MehmetSofuogluMD

Psychiatry • West Haven, CT

Associate Professor, Psychiatry, Yale University School of Medicine

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Office
950 Campbell Ave Bldg 36
West Haven, CT 06516
Phone+1 203-937-4809
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Summary

Dr. Mehmet Sofuoglu, MD is a board certified psychiatrist in West Haven, Connecticut. He is currently licensed to practice medicine in Connecticut, Pennsylvania, and New York. He is affiliated with Veterans Affairs Connecticut Healthcare System and is an Associate Professor at Yale University School of Medicine.

Education & Training

Stanford Health Care-Sponsored Stanford UniversityResidency, Psychiatry, 1993 - 1995
University of MinnesotaResidency, Psychiatry, 1991 - 1993
Hacettepe University FOMClass of 1984

Certifications & Licensure

CA State Medical License 1993 - Present
CT State Medical License 2001 - 2024
PA State Medical License 2008 - 2008
NY State Medical License 2000 - 2002
MN State Medical License 1995 - 2000
American Board of Psychiatry and Neurology Psychiatry

Clinical Trials

Effect of Progesterone on Smoking Behavior in Male and Female Smokers Start of enrollment: 2004 Sep 01
Completed
Phase 1
Cocaine Withdrawal and Pharmacotherapy Response Start of enrollment: 2007 Sep 01
Completed
Not Applicable
Galantamine Effects on Cognitive Function in Abstinent Cocaine Users Start of enrollment: 2007 Jun 01
Completed
Not Applicable
Varenicline and Nicotine Interactions in Humans (VA) Start of enrollment: 2007 Aug 01
Completed
Not Applicable
Atomoxetine Effects in Humans Start of enrollment: 2006 Jun 01
Completed
Phase 1, Phase 2
Effects of Atomoxetine Treatment in Humans Start of enrollment: 2006 Jun 01
Completed
Phase 1, Phase 2
GABA (Gamma Amino Butyric Acid) Medication for Tobacco Start of enrollment: 2007 Aug 01
Completed
Early Phase 1
Pharmacotherapy & CM for Opioid and Cocaine Dependence Start of enrollment: 2008 May 01
Completed
Phase 1, Phase 2
Dronabinol Interactions With Cognitive Enhancing Drug in Humans Start of enrollment: 2008 Sep 01
Completed
Early Phase 1
Sensitivity to Intravenous Nicotine: Genetic Moderators Start of enrollment: 2009 Jun 02
Completed
Phase 1
Galantamine Effects on Cognitive Function in Marijuana Users Start of enrollment: 2009 Aug 01
Completed
Phase 1
Progesterone for Postpartum Cocaine Relapse Start of enrollment: 2011 Feb 01
Completed
Not Applicable
Galantamine Effects on Nicotine Responses in Smokers Start of enrollment: 2010 Mar 01
Completed
Phase 1
Nicotine Reinforcement and Aversion in Young Adult Light Smokers Start of enrollment: 2017 Jan 04
Completed
Early Phase 1
Cognitive Effects of Atomoxetine in Humans: Genetic Moderators Start of enrollment: 2011 Dec 01
Completed
Not Applicable
Cognitive Enhancement as a Target for Cocaine Pharmacotherapy Start of enrollment: 2011 Sep 01
Completed
Not Applicable
A Drug Treatment for Cocaine Users Who Are Also on Methadone Maintenance Treatment Start of enrollment: 2012 Dec 01
Terminated
Not Applicable
A Study to Help People Quit Smoking. Start of enrollment: 2013 Dec 01
Completed
Not Applicable
The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users Start of enrollment: 2014 Mar 26
Completed
Not Applicable
The Effects of Minocycline in Humans Start of enrollment: 2013 Jul 08
Completed
Phase 1
The Effect of Nicotine Delivery Rate on Reinforcement Start of enrollment: 2017 Jan 05
Completed
Early Phase 1
Effects of Dronabinol in Opioid Maintained Patients Start of enrollment: 2019 May 31
Recruiting
Early Phase 1
Cognitive Function and Pain Threshold in People Who Are Methadone Maintained Start of enrollment: 2019 Jul 01
Completed
Early Phase 1
Smoking by IV Pulsed Nicotine Start of enrollment: 2019 Nov 15
Completed
Early Phase 1
Nicotine's Potential Abuse With Menthol Start of enrollment: 2021 Jun 28
Completed
Early Phase 1
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Publications & Presentations

PubMed

From taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder.
Gabriel P A Costa, R Ross MacLean, Joao P De Aquino, Jeremy Weleff, Julio C Nunes, Mehmet Sofuoglu> ;British Journal of Clinical Pharmacology. 2024 Apr 16
Efficacy of Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) in Individuals With Chronic Pain and Opioid Use Disorder: Protocol fo...
R Ross MacLean, Brett Ankawi, Mary A Driscoll, Melissa A Gordon, Tami L Frankforter, Charla Nich, Sara K Szollosy, Jennifer M Loya, Larissa Brito, Margaridha I P Ribei...> ;JMIR Research Protocols. 2024 Mar 20
The relationship of pain intensity and opioid craving with delayed methadone dose: A preliminary study of individuals with opioid use disorder.
R Ross MacLean, Suzanne Spinola, Brian Pittman, Julia Meyerovich, Sara K Szollosy, Noah R Wolkowicz, Stacy Minnix, Mehmet Sofuoglu> ;British Journal of Clinical Pharmacology. 2024 Mar 4
Brief report: The influence of childhood trauma on the effects of delta-9-tetrahydrocannabinol in persons with opioid use disorder.
Rogan, M., Xie, C., Sofuoglu, M., Pittman, B., De Aquino, J., Nunes, J.> ;The American Journal on Addictions. 2023 Dec 7
1 citations
Delta-9-tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within-subject, randomized, placebo-c...
Joao P De Aquino, Julia Meyerovich, Catherine Z Xie, Mohini Ranganathan, Peggy Compton, Brian Pittman, Michael Rogan, Mehmet Sofuoglu> ;Addiction Biology. 2023 Sep 1
Associations Between Childhood Trauma and Tobacco Use Outcomes in Adults after Overnight Abstinence.
Alexandra N Palmisano, Elizabeth K C Schwartz, Ralitza Gueorguieva, Mehmet Sofuoglu> ;Nicotine & Tobacco Research. 2024 Feb 22
1 citations
Developing non-opioid therapeutics to alleviate pain among persons with opioid use disorder: a review of the human evidence.
Oliveira, D., De Aquino, J., Weleff, J., Weleff, J., Weleff, J., Weleff, J., Weleff, J., Weleff, J., Weleff, J., Fontenele, R., Weleff, J., Sofuoglu, M.> ;International Review of Psychiatry. 2023 Jun 28
1 citations
Integrating cognitive bias modification for pain and opioid cues into medication for opioid use disorder clinical care: Feasibility, acceptability, and preliminary res...
R Ross MacLean, Alicia A Heapy, Andrew J Waters, Noah Wolkowicz, Sara K Szollosy, Julia Meyerovich, Mehmet Sofuoglu> ;Drug and Alcohol Dependence. 2023 May 1
Threshold for the pleasurable effects of nicotine are lower than its reinforcing effects during self-administration.
R Ross MacLean, Tore Eid, Suprit Parida, Ralitza Gueorguieva, Elise E DeVito, Mehmet Sofuoglu> ;Experimental and Clinical Psychopharmacology. 2023 Feb 1
Examining racial differences in smoking outcomes among smokers enrolled in an intravenous nicotine infusion study.
Elizabeth K C Schwartz, Alexandra N Palmisano, Ralitza Gueorguieva, Elise E DeVito, Mehmet Sofuoglu> ;Addictive Behaviors. 2023 May 1
A systematic review evaluating PTSD treatment effects on intermediate phenotypes of PTSD.
Alexandra N Palmisano, Sarah Meshberg-Cohen, Ismene L Petrakis, Mehmet Sofuoglu> ;Psychological Trauma. 2023 Jan 2
1 citations
Catechol-O-Methyltransferase Effects on Smoking: A Review and Proof of Concept of Sex-Sensitive Effects.
Elise E DeVito, Mehmet Sofuoglu> ;Current Behavioral Neuroscience Reports. 2022 Dec 1
4 citations
Alleviation of opioid withdrawal by cannabis and delta-9-tetrahydrocannabinol: A systematic review of observational and experimental human studies.
Joao P De Aquino, Anees Bahji, Oscar Gómez, Mehmet Sofuoglu> ;Drug and Alcohol Dependence. 2022 Dec 1
2 citations
Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopre...
Andrew M Novick, Korrina A Duffy, Rachel L Johnson, Mary D Sammel, Wen Cao, Andrew A Strasser, Mehmet Sofuoglu, Alexandra Kuzma, James Loughead, A Leslie Morrow, C Nei...> ;Biology of Sex Differences. 2022 Oct 23
2 citations
Progesterone Increases Nicotine Withdrawal and Anxiety in Male but Not Female Smokers During Brief Abstinence.
Andrew M Novick, Korrina A Duffy, Rachel L Johnson, Mary D Sammel, Wen Cao, Andrew A Strasser, Mehmet Sofuoglu, Alexandra Kuzma, James Loughead, C Neill Epperson> ;Nicotine & Tobacco Research. 2022 Nov 12
Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans.
Joao P De Aquino, Elise E DeVito, Catherine Xie, Julia Meyerovich, Suprit Parida, Ralitza Gueorguieva, Mehmet Sofuoglu> ;Psychopharmacology. 2022 Sep 1
1 citations
Modafinil Does Not Reduce Cocaine Use in Methadone-Maintained Individuals.
Elise E DeVito, James Poling, Theresa Babuscio, Charla Nich, Kathleen M Carroll, Mehmet Sofuoglu> ;Drug and Alcohol Dependence Reports. 2022 Mar 1
3 citations
Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science.
Joao P De Aquino, R Ross MacLean, Ralitza Gueorguieva, Elise E DeVito, Tore Eid, Mehmet Sofuoglu> ;Addiction Biology. 2022 Mar 1
Pilot examination of stress, heart rate variability, and alcohol craving and use among female veterans.
Cathryn Glanton Holzhauer, Elizabeth E Epstein, Laurel Bickar, Robyn A Ellis, Nnamdi Pole, Mehmet Sofuoglu, David A Smelson, Kristin Mattocks> ;Frontiers in Psychiatry. 2022 Jan 1
7 citations
Cocaine Use Disorder (CUD): Current Clinical Perspectives.
Elizabeth K C Schwartz, Noah R Wolkowicz, Joao P De Aquino, R Ross MacLean, Mehmet Sofuoglu> ;Substance Abuse and Rehabilitation. 2022 Jan 1
Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans.
Ralitza Gueorguieva, Elizabeth K C Schwartz, R Ross MacLean, Elise E DeVito, Tore Eid, Ran Wu, Stephanie S O'Malley, Mehmet Sofuoglu> ;Frontiers in Pharmacology. 2022 Jan 1
7 citations
Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies.
Joao P De Aquino, Suprit Parida, Victor J Avila-Quintero, José M. Flores, Peggy Compton, Thomas Hickey, Oscar Gómez, Mehmet Sofuoglu> ;Drug and Alcohol Dependence. 2021 Sep 22
10 citations
Reappraising Choice in Addiction: Novel Conceptualizations and Treatments for Tobacco Use Disorder.
Amanda M Palmer, Benjamin A. Toll, Matthew J. Carpenter, Eric C. Donny, Dorothy K. Hatsukami, Alana M. Rojewski, Tracy T. Smith, Mehmet Sofuoglu, Johannes Thrul, Neal ...> ;Nicotine & Tobacco Research. 2021 Jul 16
6 citations
Baseline executive functions and receiving cognitive rehabilitation can predict treatment response in people with opioid use disorder
Tara Rezapour, Javad Hatami, Ali Farhoudian, Alireza Noroozi, Reza Daneshmand, Mehmet Sofuoglu, Alex Baldacchino, Hamed Ekhtiari> ;Journal of Substance Abuse Treatment. 2021 Jul 7
6 citations
Treatment outcomes in individuals diagnosed with comorbid opioid use disorder and Posttraumatic stress disorder: A review.
Sarah Meshberg-Cohen, R. Ross MacLean, Ashley M. Schnakenberg Martin, Mehmet Sofuoglu, Ismene L. Petrakis> ;Addictive Behaviors. 2021 Jun 23
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Press Mentions

Are Hormones Responsible for Your Addiction?June 11th, 2017

Grant Support

Cognitive Enhancement As A Target For Cocaine PharmacotherapyNational Institute On Drug Abuse2011–2012
Progesterone For Postpartum Cocaine RelapseNational Institute On Drug Abuse2010–2011
Human Laboratory Studies For Stimulant AddictionNational Institute On Drug Abuse2008–2011
Sensitivity To Intravenous Nicotine: Genetic ModeratorsNational Institute On Drug Abuse2009–2010
Cocaine Withdrawal And Pharmacotherapy ResponseNational Institute On Drug Abuse2007–2010
GABA Medications For Tobacco AddictionNational Institute On Drug Abuse2006–2009
GABA Medications And Cocaine Interaction In HumansNational Institute On Drug Abuse2007
GABA Medications And Cocaine Interactions In HumansNational Institute On Drug Abuse2006
Progestrone And The Effects Of NicotineNational Institute On Drug Abuse2003–2006
GABA Medications And Cocaine Interactions In HumansNational Institute On Drug Abuse2004–2005
Progesterone Treatment On Effects Of Stimulants In FemalesNational Center For Research Resources2000–2002
Stress Hormones And Human Cocaine Use--Effects Of LabetalolNational Center For Research Resources1998–1999
Stress Hormones And Human Cocaine UseNational Center For Research Resources1998–1999

Hospital Affiliations

Veterans Affairs Connecticut Healthcare SystemWest Haven, Connecticut