StephenXSkapekMD

Pediatric Hematology & Oncology • Dallas, TX

Pediatric Sarcoma Oncology, Pediatric Solid Tumor Oncology

Professor, Interim Chair, Department of Pediatrics, University of Texas Southwestern Medical Center

Join to view full profile

Dr. Skapek is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Skapek's full profile

Already have an account?

Office
5323 Harry Hines Boulevard
Dallas, TX 75390
Phone+1 214-456-2382

Fax+1 214-456-6133
Is this information wrong?

Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Dana-Farber Cancer InstituteFellowship, Hematology and Medical Oncology, 1991 - 1994
San Antonio Uniformed Services Health Education ConsortiumResidency, Pediatrics, 1988 - 1991
Duke University School of MedicineClass of 1988

Certifications & Licensure

NC State Medical License 2024 - 2024
TX State Medical License 2011 - 2024
IL State Medical License 2007 - 2014
TN State Medical License 1999 - 2007
MA State Medical License 1991 - 1999
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Clofarabine Plus Cytarabine Versus Conventional Induction Therapy And A Study Of NK Cell Transplantation In Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2008 Aug 04
Completed
Phase 3
A Study of Pre-Operative Treatment of Newly-Diagnosed, Surgically-Resectable Osteosarcoma With Doxorubicin, Ifosfamide, Etoposide, and Cisplatin With Early Metabolic Assessment of Response Start of enrollment: 2010 Jul 01
Terminated
Phase 1
A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis Start of enrollment: 2014 Feb 01
Completed
Phase 1, Phase 2

Publications & Presentations

PubMed

Germline Genetic Testing and Survival Outcomes Among Children With Rhabdomyosarcoma: A Report From the Children's Oncology Group.
Bailey A Martin-Giacalone, He Li, Michael E Scheurer, Dana L Casey, Shannon Dugan-Perez, Deborah A Marquez-Do, Donna Muzny, Richard A Gibbs, Donald A Barkauskas, David...> ;JAMA Network Open. 2024 Mar 4
Genomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer.
Funan He, Abhik M Bandyopadhyay, Laura J Klesse, Anna Rogojina, Sang H Chun, Erin Butler, Taylor Hartshorne, Trevor Holland, Dawn Garcia, Korri Weldon, Luz-Nereida Per...> ;Nature Communications. 2023 Nov 22
Comprehensive characterization of patient-derived xenograft models of pediatric leukemia.
Anna Rogojina, Laura J Klesse, Erin Butler, Jiwoong Kim, He Zhang, Xue Xiao, Lei Guo, Qinbo Zhou, Taylor Hartshorne, Dawn Garcia, Korri Weldon, Trevor Holland, Abhik B...> ;Iscience. 2023 Nov 17
Osteosarcoma Explorer: A Data Commons With Clinical, Genomic, Protein, and Tissue Imaging Data for Osteosarcoma Research.
Donghan M Yang, Qinbo Zhou, Lauren Furman-Cline, Xian Cheng, Danni Luo, Hongyin Lai, Yueqi Li, Kevin W Jin, Bo Yao, Patrick J Leavey, Dinesh Rakheja, Tammy Lo, David H...> ;JCO Clinical Cancer Informatics. 2023 Sep 1
A pilot study evaluating the use of sirolimus in children and young adults with desmoid-type fibromatosis.
Aaron R Weiss, Sarah Dry, Clara Maygar, Anya Cutler, Christine W Lary, Carmen Khoo, Jillian E Fergione, Melanie M Hounchell, Kathleen Glick, Meghen Browning, Sun Ha Ch...> ;Pediatric Blood & Cancer. 2023 Jun 7
2 citations
Germline genetic variants and pediatric rhabdomyosarcoma outcomes: a report from the Children's Oncology Group.
Bailey A Martin-Giacalone, Melissa A Richard, Michael E Scheurer, Javed Khan, Pagna Sok, Priya B Shetty, Stephen J Chanock, Shengchao Alfred Li, Meredith Yeager, Debor...> ;Journal of the National Cancer Institute. 2023 Jun 8
Methyltransferase Inhibition Enables TgfDriven Induction ofandin Cancer Cells.
Yen-Ting Liu, Celeste Romero, Xue Xiao, Lei Guo, Xiaoyun Zhou, Mark A Applebaum, Lin Xu, Stephen X Skapek> ;Molecular and Cellular Biology. 2023 Jan 1
2 citations
Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group.
David Milewski, Hyun Jung, G Thomas Brown, Yanling Liu, Ben Somerville, Curtis Lisle, Marc Ladanyi, Erin R Rudzinski, Hyoyoung Choo-Wosoba, Donald A Barkauskas, Tammy ...> ;Clinical Cancer Research. 2023 Jan 17
Exon skipping in genes encoding lineage-defining myogenic transcription factors in rhabdomyosarcoma.
Erin Butler, Lin Xu, Dinesh Rakheja, Blake Schwettmann, Shireen Toubbeh, Lei Guo, Jiwoon Kim, Stephen X Skapek, Yanbin Zheng> ;Cold Spring Harbor Molecular Case Studies. 2022 Aug 6
75 citations
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium
Jack F. Shern, Joanna Selfe, Elisa Izquierdo, Rajesh Patidar, Hsien-Chao Chou, Young K. Song, Marielle E. Yohe, Sivasish Sindiri, Jun S. Wei, Xinyu Wen, Erin R. Rudzin...> ;Journal of Clinical Oncology. 2021 Jun 24
9 citations
Prioritization of Novel Agents for Patients with Rhabdomyosarcoma: A Report from the Children’s Oncology Group (COG) New Agents for Rhabdomyosarcoma Task Force
Holly L Pacenta, Wendy Allen-Rhoades, David M. Langenau, Peter J. Houghton, Charles Keller, Christine M. Heske, Michael D. Deel, Corinne M. Linardic, Jack F. Shern, El...> ;Journal of Clinical Medicine. 2021 Apr 1
11 citations
Rationale for the use of tyrosine kinase inhibitors in the treatment of paediatric desmoid-type fibromatosis.
Monika Sparber-Sauer, Daniel Orbach, Fariba Navid, Simone Hettmer, Stephen X. Skapek, Nadège Corradini, Michela Casanova, Aaron R. Weiss, Matthias Schwab, Andrea C. Fe...> ;British Journal of Cancer. 2021 Mar 15
17 citations
HDAC6 promotes growth, migration/invasion, and self-renewal of rhabdomyosarcoma.
Thao Pham, Kristin Robinson, Lin Xu, Maria N. Pavlova, Stephen X. Skapek, Eleanor Y. Chen> ;Oncogene. 2021 Jan 21
29 citations
Pathogenic Germline Variants in Cancer Susceptibility Genes in Children and Young Adults With Rhabdomyosarcoma.
Jung Kim, Nicholas Light, Vallijah Subasri, Erin L. Young, Talia Wegman-Ostrosky, Donald A. Barkauskas, David Hall, Philip J. Lupo, Rajesh Patidar, Luke Maese, Kristin...> ;JCO Precision Oncology. 2021 Jan 11
46 citations
Germline Cancer Predisposition Variants in Pediatric Rhabdomyosarcoma: A Report From the Children’s Oncology Group
He Li, Saumya D. Sisoudiya, Bailey Angeline Martin-Giacalone, Michael M. Khayat, Shannon Dugan-Perez, Deborah Marquez-Do, Michael E. Scheurer, Donna M. Muzny, Eric Boe...> ;Journal of the National Cancer Institute. 2020 Dec 29
2 citations
Functional imaging of RAS pathway targeting in malignant peripheral nerve sheath tumor cells and xenografts.
Erin Butler, Blake Schwettmann, Sophie Geboers, Guiyang Hao, Jiwoong Kim, Kien Nham, Xiankai Sun, Theodore W. Laetsch, Lin Xu, Noelle S. Williams, Stephen X. Skapek> ;Pediatric Blood & Cancer. 2020 Sep 25
23 citations
Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children's Oncology Group.
Pooja Hingorani, Valentin Dinu, Xiyuan Zhang, Haiyan Lei, Jack F. Shern, Jin Park, Jason Steel, Femina Rauf, David M. Parham, Julie M. Gastier-Foster, David G. Hall, D...> ;Scientific Reports. 2020 Jul 23
3 citations
Development of a Data Model and Data Commons for Germ Cell Tumors.
Bo Ci, Donghan M. Yang, Mark Krailo, Caihong Xia, Bo Yao, Danni Luo, Qinbo Zhou, Guanghua Xiao, Lin Xu, Stephen X. Skapek, Matthew J. Murray, James F. Amatruda, Lindsa...> ;JCO Clinical Cancer Informatics. 2020 Jun 22
7 citations
Bayesian Modeling Identifies PLAG1 as a Key Regulator of Proliferation and Survival in Rhabdomyosarcoma Cells
Yanbin Zheng, Lin Xu, Mohammed Hassan, Xiaoyun Zhou, Qinbo Zhou, Dinesh Rakheja, Stephen X. Skapek> ;Molecular Cancer Research. 2020 Mar 1
66 citations
A risk-based treatment strategy for non-rhabdomyosarcoma soft-tissue sarcomas in patients younger than 30 years (ARST0332): a Children's Oncology Group prospective study.
Sheri L. Spunt, Lynn Million, Yueh-Yun Chi, James R. Anderson, Jing Tian, Emily Hibbitts, Cheryl M. Coffin, M. Beth McCarville, R. Lor Randall, David M. Parham, Jennif...> ;The Lancet. Oncology. 2020 Jan 1
Testis-specific Arf promoter expression in a transposase-aided BAC transgenic mouse model.
Caroline Y. Sung, Yen Ting Liu, Lynda Bennett, Caitlin C. Devitt, Stephen X. Skapek> ;Molecular Biology Reports. 2019 Oct 3
12 citations
Novel PDGFRB rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib.
Mohammed Hassan, Erin Butler, Raphael Wilson, Angshumoy Roy, Yanbin Zheng, Priscilla Liem, Dinesh Rakheja, Dean Pavlick, Lauren L. Young, Margaret Rosenzweig, Rachel L...> ;Cold Spring Harbor Molecular Case Studies. 2019 Oct 23
77 citations
Refinement of risk stratification for childhood rhabdomyosarcoma using FOXO1 fusion status in addition to established clinical outcome predictors: A report from the Ch...
Emily Hibbitts, Yueh-Yun Chi, Douglas S. Hawkins, Frederic G. Barr, Julie A. Bradley, Roshni Dasgupta, William H. Meyer, David A. Rodeberg, Erin R. Rudzinski, Sheri L....> ;Cancer Medicine. 2019 Oct 1
23 citations
Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding.
Stephen Li, Kenian Chen, Yichi Zhang, Spencer D. Barnes, Priscilla Jaichander, Yanbin Zheng, Mohammed Hassan, Venkat S. Malladi, Stephen X. Skapek, Lin Xu, Rhonda Bass...> ;Genes & Development. 2019 Jun 1
11 citations
Clinical and mutational spectrum of highly differentiated, paired box 3:forkhead box protein o1 fusion-negative rhabdomyosarcoma: A report from the Children's Oncology...
Lisa A. Teot, Michaela Schneider, Aaron R. Thorner, Jing Tian, Yueh-Yun Chi, Matthew D. Ducar, Ling Lin, Marcin W. Wlodarski, Holcombe E. Grier, Christopher D.M. Fletc...> ;Cancer. 2018 May 1
Join now to see all

Press Mentions

Children’s Health Appoints New Chief of Cardiology for the Heart CenterSeptember 13th, 2021
UT Southwestern Develops System to Identify Genetic Anomalies Connected to CancerJuly 8th, 2018
Groundbreaking Genetic Research Could Help Diagnose and Cure Cancer in ChildrenJuly 6th, 2018
Join now to see all

Grant Support

TGF 2-2 Controls P19ARF During Eye DevelopmentNational Eye Institute2012
ARF Controls Vascular Regression During Eye DevelopmentNational Eye Institute2012
TGF 2-2 Controls P19ARF During Eye DevelopmentNational Eye Institute2010–2011
ARF Controls Vascular Regression During Eye DevelopmentNational Eye Institute2007–2011
Translation Of Predictive Cancer Biomarkers Into Clinical PracticeNational Cancer Institute2009–2010
ARF Controls Vascular Regression During Eye DevelopmentNational Eye Institute2003–2007
Cell Cycle-Dependent Regulation Of MyogenesisEunice Kennedy Shriver National Institute Of Child Health &Human Development1999
Cell Cycle-Dependent Regulation Of MyogenesisEunice Kennedy Shriver National Institute Of Child Health &Human Development1996–1998
Cell Cycle Dependent Regulation Of MyogenesisEunice Kennedy Shriver National Institute Of Child Health &Human Development1995