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Office
Barrow Brain and Spine
2910 N 3rd Ave
Phoenix, AZ 85013Phone+1 602-406-3770Fax+1 602-406-6110- Is this information wrong?
Summary
- I am a neurosurgical oncologist and my practice is devoted to patients with tumors of the brain and spine, particularly those in high-risk areas. I have operated on over 3000 brain tumor patients since 2010 and have extensive experience with intraoperative mapping techniques to identify motor and language function during tumor resection. As Director of the Ivy Brain Tumor Center, I also oversee a dedicated early-phase clinical trials program that specializes in pharmacodynamic- and pharmacokinetic-driven studies for brain cancer. My clinical and laboratory research efforts are funded by over a dozen external granting agencies, including the National Institutes of Health, and are currently supported by $132M of extramural funding. Collectively, my work has led to over 12,000 citations in the literature and first-author studies published in journals such as Nature and The New England Journal of Medicine.
Education & Training
- Barrow Neurological Institute at St Joseph's Hospital and Medical CenterFellowship, Cerebrovascular & Skull Base Surgery, 2009 - 2010
- University of California (San Francisco)Residency, Neurological Surgery, 2004 - 2009
- University of California San Francisco School of MedicinePost-Doctoral Fellowship, Neural Stem Cell Biology, 2006 - 2008
- University of California (San Francisco) School of MedicineInternship, Transitional Year, 2003 - 2004
- University of California San Francisco School of MedicineClass of 2003
- University of California at San Diego (UCSD)B.S., Animal Physiology and Neuroscience, Summa Cum Laude, 1998
Certifications & Licensure
- AZ State Medical License 2009 - 2026
- CA State Medical License 2005 - 2025
- American Board of Neurological Surgery Neurological Surgery
Awards, Honors, & Recognition
- Academy Award American Academy of Neurological Surgery, 2013
- National Brain Tumor Foundation Mahaley Award American Association of Neurological Surgeons, 2010
- Howard Naffziger Resident of the Year Award UCSF Department of Neurological Surgery, 2009
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Clinical Trials
- Fluorescence-guided Surgery for Low- and High-grade Gliomas Start of enrollment: 2010 Nov 01
- 5-ALA in Recurrent Glioma Start of enrollment: 2014 Feb 01
- A Phase 0 Study of AZD1775 in Recurrent GBM Patients Start of enrollment: 2014 Jul 01
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Publications & Presentations
PubMed
- A validated LC-MS/MS method for determination of neuro-pharmacokinetic behavior of niraparib in brain tumor patients.William Knight, Tigran Margaryan, Artak Tovmasyan, Nader Sanai> ;Journal of Pharmaceutical and Biomedical Analysis. 2024 Apr 16
- Introduction: Contemporary management of low-grade gliomas: from tumor biology to the patient's quality of life.Hugues Duffau, Mitchel Berger, Priscilla K Brastianos, Nader Sanai, Emmanuel Mandonnet, Guy M McKhann> ;Neurosurgical Focus. 2024 Feb 1
- Quisinostat is a brain-penetrant radiosensitizer in glioblastoma.Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna-Melendez, James B McNamara, Connor I White, William Knight, Saisrinidhi Ganta, Zorana Opachich, Claudia Cantoni, Won...> ;JCI Insight. 2023 Nov 22
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Journal Articles
- Contralateral Interhemispheric, Transfalcine Approach with Asleep Motor Mapping for Parasagittal Lesions near the Medial Precentral GyrusNader Sanai, MD, Journal of Neurosurgery
- Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in miceYael Kusne, Emily Goldberg, Sara S. Parker, Sophie M. Hapak, Irina Maskaykina, Wade M. Chew, Kirsten H. Limesand, Heddwen L. Brooks, Theodore J. Price, Nader Sanai, Ja..., Age, 8/16/2013
- The Impact of Adjuvant Stereotactic Radiosurgery on Atypical meningioma Recurrence Following Aggressive Microsurgical ResectionDouglas A. Hardesty, Andrew Wolf, David Brachman, Heyoung McBride, Emad Youssef, Robert F. Spetzler, and Nader Sanai, Journal of Neurosurgery, 2/8/2013
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Authored Content
- Preoperative Embolization of Skull Base Meningiomas: Outcomes in the Onyx EraMay 2018
Press Mentions
- Ivy Brain Tumor Center Builds on Innovative Clinical Trial Program by Appointing New Chief Medical OfficerMay 23rd, 2023
- Arizona Goes All in for Brain Tumor Awareness MonthMay 1st, 2023
- SonALAsense Announces Completion of First Cohort in Phase 2 Study of SONALA-001 Sonodynamic Therapy for Recurrent GlioblastomaMarch 8th, 2023
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Grant Support
- Intraoperative Confocal Microscopy for In Vivo Analysis of Low-Grade GliomasNational Institute of Biomedical Imaging and Bioengineering2014–Present
- Phase 0 Study of AZ1775 in Preoperative Glioblastoma PatientsBen & Catherine Ivy Foundation2013–Present
- Phase 0 Study of Wee1 Small Molecular Inhibitor in Recurrent Glioblastoma Patients Scheduled for Resection to Evaluate Central Nervous System PenetrationAmerican Society of Clinical Oncology2013–Present
- Molecular Mechanisms Underlying Glioma Invasion of the Human Subventricular ZoneNational Institute of Neurological Disorders and Stroke (NINDS)2013–Present
- Spectral Tracking of Human Glioblastoma Stem CellsArizona Biomedical Research Commission2011–Present
- The Development Of Germinal Zones In The Human BrainNational Institute Of Neurological Disorders And Stroke2007
Committees
- Member, Executive Committee, American Association of Neurological Surgeons (AANS) / Congress of Neurological Surgeons (CNS) Section on Tumors 2013 - Present
- Member, Development Committee, American Association of Neurological Surgeons (AANS) / Congress of Neurological Surgeons (CNS) Section on Tumors 2013 - Present
- Self-Assessment in Neurosurgery (SANS) Committee, Congress of Neurological Surgeons 2010 - Present
Professional Memberships
- Member
- Fellow
- Member
- American Society for Clinical OncologyMember
- Society for Neuro-OncologyMember
- Member
Other Languages
- Farsi, French
Hospital Affiliations
- St. Joseph's Hospital and Medical CenterPhoenix, Arizona
External Links
- Barrow Brain Tumor Research Centerhttp://www.thebarrow.org/Neurological_Services/Brain_Tumor_Center/211048
- Sanai Laboratoryhttp://www.thebarrow.org/Research/Brain_Tumor_Research_Center/220705
- Barrow Neurosurgical Associateshttp://www.bnaneuro.net/Sanai-Bio.html
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