MichaelChristopherHolmesMD

PubMed

• Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets.
  Conway, A.,Mendel, M.,Kim, K.,McGovern, K.,Boyko, A.,Zhang, L.,Miller, J. C.,DeKelver, R. C.,Paschon, D. E.,Mui, B. L.,Lin, PJC.,Tam, Y. K.,Barbosa, C.,Redelmeier, T.,...> ;Mol. Ther.. 2019 Mar 25
• Diversifying the structure of zinc finger nucleases for high-precision genome editing.
  Paschon, D. E.,Lussier, S.,Wangzor, T.,Xia, D. F.,Li, P. W.,Hinkley, S. J.,Scarlott, N. A.,Lam, S. C.,Waite, A. J.,Truong, L. N.,Gandhi, N.,Kadam, B. N.,Patil, D. P.,S...> ;Nat Commun. 2019 Mar 10
• A humanized mouse model of HIV-1 latency with enrichment of latent virus in PD-1+ and TIGIT+ CD4 T cells.
  Llewellyn, G. N.,Seclèn, E.,Wietgrefe, S.,Liu, S.,Chateau, M.,Pei, H.,Perkey, K.,Marsden, M. D.,Hinkley, S. J.,Paschon, D. E.,Holmes, M. C.,Zack, J. A.,Louie, S. G.,Ha...> ;J. Virol.. 2019 Mar 08
• ZFN-Mediated In Vivo Genome Editing Corrects Murine Hurler Syndrome.
  Ou, L.,DeKelver, R. C.,Rohde, M.,Tom, S.,Radeke, R.,St Martin, S. J.,Santiago, Y.,Sproul, S.,Przybilla, M. J.,Koniar, B. L.,Podetz-Pedersen, K. M.,Laoharawee, K.,Cooks...> ;Mol. Ther.. 2018 Dec 12
• Disruption of the BCL11A Erythroid Enhancer Reactivates Fetal Hemoglobin in Erythroid Cells of Patients with β-Thalassemia Major.
  Psatha, N.,Reik, A.,Phelps, S.,Zhou, Y.,Dalas, D.,Yannaki, E.,Levasseur, D. N.,Urnov, F. D.,Holmes, M. C.,Papayannopoulou, T.> ;Mol Ther Methods Clin Dev. 2018 Sep 06
• Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus.
  Leslie GJ, Wang J, Richardson MW, Haggarty BS, Hua KL, Duong J, Secreto AJ, Jordon APO, Romano J, Kumar KE, DeClercq JJ, Gregory PD, June CH, Root MJ, Riley JL, Holmes...> ;PLoS Pathog.. 2016-11-01
• Engineering hematopoietic stem cells toward a functional cure of human immunodeficiency virus infection.
  Wang J, Holmes MC> ;Cytotherapy. 2016-11-01
• Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects.
  Laskowski TJ, Van Caeneghem Y, Pourebrahim R, Ma C, Ni Z, Garate Z, Crane AM, Li XS, Liao W, Gonzalez-Garay M, Segovia JC, Paschon DE, Rebar EJ, Holmes MC, Kaufman D, ...> ;Stem Cell Reports. 2016-08-09
• Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates.
  Peterson CW, Wang J, Norman KK, Norgaard ZK, Humbert O, Tse CK, Yan JJ, Trimble RG, Shivak DA, Rebar EJ, Gregory PD, Holmes MC, Kiem H> ;Blood. 2016-05-19
• Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery.
  Wang, J.,DeClercq, J. J.,Hayward, S. B.,Li, P. W.,Shivak, D. A.,Gregory, P. D.,Lee, G.,Holmes, M. C.> ;Nucleic Acids Res.. 2015 Nov 04
• Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors.
  Wang, J.,Exline, C. M.,DeClercq, J. J.,Llewellyn, G. N.,Hayward, S. B.,Li, P. W.,Shivak, D. A.,Surosky, R. T.,Gregory, P. D.,Holmes, M. C.,Cannon, P. M.> ;Nat. Biotechnol.. 2015 Nov 10
• In vivo genome editing of the albumin locus as a platform for protein replacement therapy.
  Sharma R, Anguela XM, Doyon Y, Wechsler T, DeKelver RC, Sproul S, Paschon DE, Miller JC, Davidson RJ, Shivak D, Zhou S, Rieders J, Gregory PD, Holmes MC, Rebar EJ, Hig...> ;Blood. 2015-10-08
• Functional footprinting of regulatory DNA.
  Vierstra J, Reik A, Chang K, Stehling-Sun S, Zhou Y, Hinkley SJ, Paschon DE, Zhang L, Psatha N, Bendana YR, O'Neil CM, Song AH, Mich AK, Liu P, Lee G, Bauer DE, Holmes...> ;Nat. Methods. 2015-10-01
• Absence of WASp Enhances Hematopoietic And Megakaryocytic Differentiation In A Human Embryonic Stem Cell Model.
  Toscano, M. G.,Muñoz, P.,Sánchez-Gilabert, A.,Cobo, M.,Benabdellah, K.,Anderson, P.,Ramos-Mejía, V.,Real, P. J.,Neth, O.,Molinos, A.,Gregory, P. D.,Holmes, M. C.,Marti...> ;Mol. Ther.. 2015 Oct 28
• Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.
  Beane JD, Lee G, Zheng Z, Mendel M, Abate-Daga D, Bharathan M, Black M, Gandhi N, Yu Z, Chandran S, Giedlin M, Ando D, Miller J, Paschon D, Guschin D, Rebar EJ, Reik A...> ;Mol. Ther.. 2015-08-01
• Correction of the sickle-cell disease mutation in human hematopoietic stem/progenitor cells.
  Hoban, M. D.,Cost, G. J.,Mendel, M. C.,Romero, Z.,Kaufman, M. L.,Joglekar, A. V.,Ho, M.,Lumaquin, D.,Gray, D.,Lill, G. R.,Cooper, A. R.,Urbinati, F.,Senadheera, S.,Zhu...> ;Blood. 2015 Mar 04
• Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells.
  Crane, A. M.,Kramer, P.,Bui, J. H.,Chung, W. J.,Li, X. S.,Gonzalez-Garay, M. L.,Hawkins, F.,Liao, W.,Mora, D.,Choi, S.,Wang, J.,Sun, H. C.,Paschon, D. E.,Guschin, D. Y...> ;Stem Cell Reports. 2015 Mar 17
• Targeted genome editing in human repopulating haematopoietic stem cells.
  Genovese P, Schiroli G, Escobar G, Di Tomaso T, Firrito C, Calabria A, Moi D, Mazzieri R, Bonini C, Holmes MC, Gregory PD, van der Burg M, Gentner B, Montini E, Lombar...> ;Nature. 2014-06-12
• Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.
  Tebas, P.,Stein, D.,Tang, W. W.,Frank, I.,Wang, S. Q.,Lee, G.,Spratt, S. K.,Surosky, R. T.,Giedlin, M. A.,Nichol, G.,Holmes, M. C.,Gregory, P. D.,Ando, D. G.,Kalos, M....> ;N. Engl. J. Med.. 2014 Mar 07
• 112 citations
  Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection
  Chuka A. Didigu, Craig B. Wilen, Jianbin Wang, Jennifer Duong, Anthony Secreto, Gwenn Danet-Desnoyers, James L. Riley, Phillip D. Gregory, Carl H. June, Michael C. Hol...> ;Blood. 2014 Jan 2
• A southern blot protocol to detect chimeric nuclease-mediated gene repair.
  Rocca CJ, Abdul-Razak HH, Holmes MC, Gregory PD, Yáñez-Muñoz RJ> ;Methods Mol. Biol.. 2014-01-01
• 122 citations
  Robust ZFN-mediated genome editing in adult hemophilic mice.
  Xavier M. Anguela, Rajiv Sharma, Yannick Doyon, Jeffrey C. Miller, Hojun Li, Virginia Haurigot, Michelle Rohde, Sunnie Wong, Robert J. Davidson, Shangzhen Zhou, Philip...> ;Blood. 2013 Nov 7
• 209 citations
  Toward eliminating HLA class I expression to generate universal cells from allogeneic donors
  Hiroki Torikai, Andreas Reik, Frank Soldner, Edus H. Warren, Carrie Yuen, Yuanyue Zhou, Denise L. Crossland, Helen Huls, Nicholas Littman, Ziying Zhang, Scott S. Tykod...> ;Blood. 2013 Aug 22
• Genomic Editing of the HIV-1 Coreceptor CCR5 in Adult Hematopoietic Stem and Progenitor Cells Using Zinc Finger Nucleases.
  Li, L.,Krymskaya, L.,Wang, J.,Henley, J.,Rao, A.,Cao, L. F.,Tran, C. A.,Torres-Coronado, M.,Gardner, A.,Gonzalez, N.,Kim, K.,Liu, P. Q.,Hofer, U.,Lopez, E.,Gregory, P....> ;Mol. Ther.. 2013 Jun
• In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration.
  Cristea, S.,Freyvert, Y.,Santiago, Y.,Holmes, M. C.,Urnov, F. D.,Gregory, P. D.,Cost, G. J.> ;Biotechnol. Bioeng.. 2013 Mar
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