NormanShizuakiNishiokaMD

Gastroenterology • Boston, MA

Advanced Endoscopic Interventional, Esophagus Disease

Associate Professor of Medicine, Massachusetts General Hospital

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Office
55 Fruit St
Gastroenterology Associates Blk 4
Boston, MA 02114
Phone(617) 726-4422
Fax(617) 724-6832
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Education & Training

Massachusetts General HospitalFellowship, Gastroenterology, 1985 - 1987
Massachusetts General HospitalResidency, Internal Medicine, 1981 - 1984
David Geffen School of Medicine at UCLAClass of 1981

Certifications & Licensure

MA State Medical License 1983 - 2021
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012

Clinical Trials

Prospective Randomized Trial Comparing Radiofrequency Ablation (Barrx™) and Cryotherapy (TruFreeze™) for the Treatment of Barrett's Esophagus With High-Grade Dysplasia and/or Early Adenocarcinoma Start of enrollment: 2013 Nov 01Nishioka, N.S.
trūFreeze® Spray Cryotherapy Patient Registry Start of enrollment: 2013 Apr 01Greenwald, B.D.,Shaheen, N.J.,Nieto, J.M.,Kaul, V.,Coyle, W.J.,Bizekis, C.,Tsai, F.,McKinley, M.J.,Nishioka, N.S.,Hoffman, B.J.,Pleskow, D.K.,Habr, F.G.,Browning, R.F.,Abbas, A.E.,Sachdeva, A.,Dumot, J.
Pilot Study to Evaluate OFDI Surveillance and Image Guided Biopsy of the Esophagus Start of enrollment: 2010 Oct 01Nishioka, N.,Rosenberg, M.,Tearney, G.
Pilot Study to Evaluate Optical Frequency Domain Imaging as a Tool for Assessing the Tissue Response to Radiofrequency Ablation Start of enrollment: 2008 Oct 01Nishioka, N.,Tearney, G.
Optical Coherence Tomography Based Screening and Surveillance of Esophagus and Gastroesophageal Junction Start of enrollment: 2006 Sep 01Nishioka, N.,Rosenberg, M.,Tearney, G.
Adenoma Detection Rate With a New Pediatric Colonoscope With a Short Turn Radius (Pentax Retroview) Compared With a Standard Pentax Pediatric Colonoscope Norman S Nishioka, MD

Publications & Presentations

PubMed

Effect of Low-dose and Standard-dose Aspirin on PGE2 Biosynthesis Among Individuals with Colorectal Adenomas: A Randomized Clinical Trial.
David A. Drew, Madeline M. Schuck, Marina V. Magicheva-Gupta, Katheleen O. Stewart, Katherine K. Gilpin, Patrick Miller, Melanie Parziale, Emily N. Pond, Oliver Takacs...> ;Cancer Prevention Research. 2020 Jul 27
Effect of video monitor size on polyp detection: a prospective, randomized, controlled trial
Manol Jovani, Emily J. Campbell, Chin Hur, Amit D. Joshi, Norman S. Nishioka> ;Gastrointestinal Endoscopy. 2019 Aug 1
Balloon catheter-based radiofrequency ablation monitoring in porcine esophagus using optical coherence tomography.
William Lo, Néstor Uribe-Patarroyo, Katharina Hoebel, Kathy Beaudette, Martin Villiger, Norman S. Nishioka, Benjamin J. Vakoc, Brett E. Bouma> ;Biomedical Optics Express. 2019 Apr 1
Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients.
Chia-Pin Liang Liang, Jing Dong, Tim N. Ford, Rohith Reddy, Hamid Hosseiny, Hamid Farrokhi, Matthew Beatty, Kanwarpal Singh, Hany Osman, Barry Vuong, Grace E. Baldwin,...> ;Biomedical Optics Express. 2019 Mar 1
7 citations
Tethered capsule endomicroscopy for microscopic imaging of the esophagus, stomach, and duodenum without sedation in humans (with video)
Michalina Gora, Lucille Quénéhervé, Robert W. Carruth, Weina Lu, Mireille Rosenberg, Jenny Sauk, Alessio Fasano, Gregory Y. Lauwers, Norman S. Nishioka, Guillermo J. T...> ;Gastrointestinal Endoscopy. 2018 Nov 1
Analysis of factors associated with extended recovery time after colonoscopy.
Patrick Eschenfeldt, Uri Kartoun, Curtis R. Heberle, Chung Yin Kong, Norman S. Nishioka, Kenney Ng, Sagar Kamarthi, Chin Hur> ;PLOS ONE. 2018 Jun 21
Clinical Translation of Tethered Confocal Microscopy Capsule for Unsedated Diagnosis of Eosinophilic Esophagitis.
Nima Tabatabaei, Dongkyun Kang, Minkyu Kim, Tao Wu, Catriona N. Grant, Mireille Rosenberg, Norman S. Nishioka, Paul E. Hesterberg, John J. Garber, Qian Yuan, Aubrey J....> ;Scientific Reports. 2018 Feb 8
Optical coherence tomography in gastroenterology: a review and future outlook
Tsung-Han Tsai, Cadman L. Leggett, Arvind J. Trindade, Amrita Sethi, Anne Fré Swager, Virendra Joshi, Jacques J. Bergman, Hiroshi Mashimo, Norman S. Nishioka, Eman Namati> ;Journal of Biomedical Optics. 2017 Dec 1
Surgical vs Endoscopic Management of T1 Esophageal Adenocarcinoma: A Modeling Decision Analysis
Jacqueline N. Chu, Jin Choi, Angela C. Tramontano, Christopher R. Morse, David G. Forcione, Norman S. Nishioka, Julian A. Abrams, Joel H. Rubenstein, Chung Yin Kong, J...> ;Clinical Gastroenterology and Hepatology. 2017 Nov 1
Large‐area spectrally encoded confocal endomicroscopy of the human esophagus in vivo
Dongkyun Kang, Simon C. Schlachter, Robert W. Carruth, Minkyu Kim, Tao Wu, Nima Tabatabaei, Amna R. Soomro, Catriona N. Grant, Mireille Rosenberg, Norman S. Nishioka, ...> ;Lasers in Surgery and Medicine. 2017 Mar 1
2 citations
ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial
David A. Drew, Samantha M. Chin, Katherine K. Gilpin, Melanie Parziale, Emily N. Pond, Madeline M. Schuck, Kathleen O. Stewart, Meaghan Flagg, Crystal A. Rawlings, Vad...> ;Trials. 2017 Feb 1
2 citations
Radiofrequency Ablation of Barrett's Esophagus Reduces Esophageal Adenocarcinoma Incidence and Mortality in a Comparative Modeling Analysis.
Kroep, S., Heberle, C. R., Curtius, K., Kong, C. Y., Lansdorp-Vogelaar, I., Ali, A., Wolf, W. A., Shaheen, N. J., Spechler, S. J., Rubenstein, J. H., Nishioka, N. S., ...> ;Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2017 Jan 17
11 citations
Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy
Giovanni J. Ughi, Michalina Gora, Anne-Fré Swager, Amna R. Soomro, Catriona N. Grant, Aubrey R. Tiernan, Mireille Rosenberg, Jenny Sauk, Norman S. Nishioka, Guillermo ...> ;Biomedical Optics Express. 2016 Feb 1
Comprehensive confocal endomicroscopy of the esophagus in vivo
Dongkyun Kang, Simon C. Schlachter, Robert W. Carruth, Minkyu Kim, Tao Wu, Nima Tabatabaei, Paulino Vacas-Jacques, Milen Shishkov, Kevin Woods, Jenny Sauk, John Leung,...> ;Endoscopy International Open. 2014 Jul 16
Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study
Melissa J. Suter, Michalina Gora, Gregory Y. Lauwers, Thomas Arnason, Jenny Sauk, Kevin A. Gallagher, Lauren Kava, K. M. Tan, Amna R. Soomro, Timothy P. Gallagher, Jos...> ;Gastrointestinal Endoscopy. 2014 Jun 1
4 citations
Incidence and predictors of adenocarcinoma following endoscopic ablation of Barrett's esophagus.
Yasuda, K., Choi, S. E., Nishioka, N. S., Rattner, D. W., Puricelli, W. P., Tramontano, A. C., Kitano, S., Hur, C.> ;Digestive diseases and sciences. 2014 Jan 8
10 citations
Tethered confocal endomicroscopy capsule for diagnosis and monitoring of eosinophilic esophagitis
Nima Tabatabaei, Dongkyun Kang, Tao Wu, Minkyu Kim, Robert W. Carruth, John Leung, Jenny Sauk, Wayne G. Shreffler, Qian Yuan, Aubrey J. Katz, Norman S. Nishioka, Guill...> ;Biomedical Optics Express. 2014 Jan 1
Imaging the Upper Gastrointestinal Tract in Unsedated Patients Using Tethered Capsule Endomicroscopy
Michalina Gora, Jenny Sauk, Robert W. Carruth, Weina Lu, Drew T. Carlton, Amna R. Soomro, Mireille Rosenberg, Norman S. Nishioka, Guillermo J. Tearney> ;Gastroenterology. 2013 Oct 1
Interobserver agreement for the detection of Barrett's esophagus with optical frequency domain imaging.
Jenny Sauk, Emmanuel Coron, Lauren Kava, Melissa J. Suter, Michalina Gora, Kevin A. Gallagher, Mireille Rosenberg, Ashwin N. Ananthakrishnan, Norman S. Nishioka, Grego...> ;Digestive Diseases and Sciences. 2013 Mar 19
63 citations
Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure.
Michalina Gora, Jenny Sauk, Robert W. Carruth, Kevin A. Gallagher, Melissa J. Suter, Norman S. Nishioka, Lauren Kava, Mireille Rosenberg, Brett E. Bouma, Guillermo J. ...> ;Nature Medicine. 2013 Feb 1
18 citations
The cost effectiveness of radiofrequency ablation for Barrett's esophagus.
Chin Hur, Sung Eun Choi, Joel H. Rubenstein, Chung Yin Kong, Norman S. Nishioka, Dawn Provenzale, John M. Inadomi> ;Gastroenterology. 2012 Sep 1
A Mathematical Model for Predicting Outcome in Preterm Labour
Kenjiro Takagi, Kazuo Satoh, M Muraoka, Hiroyuki Seki, Masao Nakabayashi, Satoru Takeda, Koyo Yoshida, Norman S. Nishioka, Tsuyomu Ikenoue, Naohiro Kanayama, T Kanzaki...> ;Journal of International Medical Research. 2012 Aug 1
1 citations
Optical frequency domain imaging system and catheters for volumetric imaging of the human esophagus
Michalina Gora, Hongki Yoo, Melissa J. Suter, Kevin A. Gallagher, Brett E. Bouma, Norman S. Nishioka, Guillermo J. Tearney> ;Photonics Letters of Poland. 2011 Dec 29
Cyclooxygenase-2 expression in esophageal epithelium before and after photodynamic therapy for Barrett’s esophagus with high-grade dysplasia or intramucosal carcinoma
Patrick Yachimski, Mari Mino-Kenudson, Margaret E. Sherwood, William P. Puricelli, Norman S. Nishioka, Gregory Y. Lauwers> ;Virchows Archiv. 2011 Nov 13
3 citations
Reflectance confocal microscopy for the diagnosis of eosinophilic esophagitis: a pilot study conducted on biopsy specimens
Hongki Yoo, Dongkyun Kang, Aubrey J. Katz, Gregory Y. Lauwers, Norman S. Nishioka, Yukako Yagi, Pornthep Tanpowpong, Jacqueline Namati, Brett E. Bouma, Guillermo J. Te...> ;Gastrointestinal Endoscopy. 2011 Nov 1
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Authored Content

Mo1123 CRYOTHERAPY (TRUFREEZE™) VS. RADIO FREQUENCY ABLATION (BARRX™) FOR THE TREATMENT OF BARRETT’S ESOPHAGUS WITH HIGH-GRADE DYSPLASIA AND/OR EARLY ADENOCARCINOMA: AD INTERIM RESULTS OF A NON-INFERIORITY RANDOMIZED CLINICAL TRIALMay 2018
Tu1147 LIQUID NITROGEN SPRAY CRYOTHERAPY FOR PALLIATION OF INVASIVE ESOPHAGEAL CARCINOMA: RESULTS FROM A MULTICENTER U.S. REGISTRYMay 2018