MohamedSheblAbdelBakiMDMD

Pediatric Hematology & Oncology • Saint Louis, MO

Pediatric Neuro-Oncology

Director, Neuro-Oncology Program, St. Louis Children's Hospital and Associate Professor of Pediatrics, Washington University School of Medicine

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Office
660 South Euclid Ave.
Campus Box 8116
Saint Louis, MO 63110
Phone+1 314-454-6018

Fax+1 844-621-4392
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Education & Training

Baylor College of MedicineFellowship, Pediatric Hematology/Oncology, 2009 - 2012
Albany Medical CenterResidency, Pediatrics, 2006 - 2009
Cairo University School of MedicineClass of 2002

Certifications & Licensure

MO State Medical License 2020 - 2025
OH State Medical License 2015 - 2021
PA State Medical License 2011 - 2014
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Partners in Care, Partners in Hope Family Centered Care Award Nationwide Children's Hospital, 2016

Clinical Trials

Intra-tumoral Injection of Natural Killer Cells in High-Grade Gliomas Start of enrollment: 2023 Dec 01
Not yet recruiting
Phase 1
Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors Start of enrollment: 2021 Dec 03
Recruiting
Phase 1
Roles: Principal Investigator
REGN2810 in Pediatric Patients With Relapsed, Refractory Solid, or Central Nervous System (CNS) Tumors and Safety and Efficacy of REGN2810 in Combination With Radiotherapy in Pediatric Patients With Newly Diagnosed or Recurrent Glioma Start of enrollment: 2018 Sep 24
Terminated
Phase 1, Phase 2
Roles: Contact
Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma Start of enrollment: 2022 Feb 22
Recruiting
Not Applicable
Roles: Contact, Principal Investigator
Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) Start of enrollment: 2020 Dec 09
Recruiting
Phase 1
Roles: Contact
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas Start of enrollment: 2019 Apr 03
Recruiting
Phase 1
Roles: Principal Investigator, Contact
Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults Start of enrollment: 2020 Oct 02
Recruiting
Phase 1
Roles: Contact
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Publications & Presentations

PubMed

Rhabdoid tumor predisposition syndrome: A historical review of treatments and outcomes for associated pediatric malignancies.
Sarah Andres, Karen Huang, Margaret Shatara, Mohamed S Abdelbaki, Mark Ranalli, Jonathan Finlay, Ajay Gupta> ;Pediatric Blood & Cancer. 2024 Jun 1
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial.
Lindsay B Kilburn, Dong-Anh Khuong-Quang, Jordan R Hansford, Daniel Landi, Jasper van der Lugt, Sarah E S Leary, Pablo Hernáiz Driever, Simon Bailey, Sébastien Perreau...> ;Nature Medicine. 2024 Mar 11
Plasma miRNA expression profile in pediatric pineal pure germinomas.
Mona Fakhry, Moatasem Elayadi, Mariam G Elzayat, Omar Samir, Eslam Maher, Hala Taha, Mohamed El-Beltagy, Amal Refaat, Manal Zamzam, Ahmed A Sayed, Mark Kieran, Alaa El...> ;Frontiers in Oncology. 2024 Jan 1
6 citations
The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial.
Blackman, S. C., Kilburn, L. B., Kilburn, L. B., Lindsay B Kilburn, Dong-Anh Khuong-Quang, Jordan R Hansford, Daniel Landi, Jasper van der Lugt, Sarah E S Leary, Pablo...> ;Nature Medicine. 2024 Jan 1
1 citations
Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial.
Daphne A Haas-Kogan, Mariam S Aboian, Jane E Minturn, Sarah E S Leary, Mohamed S Abdelbaki, Stewart Goldman, Jennifer D Elster, Adam Kraya, Matthew R Lueder, Divya Ram...> ;Journal of Clinical Oncology. 2024 Feb 1
Risk-Adapted Treatment Strategies with Pre-Irradiation Chemotherapy in Pediatric Medulloblastoma: Outcomes from the Polish Pediatric Neuro-Oncology Group.
Anne Cochrane, Jinli Wang, Marzanna Chojnacka, Monika Drogosiewicz, Iwona Filipek, Ewa Swieszkowska, Magdalena Tarasinska, Wiesława Grajkowska, Joanna Trubicka, Paweł ...> ;Children. 2023 Aug 15
The role of neoadjuvant chemotherapy in the management of metastatic central nervous system germinoma: A meta-analysis.
Mohammad H Abu-Arja, Margaret S Shatara, M Fatih Okcu, Susan L McGovern, Jack M Su, Mohamed S Abdelbaki> ;Pediatric Blood & Cancer. 2023 Oct 1
7 citations
Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study.
Craig Erker, Martin Mynarek, Simon Bailey, Claire M Mazewski, Lorena Baroni, Maura Massimino, Juliette Hukin, Dolly Aguilera, Andrea M Cappellano, Vijay Ramaswamy, Alv...> ;Journal of Clinical Oncology. 2023 Apr 1
3 citations
Primary central nervous system germ cell tumors in children and young adults: A review of controversies in diagnostic and treatment approach.
Kee Kiat Yeo, Sumanth Nagabushan, Girish Dhall, Mohamed S Abdelbaki> ;Neoplasia. 2023 Feb 1
3 citations
Pediatric Central Nervous System Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.
Franson, A. (., Franson, A. (., Franson, A. (., Amar Gajjar, Anita Mahajan, Mohamed Abdelbaki, Clarke Anderson, Reuben Antony, Tejus Bale, Ranjit Bindra, Daniel C Bowe...> ;Journal of the National Comprehensive Cancer Network. 2022 Dec 1
2 citations
An open-label multi-center phase 1 safety study of BXQ-350 in children and young adults with relapsed solid tumors, including recurrent malignant brain tumors.
Mohamed S Abdelbaki, Mariko Dawn DeWire Schottmiller, Timothy P Cripe, Richard C Curry, Charles A Cruze, Leah Her, Suzanne Demko, Denise Casey, Bhuvana Setty> ;Heliyon. 2022 Dec 1
35 citations
Entrectinib in children and young adults with solid or primary CNS tumors harboring NTRK, ROS1, or ALK aberrations (STARTRK-NG).
Ami V Desai, Giles W Robinson, Karen Gauvain, Ellen M Basu, Margaret E Macy, Luke Maese, Nicholas S Whipple, Amit J Sabnis, Jennifer H Foster, Suzanne Shusterman, Jane...> ;Neuro-Oncology. 2022 Oct 3
3 citations
MRI-guided laser interstitial thermal therapy for deep-seated gliomas in children with neurofibromatosis type 1: report of two cases.
Kevin A Cross, Afshin Salehi, Mohamed S Abdelbaki, David H Gutmann, David D Limbrick Jr> ;Child's Nervous System. 2023 Mar 1
Multi-institutional analysis of central nervous system germ cell tumors in patients with Down syndrome.
Micah K Harris, Richard T Graham, Andréa M Cappellano, Ashley S Margol, George Michaiel, John R Crawford, Myrsini Ioakeim-Ioannidou, Joseph R Stanek, Kevin X Liu, Shan...> ;Pediatric Blood & Cancer. 2022 Oct 1
6 citations
Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified ...
Margaret Shatara, Kathleen M Schieffer, Darren Klawinski, Diana L Thomas, Christopher R Pierson, Eric A Sribnick, Jeremy Jones, Diana P Rodriguez, Carol Deeg, Elizabet...> ;Acta Neuropathologica Communications. 2021 Dec 11
12 citations
Discovery of clinically relevant fusions in pediatric cancer.
Stephanie LaHaye, James R Fitch, Kyle J Voytovich, Adam C Herman, Benjamin J Kelly, Grant E Lammi, Jeremy A Arbesfeld, Saranga Wijeratne, Samuel J Franklin, Kathleen M...> ;BMC Genomics. 2021 Dec 4
2 citations
Prognostic factors for patients with relapsed central nervous system nongerminomatous germ cell tumors
Mohammad H Abu-Arja, Diana S Osorio, Alvaro Lassaletta, Richard T Graham, Scott L. Coven, Joseph Stanek, Eric Bouffet, Jonathan L. Finlay, Mohamed S. AbdelBaki> ;Pediatric Blood & Cancer. 2022 Jan 1
Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the liter...
Micah K. Harris, Margaret Shatara, Zachary Funk, Joseph Stanek, Daniel R. Boue, Jeremy Jones, Jonathan L. Finlay, Mohamed S. AbdelBaki> ;Child's Nervous System. 2021 May 4
148 citations
Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas
Gregory K. Friedman, James M. Johnston, Asim K. Bag, Joshua D. Bernstock, Rong Li, Inmaculada Aban, Kara Kachurak, Li Nan, Kyung-Don Kang, Stacie K. Totsch, Charles Sc...> ;The New England Journal of Medicine. 2021 Apr 10
9 citations
Meta-Analysis of Treatment Modalities in Metastatic Atypical Teratoid/Rhabdoid Tumors in Children
Reena M. Underiner, Joseph Stanek, Jonathan L. Finlay, Mohamed S. AbdelBaki, Mostafa Eltobgy> ;Pediatric Neurology. 2020 Jul 1
16 citations
Intracranial growing teratoma syndrome (iGTS): an international case series and review of the literature
George Michaiel, Douglas Strother, Nicholas G. Gottardo, Ute Bartels, Hallie Coltin, Juliette Hukin, Beverly Wilson, Shayna Zelcer, Jordan R. Hansford, Tim Hassall, Mo...> ;Journal of Neuro-Oncology. 2020 Apr 15
10 citations
Pineoblastoma in children less than six years of age: The Head Start I, II, and III experience.
Mohamed S. AbdelBaki, Mohammad H Abu-Arja, Tom B. Davidson, Jason Fangusaro, Joseph Stanek, Ira J. Dunkel, Girish Dhall, Sharon Gardner, Jonathan L. Finlay> ;Pediatric Blood & Cancer. 2020 Mar 18
15 citations
GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors.
Timothy E. Richardson, Karen Tang, Varshini Vasudevaraja, Jonathan Serrano, Christopher M William, Kanish Mirchia, Christopher R. Pierson, Jeffrey R. Leonard, Mohamed ...> ;Journal of Neuropathology and Experimental Neurology. 2019 Dec 1
3 citations
The Risk of Developing Secondary Central Nervous System Tumors After Diagnostic Irradiation From Computed Tomography in Pediatrics: A Literature Review.
Lubna S. Mehyar, Mohammad H Abu-Arja, Joseph Stanek, Ismail Elbeshlawi, Mohamed S. AbdelBaki> ;Pediatric Neurology. 2019 Sep 1
9 citations
Expanding the clinical history associated with syndromic Klippel-Feil: A unique case of comorbidity with medulloblastoma.
Kathleen M. Schieffer, Elizabeth Varga, Katherine E. Miller, Vibhuti Agarwal, Daniel C. Koboldt, Patrick J. Brennan, Benjamin J. Kelly, Ashita Dave-Wala, Christopher R...> ;European Journal of Medical Genetics. 2019 Aug 1
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