NealStuartYoungMD

Hematology • Washington, DC

Chief, Hematology Branch, NHLBI

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Office
Hatfield CRC, NIH
3E-5140
Washington, DC 20011
Phone+1 301-496-9604
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Education & Training

Massachusetts General HospitalResidency, Internal Medicine, 1971 - 1973
Johns Hopkins University School of MedicineClass of 1971

Certifications & Licensure

DC State Medical License 1978 - 2024
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1985
Member American Association of Physicians

Clinical Trials

Collection of Blood From Patients With Pancytopenia Start of enrollment: 1986 Apr 30
Completed
Comparing Therapies for the Treatment of Severe Aplastic Anemia Start of enrollment: 1997 Jun 02
Completed
Phase 2
Collection of Blood and Bone Marrow From Healthy Volunteers and Patients for Research Purposes Start of enrollment: 1997 Jul 08
Completed
Combination Therapy of Severe Aplastic Anemia Start of enrollment: 2000 Mar 17
Completed
Phase 2
Collection of Biological Samples From Patients With Hepatitis-Associated Aplastic Anemia Start of enrollment: 2003 Mar 10
Completed
Improving Immunosuppressive Treatment for Patients With Severe Aplastic Anemia Start of enrollment: 2003 Jun 26
Completed
Phase 2
Cytokine Gene Polymorphisms in Bone Marrow Failure Start of enrollment: 2005 Feb 11
Completed
Telomere Repair Gene Mutation in Inflammatory Bowel Disease Start of enrollment: 2006 May 15
Completed
Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers Start of enrollment: 2007 Mar 03
Recruiting
Safety of ON 01910.Na in Patients With Myelodysplasia Start of enrollment: 2007 Sep 14
Completed
Phase 1
Screening Protocol for Subjects Being Evaluated for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Protocols Start of enrollment: 2009 Aug 06
Completed
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies Start of enrollment: 2009 Sep 09
Completed
Cellular and Molecular Characterization of the Immune Response in Healthy NIH Employees atBaseline, and After Immunization With the H1N1 or Seasonal Influenza Vaccines Start of enrollment: 2009 Sep 18
Completed
Collection of Blood, Bone Marrow, Leukapheresis, and Tissue Biopsy Samples From Patients and Their Family Members for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases Laboratory Research Studies Start of enrollment: 2010 Jul 01
Terminated
Effects of Systemically Administered Hydrocortisone on the Immune System in Healthy Volunteers Start of enrollment: 2011 Jan 21
Completed
Combined Tretinoin and Arsenic Trioxide for Patients With Newly Diagnosed Acute Promyelocytic Leukemia Followed by Risk-Adapted Postremission Therapy Start of enrollment: 2011 Jul 01
Completed
Phase 2
Immune Responses to H5N1 Vaccine With and Without AS03 Adjuvant Start of enrollment: 2012 Mar 20
Completed
Phase 1, Phase 2
Low-Dose Danazol for the Treatment of Telomere Related Diseases Start of enrollment: 2018 Feb 08
Recruiting
Phase 2
CHIP/CCUS Natural History Protocol Start of enrollment: 2020 Mar 03
Recruiting
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA) Start of enrollment: 2020 May 07
Recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Efficacy of combined low-dose ruxolitinib and cyclosporine in murine immune bone marrow failure.
Feng, X., Manley, A., Wu, Z., Li, H., Gao, S., Durrani, J., Aggarwal, N., Mizumaki, H., Chen, J., Young, N., Groarke, E.> ;Haematologica. 2023 Dec 28
Granulocyte transfusions in severe aplastic anemia.
Rajput, R., Shah, V., Shalhoub, R., West-Mitchell, K., Cha, N., Conry-Cantilena, C., Leitman, S., Young, D., Wells, B., Aue, G., Dunbar, C., Patel, B., Childs, R., You...> ;Haematologica. 2023 Dec 7
Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasu's arteritis, ANCA-associated vasculitis and giant cell arteritis.
Fernanda Gutierrez-Rodrigues, Kristina V Wells, Adrianna I Jones, Dalton Hironaka, Cameron Rankin, Massimo Gadina, Keith A Sikora, Lemlem Alemu, Rodrigo T Calado, Kait...> ;Annals of the Rheumatic Diseases. 2024 Mar 12
1 citations
Use of flow cytometric light scattering to recognize the characteristic vacuolated marrow cells in VEXAS syndrome.
Yanna Ding, Alina E Dulau-Florea, Emma M Groarke, Bhavisha A Patel, David B Beck, Peter C Grayson, Marcela A Ferrada, Neal S Young, Katherine R Calvo, Raul C Braylan> ;Blood Advances. 2023 Oct 24
2 citations
Single-cell genomics in acquired bone marrow failure syndromes.
Zhijie Wu, Neal S Young> ;Blood. 2023 Oct 5
Immunosuppressive Activity of Exosomes from Granulocytic Myeloid-Derived Suppressor Cells in a Murine Model of Immune Bone Marrow Failure.
Ash Lee Manley, Jichun Chen, Wendy Fitzgerald, Xingmin Feng, Neal S Young> ;International Journal of Molecular Sciences. 2023 Sep 28
5 citations
Early activation of inflammatory pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS.
Ombrello, A. K., Ombrello, A. K., Zhijie Wu, Shouguo Gao, Qingyan Gao, Bhavisha A Patel, Emma M Groarke, Xingmin Feng, Ash Lee Manley, Haoran Li, Daniela Ospina Cardon...> ;Cell Reports. Medicine. 2023 Aug 15
20 citations
Spectrum of clonal hematopoiesis in VEXAS syndrome.
Ombrello, A. K., Ombrello, A. K., Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna Fernandez, Terra Lasho, Ruba Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy Finke, Matth...> ;Blood. 2023 Jul 20
Effects of ruxolitinib on murine regulatory T cells are immune-context dependent.
Nidhi Aggarwal, Ash Lee Manley, Jichun Chen, Emma M Groarke, Xingmin Feng, Neal S Young> ;Experimental Hematology. 2023 Jul 17
1 citations
Conditional survival and standardized mortality ratios of patients with severe aplastic anemia surviving at least one year after hematopoietic cell transplantation or ...
Ryotaro Nakamura, Bhavisha A Patel, Soyoung Kim, F Lennie Wong, Saro H Armenian, Emma M Groarke, Kyle M Hebert, Michael Heim, Mary Eapen, Neal S Young, Keesler, D.> ;Haematologica. 2023 Dec 1
11 citations
Differential diagnosis of bone marrow failure syndromes guided by machine learning.
Fernanda Gutierrez-Rodrigues, Eric Munger, Xiaoyang Ma, Emma M Groarke, Youbao Tang, Bhavisha A Patel, Luiz Fernando B Catto, Diego V Clé, Marena R Niewisch, Raquel M ...> ;Blood. 2023 Apr 27
2 citations
What causes aplastic anaemia?
Robert Peter Gale, Wolfgang Hinterberger, Neal S Young, Andrew R Gennery, Christopher C Dvorak, Kyle M Hebert, Michael Heim, Larisa Broglie, Mary Eapen> ;Leukemia. 2023 Jun 1
2 citations
Alemtuzumab in relapsed immune severe aplastic anemia: Long-term results of a phase II study.
Nidhi Aggarwal, Ash Lee Manley, Ruba Shalhoub, Jibran Durrani, Olga Rios, Jennifer Lotter, Bhavisha A Patel, Colin O Wu, Neal S Young, Emma M Groarke> ;American Journal of Hematology. 2023 Jun 1
5 citations
Granulocytic myeloid-derived suppressor cells to prevent and treat murine immune-mediated bone marrow failure.
Xingmin Feng, Jisoo Kim, Gladys Gonzalez-Matias, Nidhi Aggarwal, Ash Lee Manley, Zhijie Wu, Sabrina Solorzano, Shouguo Gao, Jichun Chen, Neal S Young, Sai Batchu> ;Blood Advances. 2023 Jan 10
7 citations
Efficacy of JAK1/2 inhibition in murine immune bone marrow failure.
Emma M Groarke, Xingmin Feng, Nidhi Aggarwal, Ash Lee Manley, Zhijie Wu, Shouguo Gao, Bhavisha A Patel, Jichun Chen, Neal S Young> ;Blood. 2023 Jan 5
7 citations
Effects of nandrolone decanoate on telomere length and clinical outcome in patients with telomeropathies: a prospective trial.
Diego V Clé, Luiz Fernando B Catto, Fernanda Gutierrez-Rodrigues, Flávia S Donaires, Andre L Pinto, Barbara A Santana, Luiz Guilherme Darrigo, Elvis T Valera, Marcel K...> ;Haematologica. 2023 May 1
16 citations
Oligoclonal T-cell expansion in a patient with bone marrow failure after CD19 CAR-T therapy for Richter-transformed DLBCL.
Kai Rejeski, Zhijie Wu, Viktoria Blumenberg, Wolfgang G Kunz, Susanna Müller, Sachiko Kajigaya, Shouguo Gao, Veit L Bücklein, Lisa Frölich, Christian Schmidt, Michael ...> ;Blood. 2022 Nov 17
Time-Varying Gene Expression Network Analysis Reveals Conserved Transition States in Hematopoietic Differentiation between Human and Mouse.
Shouguo Gao, Ye Chen, Zhijie Wu, Sachiko Kajigaya, Xujing Wang, Neal S Young> ;Genes. 2022 Oct 18
1 citations
CellCallEXT: Analysis of Ligand-Receptor and Transcription Factor Activities in Cell-Cell Communication of Tumor Immune Microenvironment.
Shouguo Gao, Xingmin Feng, Zhijie Wu, Sachiko Kajigaya, Neal S Young> ;Cancers. 2022 Oct 10
2 citations
Anti-COX-2 autoantibody is a novel biomarker of immune aplastic anemia.
Tiina Kelkka, Mikko Tyster, Sofie Lundgren, Xingmin Feng, Cassandra Kerr, Kohei Hosokawa, Jani Huuhtanen, Mikko Keränen, Bhavisha Patel, Toru Kawakami, Yuka Maeda, Ots...> ;Leukemia. 2022 Sep 1
19 citations
Predictors of clonal evolution and myeloid neoplasia following immunosuppressive therapy in severe aplastic anemia.
Emma M Groarke, Bhavisha A Patel, Ruba Shalhoub, Fernanda Gutierrez-Rodrigues, Parth Desai, Harshraj Leuva, Yoshitaka Zaimoku, Casey Paton, Nina Spitofsky, Jennifer Lo...> ;Leukemia. 2022 Sep 1
5 citations
SARS-CoV-2 infection associated with aplastic anemia and pure red cell aplasia.
Nicholas C J Lee, Bhavisha Patel, Aaron Etra, Taha Bat, Ibrahim F Ibrahim, Madhuri Vusirikala, Mingyi Chen, Flavia Rosado, Jesse Manuel Jaso, Neal S Young, Weina Chen> ;Blood Advances. 2022 Jul 12
5 citations
Long-term eltrombopag for bone marrow failure depletes iron.
David J Young, Xing Fan, Emma M Groarke, Bhavisha Patel, Ronan Desmond, Thomas Winkler, Andre Larochelle, Katherine R Calvo, Neal S Young, Cynthia E Dunbar> ;American Journal of Hematology. 2022 Jun 1
20 citations
Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.
Shouguo Gao, Zhijie Wu, Bradley Arnold, Carrie Diamond, Valentina Giudice, Lemlem Alemu, Diego Quinones Raffo, Xingmin Feng, Sachiko Kajigaya, John Barrett, Sawa Ito, ...> ;Nature Communications. 2022 Apr 11
1 citations
Conditional deletion of mTOR discloses its essential role in early B-cell development.
Shuling Zhang, Wendy Dubois, Xingmin Feng, Joe T Nguyen, Neal S Young, Beverly A Mock> ;Molecular Carcinogenesis. 2022 Apr 1
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Abstracts/Posters

Outcomes in Pediatric Patients with Severe Aplastic Anemia Treated with Standard Immunosuppression and Eltrombopag
Neal S. Young, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Analysis of Deficiency of Adenosine Deaminase 2 Pathogenesis Based on Single Cell RNA Sequencing of Monocytes
Neal S. Young, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Deficit of Circulating CD19+CD24hiCD38hi Regulatory B Cells in Severe Aplastic Anemia
Neal S. Young, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Macrophage TNF-Α Licenses Donor T Cells in Murine Bone Marrow Failure and Can Be Implicated in Human Aplastic Anemia
Neal Young, MD, Blood, Orlando, FL, 12/9/2019
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Lectures

Bone Marrow Failure: Fanconi Anemia and Aplastic Anemia
60th American Society of Hematology Annual Meeting - 12/3/2018
Eltrombopag Improves Hematopoiesis in Patients with Low to Intermediate-2 Risk Myelodysplastic Syndrome(MDS)
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Grant Support

Viruses And HematopoiesisNational Heart, Lung, And Blood Institute2010–2011
Telomeres DiseasesNational Heart, Lung, And Blood Institute2010–2011
MyelodysplasiaNational Heart, Lung, And Blood Institute2010–2011
Immune Pathophysiology Of Aplastic Anemia And Immunosuppressive TreatmentsNational Heart, Lung, And Blood Institute2010–2011
Pathogenesis And Treatment Of Aplastic AnemiaNational Heart, Lung, And Blood Institute2009
Pathogenesis And Treatment Of Aplastic AnemiaNational Heart, Lung, And Blood Institute1990–2008
Viruses And HematopoeiesisNational Heart, Lung, And Blood Institute1996–1997
B19 Parvovirus And Adeno-Associated VirusNational Heart, Lung, And Blood Institute1994–1995
Parovirus (HUMAN) B19National Heart, Lung, And Blood Institute1988–1993
Lymphocytes And Lmyphokines In Aplastic AnemiaNational Heart, Lung, And Blood Institute1985–1988
ParovirusNational Heart, Lung, And Blood Institute1987
Viruses And Bone Marrow FailureNational Heart, Lung, And Blood Institute1986