Mark S George MD

Distinguished Professor of Psychiatry, Radiology and Neuroscience Layton McCurdy Endowed Chair Director, Brain Stimulation Laboratory at MUSC

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171 Ashley AveCharleston, SC 29425
Phone+1 843-792-1414

Education & Training

National Institutes of Health Clinical CenterResidency, Psychiatry, 1991 - 1993
Medical University of South CarolinaResidency, Psychiatry, 1985 - 1990
Medical University of South CarolinaClass of 1985

Certifications & Licensure

SC State Medical License 1986 - 2027
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013

Clinical Trials

Magnetic Brain Stimulation for the Treatment of Adult Depression Start of enrollment: 2005 Feb 01
Completed
Phase 2, Phase 3
Treatment-Resistant Depression Registry Start of enrollment: 2006 Jan 01
Completed
Transcranial Magnetic Stimulation (TMS) for Suicidal Ideation Start of enrollment: 2010 Oct 01
Unknown status
Phase 3
The Impact of Real-time Functional Magnetic Resonance Imaging (fMRI) Feedback on Response to Nicotine Cues Start of enrollment: 2010 Mar 01
Terminated
Safety and Efficacy Study of Deep Transcranial Magnetic Stimulation in Bipolar Depression Start of enrollment: 2012 May 01
Unknown status
Not Applicable
rTMS for Depressed Teens: A Sham-Controlled Trial, Part 1 Start of enrollment: 2013 Apr 01
Terminated
Not Applicable
rTMS for Depressed Teens: A Sham-Controlled Trial, Part 2 Start of enrollment: 2013 Mar 01
Terminated
Not Applicable
Evaluation of Deep Transcranial Magnetic Stimulation (DTMS) With the H-ADD Coil as an Aid to Smoking Cessation. Start of enrollment: 2014 Aug 20
Completed
Phase 3
A Safety & Efficacy Study With Deep Transcranial Magnetic Stimulation for the Treatment of Post-Traumatic Stress Disorder (PTSD) Start of enrollment: 2016 Nov 17
Terminated
Not Applicable
Focal Electrically-Administered Seizure Therapy (FEAST) Studies at Two Enrolling Sites to Further Test and Refine the Treatment Start of enrollment: 2015 Aug 01
Completed
Phase 2, Phase 3
Safety and Effectiveness of NeuroStar® Transcranial Magnetic Stimulation (TMS) Therapy in Depressed Adolescents
COMPLETED
NA
taVNS Paired With Bottle Feeding in Infants Failing Oral Feeds Start of enrollment: 2017 Oct 01
Completed
Early Phase 1
Individualizing tDCS Dose Start of enrollment: 2024 Dec 02
WITHDRAWN
NA
Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD) Start of enrollment: 2021 Jul 26
Recruiting
Not Applicable
Roles: Principal Investigator, Contact
tFUS Induced Transient Scotoma for Individual Dosing Start of enrollment: 2024 Jun 20
RECRUITING
NA
Roles: Principal Investigator, Contact
taVNS or TMS or Both for Depression Start of enrollment: 2023 Mar 14
RECRUITING
NA
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Salience Network Connectivity Predicts Response to Repetitive Transcranial Magnetic Stimulation in Smoking Cessation: A Preliminary Machine Learning Study.
Xingbao Li, Kevin A Caulfield, Andrew A Chen, Christopher S McMahan, Karen J Hartwell
Brain Connectivity. 2025-09-15
Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report.
Scott T Aaronson, Charles R Conway, Charles Gordon, Ying-Chieh Lisa Lee, Mark S George
The Journal of Clinical Psychiatry. 2025-07-14
Accelerated Prefrontal iTBS With Transauricular Vagus Nerve Stimulation for Functional Seizures and Depression: Case Report.
Charles Palmer, Noah Vieira, Elisabeth Collins, Morgan Dancy, Joseph Chasen
The Journal of Neuropsychiatry and Clinical Neurosciences. 2025-01-01

Lectures

American Psychiatric Association Publishing
American College of Physicians, Hilton Head Island, South Carolina - 10/11/2012
26th Annual Update: Disaster, Trauma & Recovery
Medical University of South Carolina Office of CME, Charleston, North Carolina - 5/30/2013

Press Mentions

3 Psychiatric Tools That Could Boost the Brain’s Natural HealingSeptember 4th, 2025
Quicker, More Intense Brain Stimulation Begun at MUSC Shows Success in DepressionAugust 19th, 2024
Electroconvulsive Therapy Works, Now Scientists Believe They Know HowAugust 7th, 2024
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Grant Support

The Impact Of Real-Time FMRI Feedback On Response To Nicotine CuesNational Institute On Drug Abuse2010–2011
Optimization Of TMS For Depression - Coordinating CenterNational Center For Research Resources2009–2010
The Impact Of Real-Time FMRI Feedback On Response To Nicotine CuesNational Institute On Drug Abuse2008–2009
Optimization Of TMS For Depression - Coordinating CenterNational Institute Of Mental Health2004–2009
Optimization Of TMS For DepressionNational Institute Of Mental Health2004–2009
MRI Study On Cerebral Activation During Specific Hand- And Finger-TasksNational Center For Research Resources2006–2008
Pilot Study Assessing The Effects Of Dar-0100 On Brain Activity In SchizophreniaNational Center For Research Resources2005
Efficacy/Safety Of Single Dose Of Ampakine (R) CX516National Center For Research Resources2004
Creating A Man-Portable Transcranial Magnetic Stimulation SystemNational Center For Research Resources2004
Mood Effects Of Deep Brain Stimulation In ParkinsonsNational Institute Of Neurological Disorders And Stroke2000–2002