MichaelBKastanMD

PubMed

• 1 citations
  Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway.
  Jennifer J McCann, Donald E Fleenor, Jing Chen, Chun-Hsiang Lai, Thomas E Bass, Michael B Kastan> ;Radiation Research. 2023 Apr 1
• ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks.
  Thomas E Bass, Donald E Fleenor, Paige E Burrell, Michael B Kastan> ;Molecular Cancer Research. 2023 Mar 1
• 14 citations
  Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia
  Abrey J. Yeo, Kok Leong Chong, Magtouf Gatei, Dongxiu Zou, Romal Stewart, Sarah L. Withey, Ernst J. Wolvetang, Robert G. Parton, Adam D. Brown, Michael B. Kastan, Davi...> ;Iscience. 2021 Jan 22
• 9 citations
  DNA-Damage-Induced Alternative Splicing of p53
  Jing Chen, Dadong Zhang, Xiaodi Qin, Kouros Owzar, Jennifer J. McCann, Michael B. Kastan> ;Cancers. 2021 Jan 12
• 1 citations
  Retrospective Diagnosis of Ataxia-Telangiectasia in an Adolescent Patient With a Remote History of T-Cell Leukemia.
  Sei Gyung K. Sze, Howard M. Lederman, Thomas O. Crawford, Michael F. Wangler, Andrea M. Lewis, Michael B. Kastan, Harpreet Dibra, Alex M. Taylor, Daniel S. Wechsler> ;Journal of Pediatric Hematology/oncology. 2021 Jan 1
• 16 citations
  Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness
  Janet B. McGill, Mariko Johnson, Stacy Hurst, William Todd Cade, Kevin E. Yarasheski, Richard E. Ostlund, Kenneth B. Schechtman, Babak Razani, Michael B. Kastan, Donal...> ;Diabetology & Metabolic Syndrome. 2019 Jan 1
• A novel DNA damage-induced alternative splicing pathway that regulates p53 and cellular senescence markers.
  Jing Chen, Michael B. Kastan> ;Oncoscience. 2017 Sep 1
• 58 citations
  Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers.
  Jing Chen, John Crutchley, Dadong Zhang, Kouros Owzar, Michael B. Kastan> ;Cancer Discovery. 2017 Jul 1
• 61 citations
  Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells
  Xinjian Liu, Fang Li, Qian Huang, Zhengxiang Zhang, Ling Zhou, Yu Deng, Min Zhou, Donald E. Fleenor, He Wang, Michael B. Kastan, Chuan-Yuan Li> ;Cell Research. 2017 Mar 24
• 21 citations
  Commentary on "Participation of p53 Protein in the Cellular Response to DNA Damage".
  Michael B. Kastan> ;Cancer Research. 2016 Jul 1
• 98 citations
  Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology
  Amy K. LeBlanc, Matthew Breen, Peter L. Choyke, Mark W. Dewhirst, Timothy M. Fan, Daniel L. Gustafson, Lee J. Helman, Michael B. Kastan, Deborah W. Knapp, Wendy J. Lev...> ;Science Translational Medicine. 2016 Feb 3
• 23 citations
  Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents
  Jaeki Min, Kexiao Guo, Praveen Kumar Suryadevara, Fangyi Zhu, Gloria Holbrook, Yizhe Chen, Clementine Feau, Brandon Young, Andrew Lemoff, Michele Connelly, Michael B. ...> ;Journal of Medicinal Chemistry. 2016 Jan 12
• 291 citations
  ATM functions at the peroxisome to induce pexophagy in response to ROS
  Jiangwei Zhang, Durga Nand Tripathi, Ji Jing, Angela Alexander, Jinhee Kim, Reid T. Powell, Ruhee Dere, Jacqueline Tait-Mulder, Ji-Hoon Lee, Tanya T. Paull, Raj K. Pan...> ;Nature Cell Biology. 2015 Oct 1
• 46 citations
  Chromatin perturbations during the DNA damage response in higher eukaryotes
  Christopher J. Bakkenist, Michael B. Kastan> ;DNA Repair. 2015 Dec 1
• 21 citations
  Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding
  Michael Goldstein, Michael B. Kastan> ;Cancer Research. 2015 Jul 1
• 34 citations
  HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.
  Minsi Zhang, Qiong Qiu, Zhizhong Li, Mohit Sachdeva, Hooney D. Min, Diana M. Cardona, Thomas F. DeLaney, Tracy Han, Yan Ma, Lixia Luo, Olga Ilkayeva, Ki Lui, Amanda G....> ;Radiation Research. 2015 May 14
• 46 citations
  The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair
  Sofia Henriksson, Hanif Rassoolzadeh, Elisabeth Hedström, Christos Coucoravas, Alexander Julner, Michael Goldstein, Gabriela Imreh, Boris Zhivotovsky, Michael B. Kasta...> ;Genes & Development. 2014 Dec 15
• 336 citations
  The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy
  Michael Goldstein, Michael B. Kastan> ;Annual Review of Medicine. 2015 Jan 14
• 198 citations
  Inactivation of the Human Papillomavirus E6 or E7 Gene in Cervical Carcinoma Cells by Using a Bacterial CRISPR/Cas RNA-Guided Endonuclease
  Edward M. Kennedy, Anand V.R. Kornepati, Michael Goldstein, Hal P. Bogerd, Brigid Chiyoko Poling, Adam W. Whisnant, Michael B. Kastan, Bryan R. Cullen> ;Journal of Virology. 2014 Oct 15
• 63 citations
  Rad17 recruits the MRE11‐RAD50‐NBS1 complex to regulate the cellular response to DNA double‐strand breaks
  Qinhong Wang, Michael Goldstein, Peter B. Alexander, Timothy P. Wakeman, Tao Sun, Junjie Feng, Zhenkun Lou, Michael B. Kastan, Xiao-Fan Wang> ;The EMBO Journal. 2014 Apr 16
• 18 citations
  Pilot study of modified LMB-based therapy for children with ataxia–telangiectasia and advanced stage high grade mature B-cell malignancies
  John T. Sandlund, Melissa M. Hudson, Wren Kennedy, Mihaela Onciu, Michael B. Kastan> ;Pediatric Blood & Cancer. 2014 Feb 1
• 27 citations
  Development of a Cell-Based, High-Throughput Screening Assay for ATM Kinase Inhibitors
  Kexiao Guo, Anang A. Shelat, R. Kiplin Guy, Michael B. Kastan> ;Journal of Biomolecular Screening. 2014 Jan 24
• 90 citations
  Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair
  Michael Goldstein, Frederick A. Derheimer, Jacqueline Tait-Mulder, Michael B. Kastan> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Oct 15
• 184 citations
  A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS
  , , , , , , , , , , , , , , , , > ;Nature Cell Biology. 2013 Oct 1
• 273 citations
  Strategies for optimizing the response of cancer and normal tissues to radiation
  Everett J. Moding, Michael B. Kastan, David G. Kirsch> ;Nature Reviews. Drug Discovery. 2013 Jul 1
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Journal Articles

• The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy  
  Goldstein M, Kastan MB, Annual Review of Medicine, 1/1/2015
• Repair versus checkpoint functions of Brca1 are differentially regulated by site of chromatin binding  
  Goldstein M, Kastan MB, Cancer Res, 1/1/2015
• ATM Functions at the Peroxisome to Induce Pexophagy in Response to ROS  
  Zhang J,, Tripathi DN, Jing, J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee J-H, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL, Nature Cell Biology, 1/1/2015
• Rad17 Recruits the MRE11-RAD50-NBS1 Complex to Regulate the Cellular Response to DNA Double-Strand Breaks  
  Wang Q, Alexander PB, Goldstein M, Wakeman TP, Sun T, Feng J, Lou Z, Kastan MB, Wang X-F, EMBO J, 1/1/2014
• The scaffold protein WRAP53beta orchestrates the ubiquitin response critical for DNA double-strand break repair  
  Henriksson S, Hedstrom S, Rassoolzadeh H, Julner A, Goldstein M, Imreh G, Zhivotovsky B, Jirstrom K, Kastan MB, Brennan DJ, Helleday T, Farnebo M, Genes and Development, 1/1/2014
• Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells using a bacterial CRISPR/Cas RNA-guided endonuclease  
  Kennedy EM, Kornepati AVI, Goldstein M, Bogerd HP, Poling BC, Whisnant AW, Kastan MB, and Cullen BR, Journal of Virology, 1/1/2014
• A tuberous sclerosis complex signaling node at the peroxisome regulates mTORC1 and autophagy in response to ROS  
  Zhang J, Jinhee K, Alexander A, Cai S, Tee A, Tait-Mulder J, Di Nardo A, Han J, Kwiatkowski E, Dunlop E, Dodd K, Folkerth R, Faust P, Kastan MB, Sahin M, Walker C, Nature Cell Biology, 1/1/2013
• Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies  
  Sandlund JT, Hudson MM, Kennedy W, Onciu M, Kastan MB, Pediatric Blood Cancer, 1/1/2013
• Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair  
  Goldstein M, Derheimer FA, Tait-Mulder J, Kastan MB, Proc Natl Acad Sci, 1/1/2013
• A new role for ATM, Regulating mitochondrial function and mitophagy  
  Valentin-Vega Y, Kastan MB, Autophagy, 1/1/2012
• Mitochondrial Dysfunction in Ataxia-Telangiectasia  
  Valentin-Vega YA, Maclean KH, Tait-Mulder J, Milasta S, Steeves M, Dorsey FC, Cleveland JL, Green DR, and Kastan MB, Blood, 1/1/2012
• Autophagy Links Inflammasomes to Atherosclerotic Progression  
  Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting J, Virgin HW, Kastan MB, and Semenkovich CF, Cell Metabolism, 1/1/2012
• Chloroquine improves hematopoietic recovery and survival following lethal low dose-rate radiation  
  Lim Y, Hedayati M, Merchant A, Zhang Y, Kastan MB, Matsui W, Deweese T, Intl J Radiat Oncol Biol Phys, 1/1/2012
• Interactions of nucleolin and ribosomal protein RPL26 in the translational control of human p53 mRNA  
  Chen J, Guo K, Kastan MB, J Biol Chem, 1/1/2012
• Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia  
  Leung W, Neale G, Behm F, Iyengar R, Finkelstein D, Kastan MB, Pui CH, Cancer Epidemiology, 1/1/2010
• Multiple roles of ATM in Monitoring and Maintaining DNA Integrity  
  Derheimer FA and Kastan MB, FEBS Letters, 1/1/2010
• 5' - 3' UTR Interactions Regulate p53 mRNA Translation and Provide a Target for Modulating p53 Induction After DNA Damage  
  Chen J and Kastan MB, Genes and Development, 1/1/2010
• ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS  
  Alexander A, Cai SL, Kim J, Nanez A, Sahin M, Maclean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL, Proc Nat Acad Sci, 1/1/2010
• Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis  
  Maclean KH, Dorsey FC, Cleveland JL, and Kastan MB, Journal of Clinical Investigation, 1/1/2008
• 2007 GHA Clowes Memorial Award Lecture, DNA Damage Responses: Mechanisms and Roles in Human Disease  
  Kastan MB, Mol Cancer Res, 1/1/2008
• Mdm2 regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26  
  Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M, Molecular Cell, 1/1/2008
• Assessment of Protein Dynamics and DNA Repair Following Generation of DNA Double-Strand Breaks at Defined Genomic Sites  
  Berkovich E, Monnat, RJ, Kastan MB, Nature Protocols, 1/1/2008
• Our Cells Get Stressed Too! Implications for Human Disease  
  Kastan MB, Blood Cells, Molecules & Diseases, 1/1/2007
• Atm Deficiency Affects both Apoptosis and Proliferation to Augment myc-Induced Lymphomagenesis  
  Maclean KH, Kastan MB, Cleveland JL, Molecular Cancer Research, 1/1/2007
• Roles of ATM and NBS1 in chromatin structure modulation and double strand break repair  
  Berkovich E, Monnat RJ, Kastan MB, Nature Cell Biology, 1/1/2007
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Books/Book Chapters

• Clinical Oncology 
  Editors: Niederhuber, Armitage, Doroshow, Kastan, and Tepper.Edition 5th,2014
• Clinical Oncology 
  Chapter: DNA Damage Response Pathways and Cancer. 
  Page 139 - 152Ford JM and Kastan MBEditors: Abeloff, Armitage, Niederhuber, Kastan, and McKenna.Edition 4th,2008
• Clinical Oncology 
  Editors: Abeloff, Armitage, Niederhuber, Kastan, and McKenna.Edition 4th,2008
• 25 Years of p53 Research. 
  Chapter: 20 Years of DNA Damage Signaling to p53. Chapter 3 
  Page 53 - 71McLure K, Kastan MBEditors: Pierre Hainaut and Klas G. Wiman.Springer, Netherlands2005
• Methods in Molecular Biology, Vol 281, Checkpoint Controls and Cancer, Volume 2: Activation and Regulation Protocols. 
  Chapter: Analyzing cell cycle checkpoints after ionizing radiation. Chapter 20 
  Page 283 - 292Xu B and Kastan MBEditors: Axel H. Schonthal.Humana Press, Totowa, NJ2004
• Clinical Oncology 
  Editors: Abeloff, Armitage, Niederhuber, Kastan, and McKenna.2004
• Principles and Practice of Pediatric Oncology 
  Chapter: Biology of Childhood Cancer. 
  Page 89 - 119Thiele CJ and Kastan MBEditors: Pizzo and Poplack.Edition 4th,2002
• Cancer: Principles and Practice of Oncology 
  Chapter: Molecular Cell Biology of Cancer: The Cell Cycle. 
  Page 91 - 109Kastan MB and Skapek SXEditors: DeVita, Hellman, and Rosenberg.Edition 6th,2001
• Clinical Oncology 
  Chapter: Regulation of the Cell Cycle. 
  Page 10 - 28Bedi A and Kastan MBEditors: Abeloff, Armitage, Lichter, and Niederhuber.Edition 2nd,2000
• Principles and Practice of Oncology 
  Chapter: Molecular biology of cancer: the cell cycle 
  Page 121 - 134Kastan MBEditors: DeVita, Hellman, Rosenberg.Edition 5th,1997
• Current Topics in Microbiology and Immunology. 
  Chapter: Genetic instability and Tumorigenesis. 
  Editors: Kastan MB.Springer-Verlag, Berlin Heidelberg1997
• Cancer Surveys V:29 
  Chapter: Checkpoint controls and cancer. 
  Editors: Kastan MB.1997
• Molecular controls of cell cycle progression following DNA damage: roles of p53 and ataxia-telangiectasia gene products. 
  Kastan MBEditors: E. Mihich and R.T. Schimke.Plenum Press1994
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Lectures

• Genome Dynamics in Neuroscience 
  Hong Kong - 1/1/2017
• Ataxia Telangiectasia Workshop 
  Milan, Italy - 1/1/2017
• Mitochondria and Cancer 
  1/1/2015
• DNA Repair Symposium 
  Washington State University - 1/1/2015
• DNA Damage Responses Symposium 
  1/1/2014
• Particle/Photon Radiotherapy Symposium 
  Denver, CO - 1/1/2014
• Frontiers in Cancer Prevention 
  New Orleans, LA - 1/1/2014
• Frontiers in Cancer Science 
  Singapore - 1/1/2014
• Frontiers in Oncology series 
  University of Maryland Cancer Center - 1/1/2014
• International Workshop on A-T/ATM 
  Birmingham, United Kingdom - 1/1/2013
• Cancer Biology Seminar Series 
  University of Wisconsin, Madison, WI - 1/1/2013
• Model Organisms to Human Biology 
  Washington, DC - 1/1/2012
• Genome Instability and DNA Repair 
  Keystone, CO - 1/1/2011
• Cell Cycle and Cancer 
  Saint Malo, France - 1/1/2011
• Oncology at the Limits 
  Stockholm, Sweden - 1/1/2011
• Energy Metabolism, Cell Cycle and Cancer 
  1/1/2010
• Protein Translation and Cancer 
  Coronado, CA - 1/1/2010
• Synthetic Lethality and Therapeutically Exploiting the Addictions of Cancer 
  Orlando, FL - 1/1/2010
• Telomere Biology and DNA Repair 
  Brisbane, Australia - 1/1/2009
• DNA Damage and Cell Cycle Checkpoints Symposium 
  Denver, CO - 1/1/2009
• Emerging Tumor Suppressors 
  Taos, NM - 1/1/2009
• Genome Instability and Repair 
  Breckenridge, CO - 1/1/2007
• Genomics and Post-Genomics of Hematological Malignancies Symposium 
  Chaim Sheba Hospital, Israel - 1/1/2007
• Mechanisms and Models of Cancer 
  La Jolla, CA - 1/1/2007
• Ataxia-telangiectasia and ATM 
  Banff, Canada - 1/1/2006
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Other

• Ataxia-telangiectasia: defective in a p53-dependent signal transduction pathway. 
  Kastan MB, Ataxia-Telangiectasia Workshop V
  1/1/1993
• DNA Methylation in Human Fibroblasts Following DNA Damage and Repair 
  Kastan MB, Ph.D. Thesis
  Washington University School of Medicine, St. Louis, MO - 1/1/1984