MatthewWallSemlerMD

Pulmonology • Nashville, TN

Critical Care Medicine, Pleural Disease

Physician

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Office
1211 22nd Ave
Nashville, TN 37232
Phone+1 615-936-2000

Fax+1 615-936-0605
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Education & Training

Vanderbilt UniversityMSc, Clinical Investigation, 2014 - 2016
Vanderbilt University Medical CenterFellowship, Pulmonary Disease and Critical Care Medicine, 2012 - 2015
Vanderbilt University Medical CenterChief Residency, Internal Medicine, 2011 - 2012
Vanderbilt University Medical CenterResidency, Internal Medicine, 2008 - 2012
University of Virginia School of MedicineClass of 2008

Certifications & Licensure

TN State Medical License 2010 - 2026
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Clinical Trials

Facilitating EndotracheaL Intubation by Laryngoscopy Technique and Apneic Oxygenation Within the Intensive Care Unit: The FELLOW Study Start of enrollment: 2014 Feb 01
Completed
Not Applicable
A Randomized Controlled Trial of a Conservative Fluid Balance Strategy for Patients With Sepsis and Cardiopulmonary Dysfunction (BALANCE Study) Start of enrollment: 2014 Jul 01
Completed
Not Applicable
Isotonic Solutions and Major Adverse Renal Events Trial in the Medical Intensive Care Unit Start of enrollment: 2015 Jun 01
Completed
Not Applicable
Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial Start of enrollment: 2015 Jul 01
Completed
Phase 4
Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG) Start of enrollment: 2015 Oct 01
Completed
Not Applicable
Saline Against Lactated Ringers or Plasmalyte in the Emergency Department Start of enrollment: 2016 Jan 01
Completed
Not Applicable
Preventing Hypoxemia With Manual Ventilation During Endotracheal Intubation (PreVent) Trial Start of enrollment: 2017 Mar 15
Completed
Not Applicable
Vanderbilt ICU Recovery Program Pilot Trial Start of enrollment: 2017 May 01
Completed
Not Applicable
Balanced Solutions and Plasma Electrolytes Start of enrollment: 2018 Jun 01
Completed
Not Applicable
Pragmatic Investigation of optimaL Oxygen Targets Trial Start of enrollment: 2018 Jul 01
Completed
Not Applicable
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Publications & Presentations

PubMed

2 citations
Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults.
Alexandra B Spicer, Emma J Graham Linck, Paul J Young, Kevin G Buell, Jonathan D Casey, Kevin P Seitz, Edward T Qian, Wesley H Self, Todd W Rice, Pratik Sinha, Matthew...> ;JAMA. 2024 Apr 9
Cefepime vs Piperacillin-Tazobactam for Acute Infection in Hospitalized Adults-Reply.
Edward T Qian, Matthew W Semler, Todd W Rice> ;JAMA. 2024 Feb 27
Impact of fludrocortisone on the outcomes of subarachnoid hemorrhage patients: A retrospective analysis.
Akshitkumar M Mistry, Janki Naidugari, Michael J Feldman, Jordan A Magarik, Dale Ding, Isaac J Abecassis, Matthew W Semler, Todd W Rice> ;Journal of Stroke and Cerebrovascular Diseases. 2024 Feb 21
2 citations
Oxygen-Saturation Targets and Cognitive and Functional Outcomes in Mechanically Ventilated Adults.
Matthew F Mart, Matthew W Semler, Cathy A Jenkins, Guanchao Wang, Jonathan D Casey, E Wesley Ely, James C Jackson, Amy L Kiehl, Patsy T Bryant, Shannon K Pugh, Li Wang...> ;American Journal of Respiratory and Critical Care Medicine. 2024 Apr 1
2 citations
Balanced crystalloids versus saline for critically ill patients (BEST-Living): a systematic review and individual patient data meta-analysis.
Fernando G Zampieri, Alexandre B Cavalcanti, Gian Luca Di Tanna, Lucas P Damiani, Naomi E Hammond, Flavia R Machado, Sharon Micallef, John Myburgh, Mahesh Ramanan, Bal...> ;The Lancet. Respiratory Medicine. 2024 Mar 1
Comparison of SAT and SBT Conduct During the ABC Trial and PILOT Trial.
Tuqa Alkhateeb, Matthew W Semler, Timothy D Girard, E Wesley Ely, Joanna L Stollings> ;Journal of Intensive Care Medicine. 2023 Nov 19
15 citations
Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial.
Edward T Qian, Jonathan D Casey, Adam Wright, Li Wang, Matthew S Shotwell, Justin K Siemann, Mary Lynn Dear, Joanna L Stollings, Brad D Lloyd, Tanya K Marvi, Kevin P S...> ;JAMA. 2023 Oct 24
Impact of Fludrocortisone on the Outcomes of Subarachnoid Hemorrhage Patients: A Retrospective Analysis.
Akshitkumar M Mistry, Janki Naidugari, Michael J Feldman, Jordan A Magarik, Dale Ding, Isaac J Abecassis, Matthew W Semler, Todd W Rice> ;Medrxiv. 2023 Sep 29
Authors response: "Etomidate as an induction agent for endotracheal intubation in critically ill patients: A meta-analysis of randomized trials".
Yuki Kotani, Matthew W Semler, Todd C Lee, Giovanni Landoni> ;Journal of Critical Care. 2024 Feb 1
Modifiable in-hospital factors for 12-month global cognition, post-traumatic stress disorder symptoms, and depression symptoms in adults hospitalized with COVID-19.
Jin H Han, James C Jackson, Onur M Orun, Samuel M Brown, Jonathan D Casey, Lindsay Clark, Sean P Collins, Kemberlyne Cordero, Adit A Ginde, Michelle N Gong, Catherine ...> ;Influenza and Other Respiratory Viruses. 2023 Sep 1
1 citations
Prophylactic Administration of Vasopressors Prior to Emergency Intubation in Critically Ill Patients: A Secondary Analysis of Two Multicenter Clinical Trials.
Mikita Fuchita, Jack Pattee, Derek W Russell, Brian E Driver, Matthew E Prekker, Christopher R Barnes, Joseph M Brewer, Kevin C Doerschug, John P Gaillard, Sheetal Gan...> ;Critical Care Explorations. 2023 Jul 1
1 citations
Piperacillin-Tazobactam Versus Anti-Pseudomonal Cephalosporins and Renal and Neurologic Outcomes in Critically Ill Adults: A Secondary Analysis of the SMART Trial.
Li Wang, Joanna L Stollings, Jonathan D Casey, Todd W Rice, Matthew W Semler, Qian, E.> ;Journal of Intensive Care Medicine. 2023 Dec 1
9 citations
Fluid Therapy for Critically Ill Adults With Sepsis: A Review.
Fernando G Zampieri, Sean M Bagshaw, Matthew W Semler> ;JAMA. 2023 Jun 13
5 citations
Conditional Treatment Effect Analysis of Two Infusion Rates for Fluid Challenges in Critically Ill Patients: A Secondary Analysis of Balanced Solution versus Saline in...
Fernando G Zampieri, Lucas P Damiani, Sean M Bagshaw, Matthew W Semler, Matthew Churpek, Luciano C P Azevedo, Rodrigo C Figueiredo, Viviane C Veiga, Rodrigo Biondi, Fl...> ;Annals of the American Thoracic Society. 2023 Jun 1
2 citations
Evolving Management Practices for Early Sepsis-induced Hypoperfusion: A Narrative Review.
Elizabeth S Munroe, Robert C Hyzy, Matthew W Semler, Manu Shankar-Hari, Paul J Young, Fernando G Zampieri, Hallie C Prescott> ;American Journal of Respiratory and Critical Care Medicine. 2023 May 15
2 citations
Laryngoscopy and Tracheal Intubation: Does Use of a Video Laryngoscope Facilitate Both Steps of the Procedure?
Matthew E Prekker, Stacy A Trent, Arianna Lofrano, Derek W Russell, Christopher R Barnes, Joseph M Brewer, Kevin C Doerschug, John P Gaillard, Sheetal Gandotra, Adit A...> ;Annals of Emergency Medicine. 2023 Oct 1
Protocol and statistical analysis plan for the PREOXI trial of preoxygenation with noninvasive ventilation vs oxygen mask.
Malhotra, R., Kevin W Gibbs, Adit A Ginde, Matthew E Prekker, Kevin P Seitz, Susan B Stempek, Caleb Taylor, Sheetal Gandotra, Heath White, Daniel Resnick-Ault, Akram K...> ;Medrxiv. 2023 Mar 24
1 citations
Protocol and statistical analysis plan for the Antibiotic Choice On ReNal outcomes (ACORN) randomised clinical trial.
Qian, E., Casey, J., Wright, A., Wang, L., Siemann, J., Dear, M., Stollings, J., Lloyd, B., Seitz, K., Nelson, G., Wright, P., Siew, E., Dennis, B., Wrenn, J., Anderec...> ;BMJ Open. 2023 Mar 10
3 citations
Effect of Laryngoscope Blade Size on First Pass Success of Tracheal Intubation in Critically Ill Adults.
Kevin R Landefeld, Seiji Koike, Ran Ran, Matthew W Semler, Christopher Barnes, Susan B Stempek, David R Janz, Todd W Rice, Derek W Russell, Wesley H Self, Derek Vonder...> ;Critical Care Explorations. 2023 Mar 1
63 citations
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
, Nathan I Shapiro, Ivor S Douglas, Roy G Brower, Samuel M Brown, Matthew C Exline, Adit A Ginde, Michelle N Gong, Colin K Grissom, Douglas Hayden, Catherine L Hough, ...> ;The New England Journal of Medicine. 2023 Feb 9
Identifying Predictors of Extubation on the day of Passing an SBT in Critically ill Adults.
Sneha Patel, Joanna L Stollings, Jonathan D Casey, Li Wang, Todd W Rice, Matthew W Semler> ;Journal of Intensive Care Medicine. 2023 Jun 1
3 citations
DirEct versus VIdeo LaryngosCopE (DEVICE): protocol and statistical analysis plan for a randomised clinical trial in critically ill adults undergoing emergency trachea...
Prekker, M., Driver, B., Trent, S., Resnick-Ault, D., Seitz, K., Russell, D., Gandotra, S., Gaillard, J., Gibbs, K., Latimer, A., Whitson, M., Ghamande, S., Vonderhaar...> ;BMJ Open. 2023 Jan 13
Fluid Bolus Administration and Cardiovascular Collapse in Critically Ill Patients Undergoing Tracheal Intubation-Reply.
Derek W Russell, Jonathan D Casey, Matthew W Semler> ;JAMA. 2022 Nov 22
43 citations
Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation.
Semler, M., Casey, J., Lloyd, B., Hastings, P., Hays, M., Stollings, J., Buell, K., Brems, J., Qian, E., Seitz, K., Wang, L., Lindsell, C., Freundlich, R., Wanderer, J...> ;The New England Journal of Medicine. 2022 Nov 10
argets (CO-PILOT) trial: protocol and statistical analysis plan.ognitiveutcomes in theragmaticnvestigation of optimaxygen
Matthew F Mart, Matthew W Semler, Gordon Bernard, Jonathan D Casey, E Wesley Ely, Robert Freundlich, James C Jackson, Amy Kiehl, Cathy Jenkins, Guanchao Wang, Christop...> ;BMJ Open. 2022 Nov 1
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Journal Articles

Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients with COVID-19
Matthew W Semler, Lindsay M Leither, Derek C Angus, Roy G Brower, Steven Y Chang, John C Eppensteiner, Michael R Filbin, Adit A Ginde, Michelle N Gong, Douglas L Hayde..., JAMA
Association Between Early Treatment with Tocilizumab and Mortality Among Critically Ill Patients with COVID-19
Kusum S Mathews, Michal L Melamed, Samantha K Brenner, Amanda Leonberg-Yoo, Edward J Schenck, Jared Radbel, Jochen Reiser, Anip Bansal, Diana Finkel, Mary Mallappallil..., JAMA Internal Medicine
Factors Associated with Death in Critically Ill Patients with Coronavirus Disease 2019 in the US
Kusum S Mathews, Michal L Melamed, Samantha K Brenner, Amanda Leonberg-Yoo, Edward J Schenck, Jared Radbel, Jochen Reiser, Anip Bansal, Alexandre M Shehata, Nitender G..., JAMA Internal Medicine

Authored Content

Rapid Training in Extracorporeal Membrane Oxygenation for a Large Health SystemJuly 2020
Factors Associated with Death in Critically Ill Patients with Coronavirus Disease 2019 in the USJuly 2020
Factors Associated with Death in Critically Ill Patients with Coronavirus Disease 2019 in the USJuly 2020

Press Mentions

Even Without Weight Loss, Nordic Diet Lowers Cholesterol and Blood SugarMarch 15th, 2022
Study Finds Similar Success Rates with Two Devices for Breathing Tube PlacementDecember 15th, 2021
How Do You Treat Coronavirus? Here Are Physicians’ Best StrategiesMarch 16th, 2021
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