Stephen S Hecht, Silvia Balbo> ;Molecular Therapy Oncolytics. 2023 Mar 16
5 citations
Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality.
Shernan G Holtan, Constanza Savid-Frontera, Kelly Walton, Anne A Eaton, Connor Demorest, Andrea Hoeschen, Ling Zhang, Kayla Reid, Tony Kurian, Zena Sayegh, Estefania J...> ;Clinical Cancer Research. 2023 Mar 14
2 citations
High cutaneous amphiregulin expression predicts fatal acute graft-versus-host disease.
Brittney Schultz, Daniel D Miller, Todd DeFor, Bruce R Blazar, Angela Panoskaltsis-Mortari, Brian C Betts, Margaret L MacMillan, Daniel J Weisdorf, Shernan G Holtan> ;Journal of Cutaneous Pathology. 2022 Jun 1
1 citations
Lessons learned from early closure of a clinical trial for steroid-refractory acute GVHD.
Gabrielle Meyers, Mehdi Hamadani, Michael Martens, Haris Ali, Hannah Choe, Peter Dawson, Andrew C. Harris, Eric van Hooren, Willem Klaassen, Eric S. Leifer, Margaret L...> ;Bone Marrow Transplantation. 2021 Nov 23
10 citations
Chronic Graft-versus-Host Disease, Nonrelapse Mortality, and Disease Relapse in Older versus Younger Adults Undergoing Matched Allogeneic Peripheral Blood Hematopoieti...
Vijaya Raj Bhatt, Tao Wang, Karen Chen, Carrie L. Kitko, Margaret L. MacMillan, Joseph A. Pidala, Monzr M. Al Malki, Sherif M. Badawy, Amer Beitinjaneh, Siddhartha Gan...> ;Transplantation and Cellular Therapy. 2021 Oct 9
Detection and treatment of cerebral toxoplasmosis in an aplastic pediatric post-allogeneic hematopoietic cell transplant patient: a case report.
Danielle Brewer, Margaret L. MacMillan, Mark R. Schleiss, Satja Issaranggoon Na Ayuthaya, Jo Anne H. Young, Christen L. Ebens> ;BMC Infectious Diseases. 2021 Sep 10
57 citations
Standardizing Definitions of Hematopoietic Recovery, Graft Rejection, Graft Failure, Poor Graft Function, and Donor Chimerism in Allogeneic Hematopoietic Cell Transpla...
Mohamed A. Kharfan-Dabaja, Ambuj Kumar, Ernesto Ayala, Mahmoud Aljurf, Taiga Nishihori, Rebecca A. Marsh, Lauri Burroughs, Navneet S. Majhail, A. Samer Al-Homsi, Zaid ...> ;Transplantation and Cellular Therapy. 2021 Aug 1
5 citations
Late-onset Acute and Chronic Graft-Versus-Host Disease in Children: Clinical features and Response to Therapy.
Takuto Takahashi, Mukta Arora, Grigori Okoev, Todd E. DeFor, Daniel J. Weisdorf, Margaret L. MacMillan> ;Transplantation and Cellular Therapy. 2021 Aug 1
6 citations
A Review of Infections After Hematopoietic Cell Transplantation Requiring PICU Care: Transplant Timeline Is Key.
Asmaa Ferdjallah, Jo Anne H. Young, Margaret L. MacMillan> ;Frontiers in Pediatrics. 2021 Jul 27
7 citations
Guidelines for the Prevention and Management of Graft-versus-Host Disease after Cord Blood Transplantation.
Doris M. Ponce, Ioannis Politikos, Amin M. Alousi, Paul A. Carpenter, Filippo Milano, Margaret L. MacMillan, Juliet N. Barker, Mitchell E. Horwitz> ;Transplantation and Cellular Therapy. 2021 Jul 1
5 citations
High incidence of thromboembolism in patients with chronic GVHD: association with severity of GVHD and donor-recipient ABO blood group.
, , , , , , , , , , , , , , , , , , , , , , > ;Blood Cancer Journal. 2021 May 18
5 citations
Multiply restimulated human thymic regulatory T cells express distinct signature regulatory T-cell transcription factors without evidence of exhaustion.
Keli L. Hippen, Scott N. Furlan, Rahul Roychoudhuri, Ena Wang, Yigang Zhang, Mark J. Osborn, Sarah C. Merkel, Sophia Hani, Margaret L. MacMillan, Frank Cichocki, Jeffr...> ;Cytotherapy. 2021 Apr 20
32 citations
First-in-human phase 1 trial of induced regulatory T cells for graft-versus-host disease prophylaxis in HLA-matched siblings.
Margaret L. MacMillan, Keli L. Hippen, David H. McKenna, Diane Kadidlo, Darin Sumstad, Todd E. DeFor, Claudio G. Brunstein, Shernan G. Holtan, Jeffrey S. Miller, Erica...> ;Blood Advances. 2021 Mar 9
14 citations
Steroid-dependent acute GVHD after allogeneic hematopoietic cell transplantation: risk factors and clinical outcomes.
Najla El Jurdi, Ahmad Rayes, Margaret L. MacMillan, Shernan G. Holtan, Todd E. DeFor, Judith Witte, Mukta Arora, Jo Anne H. Young, Daniel J. Weisdorf> ;Blood Advances. 2021 Mar 9
4 citations
Low 5-year health care burden after umbilical cord blood transplantation.
Jesus Garcia Garcia, Sonya Grillo, Qing Cao, Claudio G. Brunstein, Mukta Arora, Margaret L. MacMillan, John E. Wagner, Daniel J. Weisdorf, Shernan G. Holtan> ;Blood Advances. 2021 Feb 9
Weight-based mycophenolate mofetil dosing predicts acute GVHD and relapse after allogeneic hematopoietic cell transplantation
Nelli Bejanyan, John Rogosheske, Qing Cao, Aleksandr Lazaryan, Shernan G. Holtan, Celalettin Ustun, Pamala A. Jacobson, Margaret L. MacMillan, Daniel J. Weisdorf, John...> ;European Journal of Haematology. 2021 Feb 1
9 citations
Broad-Spectrum Antibiotics and Risk of Graft-versus-Host Disease in Pediatric Patients Undergoing Transplantation for Acute Leukemia: Association of Carbapenem Use wit...
Caitlin W Elgarten, Yimei Li, Kelly D. Getz, Michael T. Hemmer, Yuan-Shung Huang, Matthew Hall, Tao Wang, Carrie L. Kitko, Madan Jagasia, Taiga Nishihori, Hemant S. Mu...> ;Transplantation and Cellular Therapy. 2021 Feb 1
6 citations
Outcomes of chronic graft-versus-host disease following matched sibling donor versus umbilical cord blood transplant.
Grigori Okoev, Daniel J. Weisdorf, John E. Wagner, Bruce R. Blazar, Margaret L. MacMillan, Todd E. DeFor, Aleksandr Lazaryan, Najla El Jurdi, Shernan G. Holtan, Claudi...> ;Bone Marrow Transplantation. 2021 Jan 8
18 citations
Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia.
Anna Hecht, Julia Meyer, Astrid Behnert, Eric Wong, Farid F. Chehab, Adam B. Olshen, Aaron Hechmer, Catherine Aftandilian, Rukhmi Bhat, Sung Won Choi, Satheesh Chonat,...> ;Haematologica. 2020 Dec 30
3 citations
Shotgun sequencing of the faecal microbiome to predict response to steroids in patients with lower gastrointestinal acute graft-versus-host disease: An exploratory ana...
Gavin Turner, Madeline Smith, Andrea Hoeschen, Jessica A Wilson, Jessica Kennedy, Max Abramson, Qing Cao, Najla El Jurdi, Margaret L. MacMillan, Daniel J. Weisdorf, Br...> ;British Journal of Haematology. 2021 Feb 1
16 citations
Hematopoietic Stem Cell Transplantation for Shwachman-Diamond Syndrome.
Kasiani C. Myers, Kyle Hebert, Joseph H. Antin, Farid Boulad, Lauri Burroughs, Inga Hofmann, Rammurti T. Kamble, Margaret L. MacMillan, Mary Eapen> ;Biology of Blood and Marrow Transplantation. 2020 Aug 1
13 citations
Comparison of total body irradiation versus non- total body irradiation containing regimens for de novo acute myeloid leukemia in children
Christopher E. Dandoy, Stella M. Davies, Kwang Woo Ahn, Yizeng He, Anders Kolb, John E. Levine, Stephanie Bo-Subait, Hisham Abdel-Azim, Neel S. Bhatt, Joseph Chewing, ...> ;Haematologica. 2020 Jun 18
18 citations
Facilitating resolution of life-threatening acute GVHD with human chorionic gonadotropin and epidermal growth factor
Shernan G. Holtan, Andrea Hoeschen, Qing Cao, Mukta Arora, Veronika Bachanova, Claudio G. Brunstein, Jeffrey S. Miller, Armin Rashidi, Arne Slungaard, Celalettin Ustun...> ;Blood Advances. 2020 Apr 14
2 citations
Follistatin and Soluble Endoglin Predict 1-Year Nonrelapse Mortality after Allogeneic Hematopoietic Cell Transplantation.
Laura F. Newell, Todd E. DeFor, Corey Cutler, Michael R. Verneris, Bruce R. Blazar, Jeffrey S. Miller, Joseph H. Antin, Alan Howard, Juan Wu, Margaret L. MacMillan, An...> ;Biology of Blood and Marrow Transplantation. 2020 Mar 1
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Journal Articles

Amphiregulin in Intestinal Acute Graft-Versus-Host Disease: A Possible Diagnostic and Prognostic Aid
Brittney Schultz, Bruce R Blazar, Daniel J Weisdorf, Shernan G Holtan, Alexander Khoruts, Armin Rashidi, Margaret L MacMillan, Khalid Amin, Byron P Vaughn, Nature
Upper Gastrointestinal Acute Graft-Versus-Host Disease Adds Minimal Prognostic Value in Isolation or with Other Graft-Versus-Host Disease Symptoms as Currently Diagnos...
Margaret MacMillan, Sophie Paczesny, Ran Reshef, Daniel Weisdorf, Haematologica
Diffuse Alveolar Hemorrhage Is Most Often Fatal and Is Affected by Graft Source, Conditioning Regiment Toxicity, and Engraftment Kinetics
Erhan H Dincer, Erica D Warlick, Margaret L MacMillan, Patrick Arndt, Daniel J Weisdorf, Nelli Bejanyan, Claudio G Brunstein, Celalettin Ustun, Aleksandr Lazaryan, Ver..., Haematologica

Abstracts/Posters

Pre-Transplant Serum Claudin-3 Predicts Intestinal Graft-Versus-Host Disease and Non-Relapse Mortality Risk after Allogeneic Hematopoietic Cell Transplantation
Margaret L. MacMillan, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Outcomes of Chronic Graft-Versus-Host Disease (cGVHD) Following Matched Sibling Donor (MSD) Versus Umbilical Cord Blood Transplant (UCBT)
Margaret L. MacMillan, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Lectures

Adult and Pediatric BMT
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Facilitating Resolution of Life-Threatening Acute Graft-Versus-Host Disease By Supplementation of Human Chorionic Gonadotropin and Epidermal Growth Factor (Pregnyl): A...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Validation of Minnesota Acute Gvhd Risk Score and Identification of New Factors Associated with Initial Response to Steroids: Not All Gvhd Is Created Equal
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Hospital Affiliations

M Health Fairview University of Minnesota Medical CenterMinneapolis, Minnesota
M Health Fairview Masonic Children’s HospitalMinneapolis, Minnesota