MichaelIrwinMD

Psychiatry • Los Angeles, CA

Professor, Psychiatry, University of California Los Angeles David Geffen SOM

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Office
UCLA Neuropsychiatric Hospital
300 Medical Plaza, Suite 3-109
Los Angeles, CA 90095
Phone+1 310-825-8281

Fax+1 310-825-8281
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Education & Training

UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Psychiatry, 1982 - 1985
University of California San Diego School of MedicineClass of 1981

Certifications & Licensure

CA State Medical License 1983 - 2025
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com

Clinical Trials

Chronic Moderate Sleep Restriction in Older Adults Start of enrollment: 2012 Jul 01
Completed
Phase 1
Sleep and Healthy Aging Research for Depression (SHARE-D) Study Start of enrollment: 2018 Jan 01
Recruiting
Phase 1
Roles: Sponsor-Investigator, Contact, Principal Investigator
Aging and Reward System Response to Inflammation and Anxiety Study Start of enrollment: 2023 Mar 29
Recruiting
Phase 1
Roles: Contact, Sub-Investigator
Mindfulness Meditation and Insomnia in Alzheimer Disease Caregivers Start of enrollment: 2018 Jul 01
Completed
Not Applicable
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

IL-6 predicts non-suicidal self-injury over 3 months in high-risk adolescents.
Bai, S., Asarnow, J., Babeva, K., Irwin, M.> ;Bjpsych Open. 2024 Feb 26
Sleep-wake behavioral characteristics associated with depression symptoms: findings from the Multi-Ethnic Study of Atherosclerosis.
Stephen C L Lau, Gehui Zhang, Michael Rueschman, Xiaoyu Li, Michael R Irwin, Robert T Krafty, William V McCall, Elizabeth Skidmore, Sanjay R Patel, Susan Redline, Step...> ;Sleep. 2024 Apr 12
The feasibility of a sleep education program for informal dementia care dyads: A pilot randomized controlled trial.
Yeonsu Song, Anna Papazyan, Diane Lee, Michael N Mitchell, Susan M McCurry, Michael R Irwin, Edmond Teng, Cathy A Alessi, Jennifer L Martin> ;Journal of the American Geriatrics Society. 2024 Apr 1
Work Productivity Among Younger Breast Cancer Survivors: The Impact of Behavioral Interventions for Depression.
Crespi, C., Thure, K., Petersen, L., Bower, J., Ganz, P., Partridge, A., Wolff, A., Joffe, H., Irwin, M., Shih, Y.> ;Value in Health. 2024 Mar 1
Everyday discrimination, emotion, and daily interactions during adolescence.
Danny Rahal, Virginia W Huynh, Michael R Irwin, Heather McCreath, Andrew J Fuligni> ;Journal of Research on Adolescence. 2024 Mar 1
Efficacy of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction for Depression Symptoms and Sleep-Wake Disruption in Older and Younger Adults: Seconda...
Stephen F Smagula, Caitlin E Gasperetti, Daniel J Buysse, Michael R Irwin, Robert T Krafty, Sarah E Lim, Charles F Reynolds 3rd, William V McCall, Allison G Harvey> ;The American Journal of Geriatric Psychiatry. 2024 Apr 1
1 citations
Depressive symptom trajectories in older breast cancer survivors: the Thinking and Living with Cancer Study.
Zev M Nakamura, Brent J Small, Wanting Zhai, Tim A Ahles, Jaeil Ahn, Ashley L Artese, Traci N Bethea, Elizabeth C Breen, Harvey J Cohen, Martine Extermann, Deena Graha...> ;Journal of Cancer Survivorship. 2023 Nov 4
2 citations
Heightened neural activity and functional connectivity responses to social rejection in female adolescents at risk for depression: Testing the Social Signal Transducti...
Grant S Shields, Meghan Vinograd, Theresa Bui, Stassja Sichko, Michael R Irwin, George M Slavich> ;Journal of Affective Disorders. 2024 Jan 15
Inflammation-related proteins as biomarkers of treatment-related behavioral symptoms: A longitudinal study of breast cancer patients and age-matched controls.
Sunita K Patel, Elizabeth C Breen, I Benjamin Paz, Laura Kruper, Joanne Mortimer, F Lennie Wong, Michael R Irwin, Carolyn E Behrendt, Bhatia, S.> ;Brain, Behavior, & Immunity - Health. 2023 Oct 1
1 citations
Executive functioning trajectories and their prospective association with inflammatory biomarkers in schizophrenia and non-psychiatric comparison participants.
David H Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R Irwin, Dilip V Jeste, Xin M Tu, Lisa T Eyler, Ellen E Lee> ;Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2024 Jan 10
2 citations
Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis.
Michael R Irwin, Rainer H Straub, Michael T Smith> ;Nature Reviews. Rheumatology. 2023 Sep 1
4 citations
Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models.
Chloe C Boyle, Julienne E Bower, Naomi I Eisenberger, Michael R Irwin> ;Neuroscience and Biobehavioral Reviews. 2023 Sep 1
A randomized, placebo-controlled, double-blinded mechanistic clinical trial using endotoxin to evaluate the relationship between insomnia, inflammation, and affective ...
Caitlin M DuPont, Richard Olmstead, Matthew J Reid, Katrina R Hamilton, Claudia M Campbell, Patrick H Finan, Nina Sadeghi, Daisy Castillo, Michael R Irwin, Michael T S...> ;Brain, Behavior, & Immunity - Health. 2023 Jul 1
Disturbance of sleep maintenance, but not sleep duration, activates nuclear factor-κB and signal transducer and activator of transcription family proteins in older adu...
Dominique Piber, Richard Olmstead, Joshua H Cho, Michael R Irwin> ;Sleep. 2023 Oct 11
5 citations
Null results of oxytocin and vasopressin administration on mentalizing in a large fMRI sample: evidence from a randomized controlled trial.
Mark A Straccia, Adam R Teed, Perri L Katzman, Kevin M Tan, Michael H Parrish, Michael R Irwin, Naomi I Eisenberger, Matthew D Lieberman, Benjamin A Tabak> ;Psychological Medicine. 2023 Apr 1
8 citations
Enhanced Immune Activation Following Acute Social Stress Among Adolescents With Early-Life Adversity.
Kate R Kuhlman, Steve W Cole, Michelle G Craske, Andrew J Fuligni, Michael R Irwin, Julienne E Bower> ;Biological Psychiatry Global Open Science. 2023 Apr 1
11 citations
A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination.
Karine Spiegel, Amandine E Rey, Anne Cheylus, Kieran Ayling, Christian Benedict, Tanja Lange, Aric A Prather, Daniel J Taylor, Michael R Irwin, Eve Van Cauter> ;Current Biology. 2023 Mar 13
1 citations
Sleep and Healthy Aging Research on Depression (SHARE-D) randomized controlled trial: Protocol overview of an experimental model of depression with insomnia, inflammat...
Michael R Irwin, Chloe C Boyle, Joshua H Cho, Dominique Piber, Elizabeth C Breen, Nina Sadeghi, Daisy Castillo, Michael Smith, Naomi I Eisenberger, Richard Olmstead> ;Brain, Behavior, & Immunity - Health. 2023 Mar 1
2 citations
Remission of insomnia in older adults treated with cognitive behavioral therapy for insomnia (CBT-I) reduces p16gene expression in peripheral blood: secondary outcome ...
Judith E Carroll, Richard Olmstead, Steve W Cole, Elizabeth C Breen, Jesusa M Arevalo, Michael R Irwin> ;Geroscience. 2023 Aug 1
Salivary cortisol awakening levels are reduced in human subjects with intermittent explosive disorder compared with controls.
Alejandro D Meruelo, Matthew A Timmins, Michael R Irwin, Emil F Coccaro> ;Psychoneuroendocrinology. 2023 May 1
2 citations
Plasma and cerebrospinal fluid inflammatory markers and human aggression.
Emil F Coccaro, Royce Lee, Elizabeth C Breen, Michael R Irwin> ;Neuropsychopharmacology. 2023 Jun 1
4 citations
The role of early life adversity and inflammation in stress-induced change in reward and risk processes among adolescents.
Kate R Kuhlman, Steve W Cole, Michael R Irwin, Michelle G Craske, Andrew J Fuligni, Julienne E Bower> ;Brain, Behavior, and Immunity. 2023 Mar 1
Structural brain plasticity and inflammation are independently related to changes in depressive symptoms six months after an index ECT course.
John O Brooks 3rd, Jennifer L Kruse, Antoni Kubicki, Gerhard Hellemann, Randall T Espinoza, Michael R Irwin, Katherine L Narr> ;Psychological Medicine. 2024 Jan 1
4 citations
Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature.
Michael R Irwin> ;Temperature. 2023 Jan 1
Effects of Tai Chi and cognitive behavioral therapy for insomnia on improving sleep in older adults: Study protocol for a non-inferiority trial.
Danny J Yu, Angus P Yu, Shirley X Li, Rachel N Y Chan, Daniel Y Fong, Derwin K C Chan, Stanley S Hui, Ka Fai Chung, Jean Woo, Chenchen Wang, Michael R Irwin, Parco M Siu> ;Journal of Exercise Science and Fitness. 2023 Jan 1
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Press Mentions

Can’t Dream This up: Can Poor Sleep Affect Your Vaccine’s Effectiveness?March 14th, 2023
Climate Change Can Alter Sleep, Increase Susceptibility to Disease: StudyAugust 20th, 2022
Health News | Treating Insomnia with Cognitive Behavioural Therapy May Prevent Major Depression in Elders: StudyDecember 31st, 2021
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