MarkABrockmanMD

PubMed

• Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes.
  Naidoo, L.,Mzobe, Z.,Jin, S. W.,Rajkoomar, E.,Reddy, T.,Brockman, M. A.,Brumme, Z. L.,Ndung'u, T.,Mann, J. K.> ;Virology. 2019 Mar 31
• Modulation of TCR-dependent NFAT signaling is impaired in HIV-1 Nef isolates from elite controllers.
  Jin, S. W.,Markle, T. J.,Anmole, G.,Rahimi, A.,Kuang, X. T.,Brumme, Z. L.,Brockman, M. A.> ;Virology. 2019 Feb 20
• Inhibition of NF-κB-Dependent HIV-1 Replication by the Marine Natural Product Bengamide A
  Mark Brockman, MD> ;Antiviral Research. 2018 Feb 25
• In vitro functional assessment of natural HIV-1 group M Vpu sequences using a universal priming approach.
  Rahimi A, Anmole G, Soto-Nava M, Escamilla-Gomez T, Markle T, Jin SW, Lee GQ, Harrigan PR, Bangsberg DR, Martin J, Avila-Rios S, Reyes-Teran G, Brockman MA, Brumme ZL> ;J. Virol. Methods. 2017-02-01
• Novel Acylguanidine-Based Inhibitor of HIV-1.
  Mwimanzi P, Tietjen I, Miller SC, Shahid A, Cobarrubias K, Kinloch NN, Baraki B, Richard J, Finzi A, Fedida D, Brumme ZL, Brockman MA> ;J. Virol.. 2016-10-15
• Diagnostic Accuracy of the HemoCue Hb 301, STAT-Site MHgb and URIT-12 Point-of-Care Hemoglobin Meters in a Central Laboratory and a Community Based Clinic in Durban, S...
  Jaggernath M, Naicker R, Madurai S, Brockman MA, Ndung'u T, Gelderblom HC> ;PLoS ONE. 2016-01-01
• Nef Proteins from HIV-1 Elite Controllers Are Inefficient at Preventing Antibody-Dependent Cellular Cytotoxicity.
  Alsahafi N, Ding S, Richard J, Markle T, Brassard N, Walker B, Lewis GK, Kaufmann DE, Brockman MA, Finzi A> ;J. Virol.. 2015-12-30
• A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion.
  Anmole, G.,Kuang, X. T.,Toyoda, M.,Martin, E.,Shahid, A.,Le, A. Q.,Markle, T.,Baraki, B.,Jones, R. B.,Ostrowski, M. A.,Ueno, T.,Brumme, Z. L.,Brockman, M. A.> ;J. Immunol. Methods. 2015 Sep 01
• Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function.
  Shahid, A.,Olvera, A.,Anmole, G.,Kuang, X. T.,Cotton, L. A.,Plana, M.,Brander, C.,Brockman, M. A.,Brumme, Z. L.> ;J. Virol.. 2015 Sep 12
• Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors.
  Toyoda M, Ogata Y, Mahiti M, Maeda Y, Kuang XT, Miura T, Jessen H, Walker BD, Brockman MA, Brumme ZL, Ueno T> ;J. Virol.. 2015-09-01
• Immune Screening Identifies Novel T Cell Targets Encoded by Antisense Reading Frames of HIV-1.
  Berger, C. T.,Llano, A.,Carlson, J. M.,Brumme, Z. L.,Brockman, M. A.,Cedeño, S.,Harrigan, P. R.,Kaufmann, D. E.,Heckerman, D.,Meyerhans, A.,Brander, C.> ;J. Virol.. 2015 Jan 16
• Knowledge of HIV serodiscordance, transmission, and prevention among couples in Durban, South Africa.
  Kilembe W, Wall KM, Mokgoro M, Mwaanga A, Dissen E, Kamusoko M, Phiri H, Sakulanda J, Davitte J, Reddy T, Brockman M, Ndung'u T, Allen S> ;PLoS ONE. 2015-01-01
• Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors.
  Tietjen I, Ntie-Kang F, Mwimanzi P, Onguéné PA, Scull MA, Idowu TO, Ogundaini AO, Meva'a LM, Abegaz BM, Rice CM, Andrae-Marobela K, Brockman MA, Brumme ZL, Fedida D> ;PLoS ONE. 2015-01-01
• Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence.
  Payne R, Muenchhoff M, Mann J, Roberts HE, Matthews P, Adland E, Hempenstall A, Huang K, Brockman M, Brumme Z, Sinclair M, Miura T, Frater J, Essex M, Shapiro R, Walke...> ;Proc. Natl. Acad. Sci. U.S.A.. 2014-12-16
• Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure.
  Mann JK, Chopera D, Omarjee S, Kuang XT, Le AQ, Anmole G, Danroth R, Mwimanzi P, Reddy T, Carlson J, Radebe M, Goulder PJR, Walker BD, Abdool Karim S, Novitsky V, Will...> ;Virology. 2014-11-01
• Impaired Nef function is associated with early control of HIV-1 viremia.
  Kuang, X. T.,Li, X.,Anmole, G.,Mwimanzi, P.,Shahid, A.,Le, A. Q.,Chong, L.,Qian, H.,Miura, T.,Markle, T.,Baraki, B.,Connick, E.,Daar, E. S.,Jessen, H.,Kelleher, A. D.,...> ;J. Virol.. 2014 Jun 27
• Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.
  Cotton, L. A.,Kuang, X. T.,Le, A. Q.,Carlson, J. M.,Chan, B.,Chopera, D. R.,Brumme, C. J.,Markle, T. J.,Martin, E.,Shahid, A.,Anmole, G.,Mwimanzi, P.,Nassab, P.,Penney...> ;PLoS Genet.. 2014 Apr 26
• Dynamic range of Nef functions in chronic HIV-1 infection.
  Mwimanzi P, Markle TJ, Ogata Y, Martin E, Tokunaga M, Mahiti M, Kuang XT, Walker BD, Brockman MA, Brumme ZL, Ueno T> ;Virology. 2013-05-10
• Significant reductions in Gag-protease-mediated HIV-1 replication capacity during the course of the epidemic in Japan.
  Nomura S, Hosoya N, Brumme ZL, Brockman MA, Kikuchi T, Koga M, Nakamura H, Koibuchi T, Fujii T, Carlson JM, Heckerman D, Kawana-Tachikawa A, Iwamoto A, Miura T> ;J. Virol.. 2013-02-01
• No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial.
  Chopera DR, Mann JK, Mwimanzi P, Omarjee S, Kuang XT, Ndabambi N, Goodier S, Martin E, Naranbhai V, Karim SA, Karim QA, Brumme ZL, Ndung'u T, Williamson C, Brockman MA> ;PLoS ONE. 2013-01-01
• Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.
  Carlson JM, Brumme CJ, Martin E, Listgarten J, Brockman MA, Le AQ, Chui CKS, Cotton LA, Knapp DJHF, Riddler SA, Haubrich R, Nelson G, Pfeifer N, Deziel CE, Heckerman D...> ;J. Virol.. 2012-12-01
• Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.
  Chopera DR, Cotton LA, Zawaira A, Mann JK, Ngandu NK, Ntale R, Carlson JM, Mlisana K, Woodman Z, de Assis Rosa D, Martin E, Miura T, Pereyra F, Walker BD, Gray CM, Mar...> ;J. Virol.. 2012-12-01
• TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
  Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, Pereyra ...> ;Nat. Immunol.. 2012-06-10
• Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity.
  Brockman MA, Chopera DR, Olvera A, Brumme CJ, Sela J, Markle TJ, Martin E, Carlson JM, Le AQ, McGovern R, Cheung PK, Kelleher AD, Jessen H, Markowitz M, Rosenberg E, F...> ;J. Virol.. 2012-06-01
• The impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity.
  Wright, J.K., Naidoo, V.L., Brumme, Z.L., Prince, J.L., Claiborne, D.T., Goulder, P.R., Brockman, M.A., Hunter, E., Ndung'u, T.> ;J Virol. 2012 Mar
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