Alvin H Schmaier MD

Hematologic Oncology

Robert W. Kellermeyer Professor, Medicine, Case Western Reserve University School of Medicine

2103 Cornell Road, WRB2-130WRB2-130Cleveland, OH 44106
Phone+1 216-368-0796
Fax+1 216-368-1166

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Summary

Dr. Alvin Schmaier is a hematologist-physician scientist based in Cleveland, OH, with a subspecialty in hematology and oncology. He completed his fellowship in Hematology and Medical Oncology at the University of Pennsylvania Health System and his residency in Internal Medicine at Temple University Hospital. He did a research fellowship in Thrombosis at Temple University School of Medicine. Dr. Schmaier is experienced in managing hemophilia A and B, thrombotic disorders, anticoagulation, and bleeding disorders. His work has been published in various notable journals, including the Journal of Clinical Investigation, Journal of Thrombosis and Haemostasis and Blood. His bibliography is available on Pubmed and Google Scholar. His laboratory studies the plasma kallikrein/kinin system and thrombosis. He has been NIH-funded for over 45 years. He has also been involved in clinical trials evaluating treatments for hemophilia with inhibitors and anticoagulation. He has been recognized as a Regional Top Doctor by Castle Connolly and achieved CMS Meaningful Use Stage 1 Certification through various platforms. His current medical practice is on bleeding disorders only.

Education & Training

University of Pennsylvania Health SystemFellowship, Hematology and Medical Oncology, 1977 - 1980
Temple University HospitalResidency, Internal Medicine, 1974 - 1977
Virginia Commonwealth University School of MedicineClass of 1974
Kettering Health NetworkResidency, Orthopaedic Surgery

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Certifications & Licensure

OH State Medical License 2006 - 2028
MI State Medical License 1991 - 2007
PA State Medical License 1975 - 1992
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014, 2022
CMS Meaningful Use Stage 1 Certification Allscripts FollowMyHealth, Allscripts, 2015-2016
CMS Meaningful Use Stage 1 Certification Rhapsody Connect, Orion Health, 2015-2016

Clinical Trials

Initial Treatment of Patients With Immune Thrombocytopenic Purpura
TERMINATED
PHASE3
Prospective and Retrospective, Non-interventional Study to Evaluate the Safety and Effectiveness of Obizur in Real-life Practice Start of enrollment: 2016 Dec 14
COMPLETED

Publications & Presentations

PubMed

Platelet Transfusion in Patients With Low ADAMTS13-Confirmed Thrombotic Thrombocytopenic Purpura Is Associated With Increased Mortality.
Joseph O'Brien, Alvin H Schmaier, Mayher J Patel, Michael Daunov, Leland Metheny
European Journal of Haematology. 2026-07-26
Bradykinin contributes to vasogenic edema in murine experimental cerebral malaria.
Alessandro S de Sa Pinheiro, Douglas E Teixeira, Rodrigo P Silva-Aguiar, Young Jun Shim, Alona A Merkulova
The Journal of Clinical Investigation. 2026-07-14
Therapeutic Targeting of the Bradykinin B2 Receptor in Immunological and Vascular Diseases: Insights from Kinin Biology to Clinical Outcomes.
Marc A Riedl, Danny M Cohn, Markus Magerl, Henriette Farkas, Emel Aygören-Pürsün
Clinical Reviews in Allergy & Immunology. 2026-07-03

Journal Articles

Assessment of Whole Blood Coagulation with a Microfluidic Dielectric Sensor
Alvin H Schmaier, Journal of Thrombosis and Haemostasis

Abstracts/Posters

Outcomes after Treatment with Upfront Cyclophosphamide or Rituximab for Initial Acquired Thrombotic Thrombocytopenic Purpura
Alvin H. Schmaier, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Mice Deficient in ¤2-Glycoprotein I Have a Delayed Time to Thrombosis
Alvin H. Schmaier, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

Special Symposium on the Basic Science of Hemostasis and Thrombosis
60th American Society of Hematology Annual Meeting - 12/3/2018
Vascular Biology Components of Hemostasis
60th American Society of Hematology Annual Meeting - 12/2/2018
Neutrophil KLF2 Regulates Arterial and Venous Thrombosis
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

Sepsis Breakthrough Promises Better Care for Critically IllJanuary 18th, 2025
University Hospitals and Case Western Reserve University Collaborative Science Pilot Awards Infuse $250,000 to Accelerate Five Promising Research ProjectsJanuary 10th, 2025
University Hospitals and Case Western Reserve University Collaborative Science Pilot Awards Infuse $250,000 to Accelerate Five Promising Research ProjectsJanuary 9th, 2025

Grant Support

Tyrosine Kinases and ThrombosisCASE WESTERN RESERVE UNIVERSITY2022–2026
Prolylcarboxypeptidase Is A Risk Factor For Cardiovascular DiseaseNational Heart, Lung, And Blood Institute2012
Regulation Of Kinin Delivery On HuvecNational Heart, Lung, And Blood Institute2006–2012
Thrombostatin-A Thrombin Receptor InhibitorNational Heart, Lung, And Blood Institute2005–2006
Regulation Of Kinin Delivery On HuvecNational Heart, Lung, And Blood Institute1996–2005