NeeleshSharmaMD

Oncology • Cleveland, OH

Assistant Professor, Medicine, Case Western Reserve University School of Medicine

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Office
5885 Landerbrook Dr
Ste 150
Cleveland, OH 44124
Phone+1 216-767-8793

Fax+1 216-767-8778
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Education & Training

University at BuffaloFellowship, Hematology and Medical Oncology, 2010 - 2011
University at BuffaloFellowship, Hematology and Medical Oncology, 2008 - 2010
Cook County Health and Hospitals SystemResidency, Internal Medicine, 2005 - 2008
G.S.V.M Medical College KanpurClass of 2003

Certifications & Licensure

OH State Medical License 2011 - 2024
VA State Medical License 2023 - 2024
NY State Medical License 2010 - 2012

Clinical Trials

Safety Study of PLX3397 and Paclitaxel in Patients With Advanced Solid Tumors Start of enrollment: 2012 May 01
Completed
Phase 1
Erlotinib Hydrochloride and Quinacrine Dihydrochloride in Stage IIIB-IV Non-Small Cell Lung Cancer Start of enrollment: 2013 Sep 01
Completed
Phase 1
An Open-Label, Randomized, Phase 3 Trial of Nivolumab Versus Investigator's Choice Chemotherapy as First-Line Therapy for Stage IV or Recurrent PD-L1+ Non-Small Cell Lung Cancer (CheckMate 026) Start of enrollment: 2014 Mar 27
Completed
Phase 3

Publications & Presentations

PubMed

3 citations
Phase I clinical trial of temozolomide and methoxyamine (TRC-102), an inhibitor of base excision repair, in patients with advanced solid tumors
Jennifer R. Eads, Smitha S. Krishnamurthi, Joel N. Saltzman, Joseph A. Bokar, P. Savvides, Neal J. Meropol, Joseph Gibbons, Henry B. Koon, Neelesh Sharma, Lisa Rogers,...> ;Investigational New Drugs. 2021 Feb 1
74 citations
Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors:
Robert Wesolowski, Neelesh Sharma, Laura Reebel, Mary Beth Rodal, Alexandra Peck, Brian L. West, Adhirai Marimuthu, Paul Severson, David A. Karlin, Afshin Dowlati, Mai...> ;Therapeutic Advances in Medical Oncology. 2019 Jun 21
35 citations
Direct activation of PP2A for the treatment of tyrosine kinase inhibitor–resistant lung adenocarcinoma
Rita Tohme, Sudeh Izadmehr, Sai Gandhe, Giancarlo Tabaro, Sanjay Vallabhaneni, Ava Thomas, Neal Vasireddi, Neil S. Dhawan, Avi Ma'ayan, Neelesh Sharma, Matthew D. Gals...> ;JCI Insight. 2019 Feb 21
35 citations
Retinoblastoma mutation predicts poor outcomes in advanced non small cell lung cancer.
Priyanka Bhateja, Michelle Chiu, Gary Wildey, Mary Beth Lipka, Pingfu Fu, Michael Chiu Lee Yang, Fatemeh Ardeshir-Larijani, Neelesh Sharma, Afshin Dowlati> ;Cancer Medicine. 2019 Apr 1
3 citations
High UDG and BRCA1 expression is associated with adverse outcome in patients with pemetrexed treated non-small cell lung Cancer.
Nooshin Hashemi Sadraei, Yan Feng, Lingling Du, Pingfu Fu, Sulsal Haque, Afshin Dowlati, Jahnavi Gollamudi, Nathan A. Pennell, Tarek Mekhail, Stefanie Avril, Carol Far...> ;Lung Cancer. 2018 Dec 1
29 citations
KMT2D Mutation Is Associated With Poor Prognosis in Non-Small-Cell Lung Cancer.
Fatemeh Ardeshir-Larijani, Priyanka Bhateja, Mary Beth Lipka, Neelesh Sharma, Pingfu Fu, Afshin Dowlati> ;Clinical Lung Cancer. 2018 Jul 1
9 citations
Phase I study of the combination of quinacrine and erlotinib in patients with locally advanced or metastatic non small cell lung cancer.
Priyanka Bhateja, Afshin Dowlati, Neelesh Sharma> ;Investigational New Drugs. 2018 Jun 1
899 citations
STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Cancer Discovery. 2018 May 17
47 citations
Phase Ib/II Trial of NC-6004 (Nanoparticle Cisplatin) Plus Gemcitabine in Patients with Advanced Solid Tumors.
Vivek Subbiah, Juneko E. Grilley-Olson, Austin J. Combest, Neelesh Sharma, Richard H. Tran, Iulian Bobe, Atsushi Osada, Kazuhiro Takahashi, J. Balkissoon, A. Camp, Ats...> ;Clinical Cancer Research. 2018 Jan 1
16 citations
Prognostic potential of neutrophil-to-lymphocyte ratio and lymphocyte nadir in stage III non-small-cell lung cancer.
Kylie H. Kang, Jimmy T. Efird, Neelesh Sharma, Michael Yang, Afshin Dowlati, Philip A. Linden, Mitchell Machtay, Tithi Biswas> ;Future Oncology. 2017 Jul 7
129 citations
Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth
Jaya Sangodkar, Abbey L. Perl, Rita Tohme, Janna Kiselar, David B. Kastrinsky, Nilesh Zaware, Sudeh Izadmehr, Sahar Mazhar, Danica Wiredja, Caitlin M. O’Connor, Divya ...> ;The Journal of Clinical Investigation. 2017 Jun 1
3 citations
Interaction of Treatment and Biomarker in Advanced Non-small Cell Lung Cancer.
Pingfu Fu, Nathan A. Pennell, Neelesh Sharma, Qizhi Yi, Afshin Dowlati> ;Reviews on Recent Clinical Trials. 2017 Feb 28
11 citations
Radiosensitization of non-small-cell lung cancer cells and xenografts by the interactive effects of pemetrexed and methoxyamine.
Nancy L. Oleinick, Tithi Biswas, R. Patel, Mingfang Tao, Ravi Patel, Lachelle D. Weeks, Neelesh Sharma, Afshin Dowlati, Stanton L. Gerson, Pingfu Fu, Junran Zhang, Mit...> ;Radiotherapy and Oncology. 2016 Nov 1
1 citations
Afatinib plus chemotherapy versus chemotherapy alone after progression on afatinib: new insights on old question?
Priyanka Bhateja, Neelesh Sharma> ;Annals of Translational Medicine. 2016 Oct 1
Optimum treatment for mediastinal lymph node positive (N2) resectable non-small cell lung cancer: what is the role for surgery?
Musaddiq J. Awan, Neelesh Sharma, Christopher W. Towe, Jimmy T. Efird, Mitchell Machtay, Tithi Biswas> ;Expert Review of Anticancer Therapy. 2016 Oct 6
12 citations
Comparison of cisplatin/etoposide versus carboplatin/etoposide concurrent chemoradiation therapy for limited-stage small cell lung cancer (LS-SCLC) in the elderly popu...
Ellen Kim, Tithi Biswas, Paul M. Bakaki, Afshin Dowlati, Neelesh Sharma, Mitchell Machtay> ;Practical Radiation Oncology. 2016 Sep 1
62 citations
NCCN Guidelines Insights: Malignant Pleural Mesothelioma, Version 3.2016
David S. Ettinger, Douglas E. Wood, Wallace Akerley, Lyudmila Bazhenova, Hossein Borghaei, D.R. Camidge, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Thom...> ;Journal of the National Comprehensive Cancer Network. 2016 Jul 1
59 citations
Clinical correlation of extensive-stage small-cell lung cancer genomics
Afshin Dowlati, Mary Beth Lipka, Karen S. McColl, Snehal Dabir, Mohadese Behtaj, Adam Kresak, A. Miron, Michael Yang, Neelesh Sharma, Pingfu Fu, Gary Wildey> ;Annals of Oncology. 2016 Apr 1
333 citations
NCCN Guidelines ® Insights: Non-Small Cell Lung Cancer, Version 4.2016 Featured Updates to the NCCN Guidelines
David S. Ettinger, Douglas E. Wood, Wallace Akerley, Lyudmila Bazhenova, Hossein Borghaei, D.R. Camidge, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Thom...> ;Journal of the National Comprehensive Cancer Network. 2016 Mar 1
10 citations
Phase II study of erlotinib and docetaxel with concurrent intensity-modulated radiotherapy in locally advanced head and neck squamous cell carcinoma
Min Yao, C. Woods, Pierre Lavertu, Pingfu Fu, Michael K. Gibson, Rod Rezaee, Chad A. Zender, Jay Wasman, Neelesh Sharma, Mitchell Machtay, Panayiotis Savvides> ;Head & Neck. 2016 Feb 26
20 citations
Randomized Phase II Trial of Erlotinib Beyond Progression in Advanced Erlotinib-Responsive Non-Small Cell Lung Cancer
Balazs Halmos, Nathan A. Pennell, Pingfu Fu, Shumaila Saad, Shirish M. Gadgeel, Gregory A. Otterson, Tarek Mekhail, Michael R. Snell, J. Philip Kuebler, Neelesh Sharma...> ;The Oncologist. 2015 Nov 1
11 citations
Afatinib and lung cancer.
Prantesh Jain, Rashmi Khanal, Aakanksha Sharma, Feng Yan, Neelesh Sharma> ;Expert Review of Anticancer Therapy. 2014 Nov 22
48 citations
Quinacrine Overcomes Resistance to Erlotinib by Inhibiting FACT, NF-κB, and Cell-Cycle Progression in Non–Small Cell Lung Cancer
Josephine K Dermawan, Katerina Gurova, John J. Pink, Afshin Dowlati, Sarmishtha De, Goutham Narla, Neelesh Sharma, George Stark Stark> ;Molecular Cancer Therapeutics. 2014 Sep 1
14 citations
Controversies in the management of stage III non-small-cell lung cancer
Tithi Biswas, Neelesh Sharma, Mitchell Machtay> ;Expert Review of Anticancer Therapy. 2014 Feb 23
34 citations
Phase II trial of Sorafenib in conjunction with chemotherapy and as maintenance therapy in extensive-stage small cell lung cancer
Neelesh Sharma, Nathan A. Pennell, Myles Nickolich, Balazs Halmos, Patrick C. Ma, Tarek Mekhail, Pingfu Fu, Afshin Dowlati> ;Investigational New Drugs. 2014 Jan 15
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Press Mentions

Adopt Dairy Farming with Focus on Value Addition of Milk: SKUAST-VCJuly 11th, 2020
SKUAST-J Celebrates World Food DayOctober 16th, 2017
In the Clinic: Ongoing Clinical Trials Evaluating C-MET-Inhibiting DrugsNovember 1st, 2011