MinShenMD

PubMed

• 7 citations
  A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry
  Miao Xu, Manisha Pradhan, Kirill Gorshkov, Jennifer D. Petersen, Min Shen, Hui Guo, Wei Zhu, Carleen Klumpp-Thomas, Sam Michael, Misha Itkin, Zina Itkin, Marco R. Stra...> ;Biorxiv. 2021 Oct 5
• 5 citations
  Hybrid In Silico Approach Reveals Novel Inhibitors of Multiple SARS-CoV-2 Variants.
  Sankalp Jain, Daniel C. Talley, Bolormaa Baljinnyam, Jun Choe, Quinlin M Hanson, Wei Zhu, Miao Xu, Catherine Z. Chen, Wei Zheng, Xin Hu, Min Shen, Ganesha Rai, Matthew...> ;ACS Pharmacology & Translational Science. 2021 Sep 17
• 1 citations
  Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.
  Li Liu, Manshu Tang, Rajan Pragani, Frank G. Whitby, Yaqin Zhang, Bijina Balakrishnan, Yuhong Fang, Surendra Karavadhi, Dingyin Tao, Christopher A. LeClair, Matthew D....> ;Journal of Medicinal Chemistry. 2021 Sep 7
• 6 citations
  Minimal information for chemosensitivity assays (MICHA): a next-generation pipeline to enable the FAIRification of drug screening experiments.
  Ziaurrehman Tanoli, Jehad Aldahdooh, Farhan Alam, Yinyin Wang, Umair Seemab, Maddalena Fratelli, Petr Pavlis, Marian Hajduch, Florence Bietrix, Philip Gribbon, Andrea ...> ;Briefings in Bioinformatics. 2021 Sep 1
• 9 citations
  Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties.
  Tim Hempel, Katarina Elez, Nadine Krüger, Lluís Raich, Jonathan H. Shrimp, Olga Danov, Danny Jonigk, Armin Braun, Min Shen, Matthew D. Hall, Stefan Pöhlmann, Markus Ho...> ;Chemical Science. 2021 Aug 26
• 15 citations
  PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by NSD2 Mutation in Pediatric Acute Lymphoblastic Leukemia.
  Jianping Li, Julia Cathryn Hlavka-Zhang, Jonathan H. Shrimp, Crissandra Piper, Daphné Dupéré-Richer, Jacob S. Roth, Duohui Jing, Heidi L. Casellas Roman, Catalina Troc...> ;Cancer Discovery. 2021 Aug 20
• 9 citations
  The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia
  Zachary F. Caffall, Bradley J. Wilkes, Ricardo Hernández-Martínez, Joseph E. Rittiner, Jennifer T. Fox, Kanny K. Wan, Miranda K. Shipman, Steve Titus, Yaqin Zhang, Sam...> ;Science Translational Medicine. 2021 Aug 18
• 14 citations
  The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis.
  Hilary A. Kenny, Peter C. Hart, Kasjusz Kordylewicz, Madhu Lal, Min Shen, Betul Kara, Yen-Ju Chen, Niklas Grassl, Yousef Alharbi, Bikash R. Pattnaik, Karen M. Watters,...> ;Cancers. 2021 Aug 4
• 11 citations
  Discovery of Small Molecule Entry Inhibitors Targeting the Fusion Peptide of SARS-CoV-2 Spike Protein
  Xin Hu, Catherine Z. Chen, Miao Xu, Z. Hu, Hui Guo, Zina Itkin, Paul Shinn, P. Ivin, M. Leek, T. J. Liang, Min Shen, Wei Zheng, Matthew D. Hall> ;ACS Medicinal Chemistry Letters. 2021 Jul 28
• 3 citations
  Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles
  Jason M. Conley, Hongmao Sun, Kristin L. Ayers, Hu Zhu, Rong Chen, Min Shen, Matthew D. Hall, Hongxia Ren> ;The Journal of Biological Chemistry. 2021 Jun 15
• 12 citations
  Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.
  , , , , , , , , , , , , , , , , , , , , , , > ;Bioorganic & Medicinal Chemistry Letters. 2021 May 15
• 6 citations
  Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor
  Michele S. Y. Tan, Konstantinos Koussis, Chrislaine Withers-Martinez, Steven Howell, James Thomas, Fiona Hackett, Ellen Knuepfer, Min Shen, Matthew D. Hall, Ambrosius ...> ;The EMBO Journal. 2021 May 1
• 8 citations
  Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
  Jason M. Rohde, Surendra Karavadhi, Rajan Pragani, Li Liu, Yuhong Fang, Weihe Zhang, Andrew L. McIver, Hongchao Zheng, Qingyang Liu, Mindy I. Davis, Daniel J. Urban, T...> ;Journal of Medicinal Chemistry. 2021 Apr 6
• 30 citations
  Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19
  Xin Hu, Jonathan H. Shrimp, Hui Guo, Miao Xu, Catherine Z. Chen, Wei Zhu, Alexey V. Zakharov, Sankalp Jain, Paul Shinn, Anton Simeonov, Matthew D. Hall, Min Shen> ;ACS Pharmacology & Translational Science. 2021 Apr 2
• 6 citations
  Identification of SARS-CoV-2 viral entry inhibitors using machine learning and cell-based pseudotyped particle assay.
  Hongmao Sun, Yuhong Wang, Catherine Z. Chen, Miao Xu, Hui Guo, Misha Itkin, Wei Zheng, Min Shen> ;Bioorganic & Medicinal Chemistry. 2021 May 15
• 47 citations
  Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2
  Catherine Z. Chen, Paul Shinn, Zina Itkin, Richard T. Eastman, Robert Bostwick, Lynn Rasmussen, Ruili Huang, Min Shen, Xin Hu, Kelli M. Wilson, Brianna M. Brooks, Hui ...> ;Frontiers in Pharmacology. 2021 Jan 25
• 15 citations
  Identification of Antifungal Compounds against Multidrug-Resistant Candida auris Utilizing a High-Throughput Drug-Repurposing Screen.
  Yu-Shan Cheng, Jose Santinni O Roma, Min Shen, Caroline Mota Fernandes, Patricia S. Tsang, He Eun Forbes, Helena I. Boshoff, Cristina Lazzarini, Maurizio Del Poeta, We...> ;Antimicrobial Agents and Chemotherapy. 2021 Mar 18
• Discovery of TMPRSS2 inhibitors from virtual screening.
  Xin Hu, Jonathan H Shrimp, Hui Guo, Miao Xu, Catherine Z Chen, Wei Zhu, Alexey Zakharov, Sankalp Jain, Paul Shinn, Anton Simeonov, Matthew D Hall, Min Shen> ;Biorxiv. 2021 Mar 17
• 63 citations
  The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules.
  Kirill Gorshkov, Catherine Z. Chen, Robert Bostwick, Lynn Rasmussen, Bruce Nguyen Tran, Yu-Shan Cheng, Miao Xu, Manisha Pradhan, Mark J. Henderson, Wei Zhu, Eunkeu Oh,...> ;ACS Infectious Diseases. 2021 Jun 11
• 4 citations
  Minimal information for Chemosensitivity assays (MICHA): A next-generation pipeline to enable the FAIRification of drug screening experiments.
  Ziaurrehman Tanoli, Jehad Aldahdooh, Farhan Alam, Yinyin Wang, Umair Seemab, Maddalena Fratelli, Petr Pavlis, Marian Hajduch, Florence Bietrix, Philip Gribbon, Andrea ...> ;Biorxiv. 2020 Dec 4
• 44 citations
  Targeting ACE2–RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay
  Quinlin M Hanson, Kelli M. Wilson, Min Shen, Zina Itkin, Richard T. Eastman, Paul Shinn, Matthew D. Hall> ;ACS Pharmacology & Translational Science. 2020 Nov 17
• 97 citations
  Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro
  Qi Zhang, Catherine Z. Chen, Manju Swaroop, Miao Xu, Lihui Wang, Juhyung Lee, Amy Wang, Manisha Pradhan, Natalie Hagen, Lu Chen, Min Shen, Zhiji Luo, Xin Xu, Yue Xu, W...> ;Cell Discovery. 2020 Nov 4
• 72 citations
  Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles
  Catherine Z. Chen, Miao Xu, Manisha Pradhan, Kirill Gorshkov, Jennifer D. Petersen, Marco R. Straus, Wei Zhu, Paul Shinn, Hui Guo, Min Shen, Carleen Klumpp-Thomas, Sam...> ;ACS Pharmacology & Translational Science. 2020 Oct 19
• 70 citations
  An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19
  Jonathan H. Shrimp, Stephen C. Kales, Philip E. Sanderson, Anton Simeonov, Min Shen, Matthew D. Hall> ;ACS Pharmacology & Translational Science. 2020 Sep 7
• 119 citations
  Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening
  Wei Zhu, Miao Xu, Catherine Z. Chen, Hui Guo, Min Shen, Xin Hu, Paul Shinn, Carleen Klumpp-Thomas, Samuel G. Michael, Wei Zheng> ;ACS Pharmacology & Translational Science. 2020 Sep 4
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