NancyBrownMD

Internal Medicine • Nashville, TN

Chair, Department of Medicine

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Office
3601 Tvc
Nashville, TN 37232
Phone+1 615-322-3000
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Education & Training

Vanderbilt University Medical CenterResidency, Internal Medicine, 1986 - 1992
Harvard Medical SchoolClass of 1986

Certifications & Licensure

TN State Medical License 1989 - 2025
CT State Medical License 2019 - 2024
American Board of Internal Medicine Internal Medicine

Clinical Trials

Racial Variation in ACE--Genetic and Physiologic Bases Start of enrollment: 1997 Sep 01
Completed
Genes and Fibrinolytic Capacity of Human Endothelium Start of enrollment: 2000 Aug 01
Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF) Start of enrollment: 2005 Apr 01
Completed
Phase 2, Phase 3
Bradykinin Receptor Blocker in ACE Inhibitor-associated Angioedema Start of enrollment: 2007 Sep 01
Terminated
Phase 1
Effect of Sitagliptin and an ACE Inhibitor on Blood Pressure in Metabolic Syndrome Start of enrollment: 2008 Mar 01
Completed
Phase 4
Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3 Start of enrollment: 2007 Dec 01
Completed
Not Applicable
Study of Inflammation and Oxidative Stress in Persons Undergoing Dialysis Start of enrollment: 2008 Aug 01
Completed
Phase 2
Renin Angiotensin Aldosterone System (RAAS) and Fibrinolysis in Humans: ACEi and PE5i Start of enrollment: 2006 Dec 01
Completed
Not Applicable
The Effect of a Peroxisome Proliferator-activated Receptor (PPAR) Alpha Agonist on Cytochrome P450 (CYP) Monooxygenase Activity in Humans Start of enrollment: 2009 Sep 01
Completed
Phase 4
Genes, Fibrinolysis and Endothelial Dysfunction- Dialysis Aim 3 Start of enrollment: 2010 Jan 01
Terminated
Phase 3
Renin-Angiotensin and Fibrinolysis in Humans: Effect of Long-Term PDE5 Inhibition on Glucose Homeostasis Start of enrollment: 2011 Aug 01
Terminated
Phase 4
Pharmacogenetics of Ace Inhibitor-Associated Angioedema Start of enrollment: 2011 Nov 01
Completed
Not Applicable
Effect of Bradykinin Receptor Antagonism on ACE Inhibitor-associated Angioedema Start of enrollment: 2011 Aug 01
Terminated
Phase 4
Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary Syndrome Start of enrollment: 2012 Feb 01
Terminated
Phase 4
Effect of Prolonged PDE-5 Inhibition on Insulin Signaling in Skeletal Muscle. Start of enrollment: 2014 Apr 01
Completed
Phase 4
Effect of Chronic ACE and DPP4 Inhibition on Blood Pressure Start of enrollment: 2014 Jun 01
Completed
Not Applicable
Comparative Effects of Aspirin and NHP-544C Start of enrollment: 2014 Jul 01
Completed
Not Applicable
Mechanism(s) Underlying Cardiovascular Effects of ARB/NEP Inhibition - Aim 2 Start of enrollment: 2017 Sep 01
Withdrawn
Phase 2
Cardiovascular Effects of GLP-1 Receptor Activation Start of enrollment: 2017 May 01
Completed
Phase 4
Soluble Epoxide Hydrolase Inhibition and Insulin Resistance Start of enrollment: 2018 May 17
Completed
Phase 2
Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 2 Start of enrollment: 2019 Nov 01
Recruiting
Phase 4
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Publications & Presentations

PubMed

Weight Loss-Independent Effect of Liraglutide on Insulin Sensitivity in Individuals With Obesity and Prediabetes.
Mona Mashayekhi, Hui Nian, Dustin Mayfield, Jessica K Devin, Jorge L Gamboa, Chang Yu, Heidi J Silver, Kevin Niswender, James M Luther, Nancy J Brown> ;Diabetes. 2024 Jan 1
1 citations
Bradykinin Breceptor blockade and intradialytic hypotension.
Jorge L Gamboa, Cindy A Mambungu, Adrienne R Clagett, Hui Nian, Chang Yu, T Alp Ikizler, Nancy J Brown> ;BMC Nephrology. 2023 May 11
4 citations
Proneuropeptide Y and neuropeptide Y metabolites in healthy volunteers and patients with a pheochromocytoma or paraganglioma.
Philippe J Eugster, Jonathan Maurer, Céline Vocat, Karim Abid, Maurice Matter, Grégoire Wuerzner, Roman Trepp, Stefan Fischli, Christoph Henzen, Walter Kolb, Stefan Bi...> ;Clinica Chimica Acta; International Journal of Clinical Chemistry. 2022 Sep 1
7 citations
GSK2256294 Decreases sEH (Soluble Epoxide Hydrolase) Activity in Plasma, Muscle, and Adipose and Reduces F2-Isoprostanes but Does Not Alter Insulin Sensitivity in Humans.
James M. Luther, Justina Ray, Dawei Wei, John R. Koethe, LaToya Hannah, Anthony DeMatteo, Robert Manning, Andrew S. Terker, Dungeng Peng, Hui Nian, Chang Yu, Mona Mash...> ;Hypertension. 2021 Aug 30
2 citations
Association of Apparent Treatment-Resistant Hypertension With Differential Risk of End-Stage Kidney Disease Across Racial Groups in the Million Veteran Program
Elvis A. Akwo, Cassianne Robinson-Cohen, Cecilia P. Chung, Shailja C. Shah, Nancy J. Brown, T. Alp Ikizler, Otis D. Wilson, Bryce X Rowan, Megan M. Shuey, Edward D. Si...> ;Hypertension. 2021 Jun 21
6 citations
Active B-Type Natriuretic Peptide Measured by Mass Spectrometry and Response to Sacubitril/Valsartan.
Erica M. Dillon, Shouzuo D. Wei, Deepak K. Gupta, Hui Nian, Brooks S. Rodibaugh, Katherine N. Bachmann, Allen J. Naftilan, Lynne W. Stevenson, Nancy J. Brown> ;Journal of Cardiac Failure. 2021 Jun 13
1 citations
Treatment of Primary Aldosteronism Increases Plasma Epoxyeicosatrienoic Acids.
James M. Luther, Dawei S. Wei, Kakali Ghoshal, Dungeng Peng, Gail K. Adler, Adina F. Turcu, Hui Nian, Chang Yu, Carmen C. Solorzano, Ambra Pozzi, Nancy J. Brown> ;Hypertension. 2021 Feb 15
Connecting Generations of Scientists in the Council on Hypertension Through Harriet Dustan
Stephanie W. Watts, Barbara T. Alexander, Chris Baylis, Nancy J. Brown, Lisa A. Cassis, Kate M. Denton, Bina Joe, Lilach O. Lerman, Suzanne Oparil, Jane F. Reckelhoff,...> ;Hypertension. 2021 Jan 4
11 citations
Association of a glucagon-like peptide-1 receptor gene variant with glucose response to a mixed meal
Mona Mashayekhi, Jessica R. Wilson, Scott R. Jafarian-Kerman, Hui Nian, Chang Yu, Megan M. Shuey, James M. Luther, Nancy J. Brown> ;Diabetes, Obesity & Metabolism. 2021 Jan 1
52 citations
Skeletal Muscle Mitochondrial Dysfunction Is Present in Patients with CKD before Initiation of Maintenance Hemodialysis.
Jorge L. Gamboa, Baback Roshanravan, Theodore F. Towse, Chad A. Keller, Aaron M. Falck, Chang Yu, Walter R. Frontera, Nancy J. Brown, T. Alp Ikizler> ;Clinical Journal of the American Society of Nephrology. 2020 Jun 26
15 citations
Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema
Cyrielle Maroteau, Moneeza K. Siddiqui, Abirami Veluchamy, Fiona Carr, Myra White, Andrew Cassidy, Ekaterina V Baranova, Eva Rye Rasmussen, Niclas Eriksson, Katarzyna ...> ;Clinical Pharmacology and Therapeutics. 2020 Dec 1
3 citations
Retrospective cohort study to characterise the blood pressure response to spironolactone in patients with apparent therapy-resistant hypertension using electronic medi...
Megan M. Shuey, Bradley W Perkins, Hui Nian, Chang Yu, James M. Luther, Nancy J. Brown> ;BMJ Open. 2020 May 1
132 citations
Call to Action: Rural Health: A Presidential Advisory From the American Heart Association and American Stroke Association.
Robert A. Harrington, Robert M. Califf, Appathurai Balamurugan, Nancy J. Brown, Regina M. Benjamin, Wendy E. Braund, Janie Hipp, Madeleine Konig, Eduardo Sanchez, Kare...> ;Circulation. 2020 Mar 10
42 citations
Intraoperative Oxidative Damage and Delirium after Cardiac Surgery.
Marcos G. Lopez, Christopher Hughes, Anthony DeMatteo, Jason B. O’Neal, J. Brennan McNeil, Matthew S. Shotwell, Jennifer Morse, Michael R. Petracek, Ashish S. Shah, Na...> ;Anesthesiology. 2020 Mar 1
Response to Letter to the Editor: "Hypertension and Type 2 Diabetes Are Associated With Decreased Inhibition of Dipeptidyl Peptidase-4 by Sitagliptin".
Jessica R Wilson, Megan M Shuey, Nancy J. Brown, Jessica K. Devin> ;Journal of the Endocrine Society. 2020 Mar 1
8 citations
Quantification of Neuropeptide Y and Four of Its Metabolites in Human Plasma by Micro-UHPLC-MS/MS.
Céline Vocat, Marielle Dunand, Scott A. Hubers, Nicolas Bourdillon, Grégoire P. Millet, Nancy J. Brown, Grégoire Wuerzner, Eric Grouzmann, Philippe J. Eugster> ;Analytical Chemistry. 2020 Jan 7
20 citations
Sitagliptin Decreases Visceral Fat and Blood Glucose in Women With Polycystic Ovarian Syndrome
Jessica K. Devin, Hui Nian, Jorge E Celedonio, Patricia Wright, Nancy J. Brown> ;The Journal of Clinical Endocrinology and Metabolism. 2020 Jan 1
9 citations
Dipeptidyl Peptidase 4 Inhibition Increases Postprandial Norepinephrine via Substance P (NK1 Receptor) During RAAS Inhibition.
Jessica R. Wilson, Scott Reza Jafarian Kerman, Scott A. Hubers, Chang Yu, Hui Nian, Eric Grouzmann, Philippe J. Eugster, Dustin S Mayfield, Nancy J. Brown> ;Journal of the Endocrine Society. 2019 Oct 1
6 citations
Transformation to Academic Leadership: The Role of Mentorship and Executive Coaching.
W. Kimryn Rathmell, Nancy J. Brown, Richard R. Kilburg> ;Consulting Psychology Journal. 2019 Sep 1
6 citations
Higher urinary cortisol levels associate with increased cardiovascular risk.
Andrea V. Haas, Paul N. Hopkins, Nancy J. Brown, Luminita H. Pojoga, Jonathan S. Williams, Gail K. Adler, Gordon H. Williams> ;Endocrine Connections. 2019 Jun 1
25 citations
Adipose tissue in persons with HIV is enriched for CD4+ T effector memory and T effector memory RA+ cells, which show higher CD69 expression and CD57, CX3CR1, GPR56 Co...
Celestine N. Wanjalla, Wyatt J. McDonnell, Louise Barnett, Joshua D. Simmons, Briana D. Furch, Morgan C. Lima, Beverly O. Woodward, Run Fan, Ye Fei, Paxton Baker, Rame...> ;Frontiers in Immunology. 2019 Mar 19
119 citations
Call to Action: Urgent Challenges in Cardiovascular Disease: A Presidential Advisory From the American Heart Association.
Mark McClellan, Nancy J. Brown, Robert M. Califf, John J. Warner> ;Circulation. 2019 Feb 26
1 citations
Mineralocorticoid Receptor Activation and Atrial Fibrosis.
Nancy J. Brown> ;Hypertension. 2019 Feb 1
23 citations
Early urine electrolyte patterns in patients with acute heart failure.
Sean P. Collins, Cathy A. Jenkins, Adrienne Baughman, Karen F. Miller, Alan B. Storrow, Jin H. Han, Nancy J. Brown, Dandan Liu, James M. Luther, Candace D. McNaughton,...> ;ESC Heart Failure. 2019 Feb 1
22 citations
Fish Oil and Perioperative Bleeding.
Emmanuel Akintoye, Prince Sethi, William S. Harris, Paul A. Thompson, Roberto Marchioli, Luigi Tavazzi, Roberto Latini, Mias Pretorius, Nancy J. Brown, Peter Libby, Da...> ;Circulation. Cardiovascular Quality and Outcomes. 2018 Nov 1
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