PatrickVanMartin-YeboahMD

PubMed

• 30 citations
  CD25-targeted antibody–drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity
  Francesca Zammarchi, Karin Havenith, Francois Bertelli, Balakumar Vijayakrishnan, Simon Chivers, Patrick Van Berkel> ;Journal for Immunotherapy of Cancer. 2020 Sep 1
• 5 citations
  The Role of Specific ATP-Binding Cassette Transporters in the Acquired Resistance to Pyrrolobenzodiazepine Dimer-Containing Antibody-Drug Conjugates.
  Simon Corbett, Shiran Huang, Francesca Zammarchi, Howard Philip Wilson, Patrick Van Berkel, John A. Hartley> ;Molecular Cancer Therapeutics. 2020 Sep 1
• 22 citations
  Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus.
  Kate Moore, Ami Desai, Bea de Luxán Delgado, Sara Trabulo, Claire Reader, Nicholas F. Brown, Elizabeth Murray, Adam R. Brentnall, Philip Howard, Luke Masterson, France...> ;Theranostics. 2020 Feb 12
• 14 citations
  APOMAB Antibody–Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo
  Alexander H. Staudacher, Yanrui Li, Vasilios Liapis, Jeff Jia Cheng Hou, David Y. Chin, Olan Dolezal, Timothy E. Adams, Patrick Van Berkel, Michael P. Brown> ;Molecular Cancer Therapeutics. 2019 Feb 1
• 65 citations
  Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine.
  John A. Hartley, Michael Flynn, John Bingham, Simon Corbett, Halla W. Reinert, Arnaud C. Tiberghien, Luke Masterson, Dyeison Antonow, Lauren Adams, Sajidah Chowdhury, ...> ;Scientific Reports. 2018 Jul 11
• 92 citations
  ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies.
  Francesca Zammarchi, Simon Corbett, Lauren Adams, Peter Tyrer, Konstantinos Kiakos, Narinder Janghra, Teresa Marafioti, Charles E. Britten, Carin E. G. Havenith, Simon...> ;Blood. 2018 Mar 8
• 26 citations
  Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.
  Song Cho, Francesca Zammarchi, David G. Williams, Carin E. G. Havenith, Noel R. Monks, Peter Tyrer, Francois D'Hooge, Ryan Fleming, Kapil Vashisht, Nazzareno Dimasi, F...> ;Molecular Cancer Therapeutics. 2018 Jan 1
• 77 citations
  ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies
  Michael Flynn, Francesca Zammarchi, Peter Tyrer, Ayse U. Akarca, Narinder Janghra, Charles E. Britten, Carin E. G. Havenith, Jean-Noel Levy, Arnaud C. Tiberghien, Luke...> ;Molecular Cancer Therapeutics. 2016 Nov 1
• 47 citations
  Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation
  Ewald T. J. van den Bremer, Frank J. Beurskens, Marleen Voorhorst, Patrick J. Engelberts, Rob N. de Jong, Burt G van der Boom, Erika M. Cook, Margaret A. Lindorfer, Ro...> ;Mabs. 2015 Jun 2
• 58 citations
  High Turnover of Tissue Factor Enables Efficient Intracellular Delivery of Antibody–Drug Conjugates
  Bart De Goeij, David Satijn, Claudia M. Freitag, Richard Wubbolts, Wim K. Bleeker, Alisher Khasanov, Tong Zhu, Gary Chen, David Miao, Patrick Van Berkel, Paul W. H. I....> ;Molecular Cancer Therapeutics. 2015 May 1
• 56 citations
  Production of stable bispecific IgG1 by controlled Fab-arm exchange: Scalability from bench to large-scale manufacturing by application of standard approaches
  Michael Gramer, Ewald T. J. van den Bremer, Muriel D. van Kampen, Amitava Kundu, Peter Kopfmann, Eric Etter, David Stinehelfer, Justin Long, Tom Lannom, Esther H Noord...> ;Mabs. 2013 Aug 22
• 224 citations
  Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
  Aran F. Labrijn, Joyce I. Meesters, Bart De Goeij, Ewald T. J. van den Bremer, Joost J. Neijssen, Muriel D. van Kampen, Kristin Strumane, Sandra Verploegen, Amitava Ku...> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar 26
• 47 citations
  Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG
  Rebecca J. Rose, Patrick Van Berkel, Ewald T. J. van den Bremer, Aran F. Labrijn, Tom Vink, Janine Schuurman, Albert J. R. Heck, Paul W. H. I. Parren> ;Mabs. 2013 Feb 13
• 28 citations
  Online nanoliquid chromatography–mass spectrometry and nanofluorescence detection for high-resolution quantitative N-glycan analysis
  Hakan Kalay, Martino Ambrosini, Patrick Van Berkel, Paul W. H. I. Parren, Yvette van Kooyk, Juan J. García Vallejo> ;Analytical Biochemistry. 2012 Apr 1
• 35 citations
  Combined Fc-protein- and Fc-glyco-engineering of scFv-Fc fusion proteins synergistically enhances CD16a binding but does not further enhance NK-cell mediated ADCC
  Roland Repp, Christian Kellner, Anja Muskulus, Matthias Staudinger, Sahar Mohseni Nodehi, Pia Glorius, Dalia Akramiene, Michael Dechant, Georg H. Fey, Patrick Van Berk...> ;Journal of Immunological Methods. 2011 Oct 28
• 69 citations
  Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry
  Rebecca J. Rose, Aran F. Labrijn, Ewald T. J. van den Bremer, Stefan Loverix, Ignace Lasters, Patrick Van Berkel, Jan G. J. van de Winkel, Janine Schuurman, Paul W. H....> ;Structure. 2011 Sep 7
• 88 citations
  Anti-galactose-α-1,3-galactose IgE from allergic patients does not bind α-galactosylated glycans on intact therapeutic antibody Fc domains.
  Jeroen J. Lammerts van Bueren, Theo Rispens, Sandra Verploegen, Tjitske van der Palen-Merkus, Steven Stapel, Lisa J. Workman, Hayley James, Patrick Van Berkel, Jan G. ...> ;Nature Biotechnology. 2011 Jul 11
• 115 citations
  Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose
  Michael Gramer, Jackie J. Eckblad, Ruth Donahue, Joseph Brown, Carrie Shultz, Kent Vickerman, Patrick Priem, Ewald T. J. van den Bremer, Jolanda Gerritsen, Patrick Van...> ;Biotechnology and Bioengineering. 2011 Jul 1
• 33 citations
  Rapid production of recombinant human IgG With improved ADCC effector function in a transient expression system.
  Patrick Van Berkel, Jolanda Gerritsen, Edwin van Voskuilen, Gerrard J. Perdok, Tom Vink, Jan G. J. van de Winkel, Paul W. H. I. Parren> ;Biotechnology and Bioengineering. 2010 Feb 1
• 162 citations
  Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of ...
  Tanja Schneider-Merck, Jeroen J. Lammerts van Bueren, Sven Berger, Kai Rossen, Patrick Van Berkel, Stefanie Derer, Thomas Beyer, Stefan Lohse, Wim K. Bleeker, Matthias...> ;Journal of Immunology. 2010 Jan 1
• 59 citations
  N‐linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG
  Patrick Van Berkel, Jolanda Gerritsen, Gerrard J. Perdok, Jesper Valbjørn, Tom Vink, Jan G. J. van de Winkel, Paul W. H. I. Parren> ;Biotechnology Progress. 2009 Jan 1
• 163 citations
  Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells.
  Matthias Peipp, Jeroen J. Lammerts van Bueren, Tanja Schneider-Merck, Wim K. Bleeker, Michael Dechant, Thomas Beyer, Roland Repp, Patrick Van Berkel, Tom Vink, Jan G. ...> ;Blood. 2008 Sep 15
• 18 citations
  N-glycans of recombinant human acid α-glucosidase expressed in the milk of transgenic rabbits
  Susanne P Jongen, Gerrit J. Gerwig, Bas R. Leeflang, Kate Koles, Maurice L.M. Mannesse, Patrick Van Berkel, Frank Pieper, Marian A. Kroos, Arnold J. J. Reuser, Qun Zho...> ;Glycobiology. 2007 Jun 1
• 28 citations
  The Protein Structure of Recombinant Human Lactoferrin Produced in the Milk of Transgenic Cows Closely Matches the Structure of Human Milk-Derived Lactoferrin
  Ellen A. J. Thomassen, Harrie A. van Veen, Patrick Van Berkel, Jan H. Nuijens, Jan Pieter Abrahams> ;Transgenic Research. 2005 Aug 1
• 20 citations
  Influence of lactation parameters on the N-glycosylation of recombinant human C1 inhibitor isolated from the milk of transgenic rabbits.
  Kate Koles, Patrick Van Berkel, Maurice L.M. Mannesse, Raimon Zoetemelk, Johannes F.G. Vliegenthart, Johannis P. Kamerling> ;Glycobiology. 2004 Nov 1
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