Pasquale Santangeli MD PhD

Cardiac Electrophysiology

Cardiac Electrophysiology Associate Section Head and Director of the VT Program

3400 Spruce St# GroundPhiladelphia, PA 19104
Phone+1 215-662-6005

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Education & Training

University of Pennsylvania Health SystemFellowship, Clinical Cardiac Electrophysiology, 2013 - 2015
Stanford Health Care-Sponsored Stanford UniversityFellowship, Clinical Cardiac Electrophysiology, 2012 - 2013
University of Cattolica del Sacro CuoreClass of 2006

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A self-designated specialty, subspecialty, or practice area neither implies nor is equivalent to ABMS board certification or the existence of specialized training by or competence of a physician or medical specialist.

Certifications & Licensure

FL State Medical License 2025 - 2028
OH State Medical License 2022 - 2028
NJ State Medical License 2018 - 2027
PA State Medical License 2013 - 2026

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2016-2017
CMS Meaningful Use Stage 1 Certification Beacon Oncology 2014 Certified Module, Epic Systems Corporation, 2016-2017

Clinical Trials

Esophageal Cooling for AF Ablation Start of enrollment: 2018 Oct 11
COMPLETED
NA
First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Persistent Atrial Fibrillation Treatment (RAAFT-3) Start of enrollment: 2019 Sep 24
COMPLETED
PHASE3

Publications & Presentations

PubMed

Baseline QRS axis distinguishes para-Hisian PVC from outflow tract PVCs.
Masafumi Sugawara, Jakub Sroubek, Justin Lee, Bryan Baranowski, Mandeep Bhargava
Heart Rhythm. 2026-09-01
Comparative Outcomes of Direct Oral Anticoagulants Versus Aspirin After Ventricular Tachycardia Ablation.
Yong Hao Yeo, Thai Hau Koo, Min Choon Tan, Dan Sorajja, Hicham El-Masry
European Heart Journal. Quality of Care & Clinical Outcomes. 2026-08-20
Ventricular Pulsed Field Ablation from Bench to Bedside: Preclinical and Clinical Evidence from a Systematic Review and Meta-Analysis.
Paolo Compagnucci, Luca Finori, Michela Casella, Alessio Gasperetti, Henry D Huang
Europace. 2026-08-19

Journal Articles

Outcomes of Percutaneous Trans–Right Atrial Access to the Left Ventricle for Catheter Ablation of Ventricular Tachycardia in Patients with Mechanical Aortic and Mitral...
Pasquale Santangeli, Matthew C Hyman, Kalyanam Shivkumar, Francis E Marchlinski, JAMA Cardiology
P‐Wave Morphology and Multipolar Intracardiac Atrial Activation to Facilitate Non‐Pulmonary Vein Trigger Localization
Sanjay Dixit, Francis E Marchlinski, David S Frankel, Pasquale Santangeli, Erica S Zado, Gregory E Supple, Cory M Tschabrunn, David Lin, Journal of Cardiovascular Electrophysiology
Epicardial Ventricular Tachycardia in Ischemic Cardiomyopathy: Prevalence, Electrophysiological Characteristics, and Long‐Term Ablation Outcomes
Fermin C Garcia, Gregory E Supple, Andres Enriquez, Jeffrey Arkles, Pasquale Santangeli, Robert D Schaller, Francis E Marchlinski, Sanjay Dixit, David Lin, Erica S Zad..., Journal of Cardiovascular Electrophysiology

Authored Content

Risk Stratification in Arrhythmogenic RV Cardiomyopathy/Dysplasia Without an ICDFebruary 2019
Risk Stratification in Arrhythmogenic RV Cardiomyopathy/Dysplasia Without an ICDFebruary 2019

Press Mentions

Procedural Volumes Matter for VT AblationMay 12th, 2025
Watchman FLX Stays on Track for Stroke PreventionJuly 22nd, 2021
BioSig to Host Presentations from Physician Users of Its Signal Processing System for Arrhythmia Care During the Annual Heart Rhythm 2021 ConventionJuly 20th, 2021