MounzerEAghaMD

Hematology • Pittsburgh, PA

Hematologic Oncology

Director, Mario Lemieux Center for Blood Cancers

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Office
5115 Centre Ave
3rd Floor
Pittsburgh, PA 15232
Phone+1 412-864-6648

Fax+1 412-864-6666
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Education & Training

University of WashingtonFellowship, Hematology and Medical Oncology, 1989 - 1992
Penn State Milton S Hershey Medical CenterResidency, Internal Medicine, 1986 - 1989
University of Aleppo Faculty of MedicineClass of 1983

Certifications & Licensure

PA State Medical License 1987 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology

Clinical Trials

Peripheral Blood Stem Cell Transplant vs Bone Marrow Transplant in Individuals With Hematologic Cancers (BMT CTN 0201) Start of enrollment: 2004 Jan 01
Completed
Phase 3
Autologous or Donor Stem Cell Transplantation in Treating Patients With Recurrent Non-Hodgkin's Lymphoma (BMT CTN 0202) Start of enrollment: 2004 Aug 01
Terminated
Phase 2, Phase 3
Phase I/II Study of Mitoxantrone, Etoposide and Gemtuzumab Ozogamicin for Acute Myeloid Leukemia Start of enrollment: 2008 Sep 01
Terminated
Phase 1
Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65 Start of enrollment: 2010 Oct 01
Active, not recruiting
Phase 3
Phase II Clofarabine and Cytarabine for Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2013 Oct 01
Terminated
Phase 2
Nonmyeloablative Hematopoietic Cell Transplantation (HCT) for Patients With Hematologic Malignancies Using Related, HLA-Haploidentical Donors: A Pilot Trial of Peripheral Blood Stem Cells (PBSC) as the Donor Source Start of enrollment: 2015 Feb 11
Completed
Phase 1
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Publications & Presentations

PubMed

Failure of CAR-T cell therapy in relapsed and refractory large cell lymphoma and multiple myeloma: An urgent unmet need.
Yasmine St Martin, Joseph K Franz, Mounzer E Agha, Hillard M Lazarus> ;Blood Reviews. 2023 Apr 29
Therapy with Allogeneic SARS-CoV-2-specific T-cells for Persistent COVID-19 in Immunocompromised Patients.
Ghady Haidar, Jana L Jacobs, Kailey Hughes Kramer, Asma Naqvi, Amy Heaps, Urvi Parikh, Kevin D McCormick, Michele D Sobolewski, Mounzer Agha, Tatiana Bogdanovich, Vasi...> ;Clinical Infectious Diseases. 2023 Apr 20
36 citations
Ciltacabtagene Autoleucel, an Anti-B-cell Maturation Antigen Chimeric Antigen Receptor T-Cell Therapy, for Relapsed/Refractory Multiple Myeloma: CARTITUDE-1 2-Year Fol...
Thomas Martin, Saad Z Usmani, Jesus G Berdeja, Mounzer Agha, Adam D Cohen, Parameswaran Hari, David Avigan, Abhinav Deol, Myo Htut, Alexander Lesokhin, Nikhil C Munshi...> ;Journal of Clinical Oncology. 2023 Feb 20
Prognostic significance of blast immunophenotype on first post-induction bone marrow biopsy.
Konstantinos Lontos, Anastasia Tsagianni, Mounzer Agha, Anastasios Raptis, Jing-Zhou Hou, Rafic Farah, Robert L Redner, Annie Im, Kathleen A Dorritie, Alison Sehgal, J...> ;Leukemia & Lymphoma. 2023 Mar 1
A nomogram using cytogenetics, TP53, and NPM1 mutational status can predict responses to induction chemotherapy in AML.
Konstantinos Lontos, Anastasia Tsagianni, Mounzer Agha, Anastasios Raptis, Jing-Zhou Hou, Rafic Farah, Robert L Redner, Annie Im, Kathleen A Dorritie, Alison Sehgal, J...> ;Leukemia & Lymphoma. 2022 Dec 1
Correction: Mu heavy chain disease with MYD88 L265P mutation: An unusual manifestation of lymphoplasmacytic lymphoma.
Vandana Baloda, Sarah E Wheeler, David L Murray, Mindy C Kohlhagen, Jeffrey A Vos, Svetlana A Yatsenko, Mounzer E Agha, Miroslav Djokic, Steven H Swerdlow, Nathanael G...> ;Diagnostic Pathology. 2022 Oct 20
1 citations
Health-related quality of life in patients given ciltacabtagene autoleucel for relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b-2, open-label study.
Thomas Martin, Yi Lin, Mounzer Agha, Adam D Cohen, Myo Htut, A Keith Stewart, Parameswaran Hari, Jesus G Berdeja, Saad Z Usmani, Tzu-Min Yeh, Yunsi Olyslager, Jenna D ...> ;The Lancet. Haematology. 2022 Dec 1
Prospective Evaluation of Coronavirus Disease 2019 (COVID-19) Vaccine Responses Across a Broad Spectrum of Immunocompromising Conditions: the COVID-19 Vaccination in t...
Ghady Haidar, Mounzer Agha, Andrew Bilderback, Amy Lukanski, Kelsey Linstrum, Rachel Troyan, Scott Rothenberger, Deborah K McMahon, Melissa D Crandall, Michele D Sobol...> ;Clinical Infectious Diseases. 2022 Aug 24
1 citations
Mu heavy chain disease with MYD88 L265P mutation: an unusual manifestation of lymphoplasmacytic lymphoma.
Vandana Baloda, Sarah E Wheeler, David L Murray, Mindy C Kohlhagen, Jeffrey A Vos, Svetlana A Yatsenko, Mounzer E Agha, Miroslav Djokic, Steven H Swerdlow, Nathanael G...> ;Diagnostic Pathology. 2022 Aug 5
CD-19 CART therapy and orthostatic hypotension: a single center retrospective cohort study.
Ashish Patel, Joshua Levenson, Ziyu Huang, Mounzer Agha, Kathleen Dorritie> ;Cardio-Oncology. 2022 Apr 5
Rates and Predictors of Nonadherence to the Post-Allogeneic Hematopoietic Cell Transplantation Medical Regimen in Patients and Caregivers.
Donna M Posluszny, Dana H Bovbjerg, Karen L Syrjala, Mounzer Agha, Rafic Farah, Jing-Zhou Hou, Anastasios Raptis, Annie P Im, Kathleen A Dorritie, Michael M Boyiadzis,...> ;Transplantation and Cellular Therapy. 2022 Mar 1
3 citations
Adjusted Comparison of Outcomes between Patients from CARTITUDE-1 versus Multiple Myeloma Patients with Prior Exposure to PI, Imid and Anti-CD-38 from a German Registry
Maximilian Merz, Hartmut Goldschmidt, Parameswaran Hari, Mounzer Agha, Joris Diels, Francesca Ghilotti, Nolen J. Perualila, Jedelyn Cabrieto, Benjamin Haefliger, Henri...> ;Cancers. 2021 Nov 29
3 citations
A prospective study of the use of central venous catheters in patients newly diagnosed with acute myeloid leukemia treated with induction chemotherapy.
Christi McKeown, Asha Ricciuti, Mounzer Agha, Anastasios Raptis, Jing-Zhou Hou, Rafic Farah, Robert L. Redner, Annie Im, Kathleen A. Dorritie, Alison R. Sehgal, James ...> ;Supportive Care in Cancer. 2021 Sep 25
43 citations
Suboptimal Response to Coronavirus Disease 2019 Messenger RNA Vaccines in Patients With Hematologic Malignancies: A Need for Vigilance in the Postmasking Era
Mounzer Agha, Maggie Blake, Charles Chilleo, Alan Wells, Ghady Haidar> ;Open Forum Infectious Diseases. 2021 Jun 30
271 citations
Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CART...
Jesus G. Berdeja, Deepu Madduri, Saad Z. Usmani, Andrzej Jakubowiak, Mounzer Agha, Adam D. Cohen, A. Keith Stewart, Parameswaran Hari, Myo Htut, Alexander M. Lesokhin,...> ;Lancet. 2021 Jul 24
73 citations
Suboptimal response to COVID-19 mRNA vaccines in hematologic malignancies patients
Mounzer Agha, Maggie Blake, Charles Chilleo, Alan Wells, Ghady Haidar> ;Medrxiv. 2021 Apr 7
26 citations
Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-M...
Matthew K Hensley, William Bain, Jana L. Jacobs, Sham Nambulli, Urvi M. Parikh, Anthony R. Cillo, Brittany Staines, Amy Heaps, Michele D. Sobolewski, Linda J. Rennick,...> ;Clinical Infectious Diseases. 2021 Aug 2
3 citations
Multifocal Necrotizing Leukoencephalopathy With Preferential Microglia Toxicity in a Patient Treated With Chimeric Antigen Receptor T-Cells and Review of the Literature
Daniel F. Marker, Julia Kofler, Joseph A Mettenburg, Mounzer E Agha, Clayton A. Wiley> ;Journal of Neuropathology and Experimental Neurology. 2020 Oct 1
2 citations
Outcomes of Patients With Acute Myeloid Leukemia Who Relapse After 5 Years of Complete Remission.
Arisha Patel, Mounzer Agha, Anastasios Raptis, Jing-Zhou Hou, Rafic Farah, Robert L. Redner, Annie Im, Kathleen A. Dorritie, Alison R. Sehgal, James M. Rossetti, Melis...> ;Oncology Research. 2021 Sep 7
More on Blastic Plasmacytoid Dendritic-Cell Neoplasms.
Agha, M. E., Monaghan, S. A., Swerdlow, S. H.> ;The New England journal of medicine. 2019 Feb 15
20 citations
Correlates of anxiety and depression symptoms among patients and their family caregivers prior to allogeneic hematopoietic cell transplant for hematological malignancies.
Donna M. Posluszny, Dana H. Bovbjerg, Karen L. Syrjala, Mounzer Agha, Mary Amanda Dew> ;Supportive Care in Cancer. 2019 Feb 1
32 citations
Venetoclax in a Patient with a Blastic Plasmacytoid Dendritic-Cell Neoplasm.
Mounzer Agha, Sara A. Monaghan, Steven H. Swerdlow> ;The New England Journal of Medicine. 2018 Oct 10
8 citations
A Phase 1 Study of Dasatinib plus All-Trans Retinoic Acid in Acute Myeloid Leukemia
Robert L. Redner, Jan H. Beumer, Patricia Kropf, Mounzer Agha, Michael Boyiadzis, Kathleen A. Dorritie, Rafic Farah, Jing-Zhao Hou, Annie Im, Seah H. Lim, Anastasios R...> ;Leukemia & Lymphoma. 2018 Apr 4
12 citations
Patient and family caregiver dyadic adherence to the allogeneic hematopoietic cell transplantation medical regimen.
Donna M. Posluszny, Dana H. Bovbjerg, Mounzer Agha, Jing-Zhou Hou, Anastasios Raptis, Michael Boyiadzis, Jacqueline Dunbar-Jacob, Richard Schulz, Mary Amanda Dew> ;Psycho-Oncology. 2018 Jan 1
101 citations
Phase 1 clinical trial of adoptive immunotherapy using "off-the-shelf" activated natural killer cells in patients with refractory and relapsed acute myeloid leukemia.
Michael Boyiadzis, Mounzer Agha, Robert L. Redner, Alison R. Sehgal, Annie Im, Jing-Zhou Hou, Rafic Farah, Kathleen A. Dorritie, Anastasios Raptis, Seah H. Lim, Hong W...> ;Cytotherapy. 2017 Oct 1
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Press Mentions

$Rethinking Treatment Schemas in Relapsed/Refractory Multiple Myeloma$
Rethinking Treatment Schemas in Relapsed/Refractory Multiple MyelomaJuly 10th, 2019
Teen Organizes Blood Drive to Help Patients like Her Mom Who Are Battling CancerAugust 5th, 2016
Who Qualifies for a Coronavirus Booster Shot? Why It’s Still UnclearAugust 13th, 2021
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