MichaelWSchmittMD

PubMed

• 1 citations
  Accurate detection of subclonal variants in paired diagnosis-relapse acute myeloid leukemia samples by next generation Duplex Sequencing.
  Ashwini S Kamath-Loeb, Jiang-Cheng Shen, Michael W Schmitt, Brendan F Kohrn, Keith R Loeb, Elihu H Estey, Jin Dai, Sylvia Chien, Lawrence A Loeb, Pamela S Becker> ;Leukemia Research. 2022 Apr 1
• 9 citations
  Intra-host changes in Kaposi sarcoma-associated herpesvirus genomes in Ugandan adults with Kaposi sarcoma.
  Jan Clement Santiago, Jason D Goldman, Hong Zhao, Alec P. Pankow, Fred Okuku, Michael W. Schmitt, Lennie Chen, C. Alexander Hill, Corey Casper, Warren Phipps, James I....> ;Plos Pathogens. 2021 Jan 19
• 20 citations
  Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias.
  Michael W. Schmitt, Justin R. Pritchard, Scott M. Leighow, Bella I. Aminov, Lan Beppu, Daniel S. Kim, J. Graeme Hodgson, Victor M. Rivera, Lawrence A. Loeb, Jerald P. ...> ;Clinical Cancer Research. 2018 Nov 1
• 280 citations
  Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations.
  Jesse J. Salk, Michael W. Schmitt, Lawrence A. Loeb> ;Nature Reviews. Genetics. 2018 Mar 26
• 110 citations
  Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues
  Jeffrey D. Krimmel, Michael W. Schmitt, Maria I. Harrell, Kathy Agnew, Scott R. Kennedy, Mary J. Emond, Lawrence A. Loeb, Elizabeth M. Swisher, Rosa Ana Risques> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 May 24
• 157 citations
  The influence of subclonal resistance mutations on targeted cancer therapy
  Michael W. Schmitt, Lawrence A. Loeb, Jesse J. Salk> ;Nature Reviews. Clinical Oncology. 2016 Jun 1
• 99 citations
  Sequencing small genomic targets with high efficiency and extreme accuracy
  Michael W. Schmitt, Edward J. Fox, Marc J. Prindle, Kate S Reid-Bayliss, Lawrence D. True, Jerald P. Radich, Lawrence A. Loeb> ;Nature Methods. 2015 May 1
• Botulinum toxin induces muscle paralysis and inhibits bone regeneration in zebrafish.
  Recidoro, A. M.,Roof, A. C.,Schmitt, M.,Worton, L. E.,Petrie, T.,Strand, N.,Ausk, B. J.,Srinivasan, S.,Moon, R. T.,Gardiner, E. M.,Kaminsky, W.,Bain, S. D.,Allan, C. H...> ;J. Bone Miner. Res.. 2014 May 09
• 278 citations
  Detecting ultralow-frequency mutations by Duplex Sequencing
  Scott R. Kennedy, Michael W. Schmitt, Edward J. Fox, Brendan F. Kohrn, Jesse J. Salk, Eun Hyun Ahn, Marc J. Prindle, Kawai J. Kuong, Jiang Cheng Shen, Rosa Ana Risques...> ;Nature Protocols. 2014 Nov 1
• 5 citations
  Risks of double-counting in deep sequencing.
  Michael W. Schmitt, Edward J. Fox, Jesse J. Salk> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 Apr 22
• 248 citations
  Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage
  Scott R. Kennedy, Jesse J. Salk, Michael W. Schmitt, Lawrence A. Loeb> ;Plos Genetics. 2013 Sep 26
• 13 citations
  A Substitution in the Fingers Domain of DNA Polymerase δ Reduces Fidelity by Altering Nucleotide Discrimination in the Catalytic Site
  Marc J. Prindle, Michael W. Schmitt, Fabio Parmeggiani, Lawrence A. Loeb> ;The Journal of Biological Chemistry. 2013 Feb 22
• 659 citations
  Detection of ultra-rare mutations by next-generation sequencing
  Michael W. Schmitt, Scott R. Kennedy, Jesse J. Salk, Edward J. Fox, Joseph Hiatt, Lawrence A. Loeb> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Sep 4
• 46 citations
  Implications of genetic heterogeneity in cancer.
  Michael W. Schmitt, Marc J. Prindle, Lawrence A. Loeb> ;Annals of the New York Academy of Sciences. 2012 Sep 1
• 31 citations
  The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ
  Ashwini S. Kamath-Loeb, Jiang Cheng Shen, Michael W. Schmitt, Lawrence A. Loeb> ;The Journal of Biological Chemistry. 2012 Apr 6
• 11 citations
  The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparum
  Scott R. Kennedy, Cheng Yao Chen, Michael W. Schmitt, Cole N. Bower, Lawrence A. Loeb> ;Journal of Molecular Biology. 2011 Jul 1
• 15 citations
  Active Site Mutations in Mammalian DNA Polymerase δ Alter Accuracy and Replication Fork Progression
  Michael W. Schmitt, Ranga N. Venkatesan, Marie Jeanne Pillaire, Jean Sébastien Hoffmann, Julia M. Sidorova, Lawrence A. Loeb> ;The Journal of Biological Chemistry. 2010 Oct 15
• 3 citations
  Molecularly Evolved Thymidylate Synthase Inhibits 5-Fluorodeoxyuridine Toxicity in Human Hematopoietic Cells
  Jason H. Bielas, Michael W. Schmitt, Amalia Icreverzi, Nolan G. Ericson, Lawrence A. Loeb> ;Human Gene Therapy. 2009 Dec 1
• 78 citations
  High fidelity and lesion bypass capability of human DNA polymerase δ
  Michael W. Schmitt, Yoshihiro Matsumoto, Lawrence A. Loeb> ;Biochimie. 2009 Sep 1
• Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells.
  Hapke S, Kessler H, Arroyo de Prada N, Benge A, Schmitt M, Lengyel E, Reuning U> ;J. Biol. Chem.. 2001-07-13
• A novel type of bifunctional inhibitor directed against proteolytic activity and receptor/ligand interaction. Cystatin with a urokinase receptor binding site.
  Muehlenweg B, Assfalg-Machleidt I, Parrado SG, Bürgle M, Creutzburg S, Schmitt M, Auerswald EA, Machleidt W, Magdolen V> ;J. Biol. Chem.. 2000-10-27
• Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor.
  Ried S, Jäger C, Jeffers M, Vande Woude GF, Graeff H, Schmitt M, Lengyel E> ;J. Biol. Chem.. 1999-06-04
• A review of parameters for the bioelectrical characterization of breast tissue.
  Jossinet J, Schmitt M> ;Ann. N. Y. Acad. Sci.. 1999-04-20
• Evolution of the Friedreich's ataxia trinucleotide repeat expansion: founder effect and premutations.
  Cossée M, Schmitt M, Campuzano V, Reutenauer L, Moutou C, Mandel JL, Koenig M> ;Proc. Natl. Acad. Sci. U.S.A.. 1997-07-08
• T cell-dependent antibody production by Ly-1 B cells.
  Taki S, Schmitt M, Tarlinton D, Förster I, Rajewsky K> ;Ann. N. Y. Acad. Sci.. 1992-05-04
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