MotiLTikuMD

PubMed

• 3 citations
  Intra-articular injection of epigallocatechin (EGCG) crosslinks and alters biomechanical properties of articular cartilage, a study via nanoindentation.
  Mary Pat Reiter, Shawn H Ward, Barbara Perry, Adrian Mann, Joseph W Freeman, Moti L Tiku> ;Plos One. 2022 Jan 1
• 24 citations
  Preserving the longevity of long-lived type II collagen and its implication for cartilage therapeutics.
  Moti L. Tiku, Balaraman Madhan> ;Ageing Research Reviews. 2016 Jul 1
• 40 citations
  Intra-Articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics.
  Venkatachalam Natarajan, Balaraman Madhan, Moti L. Tiku> ;Plos One. 2015 Jun 5
• 37 citations
  Cartilage regeneration for treatment of osteoarthritis: a paradigm for nonsurgical intervention.
  Moti L. Tiku, Hatem E. Sabaawy> ;Therapeutic Advances in Musculoskeletal Disease. 2015 Mar 17
• 64 citations
  Release of oxygen radicals by articular chondrocytes: a study of luminol-dependent chemiluminescence and hydrogen peroxide secretion.
  Chamu Rathakrishnan, Katherine Tiku, Anuradha Raghavan, Moti L. Tiku> ;Journal of Bone and Mineral Research. 2009 Dec 3
• 22 citations
  Glucosamine prevents in vitro collagen degradation in chondrocytes by inhibiting advanced lipoxidation reactions and protein oxidation
  Moti L. Tiku, Haritha Narla, Mohit Jain, Praveen Yalamanchili> ;Arthritis Research & Therapy. 2007 Aug 8
• Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes.
  Raggatt, L. J., Jefcoat, S. C., Choudhury, I., Williams, S., Tiku, M., Partridge, N. C.> ;Osteoarthr Cartil. 2006 Jul
• 49 citations
  The presence of molecular markers of in vivo lipid peroxidation in osteoarthritic cartilage : A pathogenic role in osteoarthritis
  Rahul Shah, Karel Raska, Moti L. Tiku> ;Arthritis and Rheumatism. 2005 Sep 1
• Malondialdehyde oxidation of cartilage collagen by chondrocytes.
  Tiku, M. L., Allison, G. T., Naik, K., Karry, S. K.> ;Osteoarthr Cartil. 2003 Mar
• 185 citations
  Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis.
  Moti L. Tiku, Rahul Shah, Gregory Allison> ;The Journal of Biological Chemistry. 2000 Jun 30
• Successful treatment of methotrexate induced nodulosis with D-penicillamine.
  Dash, S., Seibold, J. R., Tiku, M. L.> ;J Rheumatol. 1999 Jun
• 83 citations
  Aggrecan degradation in chondrocytes is mediated by reactive oxygen species and protected by antioxidants.
  Moti L. Tiku, Shakunmala Gupta, Devendra R. Deshmukh> ;Free Radical Research. 1999 May 1
• 37 citations
  Hydroxyl radical formation in chondrocytes and cartilage as detected by electron paramagnetic resonance spectroscopy using spin trapping reagents
  Moti L. Tiku, Yong Ping Yan, Kuang Yu Chen> ;Free Radical Research. 1998 Sep 1
• 16 citations
  Posterior tibial neuropathy from ruptured Baker's cyst.
  Subasini Dash, Swarnalatha R. Bheemreddy, Moti L. Tiku> ;Seminars in Arthritis and Rheumatism. 1998 Apr 1
• 44 citations
  Bone cell behavior on Matrigel-coated Ca/P coatings of varying crystallinities.
  Suzanne H. Maxian, Tony Di Stefano, Mora C. Melican, Moti L. Tiku, Joseph P. Zawadsky> ;Journal of Biomedical Materials Research. 1998 May 1
• 116 citations
  Development of fibroblast-seeded ligament analogs for ACL reconstruction
  Michael G. Dunn, Janice B. Liesch, Moti L. Tiku, Joseph P. Zawadsky> ;Journal of Biomedical Materials Research. 1995 Nov 1
• 15 citations
  Posterior interosseous nerve entrapment in rheumatoid arthritis
  Ana M. Fernandez, Moti L. Tiku> ;Seminars in Arthritis and Rheumatism. 1994 Aug 1
• 31 citations
  Lucigenin-dependent chemiluminescence in articular chondrocytes.
  Chamu Rathakrishnan, Moti L. Tiku> ;Free Radical Biology & Medicine. 1993 Aug 1
• 24 citations
  Splenic infarction associated with anticardiolipin antibodies in a patient with acquired immunodeficiency syndrome
  Mitchell S. Cappell, Todd Simon, Moti L. Tiku> ;Digestive Diseases and Sciences. 1993 Jun 1
• Tripeptide RGD-dependent adhesion of articular chondrocytes to synovial fibroblasts.
  Ramachandrula, A., Tiku, K., Tiku, M. L.> ;J Cell Sci. 1992 Apr
• 35 citations
  Articular chondrocytes secrete IL-1, express membrane IL-1, and have IL-1 inhibitory activity.
  Katherine Tiku, Smita Thakker-Varia, Anand Ramachandrula, Moti L. Tiku> ;Cellular Immunology. 1992 Mar 1
• Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines.
  Tiku, M. L., Liesch, J. B., Robertson, F. M.> ;J Immunol. 1990 Jul 15
• 10 citations
  Characterization of astrocyte plasminogen activator
  Pradip K. Toshniwal, Susan L. Firestone, Grant H. Barlow, Moti L. Tiku> ;Journal of the Neurological Sciences. 1987 Sep 1
• 13 citations
  Secretion of plasminogen activator by cerebral astrocytes and its modulation.
  Pradip K. Toshniwal, Moti L. Tiku, Katherine Tiku, John L. Skosey> ;Journal of the Neurological Sciences. 1987 Sep 1
• Interleukin 1 production by human polymorphonuclear neutrophils.
  Tiku, K., Tiku, M. L., Skosey, J. L.> ;J Immunol. 1986 May 15
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Journal Articles

• Preserving the longevity of long-lived collagen type II and its implication for cartilage therapeutics  
  Tiku ML and Madhan, B, Aging Research Review, 1/1/2016
• Cartilage regeneration for treatment of osteoarthritis: A paradigm for non-surgical intervention  
  Tiku ML and Sabaawy HE, Therapeutic Advances in Musculoskeletal Disease, 1/1/2015
• Glucosamine prevents collagen degradation by inhibiting advanced lipoxidation reaction in chondrocytes and inhibits protein oxidation  
  Tiku ML, Haritha Narla, Mohit Jain and Parveen Yalamanchilli, Arthritis Research & Therapy, 1/8/2007
• Matrix metalloproteinase-13 influences ERK signaling in articular rabbit chondrocytes  
  Raggatt, LJ, Jefcoat SC, Choudhury I, Williams S, Tiku, and Partridge NC, Osteoarthritis & Cartilage, 1/1/2006
• The presence of molecular markers of in-vivo lipid peroxidation in osteoarthritic cartilage: A pathogenic role in osteoarthritis  
  Shah R, Raska KR, and Tiku ML, Arthritis & Rheumatism, 1/1/2005
• Malondialdehyde oxidation of cartilage collagen by chondrocytes  
  Tiku ML, Allison G, Karishma Naik and Shailender K. Karry, Osteoarthritis & Cartilage, 1/1/2003
• Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation: Possible role in cartilage aging and the pathogenesis of osteoarthritis  
  Tiku ML, R. Shah, Allison G, J Biological Chem, 1/1/2000
• Chondrocyte-derived reactive oxygen species mediate aggrecan degradation and protection by antioxidants  
  Tiku ML, Gupta S, Deshmukh DR, Free Radical Research, 1/1/1999
• Successful treatment of methotrexate induced nodulosis with D-penicillamine  
  Dash S. Seibold JR, Tiku, ML, Journal of Rheumatology, 1/1/1999
• Hydroxyl free radical formation in chondrocytes and cartilage as detected by Electron Paramagnetic Resonance Spectroscopy using spin trapping agents  
  Tiku ML, Yan YP, Chen KY, Free Radical Research, 1/1/1998
• Bone cell behavior on Matrigel coated Ca/P coatings of varying crystallinities  
  Maxiam SH, Distefano T, Melican MC, Tiku ML and Zawadsky JP, Journal of Biomedical Materials Research, 1/1/1998
• Posterior tibial neuropathy for ruptured Baker�s cyst  
  Dash S, Bheemreddy SR,Tiku ML, Seminars in Arthritis and Rheumatism, 1/1/1998
• Development of fibroblast-seeded ligament analogs for ACL reconstruction  
  Dunn MG, Liesch JB, Tiku ML and Zawadsky JP, J of Biomedical Materials Research, 1/1/1995
• The tissue engineering approach to ligament reconstruction  
  Dunn MG, Liesch JB, Tiku ML, Maxiam SH, Zawadsky JP, Mat Res Soc Proc, 1/1/1994
• Posterior interosseous nerve entrapment in rheumatoid arthritis: Case report of a spontaneous resolution with methotrexate treatment  
  Fernandez A, Tiku ML, Seminars in Arthritis and Rheumatism, 1/1/1994
• Splenic infarction associated with anti- cardiolipin antibodies in a patient with the acquired immuno deficiency syndrome  
  Cappell MS, Simon T, ML Tiku, Digestive Disease and Sciences, 1/1/1993
• Lucigenin-dependent chemiluminescence by articular chondrocytes  
  Rathakrishnan C, Tiku ML, Free Radicals in Biology & Medicine, 1/1/1993
• Articular chondrocytes secrete IL-l, express membrane IL-l and have IL-l inhibitory activity  
  Tiku K, Thakker-Varia S, Ramachandrula A, Tiku, ML, Cellular Immunology, 1/1/1992
• The release of oxygen radicals by articular chondrocytes: A study of Luminol-dependent chemiluminescence and hydrogen peroxide secretion  
  Rathakrishnan C. Tiku K, Raghavan A, Tiku ML, Journal of Bone and Mineral Research, 1/1/1992
• RGD-dependent adhesion of chondrocytes to synovial fibroblasts  
  Ramachandrula A, Tiku K, Tiku ML, Journal of Cell Sciences, 1/1/1992
• Reactive oxygen radical production by chondrocytes  
  Tiku ML, Liesch JB, Robertson FM, J Immunology, 1/1/1990
• Astrocyte plasminogen activator is tissue type  
  Toshniwal P, Firestone S, Barlow G, Tiku ML, J of Neuro Sciences, 1/1/1987
• Secretion of plasminogen activator by cerebral astrocytes and its modulation  
  Toshniwal P, Tiku K, Skosey JL, Tiku ML, J of Neuro Sciences, 1/1/1987
• Normal human neutrophils are a source of a specific interleukin-l inhibitor  
  Tiku K, Tiku ML, Liu S, Skosey JL, J Immunology, 1/1/1986
• Interleukin-l production by human polymorphonuclear neutrophils  
  Tiku K, Tiku ML, Skosey JL, J Immunology, 1/1/1986
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Books/Book Chapters

• 6th International Congress of Immunology 
  Chapter: Immunopathology of hepatitis B infection Immunopathology. 
  Page 236 - 241Ogra PL, Beutner KR, Tiku ML, Makhdoomi GMKarger, New York, NY; Basel, Switzerland1979
• Liver and Biliary system in Infants and Children 
  Chapter: Acute viral liver injury. 
  Page 146 - 159Tiku ML, Ogra PLEditors: RK Chandra.Churchill, Livingston, London, United Kingdom1979
• Viral Hepatitis 
  Chapter: Immune complexes and cellular immune reactivity in HBV infection. 
  Page 285 - 294Beutner KR, Tiku ML, Ogra PLEditors: GN Vyas, SN Cohn, R. Schmid.Franklin Institute Press1978
• New Developments in Ped Res XVth International Congress of Pediatrics, New Delhi, India 
  Chapter: Immune response in hepatitis B virus infection. 
  Page 837 - 844Orga PL, TIku MLEditors: OP Ghai.Interprint, New Delhi, India1977
• Viral Immunology & Immunopathology 
  Chapter: Humoral immune response to viral infections. 
  Page 57 - 77Ogra PL, Morag A, Tiku MLEditors: AL Notkins.Academic Press, New York, NY1975
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Abstracts/Posters

• Unexplained severe vitamin B 12 deficiency induced anemia in SLE patient.
  Patel P, Sefah AO and Tiku ML, NJ chapter: ACP, Fall, 1/1/2006
• Aggrecan protects cartilage collagen matrix from chondrocyte-derived reactive oxygen damage.
  Wilky BA and Tiku ML, ACR Annual Scientific Meeting, San Diego, CA, 1/1/2005
• Glucosamine inhibits advanced lipoxidation reactions and chemical modification of lipoproteins by scavenging reactive carbonyl intermediates.
  Tiku ML, Narla H, Karry S, Naik, Annual Scientific Meeting of ACR, New Orleans, LA, 1/24/2002
• Evidence linking oxidative stress and carilage degradation: A possible role in cartilage aging and osteoarthritis pathogenesis.
  Tiku ML, International Cartilage Repair Society 4th Symposium, Toronto, Canada, 1/15/2002
• Chondrocyle-dependent aldehyde protein oxidation Bof cartilage collagen.
  Tiku JL, Allison GT, FASEB J, 1/1/1999
• Formation of aldehyde-protein adducts in chondrocytes results in cartilage matrix degradation.
  Allison GT, Shah R, Tiku ML, FASEB J, 1/1/1998
• Demonstration of malondialdehyde and hydroxynonenal protein adducts in osteoarthritic articular cartilage.
  Tiku ML, Shah R, Tria AJ, Zawadsky JP, FASEB J, 1/1/1998
• Effect of amount of DBM in polymer/collagen scaffolds on cell behavior.
  Abboudi RL, Zawadsky JP, Tiku Ml Maxian SH, Fifth World Biomaterials Congress, Toronto, Canada, 1/29/1996
• Development of organic and polymer carriers for demineralized bone matrix: effect on bone cell behavior.
  Abboudi RL, Zawadsky JP, Tiku ML, Maxian SH, Fifth World Biomaterials Congress, Toronto, Canada, 1/29/1996
• Chondrocyte-induced oxidative damage is the principal mechanism of cartilage collagen matrix degradation in an invitro model system.
  Tiku ML, Adabala R, Dunham JS, Potturi S, Arthritis and Rheumatism, 1/1/1996
• Direct evidence of Cartilage matrix degradation by the nitric oxide produced by chondrocytes.
  Gupta S, Kondle YM, Ghole VS, Deshmukh DR, Tiku ML, Arthritis and Rheumatism, 1/1/1995
• Antioxidants and spin trapping agent, N-tert-butyl-phenylnitrone, inhibits the release of labelled aggrecan by the LPS-stimulated chondrocytes.
  Gupta S, Tiku ML, Arthritis and Rheumatism, 1/1/1995
• Antioxidants and spin trapping agent N-tert-butyl-phenylnitrone inhibit the release of labelled aggrecan by LPS stimulated chondrocytes.
  Gupta S, ML Tiku, FASEB J, 1/1/1995
• Evidence linking production of reactive oxygen intermediates by chondrocytes to the cartilage matrix degradation.
  Tiku ML, FASEB J, 1/1/1995
• Effect of Matrigel on bone cell Behavior on hydroxyapatite-coated implants of varying crystallinities.
  Maxian SH, Tiku ML, Zawadsky JP, Dunn MG, Trans 20th Annual Meeting of the Society of Biomaterials, 1/1/1994
• Direct evidence lining production of reactive oxygen intermediates by chondrocytes to the cartilage matrix degradation.
  Tiku ML, Arthritis and Rheumatism, 1/1/1994
• Electron spin resonance/spin trapping evidence for hydroxyl radical formation by chondrocytes and cartilage.
  Tiku ML, Yan R, Liesch JB, Tiku K, Vishnuvajjiala S, Chen KY, Arthritis and Rheumatism, 1/1/1994
• Posttranscriptional activation of human stromelysin and collagenase genes in-vivo, analysis by RT-PCR of hnRNA and mRNA.
  Yang M, Liesch JB, Kurkinen M, Tiku ML, FASEB J, 1/1/1994
• Electron spin resonance/spin trapping evidence for hydroxyl radical formation by chondrocytes and cartilage.
  Tiku ML, Yan R. Liesch JB, Tiku K, Chen KY, FASEB Journal, 1/1/1994
• Hydroxyapatite coating of varying crystallinity.
  Maxian SH, Liesch JB, Tiku ML, Zawadsky JP,Dunn MG, Materials Research Society Symposium Proceedings, 1/1/1994
• Tissue engineering approach to ligament reconstruction.
  Dunn MG, Liesch JB, Tiku ML, Maxian SH, Zawadsky JP, Materials Research Society Symposium Proceedings; Materials Research Society Fall Presentation, 1/1/1994
• Effect of Matrigel on Bone Cell Behavior on Hydorxyapatite-Coated Implants of Varing Crystallinities.
  Maxian SH, Tiku ML, Zawadsky JP, Dunn MG, Trans 20th Annual Meeting of the Society for Biomaterials, 1/1/1994
• Fibroblast-seeded autograft analogues for ACL regeneration.
  Dunn MG, Liesch JB, Tiku ML, Maxian Sh, Zawadsky JP, 19th Annual Meeting of the Society for Biomaterials, Birmingham, AL, 1/1/1993
• Evaluation of hydroxyapatite coatings of varying crystallin ity: Cell culture and non-interference fit surgical studies.
  Maxian SH, Liesch JB, Tiku ML, Zawadsky JP, Dunn MG, 19th Annual Meeting of the Society for Biomaterials, Birmingham, AL, 1/1/1993
• The production of cartilage matrix-degradation promoting cytokines and inhibitors by articular chondrocytes.
  Tiku K, Smita Thakker-Varia, Tiku ML, Journal of Immunology, 1/1/1993
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Lectures

• Collagen protection as model strategy to treat osteoarthritis. 
  RWJ Medical School - 1/1/2006
• Update in Internal Medicine, New Ways to look at old problems. 
  1/13/2005
• Advances in Osteoarthritis 
  RWJ Medical School - 1/16/2004
• Discovery of mechanism of action of osteoarthritic drug: Can it lead to better drugs 
  1/16/2003
• Role of nutritional supplements in osteoarthritis. 
  Cook College, Rutgers University - 1/1/2003
• Chondrocyte-dependent oxidative mechanism of cartilage collagen degradation. 
  RWJMS-UMDNJ - 1/28/1997
• Oxidative biology of chondrocytes. 
  Rutgers University - 1/3/1997
• Polymyalgia Rheumatica. 
  St. Peters Medical Center, New Brunswick, NJ - 1/17/1992
• Mechanisms of Vascular and Tissue Damage in Demyelination Diseases 
  Viterbo, Italy - 1/3/1990
• Immunobiology of Chondrocytes. 
  Rutgers University, Newark, NJ - 1/3/1989
• Oxygen Radical Production by Chondrocytes. 
  Wilmington, DE, 1989; New York University, 1989 - 1/2/1989
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Other

• Thesis: Study of Nervous System Involvement of Leprosy 
  Tiku ML
  University of Delhi - 1/1/1969