MarkASagerMD

Geriatrics • Madison, WI

Professor, Medicine, University of Wisconsin Medical School

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Office
2880 University Ave
Madison, WI 53705
Phone+1 608-829-3300

Fax+1 608-829-3315
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Summary

Emeritus Professor of Medicine, University of Wisconsin School of Medicine, Madison, WI. Founder and former Director of the Wisconsin Alzheimer's Institute.

Education & Training

University of Wisconsin Hospitals and ClinicsFellowship, Geriatric Medicine (Internal Medicine), 1985 - 1987
University of MinnesotaResidency, Internal Medicine, 1972 - 1975
University of Michigan Medical SchoolClass of 1972

Certifications & Licensure

WI State Medical License 1975 - 2017

Publications & Presentations

PubMed

3 citations
Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer's Disease.
Julian M Gaitán, Sanjay Asthana, Cynthia M Carlsson, Corinne D Engelman, Sterling C Johnson, Mark A Sager, Dan Wang, Dena B Dubal, Ozioma C Okonkwo> ;Journal of Alzheimer's Disease. 2022 Jan 1
1 citations
AD-associated CSF biomolecular changes are attenuated in KL-VS heterozygotes.
Ira Driscoll, Yue Ma, Sarah R Lose, Catherine L Gallagher, Sterling C Johnson, Sanjay Asthana, Bruce P Hermann, Mark A Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M...> ;Alzheimer's & Dementia. 2022 Jan 1
Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease.
Clayton J Vesperman, Rui Wang, Stephanie A Schultz, Lena L Law, Ryan J Dougherty, Yue Ma, Jennifer M Oh, Dorothy F Edwards, Catherine L Gallagher, Nathaniel A Chin, Sa...> ;Alzheimer's & Dementia. 2022 Jan 1
17 citations
Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study.
Rui Wang, Jennifer M. Oh, Alice Motovylyak, Yue Ma, Mark A. Sager, Howard A. Rowley, Kevin M. Johnson, Catherine L. Gallagher, Cynthia M. Carlsson, Barbara B. Bendlin,...> ;Journal of Cerebral Blood Flow and Metabolism. 2021 Jun 8
11 citations
Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes.
Ira Driscoll, Yue Ma, Catherine L Gallagher, Sterling C Johnson, Sanjay Asthana, Bruce P Hermann, Mark A Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M Carlsson, Cor...> ;Journal of Alzheimer's Disease. 2021 Jan 1
1 citations
Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes.
Ira Driscoll, Yue Ma, Catherine L Gallagher, Sterling C Johnson, Sanjay Asthana, Bruce P Hermann, Mark A Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M Carlsson, Cor...> ;Journal of Alzheimer's Disease. 2021 Jan 1
2 citations
Cardiorespiratory Fitness Associates with Cerebral Vessel Pulsatility in a Cohort Enriched with Risk for Alzheimer's Disease.
Kaitlin M. Maxa, Carson Hoffman, Leonardo A. Rivera-Rivera, Alice Motovylyak, Patrick A. Turski, Carol Mitchell, Yue Ma, Sara E. Berman, Catherine L. Gallagher, Barbar...> ;Brain Plasticity. 2020 Oct 1
22 citations
Fitness, independent of physical activity is associated with cerebral blood flow in adults at risk for Alzheimer’s disease
Ryan J. Dougherty, Elizabeth A. Boots, Jacob B. Lindheimer, Aaron J. Stegner, Stephanie M. Van Riper, Dorothy F. Edwards, Catherine L. Gallagher, Cynthia M. Carlsson, ...> ;Brain Imaging and Behavior. 2020 Aug 1
32 citations
Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal ...
Alexa Pichet Binette, Etienne Vachon-Presseau, John C. Morris, Randall J. Bateman, Tammie L.S. Benzinger, D. Louis Collins, Judes Poirier, John C.S. Breitner, Sylvia V...> ;Biological Psychiatry. 2021 Apr 15
23 citations
Addressing Disparities in Alzheimer's Disease and African-American Participation in Research: An Asset-Based Community Development Approach.
Gina Green-Harris, Sheryl L. Coley, Rebecca L. Koscik, Nia Norris, Stephanie Houston, Mark A. Sager, Sterling C. Johnson, Dorothy F. Edwards> ;Frontiers in Aging Neuroscience. 2019 May 31
33 citations
KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD
Claire M. Erickson, Stephanie A. Schultz, Jennifer M. Oh, Burcu F. Darst, Yue Ma, Derek Norton, Tobey J. Betthauser, Catherine L. Gallagher, Cynthia M. Carlsson, Barba...> ;Neurology. 2019 Apr 16
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
Kunkle, B. W.,Grenier-Boley, B.,Sims, R.,Bis, J. C.,Damotte, V.,Naj, A. C.,Boland, A.,Vronskaya, M.,van der Lee, S. J.,Amlie-Wolf, A.,Bellenguez, C.,Frizatti, A.,Chour...> ;Nat. Genet.. 2019 Mar 02
21 citations
Social support and verbal interaction are differentially associated with cognitive function in midlife and older age
Megan Zuelsdorff, Rebecca L. Koscik, Ozioma C. Okonkwo, Paul E. Peppard, Bruce P. Hermann, Mark A. Sager, Sterling C. Johnson, Corinne D. Engelman> ;Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition. 2019 Mar 1
8 citations
Characterizing the Effects of Sex, APOE ɛ4, and Literacy on Mid-life Cognitive Trajectories: Application of Information-Theoretic Model Averaging and Multi-model Infer...
Rebecca L. Koscik, Derek Norton, Samantha L. Allison, Erin M. Jonaitis, Lindsay R. Clark, Kimberly D. Mueller, Bruce P. Hermann, Corinne D. Engelman, Carey E. Gleason,...> ;Journal of the International Neuropsychological Society. 2019 Feb 1
4 citations
Cardiorespiratory Fitness Modifies Influence of Sleep Problems on Cerebrospinal Fluid Biomarkers in an At-Risk Cohort.
Lena L. Law, Kate E. Sprecher, Ryan J. Dougherty, Dorothy F. Edwards, Rebecca L. Koscik, Catherine L. Gallagher, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, S...> ;Journal of Alzheimer's Disease. 2019 Jan 1
20 citations
Cardiorespiratory fitness attenuates age-associated aggregation of white matter hyperintensities in an at-risk cohort
Clayton J. Vesperman, Vincent Pozorski, Ryan J. Dougherty, Lena L. Law, Elizabeth A. Boots, Jennifer M. Oh, Catherine L. Gallagher, Cynthia M. Carlsson, Howard A. Rowl...> ;Alzheimer's Research & Therapy. 2018 Sep 24
18 citations
Author response: Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of t...
Ronald C Petersen, Oscar Lopez, Melissa J Armstrong, Thomas S D Getchius, Mary Ganguli, David Gloss, Gary S Gronseth, Daniel Marson, Tamara Pringsheim, Gregory S Day, ...> ;Neurology. 2018 Aug 21
14 citations
Cognitive decline in the middle-aged after surgery and anaesthesia: results from the Wisconsin Registry for Alzheimer's Prevention cohort.
Lisa C. Bratzke, Rebecca L. Koscik, K. J. Schenning, Lindsay R. Clark, Mark A. Sager, Sterling C. Johnson, Bruce P. Hermann, Kirk J. Hogan> ;Anaesthesia. 2018 May 1
3 citations
Reliability of a Novel Social Activity Questionnaire: Perceived Social Support and Verbal Interaction in the Wisconsin Registry for Alzheimer’s Prevention:
Megan Zuelsdorff, Rebecca L. Koscik, Ozioma C. Okonkwo, Paul E. Peppard, Bruce P. Hermann, Mark A. Sager, Sterling C. Johnson, Corinne D. Engelman> ;Journal of Aging and Health. 2018 Feb 1
530 citations
Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Acade...
Ronald C Petersen, Oscar Lopez, Melissa J Armstrong, Thomas S D Getchius, Mary Ganguli, David Gloss, Gary S Gronseth, Daniel Marson, Tamara Pringsheim, Gregory S Day, ...> ;Neurology. 2018 Jan 16
51 citations
Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer's disease.
Lena L. Law, Rachael N. Rol, Stephanie A. Schultz, Ryan J. Dougherty, Dorothy F. Edwards, Rebecca L. Koscik, Catherine L. Gallagher, Cynthia M. Carlsson, Barbara B. Be...> ;Alzheimer's & Dementia. 2018 Jan 1
157 citations
The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions.
Sterling C. Johnson, Rebecca L. Koscik, Erin M. Jonaitis, Lindsay R. Clark, Kimberly D. Mueller, Sara E. Berman, Barbara B. Bendlin, Corinne D. Engelman, Ozioma C. Oko...> ;Alzheimer's & Dementia. 2018 Jan 1
18 citations
Vascular, inflammatory, and metabolic factors associated with cognition in aging persons with chronic epilepsy
Bruce P. Hermann, Mark A. Sager, Rebecca L. Koscik, Kate Young, Keith P. Nakamura> ;Epilepsia. 2017 Sep 5
595 citations
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Rebecca Sims, Sven J. van der Lee, Adam C. Naj, Céline Bellenguez, Nandini Badarinarayan, Johanna Jakobsdottir, Brian W. Kunkle, Anne Boland, Rachel Raybould, Joshua C...> ;Nature Genetics. 2017 Sep 1
131 citations
Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults.
Kate E. Sprecher, Rebecca L. Koscik, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Ozioma C. Okonkwo, Mark A. Sager, Sanjay Asthana, Sterling C. Johnson, Ruth M...> ;Neurology. 2017 Aug 1
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Press Mentions

Could Common Vaccines Protect Against Alzheimer’s Disease?July 29th, 2020
What We Have to Gain from Making Machines More HumanSeptember 11th, 2018
Poor Sleep Linked to Multiple Brain Changes Associated with Alzheimer's DiseaseJuly 5th, 2017
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Grant Support

Education And Information Transfer CoreNational Institute On Aging2009–2012
Wisconsin Registry For Alzheimer Prevention: Biomarkers Of Preclinical ADNational Institute On Aging2007–2011
Wisconsin Registry For Alzheimer'S Prevention: Biomarkers Of Preclinical ADNational Center For Research Resources2007
Wisconsin Registry For Alzheimer'S Prevention (WRAP)National Center For Research Resources2004–2005
Impact Of Medicare Policy On Long Term CareAgency For Healthcare Research And Quality1986

MarkASagerMD

Dr. Sager is on Doximity

Summary

Education & Training

Certifications & Licensure

Publications & Presentations

Press Mentions

Grant Support

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