PatrickJosephGroharMDPhD

PubMed

• Cell Context is the third axis of synergy for the combination of ATR inhibition and cisplatin in Ewing sarcoma.
  Jennifer Jess, Kathleen M Sorensen, Elissa A Boguslawski, Matthew C Stout, Zachary B Madaj, Benjamin P Caiello, Elizabeth R Wilson, Seneca S Kinn-Gurzo, Curtis C Parke...> ;Clinical Cancer Research. 2024 Mar 20
• Long-Term Outcomes in Patients With Localized Ewing Sarcoma Treated With Interval-Compressed Chemotherapy on Children's Oncology Group Study AEWS0031.
  Thomas Cash, Mark D Krailo, Allen B Buxton, Bruce R Pawel, John H Healey, Odion Binitie, Karen J Marcus, Holcombe E Grier, Patrick J Grohar, Damon R Reed, Aaron R Weis...> ;Journal of Clinical Oncology. 2023 Oct 20
• Children's Oncology Group's 2023 blueprint for research: Bone tumors.
  Damon R Reed, Patrick Grohar, Elyssa Rubin, Odion Binitie, Mark Krailo, Jessica Davis, Steven G DuBois, Katherine A Janeway> ;Pediatric Blood & Cancer. 2023 Sep 1
• Importance of pharmacologic considerations in the development of targeted anticancer agents for children.
  Sridhar M Veluvolu, Patrick J Grohar> ;Current Opinion in Pediatrics. 2023 Feb 1
• 17 citations
  An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma.
  Shulman, D., Whittle, S., Surdez, D., Bailey, K., de Álava, E., Yustein, J., Shlien, A., Hayashi, M., Bishop, A., Crompton, B., DuBois, S., Shukla, N., Leavey, P., Les...> ;NPJ Precision Oncology. 2022 Sep 17
• 7 citations
  Lurbinectedin Inhibits the EWS-WT1 Transcription Factor in Desmoplastic Small Round Cell Tumor.
  Jenna M Gedminas, Rebecca Kaufman, Elissa A Boguslawski, Amy C Gross, Marie Adams, Ian Beddows, Susan M Kitchen-Goosen, Ryan D Roberts, Patrick J Grohar> ;Molecular Cancer Therapeutics. 2022 Aug 2
• 4 citations
  Ewing sarcoma and related FET family translocation-associated round cell tumors: A century of clinical and scientific progress.
  Robert G Maki, Patrick J Grohar, Cristina R Antonescu> ;Genes, Chromosomes & Cancer. 2022 Aug 1
• 5 citations
  Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1.
  Qu Deng, Ramakrishnan Natesan, Florencia Cidre-Aranaz, Shehbeel Arif, Ying Liu, Reyaz Ur Rasool, Pei Wang, Erick Mitchell-Velasquez, Chandan Kanta Das, Endrit Vinca, Z...> ;Cell Reports. 2022 Jun 14
• 9 citations
  One oncogene, several vulnerabilities: EWS/FLI targeted therapies for Ewing sarcoma
  Guillermo Flores, Patrick J. Grohar> ;Journal of Bone Oncology. 2021 Dec 1
• 6 citations
  Charting a path for prioritization of novel agents for clinical trials in osteosarcoma: A report from the Children's Oncology Group New Agents for Osteosarcoma Task Fo...
  Sarah B. Whittle, Katharine Offer, Ryan D. Roberts, Amy K. LeBlanc, Cheryl A. London, Robbie G. Majzner, Alex Yee-Chen Huang, Peter J. Houghton, E. Alejandro Sweet Cor...> ;Pediatric Blood & Cancer. 2021 Jun 16
• 7 citations
  Mithramycin induces promoter reprogramming and differentiation of rhabdoid tumor.
  Maggie H. Chasse, Benjamin K. Johnson, Elissa Boguslawski, Katie M. Sorensen, Jessica E Rosien, Min H. Kang, C. Patrick Reynolds, Lyong Heo, Zachary Madaj, Ian Beddows...> ;EMBO Molecular Medicine. 2021 Feb 5
• 12 citations
  Survey of Paediatric Oncologists and Pathologists regarding Their Views and Experiences with Variant Translocations in Ewing and Ewing-Like Sarcoma: A Report of the Ch...
  Michael D. Kinnaman, Chong Zhu, Daniel A. Weiser, Pooja Hingorani, Michael Roth, Jonathan Gill, Katherine A. Janeway, Richard Gorlick, Stephen L. Lessnick, Patrick J. ...> ;Sarcoma. 2020 Dec 5
• 27 citations
  Desmoplastic small round cell tumor is dependent on the EWS-WT1 transcription factor.
  Jenna M. Gedminas, Maggie H. Chasse, Mitchell McBrairty, Ian Beddows, Susan M. Kitchen-Goosen, Patrick J. Grohar> ;Oncogenesis. 2020 Apr 28
• 11 citations
  CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma
  Guillermo Flores, Joel H. Everett, Elissa Boguslawski, Brandon Oswald, Zachary Madaj, Ian Beddows, Sergey Dikalov, Marie Adams, Carleen Klumpp-Thomas, Susan M. Kitchen...> ;Molecular Cancer Therapeutics. 2020 Jan 1
• 19 citations
  Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters.
  , , , , , , , , , , , , , , , , , > ;Molecular Pharmacology. 2019 Aug 1
• 49 citations
  Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children's Oncology Group (COG) New Agents for Ewing Sarcoma Task Force.
  Kelly M. Bailey, Carrye R. Cost, Ian J. Davis, Julia Glade-Bender, Patrick J. Grohar, Peter J. Houghton, Michael S. Isakoff, Elizabeth Stewart, Nadia N. Laack, Jason T...> ;F1000research. 2019 Apr 15
• 27 citations
  Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner.
  Matt Harlow, Maggie H. Chasse, Elissa Boguslawski, Katie M. Sorensen, Jenna M. Gedminas, Susan M. Kitchen-Goosen, Scott B. Rothbart, Cenny Taslim, Stephen L. Lessnick,...> ;Clinical Cancer Research. 2019 Jun 1
• 50 citations
  A phase I/II trial and pharmacokinetic study of mithramycin in children and adults with refractory Ewing sarcoma and EWS-FLI1 fusion transcript.
  Patrick J. Grohar, John Glod, Cody J. Peer, Tristan M. Sissung, Fernanda I. Arnaldez, Lauren Long, William D. Figg, Patricia Whitcomb, Lee J. Helman, Brigitte C. Widemann> ;Cancer Chemotherapy and Pharmacology. 2017 Jul 22
• 28 citations
  Wnt Signaling in Ewing Sarcoma, Osteosarcoma, and Malignant Peripheral Nerve Sheath Tumors.
  Matthew G Pridgeon, Patrick J. Grohar, Matthew R. Steensma, Bart O. Williams> ;Current Osteoporosis Reports. 2017 Aug 1
• 19 citations
  Advances in the Treatment of Pediatric Bone Sarcomas
  Patrick J. Grohar, Katherine A. Janeway, Luke D. Mase, Joshua D. Schiffman> ;American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 2017 Jan 1
• Advances in the Treatment of Pediatric Bone Sarcomas.
  Grohar, P. J., Janeway, K. A., Mase, L. D., Schiffman, J. D.> ;American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 2017 May 1
• 49 citations
  Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus.
  Matt Harlow, Nichole Maloney, Joseph T. Roland, Guillén Navarro María José, Matthew K. Easton, Susan M. Kitchen-Goosen, Elissa Boguslawski, Zachary Madaj, Ben K. Johns...> ;Cancer Research. 2016 Nov 15
• 12 citations
  Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity.
  J Herzog, F von Klot-Heydenfeldt, Susanne Jabar, Andreas Ranft, Claudia Rossig, Uta Dirksen, J Van den Brande, Maurizio D'Incalci, I. von Luettichau, Patrick J. Grohar...> ;Sarcoma. 2016 Oct 24
• 10 citations
  18 F-FLT Positron Emission Tomography (PET) is a Pharmacodynamic Marker for EWS-FLI1 Activity and Ewing Sarcoma
  Christy L. Osgood, Mohammed N. Tantawy, Nichole Maloney, Zachary Madaj, Anderson Peck, Elissa Boguslawski, Jennifer Jess, Jason R. Buck, Mary E. Winn, H. Charles Manni...> ;Scientific Reports. 2016 Sep 27
• 48 citations
  Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor
  Christy L. Osgood, Nichole Maloney, Christopher G. Kidd, Susan M. Kitchen-Goosen, Laura E. Segars, Meti Gebregiorgis, Girma M. Woldemichael, Min He, Savita Sankar, Ste...> ;Clinical Cancer Research. 2016 Aug 15
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