Tim F Greten MD

Hematology•Bethesda, MD

Physician

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Nci Building 10 Rm 12n22610 Center DriveBethesda, MD 20892
Phone+1 240-760-6114

Education & Training

University of Kiel Faculty of MedicineClass of 1992

Certifications & Licensure

MD State Medical License 2011 - 2026

Clinical Trials

Elimination of CD4+CD25+ Regulatory T Cells in Patients With Hepatocellular Carcinoma Start of enrollment: 2007 Feb 01
Completed
Phase 3
Sorafenib and TRC105 in Hepatocellular Cancer Start of enrollment: 2011 Feb 11
Completed
Phase 1, Phase 2
Acquisition of Blood and Tumor Tissue Samples From Patients With Gastrointestinal Cancer Start of enrollment: 2011 Mar 02
RECRUITING
TRC105 for Liver Cancer That Has Not Responded to Sorafenib Start of enrollment: 2011 Jun 22
Completed
Phase 2
Pembrolizumab, a Monoclonal Antibody Against PD-1, in Combination With Capecitabine and Oxaliplatin (CAPOX) in People With Advanced Biliary Tract Carcinoma (BTC) Start of enrollment: 2017 Jun 14
Completed
Phase 2
VB-111 in Combination With Nivolumab in People With Metastatic Colorectal Cancer (mCRC) Start of enrollment: 2020 Aug 09
Completed
Phase 2
GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Hepatocellular Carcinoma (HCC) Start of enrollment: 2021 Dec 08
RECRUITING
PHASE1
Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC). Start of enrollment: 2022 Feb 15
Terminated
Phase 2
Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma or Biliary Tract Carcinoma Start of enrollment: 2021 Mar 10
ACTIVE_NOT_RECRUITING
PHASE2
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Publications & Presentations

PubMed

SPP1 + macrophages cause exhaustion of tumor-specific T cells in liver metastases.
Rajiv Trehan, Patrick Huang, Xiao Bin Zhu, Xin Wang, Marlaine Soliman
Nature Communications. 2025-05-07
1 citations
Multiomics analysis of immune correlatives in hepatocellular carcinoma patients treated with tremelimumab plus durvalumab.
Yuta Myojin, Sepideh Babaei, Rajiv Trehan, Christoph Hoffman, Noemi Kedei
Gut. 2025-05-07
1 citations
Hepatic immune environment differences among common mouse strains in models of MASH and liver cancer.
Patrick Huang, Francisco J Rodriguez-Matos, Jonathan Qi, Rajiv Trehan, Yuta Myojin
JHEP Reports. 2025-05-01

Press Mentions

TACE-Based Treatment Combinations Effective Against Intermediate-Stage Liver CancerMarch 7th, 2025
Drugs for Advanced Breast Cancer Could Help Patients with Rare Cancer That Affects Bile DuctsOctober 23rd, 2024
Treatments Used for HER2-Positive Breast Cancers Could Help Patients with Rare Gastrointestinal CancerOctober 23rd, 2024
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Other Languages

German