Michael B Kastan MD

PubMed

• ATM interaction with GRP94 modulates oncogenic receptor expression and signaling and microglial activation.
  Paige E Burrell, Donald E Fleenor, Olivia M Nicholson, Changjuan Shao, Michael B Kastan
  Proceedings of the National Academy of Sciences of the United States of America. 2025-12-30
• 14 citations
  A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors.
  Tona M Gilmer, Chun-Hsiang Lai, Kexiao Guo, Katherine Deland, Kathleen A Ashcraft
  Molecular Cancer Therapeutics. 2024-06-04
• 4 citations
  Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway.
  Jennifer J McCann, Donald E Fleenor, Jing Chen, Chun-Hsiang Lai, Thomas E Bass
  Radiation Research. 2023-04-01

Journal Articles

• The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy  
  Goldstein M, Kastan MB, Annual Review of Medicine, 1/1/2015
• Repair versus checkpoint functions of Brca1 are differentially regulated by site of chromatin binding  
  Goldstein M, Kastan MB, Cancer Res, 1/1/2015
• ATM Functions at the Peroxisome to Induce Pexophagy in Response to ROS  
  Zhang J,, Tripathi DN, Jing, J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee J-H, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL, Nature Cell Biology, 1/1/2015

Books/Book Chapters

• Clinical Oncology 
  Editors: Niederhuber, Armitage, Doroshow, Kastan, and Tepper.Edition 5th,2014
• Clinical Oncology 
  Chapter: DNA Damage Response Pathways and Cancer. 
  Page 139 - 152Ford JM and Kastan MBEditors: Abeloff, Armitage, Niederhuber, Kastan, and McKenna.Edition 4th,2008
• Clinical Oncology 
  Editors: Abeloff, Armitage, Niederhuber, Kastan, and McKenna.Edition 4th,2008

Lectures

• Genome Dynamics in Neuroscience 
  Hong Kong - 1/1/2017
• Ataxia Telangiectasia Workshop 
  Milan, Italy - 1/1/2017
• Mitochondria and Cancer 
  1/1/2015

Other

• Ataxia-telangiectasia: defective in a p53-dependent signal transduction pathway. 
  Kastan MB, Ataxia-Telangiectasia Workshop V
  1/1/1993
• DNA Methylation in Human Fibroblasts Following DNA Damage and Repair 
  Kastan MB, Ph.D. Thesis
  Washington University School of Medicine, St. Louis, MO - 1/1/1984