Neil A. Segal MD MS

PubMed

• Diagnostic value of MRI for detection of knee cartilage lesions vs. weight-bearing CT arthrography (WBCTa).
  Susan Li, Frank W Roemer, Ali Guermazi, Michael C Nevitt, John A Lynch
  Skeletal Radiology. 2025-12-01
• Effect of Knee Extensor Power on Knee Pain in Adults With or at Risk for Osteoarthritis: The Multicenter Osteoarthritis Study.
  Chun-Hao Huang, Neil A Segal, David T Felson, David A Sherman, Cara L Lewis
  The Journal of Rheumatology. 2025-10-15
• Measures of Patellofemoral Morphology Predict the Risk of Local Cartilage Damage Progression: A Yale/MOST Collaborative Study.
  Nancy Park, Johannes M Sieberer, Brooke McGinley, Armita R Manafzadeh, John Lynch
  The American Journal of Sports Medicine. 2025-10-01

Journal Articles

• Association of Diabetes Mellitus and Biomarkers of Abnormal Glucose Metabolism with Incident Radiographic Knee Osteoarthritis  
  Nancy E Lane, David T Felson, Neil A Segal, Cora E Lewis, Ann V Schwartz, Arthritis Care & Research
• Pain Susceptibility Phenotypes in Those Free of Knee Pain with or at Risk of Knee Osteoarthritis: The Multicenter Osteoarthritis Study  
  Neil A Segal, Michael Nevitt, Arthritis & Rheumatology
• The Sex‐Specific Influence of Quadriceps Weakness on Worsening Patellofemoral and Tibiofemoral Cartilage Damage: The MOST Study  
  Neil A Segal, Ali Guermazi, David T Felson, Joshua J Stefanik, Arthritis Care & Research
• Thresholds in the Relationship of Quadriceps Strength with Functional Limitations in Women with Knee Osteoarthritis  
  Cora E Lewis, David T Felson, Neil A Segal, Arthritis Care & Research
• Predicting Meniscal Tear Stability Across Knee-Joint Flexion Using Finite-Element Analysis  
  Neil Segal, MD, Knee Surgery, Sports Traumatology, Arthroscopy
• Reliability of Highly Automated Computational Methods for Estimating Tibiofemoral Articular Contact Stress in the MOST Study.  
  Anderson DD, Segal NA, Kern A, Lynch J, Torner JC, Nevitt M, Computational and Mathematical Methods in Medicine
• MOST Study Making Much Of OA, Pain Data.  
  Rosemary Frei M, Pain Medicine News
• Effects of an aquatic power-training program for older adults with symptomatic knee osteoarthritis.  
  Segal NA and Wallace R, Arthritis
• Malalignment of the knee is associated with an increased risk for incident and enlarging subchondral bone marrow lesions in the more loaded compartments: The MOST Study.  
  Hayashi D, Englund M, Roemer FW, Niu J, Sharma L, Felson DT, Segal NA, Lewis C, Nevitt MC, Guermazi A, Arthritis Rheum
• Association between chair stand strategy and mobility limitations in older adults with symptomatic knee osteoarthritis.  
  Segal NA, Hageman E, Wallace R, Torner JC, Yack HJ, Archives of Physical Medicine and Rehabilitation
• Higher contact stress predicts risk for knee joint structural worsening.  
  Segal NA, Kern A, Anderson DD, Niu J, Lynch J, Torner JC, Brown TD, Nevitt M., Osteoarthritis Cartilage
• Osteoarthritis Supplement Conclusion.  
  Kennedy DJ, Segal NA, PM&R
• Does quadriceps muscle strength mediate risk for knee osteoarthritis?  
  Segal NA, Glass NA, The Physician and Sportsmedicine
• Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis.  
  Stefanik JJ, Guermazi A, Zhu Y, Zumwalt AC, Gross KD, Clancy M, Lynch JA, Segal NA, Lewis CE, Roemer FW, Powers CM, and Felson DT, Arthritis Care Res
• Does measurement of the anatomic axis consistently predict hip-knee-ankle angle (HKA) for knee alignment studies in osteoarthritis.  
  Sheehy L, Felson D, Segal NA, Zhang Y, Niu J, and Cooke TD, Osteoarthritis Cartilage
• Health coverage and its relation to symptomatic knee osteoarthritis prevalence and intensity.  
  Clearfield JS, Segal NA, J Investig
• Occipital horn syndrome and a mild Menkes phenotype associated with splice site mutations at the MNK locus.  
  Kaler SG, Gallo LK, Proud VK, Percy AK, Mark Y, Segal NA, Goldstein DS, Holmes CS, Gahl WA, Nat Genet
• Pregnancy Leads to Lasting Changes in Foot Structure.  
  Segal NA, Boyer E, Teran-Yengle P, Glass N, Hillstrom H, and and Yack HJ, Am J PM&R
• The longitudinal relationship between thigh muscle mass and the development of knee osteoarthritis.  
  Segal NA, Findlay C, Wang K, Torner JC, Nevitt M, Osteoarthritis Cartilage
• Vibration Platform Training in Women at Risk for Symptomatic Knee Osteoarthritis.  
  Segal NA, Glass NA, Shakoor N, and Wallace R, Am J PM&R
• Real-time feedback for modifying frontal plane kinetics in elderly patients with knee OA.  
  Yack HJ, Segal NA, Teran-Yengle P, Singh B, J Biomech
• Improving mobility for older adults with symptomatic knee osteoarthritis: effects of gait and power training.  
  Segal NA, Clearfield J, Yack HJ, Torner JC, Wallace, R, Am J Phys Med Rehabil
• Home training, local corticosteroid injection or radial shockwave therapy for greater trochanter pain syndrome.  
  Rompe JD, Segal NA, Cacchio A, Furia JP, Morral A, Maffulli N, Am J Sports Med
• Correcting for fat mass improves DXA quantification of quadriceps specific strength in obese adults Aged 50-59.  
  Segal NA, Glass NA, Baker JL, Torner J, J Clin Densitom
• The effect of thigh strength on incident symptomatic and radiographic knee osteoarthritis in a longitudinal cohort.  
  Segal NA, Torner JC, Felson D, Niu J, Lewis CE, Sharma L, Nevitt MC, Arthritis Rheum
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Abstracts/Posters

• Strength Does Not Alter Risk for Incident Knee Pain or Stiffness in the MOST Study.
  NA Segal, J Torner, J Niu, D Felson, L Sharma, M Nevitt, C Lewis, American College of Rheumatology 71st Scientific Meeting
• Measurement of “chaos” in leg motion for quantification of gait impairments in adults with symptomatic knee OA.
  Y Tochigi, NA Segal, T Vaseenon, TD Brown, 7th Combined Meeting of Orthopaedic Research Societies
• Decreases complexity in leg motion patterns during walking in knee osteoarthritis.
  Y Tochigi, NA Segal, T Vaseenon, TD Brown, Annual Meeting of the American Society of Biomechanics
• Isokinetic quadriceps strength measurements differ by hamstring co-activation level in the Multicenter Osteoarthritis (MOST) study.
  NA Segal, L Frey-Law, K Wang, JC Torner, M Nevitt, CE Lewis, D Felson, 2010 World Congress on Osteoarthritis
• Recent knee joint buckling is not associated with co-activation of the hamstrings during isokinetic quadriceps activation.
  NA Segal, L Frey-Law, K Wang, JC Torner, M Nevitt, CE Lewis, D Felson, World Congress on Osteoarthritis
• Knee Buckling and its Relationship with Physical Function in Knee Osteoarthritis.
  Leena Sharma, David Felson, Dorothy Dunlop, Michael Nevitt, Joseph Buckwalter, Jean Hietpas, Jeff Curtis, Neil Segal, Jing Song, Hui Xie, Cora E. Lewis, American College of Rheumatology 69th Annual Meeting
• Knee Extensor Weakness is More Strongly Related to Reduced Muscle Mass than to Reduced Activity Levels or Bone Mineral Density in Adults over Age 50.
  NA Segal, J Torner, D Felson, M Nevitt, American College of Rheumatology 69th Annual Meeting
• Body mass distribution does not alter external knee adduction moment in obese adults during walking and stair activities.
  NA Segal, P Khole, HJ Yack, Association of Academic Physiatrists
• Obesity, Gender, And In Men, Prior Knee Injuries Are Associated With Incident Symptomatic Knee OA In A High Risk Cohort: The Multicenter Osteoarthritis Study.
  M Chang, N Lane, J Hietpas, D Felson, Y Zhu, L Sharma, N Segal, J Curtis, M Nevitt, American College of Rheumatology 70th Scientific Meeting
• Relationship of Varus-Valgus Alignment to Incident Knee Symptoms.
  L Sharma, D Felson, C McCulloch, J Niu, D Dunlop, J Torner, CE Lewis, N Segal, J Curtis, J Hietpas, A Guermazi, M Nevitt, American College of Rheumatology 70th Scientific Meeting
• Greater Trochanteric Pain Syndrome: Epidemiology and Associated Factors.
  N Segal, J Torner, H Xie, D Felson, J Curtis, M Nevitt, Musculoskeletal Grand Rounds Presentation
• Benefits of a Laterally Wedged Insole Over Concurrent Use of an Ankle Support.
  N Segal, N Foster, S Dhamani, R Myers, HJ Yack, K Ohashi, American Academy of PM&R Annual Meeting
• Biomechanical Modeling To Identify Risk Factors In Knee OA: Model Dependence Upon Source MRI Field Strength.
  DD Anderson, NA Segal, JC Torner, TD Brown, American Society of Biomechanics Annual Meeting
• Clinical Risk Factors, Symptoms and Signs Can Identify Persons with Radiographic Knee Osteoarthritis: the MOST Study.
  JR Curtis, J Niu, D Felson, M Nevitt, K Saag, N Segal, C Lewis, American College of Rheumatology 71st Scientific Meeting
• Symptomatic Knee Osteoarthritis is a Risk Factor for Widespread Pain.
  JR Curtis, GG Teng, D Felson, M Nevitt, J Niu, K Saag, N Segal, C Lewis, American College of Rheumatology 71st Scientific Meeting
• Personal Characteristics Associated with Widespread Tenderness in the MOST Study.
  NA Segal, J Regier, J Niu, J Curtis, J Torner, American College of Rheumatology 71st Scientific Meeting
• Measurement of “chaos” in leg motion for quantification of changes in gait with aging.
  Y Tochigi, NA Segal, T Vaseenon, TD Brown, 7th Combined Meeting of Orthopaedic Research Societies
• Biomechanical modeling to predict the risk of developing painful knee OA.
  KS Iyer, DD Anderson, J Baker, JC Torner, TD Brown, NA Segal, North American Congress on Biomechanics
• Gait Alterations in Functionally Limited Older Adults With Symptomatic Knee Osteoarthritis.
  NA Segal, HJ Yack, JC Torner, R Wallace, Association of Academic Physiatrists 2008 Annual Meeting
• Association of Dynamic Joint Power with Functional Limitations in Older Adults With Symptomatic Knee Osteoarthritis.
  NA Segal, HJ Yack, JC Torner, R Wallace, American Geriatrics Society Annual Scientific Meeting
• Baseline Articular Contact Stress is Predictive of Incident Symptomatic Knee Osteoarthritis.
  NA Segal, DD Anderson, KS Iyer, J Baker, JC Torner, TD Brown, 2008 World Congress on Osteoarthritis
• High BMD Predicts T-F Cartilage Loss Assessed By MRI In Knees Without Radiographic OA: Data From MOST.
  MC Nevitt, JA Lynch, J Niu, M Javaid, JR Curtis, T Neogi, NA Segal, A Guermazi, L Sharma, YQ Zhang, 2008 World Congress on Osteoarthritis
• Varus And Valgus Malalignment and Incident and Progressive Knee OA in MOST.
  L Sharma, J Song, D Dunlop, D Felson, J Torner, N Segal, CE Lewis, J Lynch, DV Cooke, J Hietpas, M Nevitt, 2008 World Congress on Osteoarthritis
• Progression of Radiographic Knee Osteoarthritis is Unrelated to Quadriceps Muscle Weakness in the MOST Study.
  NA Segal , NA Glass, J Torner, M Yang, DT Felson, L Sharma, M Nevitt, CE Lewis, American College of Rheumatology Scientific Meeting
• Leg Length Discrepancy is a Risk Factor for Progressive Knee Osteoarthritis: Data from the MOST Study.
  WF Harvey, NA Segal , M Yang, TD Cooke, N Lane, DT Felson, American College of Rheumatology Scientific Meeting
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Lectures

• Optimizing Movement in Older Adults with Osteoarthritis 
• Optimizing Mobility in Elders with Knee Osteoarthritis. 
• Introduction to Concepts of Core Stability. 
  Physical Medicine & Rehabilitation Symposium
• Knee Osteoarthritis. 
  University of Iowa Carver College of Medicine
• Update in Treatment of Knee Osteoarthritis. 
  Eastern Iowa Arthritis Foundation Arthritis Wellness Expo
• Roles for Observational and Randomized Controlled Clinical Studies of Knee OA. 
  Multicenter Orthopedic Outcomes
• Weighted Vest Power Training for Older Adults with Symptomatic Knee OA. 
  Veterans Affairs Medical Center
• Treatment of Knee Osteoarthritis in Older Adults (7/5/07) 
  Old Capital Kiwanis Club
• On the Front Lines of US Rehabilitation Medicine. 
  Osaka University Graduate School of Medicine
• Compensatory Movement Strategies in Functionally Limited Older Adults With Knee Osteoarthritis. 
  American Geriatrics Society
• The Impact of Obesity on Strength in Relation to Knee Osteoarthritis. 
  Association of Academic Physiatrists
• UI Rehabilitation Medicine II: Image Guided MSK Assessment. 
  University of Iowa Rheumatology
• The Current State of Health and Welfare Services of Japan. 
  Osaka University Medical Center
• Treatment of Knee Osteoarthritis & The Multicenter Knee Osteoarthritis (MOST) Study. 
  Mercy Medical Center
• Rehabilitation of the Total Knee and Total Hip Arthroplasty Patient. 
  Veterans Affairs Medical Center
• Knee Osteoarthritis: Conservative Management. 
  University of Iowa Health Care
• Geriatric Rehabilitation. 
  Veterans Affairs Medical Center
• Mimizing Complications of Lumbar Spine Injections. 
  3rd Annual Physical Medicine and Rehabilitation
• Non-Operative Management of Knee Osteoarthritis. 
  21st Annual Update in Physical Medicine and Rehabilitation
• Fundamentals of Musculoskeletal Ultrasound. 
  Physical Medicine & Rehabilitation Symposium
• Stroke Rehabilitation. 
  Veterans Affairs Medical Center
• Acupuncture: Overview of Theory and Practice in the United States. 
  Vanderbilt University Medical School
• MagnaBloc™ Therapy for Inflammatory and Neurological Disorders. 
  National Academy of Orthopedic Nurses
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Other

• Magnet Therapy for Pain: What’s the Attraction? ABC News (1/5/05). 
  Haran, C
  http://www.netsurgery.com/focus_article.asp?b=healthology&f=bodyaches&c=arthritis_magnets&spg=ART
• Nadler, DO, Research Grant. 
  Scott F
  http://www.aapmr.org/passor/research/researchaward.htm
• PM&R Foundation Announces 2005 ERF Winners. 
  Segal NA
  http://www.foundationforpmr.org/docs/UPDATE2005.pdf
• The effects of Pilates training on flexibility & body composition. 
  Segal NA
  http://www.coreminutes.com/medicalinfo
• Jahnigen Career Development Scholars Award. 
  Dennis W
  http://www.americangeriatrics.org/news/meeting/2006_ags_awards.shtml
• Beeson Career Development Awards in Aging Research Program. 
  Paul B
  http://www.beeson.org/person.cfm?Beeson_ID=426
• Knee Osteoarthritis Study. 
  Segal NA
  http://www.uihealthcare.com/kxic/2008/08/osteoarthritis.html
  University of Iowa Health Care
• Knee Osteoarthritis Study. 
  Segal NA, Numerous Sources
  http://www.google.com/search?client=safari&rls=en&q=segal+strength+osteoarthritis&ie=UTF-8&oe=UTF-8
• Risk of Knee Osteoarthritis in Runners. 
  Segal NA
  http://www.webmedcentral.com/Article_Review_View/1207
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