Ophir David Klein MD

Clinical Genetics, Ph.D. Medical Genetics

Executive Director, Cedars-Sinai Guerin Children’s Executive Vice Dean for Children’s Services David and Meredith Kaplan Distinguished Chair in Children’s Health

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8700 Beverly BlvdLos Angeles, CA 90048

Summary

Dr. Ophir Klein is a medical genetics specialist based in Los Angeles, CA, with subspecialties in Clinical Genetics and holding a Ph.D. in Medical Genetics. He completed his medical education at Yale School of Medicine and underwent residencies in Pediatrics at Yale-New Haven Medical Center and Medical Genetics and Genomics at UCSF. Currently, he serves as the Executive Vice Dean for Children’s Services and Executive Director of Guerin Children’s at Cedars-Sinai, as well as an Adjunct Professor at UCSF. His recent research includes studies of development and adult stem cells, and his work contributes to clinical trials on X-linked Hypohidrotic Ectodermal Dysplasia.

Education & Training

University of California (San Francisco)Residency, Medical Genetics and Genomics, 2003 - 2007
Yale-New Haven Medical CenterResidency, Pediatrics, 2000 - 2003
Yale School of MedicineClass of 2000
Yale University School of MedicinePhD, Genetics, 1995 - 1999
University of California, BerkeleyBA, Spanish, Cum Laude, 1989 - 1993

Certifications & Licensure

CA State Medical License 2003 - 2027
American Board of Medical Genetics and Genomics Clinical Genetics and Genomics

Awards, Honors, & Recognition

Fellow (FAAP) American Academy of Pediatrics

Clinical Trials

Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected by Hypohidrotic Ectodermal Dysplasia - A Start of enrollment: 2011 Feb 01
Completed
A Phase 1, Open-label, Multicenter, Safety and Pharmacokinetic Study of EDI200 Start of enrollment: 2012 May 01
Completed
Phase 1
Phase 2 Study to Evaluate Safety, Pharmacokinetics, Immunogenicity and Pharmacodynamics/Efficacy of EDI200 in Male Infants With X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED) Start of enrollment: 2013 Apr 01
Completed
Phase 2

Publications & Presentations

PubMed

4 citations
Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization.
Austin J Graham, Michelle W L Khoo, Vasudha Srivastava, Sara Viragova, Honesty Kim
Biorxiv. 2025-09-04
1 citations
Partially differentiated ileal and distal-colonic human F508del-cystic fibrosis-enteroids secrete fluid in response to forskolin and linaclotide.
Yan Rong, Zixin Zhang, Hugo R de Jonge, Ruxian Lin, Huimin Yu
Iscience. 2025-05-16
6 citations
Engineered epithelial curvature controls Paneth cell localization in intestinal organoids.
F Max Yavitt, Alex Khang, Kaustav Bera, Delaney L McNally, Michael R Blatchley
Cell Biomaterials. 2025-04-22

Journal Articles

Mechanoresponsive Stem Cells Acquire Neural Crest Fate in Jaw Regeneration
Ryan C Ransom, Michael L Lopez, Ophir D Klein, Derrick C Wan, Michael T Longaker, Nature
The Intestinal Epithelial Response to Damage
Ophir Klein, MD, Science China. Life Sciences
Publisher Correction: Parasitic Helminths Induce Fetal-like Reversion in the Intestinal Stem Cell Niche
Ophir D Klein, Richard M Locksley, Nature

Press Mentions

Gut Bacteria Drive Process That Protects Colon TissueMarch 10th, 2026
Cedars-Sinai and Caltech Partner to Innovate Healthcare, AcademiaFebruary 10th, 2026
Researchers Work to Improve Mouth GraftsOctober 21st, 2025

Grant Support

A Team Science Approach to the Co Development of Oral Mucosa for Therapeutic PurposesCEDARS-SINAI MEDICAL CENTER2025–2030
Mechanisms of hyperactive Ras signaling in craniofacial and dental diseasesCEDARS-SINAI MEDICAL CENTER2025–2030
Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to TherapyCEDARS-SINAI MEDICAL CENTER2024–2029
Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to TherapyCEDARS-SINAI MEDICAL CENTER2024–2029
Developmental and molecular basis for a craniofacial metabolic syndromeUNIVERSITY OF CALIFORNIA, SAN FRANCISCO2025–2027