NabilFSabaMD

Head & Neck Cancer

Professor and Vice Chair, Lynne and Howard Halpern Chair in HNCA research, Director of the Head and Neck Oncology, Emory University

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Office
1365 Clifton Rd Ne
Atlanta, GA 30322
Phone+1 404-778-1900
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Education & Training

University of TorontoFellowship, Stem cell transplantation , 1998 - 1999
Brown UniversityFellowship, Hematology and Medical Oncology, 1994 - 1997
Brigham and Women's HospitalResidency, Internal Medicine, 1992 - 1994
University of Wisconsin Hospitals and ClinicsResidency, Internal Medicine, 1990 - 1992
American University of Beirut Faculty of MedicineClass of 1990

Certifications & Licensure

GA State Medical License 2003 - 2025
MA State Medical License 1993 - 2004
MN State Medical License 1999 - 2004
RI State Medical License 1995 - 1996

Awards, Honors, & Recognition

Atlanta Magazine: Top Doctors Castle Connolly, 2005, 2016
Distinguished Doctor Expert Network, 2015
Top Doctor Castle Connolly, 2011, 2014
Outstanding Contribution To Fellowship Program University of Minnesota, 2003
Fellow (FACP) American College of Physicians, 2002
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Clinical Trials

Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Start of enrollment: 2008 Aug 08
Active, not recruiting
Phase 3
Study of Cetuximab and Bevacizumab in Cancer of the Esophagus After Failure of Patient's First Therapy Start of enrollment: 2008 Oct 01
Withdrawn
Phase 2
Dasatinib in Treating Patients With Recurrent or Metastatic Malignant Salivary Gland Tumors Start of enrollment: 2009 Mar 16
Completed
Phase 2
A Study of Carboplatin, Cetuximab and RAD001 in Advanced Head and Neck Cancer Start of enrollment: 2011 Jan 01
Completed
Phase 1, Phase 2
Trial of XELOX Followed by Radiation Combined With Carboplatin and RAD001 for Esophageal Cancer Start of enrollment: 2012 Feb 01
Completed
Phase 1
A Phase Ib/II Study of BYL719 and Cetuximab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Start of enrollment: 2012 Nov 12
Terminated
Phase 1, Phase 2
Chemotherapy Plus Cetuximab in Combination With VTX-2337 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Start of enrollment: 2013 Oct 14
Completed
Phase 2
Soy Isoflavone in Combination With Radiation Therapy and Cisplatin in SCC of the Head and Neck Start of enrollment: 2013 Nov 01
Completed
Phase 1
Trial of Nivolumab vs Therapy of Investigator's Choice in Recurrent or Metastatic Head and Neck Carcinoma (CheckMate 141) Start of enrollment: 2014 May 29
Completed
Phase 3
Pembrolizumab & Cabozantinib in Patients With Head and Neck Squamous Cell Cancer Start of enrollment: 2018 Sep 18
Active, not recruiting
Phase 2
Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery Start of enrollment: 2019 Mar 12
Recruiting
Phase 2
Intensity-Modulated Radiation Therapy & Nivolumab for Recurrent or Second Primary Head & Neck Squamous Cell Cancer Start of enrollment: 2018 Jun 28
Active, not recruiting
Phase 2
Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer Start of enrollment: 2019 Aug 16
Recruiting
Phase 3
VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Head and Neck Cancer Start of enrollment: 2018 Nov 01
Recruiting
Phase 1
Roles: Contact
Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer Start of enrollment: 2022 Feb 17
Recruiting
Early Phase 1
Roles: Contact
Study of Induction Docetaxel, Cisplatin and 5-Fluorouracil Start of enrollment: 2006 Aug 01
Terminated
Phase 2
Study of Durvalumab Versus Placebo in Combination With Definitive Chemoradiation Therapy in Patient With ESCC Start of enrollment: 2020 Oct 19
Active, not recruiting
Phase 3
Ganetespib Window of Opportunity Study in Head and Neck Cancers Start of enrollment: 2014 Dec 01
Terminated
Phase 1
A Study of Penpulimab (AK105) in the First-line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma Start of enrollment: 2021 Aug 16
Recruiting
Phase 3
Phase II Study of Pre-Operative Chemotherapy in Patients With Resectable Local-Regional Carcinoma of Esophagus Start of enrollment: 1996 Jan 01
Terminated
Phase 2
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers Start of enrollment: 2023 Mar 13
Recruiting
Phase 2, Phase 3
A Phase 1 Study in Patients With HPV16+ Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma Start of enrollment: 2019 Jul 30
Active, not recruiting
Phase 1
The BURAN Study of Buparlisib in Patients With Recurrent or Metastatic HNSCC Start of enrollment: 2020 Dec 12
Active, not recruiting
Phase 3
Testing the Addition of M3814 (Peposertib) to Radiation Therapy for Patients With Advanced Head and Neck Cancer Who Cannot Take Cisplatin Start of enrollment: 2021 Dec 20
Recruiting
Phase 1
Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer Start of enrollment: 2020 Jul 08
Recruiting
Phase 2, Phase 3
Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer Start of enrollment: 2011 Jun 01
Active, not recruiting
Phase 3
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer Start of enrollment: 2019 Oct 09
Suspended
Phase 2, Phase 3
Safety Testing of Adding Nivolumab to Chemotherapy in Patients With Intermediate and High-Risk Local-Regionally Advanced Head and Neck Cancer Start of enrollment: 2016 Jun 01
Completed
Phase 1
Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer Start of enrollment: 2011 Feb 14
Completed
Phase 3
Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery Start of enrollment: 2019 May 03
Suspended
Phase 2, Phase 3
Efficacy and Safety Trial of ADU-S100 and Pembrolizumab in Head and Neck Cancer Start of enrollment: 2019 Aug 26
Terminated
Phase 2
Phase I Chemoprevention Trial With Green Tea Polyphenon E & Erlotinib in Patients With Premalignant Lesions of the Head & Neck Start of enrollment: 2010 Mar 01
Completed
Phase 1
Phase I/II Study of Chemoprevention With EGFR and COX-2 Inhibitor Start of enrollment: 2006 Oct 01
Completed
Phase 1, Phase 2
Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With Stage III or Stage IV Head and Neck Cancer Start of enrollment: 2005 Nov 01
Completed
Phase 3
Durvalumab, Cetuximab and Radiotherapy in Head Neck Cancer Start of enrollment: 2018 Jan 01
Not yet recruiting
Phase 1, Phase 2
Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin Start of enrollment: 2018 Apr 03
Active, not recruiting
Phase 2, Phase 3
Radiation Therapy With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer Start of enrollment: 2009 Nov 01
Active, not recruiting
Phase 3
Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer Start of enrollment: 2022 Jun 06
Recruiting
Phase 2
Safety and Efficacy of Repeat Administration of Ad/PNP and Fludarabine Phosphate in Patients With Local Head/Neck Cancer Start of enrollment: 2019 Feb 11
Recruiting
Phase 1, Phase 2
Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX) Start of enrollment: 2024 Jan 18
Recruiting
Phase 1
Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Start of enrollment: 2023 Nov 30
Recruiting
Phase 2, Phase 3
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Publications & Presentations

PubMed

ThyroSeq overview on indeterminate thyroid nodules: An institutional experience.
Chao Zhang, Dehong Li, Amanda Kornfield, Sam Sirotnikov, Christopher C Griffith, Daniel Lubin, Nabil F Saba, Amy Chen, Qiuying Shi> ;Diagnostic Cytopathology. 2024 Mar 30
Combined IL6 and CCR2 blockade potentiates antitumor activity of NK cells in HPV-negative head and neck cancer.
Fan Yang, Chenyang Yuan, Fanghui Chen, Zhaohui S Qin, Nicole C Schmitt, Gregory B Lesinski, Nabil F Saba, Yong Teng> ;Journal of Experimental & Clinical Cancer Research. 2024 Mar 12
Initial surgical management of sporadic medullary thyroid cancer: Guidelines based optimal care - A systematic review.
Oded Cohen, Sharon Tzelnick, Gregory Randolph, Alessandra Rinaldo, Fernando Álvarez, Juan P Rodrigo, Nabil F Saba, Sandra Nuyts, June Corry, Antti A Mäkitie, Vincent V...> ;Clinical Endocrinology. 2024 May 1
Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact.
Coca-Pelaz, A., Rodrigo, J., Agaimy, A., Williams, M., Saba, N., Nuyts, S., Randolph, G., López, F., Vander Poorten, V., Kowalski, L., Civantos, F., Zafereo, M., Mäkit...> ;Virchows Archiv. 2024 Feb 24
HSP90 inhibition suppresses tumor glycolytic flux to potentiate the therapeutic efficacy of radiotherapy for head and neck cancer.
Fanghui Chen, Chris Tang, Fan Yang, Asari Ekpenyong, Richard Qin, Jin Xie, Fatemeh Momen-Heravi, Nabil F Saba, Yong Teng> ;Science Advances. 2024 Feb 23
Update on olfactory neuroblastoma.
Fernando Lopez, Abbas Agaimy, Alessandro Franchi, Carlos Suárez, Vincent Vander Poorten, Antti A Mäkitie, Akihiro Homma, Avraham Eisbruch, Kerry D Olsen, Nabil F Saba,...> ;Virchows Archiv. 2024 Feb 22
The effect of neighborhood socioeconomic disadvantage on smoking status, quit attempts, and receipt of cessation support among adults with cancer: Results from nine EC...
Walter, A., Lee, J., Streck, J., Gareen, I., Herman, B., Kircher, S., Carlos, R., Kumar, S., Mayer, I., Saba, N., Fenske, T., Neal, J., Atkins, M., Hodi, F., Kyriakopo...> ;Cancer. 2024 Feb 1
Cancer metabolism and carcinogenesis.
Yang, J., Shay, C., Teng, Y., Saba, N.> ;Experimental Hematology & Oncology. 2024 Jan 29
Rescue of NLRC5 expression restores antigen processing machinery in head and neck cancer cells lacking functional STAT1 and p53.
Kinney, B., Gunti, S., Kansal, V., Parrish, C., Teng, Y., Henry, M., Su, F., Kwong, G., Saba, N., Schmitt, N.> ;Cancer Immunology, Immunotherapy. 2024 Jan 17
A Phase 1b/2 Study of Alpelisib in Combination with Cetuximab in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Albiruni R Abdul Razak, Hung-Ming Wang, Jang-Yang Chang, Myung-Ju Ahn, Pamela Munster, George Blumenschein Jr, Benjamin Solomon, Darren Wan-Teck Lim, Ruey-Long Hong, D...> ;Targeted Oncology. 2023 Nov 1
1 citations
Iron, Ferroptosis, and Head and Neck Cancer.
Yong Teng, Lixia Gao, Antti A Mäkitie, Ewa Florek, Agata Czarnywojtek, Nabil F Saba, Alfio Ferlito> ;International Journal of Molecular Sciences. 2023 Oct 12
Associations of differentially expressed genes with psychoneurological symptoms in patients with head and neck cancer: A longitudinal study.
Yufen Lin, Gang Peng, Deborah W Bruner, Andrew H Miller, Nabil F Saba, Kristin A Higgins, Dong M Shin, Henry Claussen, H Richard Johnston, Madelyn C Houser, Evanthia C...> ;Journal of Psychosomatic Research. 2023 Dec 1
Radiotherapy Plus Cisplatin With or Without Lapatinib for Non-Human Papillomavirus Head and Neck Carcinoma: A Phase 2 Randomized Clinical Trial.
Stuart J Wong, Pedro A Torres-Saavedra, Nabil F Saba, George Shenouda, Jeffrey M Bumpous, Robert E Wallace, Christine H Chung, Adel K El-Naggar, Clement K Gwede, Barba...> ;JAMA Oncology. 2023 Nov 1
1 citations
Review of Outcomes after Salvage Surgery for Recurrent Squamous Cell Carcinoma of the Head and Neck.
Dana M Hartl, Joanne Guerlain, Philippe Gorphe, Madan Kapre, Neeti Kapre Gupta, Nabil F Saba, K Thomas Robbins, Ohad Ronen, Juan P Rodrigo, Primož Strojan, Antti A Mäk...> ;Cancers. 2023 Sep 23
1 citations
Progress and emerging strategies to preserve function in the treatment of sinonasal cancer.
Kevin T Robbins, Ohad Ronen, Nabil F Saba, Primoz Strojan, Vincent Vander Poorten, Antti Mäkitie, Fernando López, Juan P Rodrigo, Akihiro Homma, Ehab Hanna, Alfio Ferlito> ;Head & Neck. 2023 Nov 1
Circulating short chain fatty acids and fatigue in patients with head and neck cancer: A longitudinal prospective study.
Canhua Xiao, Veronika Fedirko, Henry Claussen, H Richard Johnston, Gang Peng, Sudeshna Paul, Kristal M Maner-Smith, Kristin A Higgins, Dong M Shin, Nabil F Saba, Evant...> ;Brain, Behavior, and Immunity. 2023 Oct 1
1 citations
Randomized Phase II Trial of Ficlatuzumab With or Without Cetuximab in Pan-Refractory, Recurrent/Metastatic Head and Neck Cancer.
Julie E Bauman, Nabil F Saba, Denise Roe, Jessica R Bauman, John Kaczmar, Aarti Bhatia, Jameel Muzaffar, Ricklie Julian, Steven Wang, Shethal Bearelly, Audrey Baker, C...> ;Journal of Clinical Oncology. 2023 Aug 1
Survival Outcomes in T3 Laryngeal Cancers: Primary Total Laryngectomy vs. Concurrent Chemoradiation or Radiation Therapy-A Meta-Analysis.
Karthik Nagaraja Rao, Prathamesh S Pai, Prajwal Dange, Luiz P Kowalski, Primož Strojan, Antti A Mäkitie, Orlando Guntinas-Lichius, K Thomas Robbins, Juan P Rodrigo, Av...> ;Biomedicines. 2023 Jul 28
1 citations
The evolving landscape of salivary gland tumors.
Conor E Steuer, Glenn J Hanna, Kartik Viswanathan, James E Bates, Azeem S Kaka, Nicole C Schmitt, Alan L Ho, Nabil F Saba> ;CA. 2023 Jul 25
3 citations
Efficacy of Systemic Bevacizumab for Recurrent Respiratory Papillomatosis with Pulmonary Involvement.
Raymond J So, Julio C Hidalgo Lopez, Samir A Ballestas, Adam M Klein, Conor Steuer, Dong M Shin, Marin Abousaud, Yong Teng, Nabil F Saba, Andrew T Tkaczuk, Eric S Scha...> ;The Laryngoscope. 2024 Feb 1
Cigarette and Alternative Tobacco Product Use among Adult Cancer Survivors Enrolled in 9 ECOG-ACRIN Clinical Trials.
Joanna M Streck, Ju-Whei Lee, Angela Wangari Walter, Rachel L Rosen, Ilana F Gareen, Sheetal Mehta Kircher, Benjamin A Herman, Ruth C Carlos, Shaji Kumar, Ingrid A May...> ;Cancer Epidemiology, Biomarkers & Prevention. 2023 Nov 1
1 citations
Associations of inflammation with neuropsychological symptom cluster in patients with Head and neck cancer: A longitudinal study.
Zahra Amirkhanzadeh Barandouzi, Deborah W Bruner, Andrew H Miller, Sudeshna Paul, Jennifer C Felger, Evanthia C Wommack, Kristin A Higgins, Dong M Shin, Nabil F Saba, ...> ;Brain, Behavior, & Immunity - Health. 2023 Jul 1
1 citations
Unsupervised Hierarchical Clustering of Head and Neck Cancer Patients by Pre-Treatment Plasma Metabolomics Creates Prognostic Metabolic Subtypes.
Ronald C Eldridge, Zhaohui S Qin, Nabil F Saba, Madelyn C Houser, D Neil Hayes, Andrew H Miller, Deborah W Bruner, Dean P Jones, Canhua Xiao> ;Cancers. 2023 Jun 14
Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer.
Shuyuan Huang, Yan Zhan, Sangchoon Jeon, Deborah W Bruner, Andrew H Miller, Jennifer C Felger, Evanthia C Wommack, Nabil F Saba, Kristin A Higgins, Melinda L Irwin, Re...> ;Head & Neck. 2023 Aug 1
3 citations
Artificial Intelligence in Head and Neck Cancer: A Systematic Review of Systematic Reviews.
Antti A Mäkitie, Rasheed Omobolaji Alabi, Sweet Ping Ng, Robert P Takes, K Thomas Robbins, Ohad Ronen, Ashok R Shaha, Patrick J Bradley, Nabil F Saba, Sandra Nuyts, As...> ;Advances in Therapy. 2023 Aug 1
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Journal Articles

Concurrent Chemoradiotherapy with Weekly Versus Triweekly Cisplatin in Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Comparative Analysis
Rathi Pillai, Fadlo R Khuri, Nabil F Saba, Conor Steuer, Suchita Pakkala, Kristin Higgins, Jonathan J Beitler, Suresh S Ramalingam, Brandon Twardy, Kelly Schrapp, Taof..., Head & Neck
Disparities in Postoperative Therapy for Salivary Gland Adenoid Cystic Carcinomas
Jonathan J Beitler, Ryan H Belcher, Richard J Cassidy, Jim Zhong, Conor E Steuer, Nabil F Saba, The Laryngoscope
Interleukin-6/STAT3 Signaling Is Prominent and Associated with Reduced Overall Survival in p16 Negative Oropharyngeal Squamous Cell Carcinoma
Nabil F Saba, Dong M Shin, Head and Neck Pathology
Article MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
Guojing Zhang, Fadlo R Khuri, Taofeek K Owonikoko, Dan Li, Conor E Steuer, Nabil F Saba, Dong M Shin, Sagar Lonial, ScienceDirect
Prognosis of Subglottic Carcinoma: Is It Really Worse?
William M Mendenhall, Nabil F Saba, Ashok R Shaha, Head & Neck
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Lectures

Nivolumab (nivo) vs investigatoras choice (IC) in patients (pts) with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN): Analysis of C...
2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018

Other

Posttreatment surveillance of squamous carcinoma of the head and neck
Saba NF
http://www.uptodate.com/contents/posttreatment-surveillance-of-squamous-carcinoma-of-the-head-and-ne
UpToDate, Wolters Kluwer Health - 2013-01-22

Press Mentions

Head and Neck Cancer Awareness Month: 2022 Immunotherapy Research UpdatesApril 3rd, 2022
Dr. Nabil F. Saba Answers Questions About Head and Neck Cancer and Immunotherapy After the 2021 CRI Virtual Immunotherapy Patient SummitDecember 10th, 2021
Research Roundup: Recent Grants and Publications for Emory Faculty and StaffDecember 15th, 2020
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Committees

Chair, Chair- NCI steering committee task force on RM HNCA 2017 - Present
Member, Dean's advisory committee - Emory University School of Medicine 2017 - Present
Chair, Chair-NCI head and neck cancer steering committee on rare diseases 2016 - Present
Member, NRG- Head and Neck Cancer Core Committee 2016 - Present
Member, Member - head and neck cancer steering committee on metastatic disease 2015 - Present
Principal Author, Member, Committee on Appropriateness Criteria, Expert Panel on Radiation Oncology - Head & Neck Cancer, American College of Radiology 2015 - Present
Member, ECOG Head and Neck Cancer core committee 2006 - Present