CarlKoschmannMD

PubMed

• Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma.
  Erik R Peterson, Peter Sajjakulnukit, Andrew J Scott, Caleb Heaslip, Anthony Andren, Kari Wilder-Romans, Weihua Zhou, Sravya Palavalasa, Navyateja Korimerla, Angelica ...> ;Cancer & Metabolism. 2024 Apr 9
• Chaetocin-mediated SUV39H1 inhibition targets stemness and oncogenic networks of diffuse midline gliomas and synergizes with ONC201.
  Dazhuan Eric Xin, Yunfei Liao, Rohit Rao, Sean Ogurek, Soma Sengupta, Mei Xin, Arman Esshaghi Bayat, William L Seibel, Richard T Graham, Q Richard Lu, Carl Koschmann> ;Neuro-Oncology. 2024 Apr 5
• The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models.
  Daniel de la Nava, Iker Ausejo-Mauleon, Virginia Laspidea, Marisol Gonzalez-Huarriz, Andrea Lacalle, Noelia Casares, Marta Zalacain, Lucía Marrodan, Marc García-Moure,...> ;Neuro-Oncology. 2024 Mar 30
• Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.
  Ayse Bahar Ercan, Melyssa Aronson, Nicholas R Fernandez, Yuan Chang, Adrian Levine, Zhihui Amy Liu, Logine Negm, Melissa Edwards, Vanessa Bianchi, Lucie Stengs, Jiil C...> ;The Lancet. Oncology. 2024 Mar 26
• Family Recall of and Response to Germline Pathologic Variants Found on Paired Tumor-Germline Sequencing in Pediatric Oncology.
  Michelle F Jacobs, Joshua W Goldman, Sarah Austin, Erika S Koeppe, Andrea M Murad, Carl J Koschmann, Arul M Chinnaiyan, Rajen J Mody> ;JCO Precision Oncology. 2024 Mar 1
• Safety and pharmacokinetics of ONC201 (dordaviprone) administered two consecutive days per week in pediatric patients with H3K27M-mutant glioma.
  Odia, Y., Koschmann, C., Vitanza, N., de Blank, P., Aguilera, D., Allen, J., Daghistani, D., Hall, M., Khatib, Z., Kline, C., MacDonald, T., Mueller, S., Faison, S., A...> ;Neuro-Oncology. 2024 Feb 24
• Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti-PD-1 Monotherapy: A Report from the International RRD Con...
  Das, A., Fernandez, N., Levine, A., Bianchi, V., Stengs, L., Chung, J., Negm, L., Dimayacyac, J., Chang, Y., Nobre, L., Ercan, A., Sanchez-Ramirez, S., Sudhaman, S., E...> ;Cancer Discovery. 2024 Feb 8
• PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma.
  Kilburn, L. B., Kilburn, L. B., Ryan J Duchatel, Evangeline R Jackson, Sarah G Parackal, Dylan Kiltschewskij, Izac J Findlay, Abdul Mannan, Dilana E Staudt, Bryce C Th...> ;The Journal of Clinical Investigation. 2024 Feb 6
• A road map for the treatment of pediatric diffuse midline glioma.
  Franson, A. (., Franson, A. (., Franson, A. (., Kilburn, L. B., Kilburn, L. B., Carl Koschmann, Wajd N Al-Holou, Marta M Alonso, Jamie Anastas, Pratiti Bandopadhayay, ...> ;Cancer Cell. 2024 Jan 8
• Rational combination platform trial design for children and young adults with Diffuse Midline Glioma: a report from PNOC.
  Franson, A., van der Lugt, J., Prados, M., Waszak, S., Plasschaert, S., Molinaro, A., Nazarian, J., Mueller, S., Kline, C., Koschmann, C.> ;Neuro-Oncology. 2023 Dec 20
• 1 citations
  Liquid Biopsy in H3K27M Diffuse Midline Glioma.
  Franson, A. (., Franson, A. (., Franson, A. (., Franson, A. (., Jina Patel, Rayan Aittaleb, Robert Doherty, Ananya Gera, Benison Lau, Dana Messinger, Jack Wadden, Andr...> ;Neuro-Oncology. 2023 Dec 14
• 2 citations
  Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations.
  Holly J Roberts, Sunjong Ji, Alberto Picca, Marc Sanson, Mekka Garcia, Matija Snuderl, Ulrich Schüller, Thiébaud Picart, François Ducray, Adam L Green, Yoshiko Nakano,...> ;Acta Neuropathologica. 2023 Dec 1
• 6 citations
  TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory.
  Iker Ausejo-Mauleon, Sara Labiano, Daniel de la Nava, Virginia Laspidea, Marta Zalacain, Lucía Marrodán, Marc García-Moure, Marisol González-Huarriz, Irati Hervás-Corp...> ;Cancer Cell. 2023 Nov 13
• 1 citations
  Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence.
  Monika Sharma, Ivana Barravecchia, Robert Teis, Jeanette Cruz, Rachel Mumby, Elizabeth K Ziemke, Carlos E Espinoza, Varunkumar Krishnamoorthy, Brian Magnuson, Mats Lju...> ;Molecular Cancer Therapeutics. 2024 Jan 3
• Adaptive rewiring of purine metabolism promotes treatment resistance in H3K27M-mutant diffuse midline glioma.
  Erik R Peterson, Peter Sajjakulnukit, Andrew J Scott, Caleb Heaslip, Anthony Andren, Kari Wilder-Romans, Weihua Zhou, Sravya Palavalasa, Navyateja Korimerla, Angelica ...> ;Research Square. 2023 Sep 11
• Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma.
  Monika Sharma, Ivana Barravecchia, Brian Magnuson, Sarah F Ferris, April Apfelbaum, Nneka E Mbah, Jeanette Cruz, Varunkumar Krishnamoorthy, Robert Teis, McKenzie Kauss...> ;Neoplasia. 2023 Oct 1
• Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid.
  Christopher Douville, Samuel Curtis, Mahmoud Summers, Tej D Azad, Jordina Rincon-Torroella, Yuxuan Wang, Austin Mattox, Bracha Avigdor, Jonathan Dudley, Joshua Materi,...> ;Cell Reports. Medicine. 2023 Aug 15
• 7 citations
  OpenPBTA: The Open Pediatric Brain Tumor Atlas.
  Joshua A Shapiro, Krutika S Gaonkar, Stephanie J Spielman, Candace L Savonen, Chante J Bethell, Run Jin, Komal S Rathi, Yuankun Zhu, Laura E Egolf, Bailey K Farrow, Da...> ;Cell Genomics. 2023 Jul 12
• 1 citations
  H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Pediatric High-Grade Gliomas.
  Maria B Garcia-Fabiani, Santiago Haase, Kaushik Banerjee, Brandon McClellan, Ziwen Zhu, Anzar Mujeeb, Yingxiang Li, Jin Yu, Padma Kadiyala, Ayman Taher, Felipe J Núñez...> ;Biorxiv. 2023 Jun 13
• Applying collaborative brain power to pull us out of the dark ages of pediatric neuro-oncology.
  Carl Koschmann, Michael Prados> ;Neoplasia. 2023 Jul 1
• ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma.
  Evangeline R Jackson, Ryan J Duchatel, Dilana E Staudt, Mika L Persson, Abdul Mannan, Sridevi Yadavilli, Sarah Parackal, Shaye Game, Wai Chin Chong, W Samantha Nilanth...> ;Cancer Research. 2023 May 5
• 2 citations
  Developing H3K27M mutant selective radiosensitization strategies in diffuse intrinsic pontine glioma.
  Leslie A Parsels, Daniel R Wahl, Carl Koschmann, Meredith A Morgan, Qiang Zhang> ;Neoplasia. 2023 Mar 1
• 17 citations
  The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science.
  Franson, A. (., Franson, A. (., Jena V Lilly, Jo Lynne Rokita, Jennifer L Mason, Tatiana Patton, Stephanie Stefankiewiz, David Higgins, Gerri Trooskin, Carina A Larouc...> ;Neoplasia. 2023 Jan 1
• 35 citations
  The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.
  Ilon Liu, Li Jiang, Erik R Samuelsson, Sergio Marco Salas, Alexander Beck, Olivia A Hack, Daeun Jeong, McKenzie L Shaw, Bernhard Englinger, Jenna LaBelle, Hafsa M Mire...> ;Nature Genetics. 2022 Dec 1
• 18 citations
  H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models.
  Santiago Haase, Kaushik Banerjee, Anzar A Mujeeb, Carson S Hartlage, Fernando M Núñez, Felipe J Núñez, Mahmoud S Alghamri, Padma Kadiyala, Stephen Carney, Marcus N Bar...> ;The Journal of Clinical Investigation. 2022 Nov 15
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