Matthew I Milowsky MD

Oncology•Chapel Hill, NC

Genitourinary Oncology

Professor of Medicine, Vice Chief of Research, Section Chief, Genitourinary Oncology, Division of Oncology and Co-Director, Urologic Oncology Program, UNC Lineberger Comprehensive Cancer Center

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101 Manning DrChapel Hill, NC 27514
Phone+1 984-974-0000
Fax+1 919-843-6949

Education & Training

New York Presbyterian Hospital (Cornell Campus)Fellowship, Hematology and Medical Oncology, 1999 - 2002
Tufts Medical CenterResidency, Internal Medicine, 1996 - 1999
State University of New York Downstate Medical Center College of MedicineClass of 1996

Certifications & Licensure

NC State Medical License 2011 - 2026
NY State Medical License 1999 - 2013
American Board of Internal Medicine Medical Oncology

Clinical Trials

Gemcitabine and Split-dose Cisplatin (GC) Plus Sorafenib in Chemotherapy-naïve Patients With Locally Advanced or Metastatic Urothelial Carcinoma Start of enrollment: 2008 Jul 01
Terminated
Phase 2
Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer Start of enrollment: 2009 Jul 15
Completed
Phase 3
Neoadjuvant Dose Dense Gemcitabine and Cisplatin (DD GC) In Patients With Muscle-Invasive Bladder Cancer Start of enrollment: 2012 Apr 01
Completed
Phase 2
Positron Emission Tomography (PET) Study for Staging of Muscle Invasive Bladder Cancer Start of enrollment: 2012 Jul 24
Completed
Not Applicable
3-arm Study of Abiraterone Acetate Alone, Abiraterone Acetate Plus Degarelix, a GnRH Antagonist, and Degarelix Alone for Patients With Prostate Cancer With a Rising PSA or a Rising PSA and Nodal Disease Following Definitive Radical Prostatectomy Start of enrollment: 2012 Dec 18
Completed
Phase 2
Paclitaxel, Ifosfamide and Cisplatin (TIP) Versus Bleomycin, Etoposide and Cisplatin (BEP) for Patients With Previously Untreated Intermediate- and Poor-risk Germ Cell Tumors
ACTIVE_NOT_RECRUITING
PHASE2
Observational Longitudinal Study of Pain in Men With Metastatic Castrate-Resistant Prostate Cancer Start of enrollment: 2014 Jan 23
Completed
Using Walk With Ease Walking Program With Men 65 and Older Being Treated for Prostate Cancer Start of enrollment: 2013 Oct 01
Terminated
Phase 2 Study of Pembrolizumab in Combination With Gemcitabine and Cisplatin as Neoadjuvant Therapy
ACTIVE_NOT_RECRUITING
PHASE2
Sapanisertib in Treating Patients With Locally Advanced or Metastatic Bladder Cancer With TSC1 and/or TSC2 Mutations Start of enrollment: 2017 Aug 24
ACTIVE_NOT_RECRUITING
PHASE2
Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer Start of enrollment: 2020 Sep 23
ACTIVE_NOT_RECRUITING
PHASE2
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Publications & Presentations

PubMed

Adjuvant nivolumab in muscle-invasive urothelial carcinoma: exploratory biomarker analysis of the randomized phase 3 CheckMate 274 trial.
Matthew D Galsky, Dean F Bajorin, Yoshihiko Tomita, Dingwei Ye, Mads Agerbaek
Nature Medicine. 2025-08-07
Engagement in cancer clinical trials among a nationally representative cancer survivor sample: Motivators, barriers and opportunities for improvement.
Zachary S Feuer, Richard S Matulewicz, Ramsankar Basak, Donna A Culton, Kimberly Weaver
Tumori. 2025-08-01
Mechanistic Insights and Future Directions for Enfortumab Vedotin in Urothelial Carcinoma: Highlights from the 10th Annual Leo & Anne Albert Institute for Bladder Canc...
Catherine C Fahey, Sean Clark-Garvey, Sima Porten, Ashish M Kamat, Thomas W Flaig
Current Oncology. 2025-05-14

Lectures

Cost-effectiveness of CHOP in treating DLBCL in Malawi.
2019 ASCO Annual Meeting - 6/1/2019

Press Mentions

Bladder Cancer Survival Better with Nivolumab Than Placebo in New AnalysisFebruary 21st, 2025
Adjuvant Nivolumab Boosts Survival Outcomes in Muscle-Invasive Bladder CancerFebruary 17th, 2025
Bladder Cancer Biomarkers Promise Improved SurvivalNovember 14th, 2024
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Grant Support

UNC Lead Academic Participating SiteUNIV OF NORTH CAROLINA CHAPEL HILL2019–2026

Professional Memberships

American Society of Clinical Oncology - ASCO
Member
American Urological Association - AUA
Member
American Association for Cancer Research - AACR
Member