PatrickHinesMDPh.D

PubMed

• 2 citations
  GBT1118, a voxelotor analog, protects red blood cells from damage during severe hypoxia.
  Michael Tarasev, Marta Ferranti, Andrew Herppich, Patrick Hines> ;American Journal of Translational Research. 2022 Jan 1
• 7 citations
  Cross-sectional analysis of adhesion in individuals with sickle cell disease using a standardized whole blood adhesion bioassay to VCAM-1
  Jennell White, Moira Lancelot, Xiufeng Gao, Bettina Joi McGraw, Carl Tabb, Patrick C. Hines> ;Blood Cells, Molecules & Diseases. 2020 Mar 1
• 8 citations
  Sevuparin blocks sickle blood cell adhesion and sickle-leucocyte rolling on immobilized L-selectin in a dose dependent manner.
  Jennell White, Maria Lindgren, Ke Liu, Xiufeng Gao, Lena Jendeberg, Patrick C. Hines> ;British Journal of Haematology. 2019 Mar 1
• 13 citations
  Low molecular weight heparin inhibits sickle erythrocyte adhesion to VCAM-1 through VLA-4 blockade in a standardized microfluidic flow adhesion assay.
  Moira M. Lancelot, Jennell White, Sharada A. Sarnaik, Patrick C. Hines> ;British Journal of Haematology. 2017 Aug 1
• 20 citations
  VLA-4 blockade by natalizumab inhibits sickle reticulocyte and leucocyte adhesion during simulated blood flow.
  Jennell White, Sriram Krishnamoorthy, Dipti Gupta, Moira M. Lancelot, Nancy Moore, Sharada A. Sarnaik, William E. Hobbs, David R. Light, Patrick C. Hines> ;British Journal of Haematology. 2016 Sep 1
• 2 citations
  TR2/TR4 overexpression in a humanized sickle cell disease mouse model decreases RBC adhesion to VCAM-1.
  Jennell White, Amrita Pawar, Gratiana Fu, Shuaiying Cui, Mariam Hamid, David Harro, Donald A. Giacherio, Andrew D. Campbell, Patrick C. Hines> ;Blood Cells, Molecules & Diseases. 2015 Dec 1
• 23 citations
  Increased erythrocyte adhesion to VCAM-1 during pulsatile flow: Application of a microfluidic flow adhesion bioassay.
  Jennell White, Moira M. Lancelot, Sharada A. Sarnaik, Patrick C. Hines> ;Clinical Hemorheology and Microcirculation. 2015 Jan 1
• 11 citations
  A novel role of h2-calponin in regulating whole blood thrombosis and platelet adhesion during physiologic flow.
  Patrick C. Hines, Xiufeng Gao, Jennell White, Ashley D’Agostino, Jian Ping Jin> ;Physiological Reports. 2014 Dec 1
• 12 citations
  Copeptin as a marker of relative arginine vasopressin deficiency after pediatric cardiac surgery
  Christopher W. Mastropietro, Meredith Mahan, Kevin Valentine, Jeff A. Clark, Patrick C. Hines, Henry L. Walters, Ralph E. Delius, Ashok P. Sarnaik, Noreen F. Rossi> ;Intensive Care Medicine. 2012 Oct 24
• 11 citations
  Central nervous system events in children with sickle cell disease presenting acutely with headache.
  Patrick C. Hines, Therese P. McKnight, Wendy Seto, Janet L. Kwiatkowski> ;The Journal of Pediatrics. 2011 Sep 1
• 104 citations
  Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-αvβ3 interactions
  Rahima Zennadi, Patrick C. Hines, Laura M. De Castro, Jean Pierre Cartron, Leslie V. Parise, Marilyn J. Telen> ;Blood. 2004 Dec 1
• 128 citations
  Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion
  Patrick C. Hines, Qin Zen, Sharran N. Burney, Deborah A. Shea, Kenneth I. Ataga, Eugene P. Orringer, Marilyn J. Telen, Leslie V. Parise> ;Blood. 2003 Apr 15
• 55 citations
  Sickle cell adhesion to laminin : Potential role for the α5 chain
  Sheritha P. Lee, Michelle L. Cunningham, Patrick C. Hines, Christopher C. Joneckis, Eugene P. Orringer, Leslie V. Parise> ;Blood. 1998 Oct 15
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Journal Articles

• Low Molecular Weight Heparin (LMWH) Inhibits Sickle Erythrocyte Adhesion to VCAM-1 through VLA-4 Blockade in a Standardized Microfluidic Flow Adhesion Assay  
  Lancelot MM, White JC, and Sarnaik SA, Hines PC, British Journal of Hematology, 1/1/2016
• Natalizumab Blocks VLA-4 Mediated Red Blood Cell Adhesion and is a Potential Therapy for Sickle-Cell Disease  
  White JC, Krishnamoorthy S, Hobbs W, Light D, Hines PC, British Journal of Hematology, 1/1/2016
• TR2/TR4 Overexpression in a Humanized Sickle Cell Disease Mouse Model Decreases RBC Adhesion to VCAM-1  
  White JC; Pawar A; Fu G; Cui S; Tavernier F; Hamid M; Harro D; Giacherio D; Campbell A; Hines PC, Blood Cells, Molecules, and Diseases, 1/1/2015
• Pulsatile Flow Promotes Adhesion in Sickle Cell Disease: Clinical Application of a Microfluidic Bioassay  
  White, JC, Lancelot, M, Sarnaik S, Hines PC, Clinical Hemorheology and Microcirculation, 1/1/2015
• Central Nervous System Events in Children with Sickle Cell Disease Presenting Acutely with Headache  
  Hines PC, McKnight T, Seto W, Kwiatkowski JL, Journal of Pediatrics, 1/1/2011
• Ghosal Hematodiaphyseal Dysplasia: A Rare Cause Of A Myelophthisic Anemia  
  Mazaheri, P, Nadkarni, G, Lowe, E, Hines, PC, Griffin, M, Resar, L, Pediatr Blood Cancer, 1/1/2010
• Pulsed-dosing with oral sodium phenylbutyrate increases hemoglobin F in a patient with sickle cell anemia  
  Hines, PC, Dover, GJ, Resar, LMS, Pediatr Blood Cancer, 1/1/2008
• Epinephrine Acts Via Erythroid Signaling Pathways to Activate Sickle Cell Adhesion to Endothelium Via LW-alphavbeta3 Interactions  
  Zennadi, R, Hines, PC, De Castro, LM, Cartron J, Parise, LV, Telen, MJ, Blood, 1/1/2004
• Novel Epinephrine and Cyclic AMP-Mediated Activation of B-CAM/Lu-Dependent Sickle (SS) RBC Adhesion  
  Hines PC, Zen Q, Burney SN, Shea DI, Ataga KA, Orringer EP, Telen MJ, Parise LV, Blood, 1/1/2003
• Identification of a Region of Laminin That Adheres to Red Blood Cells of Sickle Cell Anemia Patients  
  Hines PC, Parise LV, Fax, 1/1/1997
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Abstracts/Posters

• PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation
  Patrick C. Hines, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Epinephrine Stimulates PKA-Dependent Sickle (SS) RBC Adhesion to Laminin via B-CAM/LU: Potential Predictor of SSRBC Response to Stress.
  Hines PC, Burnery SN, Shea DI, Ataga, KA, Zen Q, Telen M, Parise, LV, Blood, Orlando, FL, 2001, 2017, 1/1/2017
• Sevuparin Blocks Sickle Blood Cell Adhesion and Sickle-Leukocyte Rolling on Immobilized L-Selectin in a Dose Dependent Manner.
  Maria Lindgren, PhD, Jennell White, PhD, Ke Liu, PhD, Lena Jendeberg, PhD and Patrick C. Hines, MD, PhD, Blood, 1/1/2016
• Evaluation of Purified Poloxamer-188 (vepoloxamer) on Sickle Red Blood Cell (RBC) Membrane Function Properties.
  White JC, Liu K, Benjamin LJ, Gao X, Emanuele M, Hines, PC, Blood; ASH Annual Meeting Abstracts, 1/1/2015
• Application of a Microfluidic Flow-based Thrombosis Assay for Post-operative Pediatric Cardiac Surgery Patients.
  Othman N, Gao X, Walters HL, Hines PC, Journal of Thrombosis and Hemostasis, 1/1/2015
• Evaluation of purified poloxamer-188 (vepoloxamer) on sickle red blood cell (RBC) adhesion and membrane fragility utilizing microfluidic pulsatile flow adhesion bioass...
  White JC, Liu K, Benjamin LJ, Gao X, Emanuele M, Hines, PC, JSCDH, 1/1/2015
• A Novel Role of h2-calponin in the Regulation of Platelet Adhesion.
  Hines PC, Gao X, Jin J-P, 7th Annual Conference on Symposium on Hemostasis, Chapel Hill, NC, 1/1/2014
• Natalizumab Blocks VLA-4 Mediated Red Blood Cell Adhesion and is a Potential Therapy for Sickle-Cell Disease.
  White JC, Krishnamoorthy S, Hobbs W, Light D, Hines PC, Blood, 1/1/2014
• Blockade of alpha-4 integrin by natalizumab inhibits adhesion of Sickle Cell Disease blood cells to activated endothelial cells.
  Krishnamoorthy S, Gupta D, White J, Hines PC, Hobbs WE, Peters R, Jiang H, and Light DR, Sickle Cell in Focus, NIH, Bethesda, MD, 1/1/2014
• VLA-4 Blockade by Low Molecular Weight Heparin: A Novel Therapeutic Approach in Sickle Cell Disease.
  Lancelot MM, White JC, and Sarnaik SA, Hines PC, Blood, 1/1/2012
• Sickle RBCs Form Microaggregates in Autologous Plasma Following Epinephrine Stimulation: A Role for Endogenous, Soluble Laminin.
  Hines, PC, Okafor, C, Zen Q, Telen MJ, Ataga KI, Orringer EO, Parise LV, Blood, San Diego, CA, 1/1/2003
• Intracellular Cyclic AMP Promotes Sickle RBC Aggregation and Adhesion to Laminin.
  Hines PC, Burnery SN, Orringer EP, Parise LV, Blood, San Francisco, CA, 1/1/2000
• Application of Microfluidic Technology to Evaluate the Influence of Pulsatile Blood Flow On Adhesion of Pediatric Sickle Erythrocytes.
  White JC, Lancelot MM, and Sarnaik SA, Hines PC, Blood
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Lectures

• A Standardized Clinical Flow Adhesion Assay of Whole Blood Adhesion to VCAM-1 Predicts Severe SCD Phenotypes in a 2-Yr Prospective Observational Follow-up of the Origi... 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
• Longitudinal Evaluation of a Standardized P-Selectin Flow Adhesion Bioassay: Potential Role for the Assessment and Prediction of Vaso-Occlusive Episodes in Sickle Cell... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• A Longitudinal Study to Identify and Assess Adhesion Indices during Vaso-Occlusive Crises in Adults and Adolescents with Sickle Cell Disease 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Designing Better Blood Function Diagnostics: A Model for PICU-Based Multidisciplinary Collaboration 
  University of North Carolina-Chapel Hill - 1/1/2014
• Sickle Cell Anti-Adhesive Therapy: A 30-year Journey from Discovery to Therapeutics 
  Children�s Hospital of Michigan - 1/1/2013
• Moya-Moya Disease and Revascularization Surgery 
  1/1/2011
• Pediatric Pulmonary Hypertension in the Context of Surgical Critical Care 
  1/1/2011
• Pulmonary Hypertension and Right Heart Failure in Sickle Disease: A Potential Role of Beta Agonist-Stimulated Erythrocyte Adhesion 
  Wayne State University School of Medicine - 1/1/2011
• Sedation and Analgesia Part I and Part II. Neuromuscular Blocking Agents. 
  Children�s Hospital of Michigan - 1/1/2010
• Pulmonary Complications in Sickle Cell Disease 
  Children�s Hospital of Michigan - 1/1/2010
• Role of beta-adrenergic receptor-mediated RBC adhesion in critical illness 
  Children�s Hospital of Michigan - 1/1/2010
• The role of beta-adrenergic agonists in erythrocyte adhesion and microvascular occlusion in sickle cell disease and critical illness 
  1/1/2009
• 4 year-old boy presenting with hypothermic cardiac arrest 
  Children�s Hospital of Philadelphia - 1/1/2008
• 5 week-old infant with massive GI bleed and hemodynamic instability. 
  Children�s Hospital of Philadelphia - 1/1/2008
• 5 year old with gastrointestinal bleed � when parents refuse transfusion 
  Children�s Hospital of Philadelphia - 1/1/2008
• Air leak syndrome in a 6 year-old with sickle cell and acute chest syndrome 
  Children�s Hospital of Philadelphia - 1/1/2008
• Unstable SVT in a 26 day-old infant: Transfer from an outside institution 
  Children�s Hospital of Philadelphia - 1/1/2008
• Neurofibromatosis type I patient with massive stroke following C3-5 laminectomy 
  1/1/2007
• 3 year-old female presenting with digoxin toxicity 
  1/1/2005
• 18 year-old with Paroxysmal Nocturnal Hemoglobinuria and moya-moya: Management of an arterial thrombus. 
  1/1/2005
• 5-year-old male with sickle cell disease with bilateral sphenoid bone infarction presenting as bilateral periorbital edema. 
  1/1/2005
• Physicians and Scientists in Training: Challenges of Stimulating Interest in Sickle Cell Management and Research 
  1/1/2000
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Other

• Intracellular Cyclic AMP Promotes Sickle RBC Aggregation and Adhesion to Laminin [dissertation]. 
  Hines PC
  UNC-Chapel Hill, Chapel Hill, NC - 1/1/2002