PaulSamuelGaynonMD

Pediatric Hematology & Oncology • Los Angeles, CA

Professor, Pediatrics, USC School of Medicine

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Office
4650 Sunset Blvd
Los Angeles, CA 90027
Phone+1 323-361-2163

Fax+1 323-361-7128
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Education & Training

Stanford Health Care-Sponsored Stanford UniversityResidency, Pediatrics, 1974 - 1976
University of Illinois College of MedicineClass of 1974
Children's Hospital/Boston Medical CenterFellowship, Pediatric Hematology/Oncology

Certifications & Licensure

CA State Medical License 1998 - 2024
WI State Medical License 1987 - 1999
IL State Medical License 1976 - 1990
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com

Clinical Trials

Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia Start of enrollment: 2002 Nov 01
Completed
Phase 2
ABT-751 With Chemotherapy for Relapsed Pediatric ALL Start of enrollment: 2006 May 22
Terminated
Phase 1, Phase 2
Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224) Start of enrollment: 2009 Apr 13
Terminated
Phase 1
T2007-002 Clofarabine, Etoposide, Cyclophosphamide in Relapsed Acute Myelogenous Leukemia (AML) Start of enrollment: 2009 Jul 10
Terminated
Phase 2
Trial of Nelarabine, Etoposide and Cyclophosphamide in Relapsed T-cell ALL and T-cell LL Start of enrollment: 2010 Jun 01
Terminated
Phase 1, Phase 2
A Study Of Panobinostat In Children With Refractory Hematologic Malignancies Start of enrollment: 2011 Mar 01
Completed
Phase 1
A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL Start of enrollment: 2011 Dec 01
Terminated
Phase 1, Phase 2
A Phase 1 Dose Escalation and Expanded Cohort Study of EPZ-5676 in the Treatment of Pediatric Patients With Relapsed/Refractory Leukemias Bearing a Rearrangement of the MLL Gene Start of enrollment: 2014 May 01
Completed
Phase 1
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Publications & Presentations

PubMed

Efficacy and safety of FLAG-IDA as front-line therapy in de novo paediatric acute myeloid leukaemia population.
Andrew Doan, Holly K T Huang, Ari J Hadar, Jemily Malvar, Teresa Rushing, Gordana Raca, Alexandra E Kovach, David R Freyer, Chintan Parekh, Jamie Stokke, Leila C Posch...> ;British Journal of Haematology. 2023 Jul 1
6 citations
Nelarabine, etoposide, and cyclophosphamide in relapsed pediatric T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma (study T2008-002 NECTAR).
James A Whitlock, Jemily Malvar, Luciano Dalla-Pozza, John M Goldberg, Lewis B Silverman, David S Ziegler, Andishe Attarbaschi, Patrick A Brown, Rebecca A Gardner, Pau...> ;Pediatric Blood & Cancer. 2022 Nov 1
Survival of pediatric Hodgkin lymphoma patients treated with doxorubicin, bleomycin, vincristine, etoposide, prednisone, and cyclophosphamide (ABVE-PC) versus doxorubi...
Sebastian de Armas, Carolina Huertas-Ayala, Randall Y Chan, Yueh-Yun Chi, Winston W Huh, Amanda Termuhlen, Paul S Gaynon, Alexandra E Kovach, Andrew Doan> ;Pediatric Blood & Cancer. 2022 May 1
8 citations
Temsirolimus combined with cyclophosphamide and etoposide for pediatric patients with relapsed/refractory acute lymphoblastic leukemia: a Therapeutic Advances in Child...
Sarah K Tasian, Lewis B Silverman, James A Whitlock, Richard Sposto, Joseph P Loftus, Eric S Schafer, Kirk R Schultz, Raymond J Hutchinson, Paul S Gaynon, Etan Orgel, ...> ;Haematologica. 2022 Oct 1
1 citations
Acute myeloid leukemia with t(X;6)9p11;q23);MYB-GATA1 and female sex: GATA1 insufficiency may be insufficient for pathogenesis.
Alexandra E Kovach, Elena Zerkalenkova, Ludmila Zemtsova, Aleksandra Borkovskaya, Marina Gaskova, Marat Kazanov, Alexander Popov, Liudmila Baidun, Michael Maschan, Ale...> ;Cancer Genetics. 2022 Jan 1
1 citations
A new standard of care for childhood T-cell acute lymphoblastic leukemia?
Paul S. Gaynon, Chintan Parekh> ;Pediatric Blood & Cancer. 2021 Jul 24
2 citations
Preexisting or therapy-induced mutations in relapsed acute lymphoblastic leukemia?
Paul S. Gaynon, Etan Orgel, Lingyun Ji> ;Blood. 2020 Nov 5
22 citations
Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study
Michael J. Burke, Rumen Kostadinov, Richard Sposto, Lia Gore, Shannon Kelley, Cara A Rabik, Jane B. Trepel, Min-Jung Lee, Akira Yuno, Sunmin Lee, Deepa Bhojwani, Sima ...> ;Clinical Cancer Research. 2020 Jan 22
11 citations
A phase I study of panobinostat in children with relapsed and refractory hematologic malignancies
John Goldberg, Maria Luisa Sulis, Julia Glade Bender, Sima Jeha, Rebecca Gardner, Jessica A. Pollard, Victor M. Aquino, Theodore W. Laetsch, Naomi J. Winick, Cecilia F...> ;Pediatric Hematology and Oncology. 2020 Apr 27
Methotrexate and asparaginase: not so simple.
Paul S. Gaynon> ;Leukemia & Lymphoma. 2019 Sep 26
13 citations
Excellent long-term survival of children with Down syndrome and standard-risk ALL: a report from the Children’s Oncology Group
Yousif Matloub, Karen R. Rabin, Lingyun Ji, Meenakshi Devidas, Johann Hitzler, Xinxin Xu, Bruce Bostrom, Linda C. Stork, Naomi J. Winick, Julie M. Gastier-Foster, Nyla...> ;Blood Advances. 2019 Jun 11
8 citations
Treatment of higher risk acute lymphoblastic leukemia in young people (CCG-1961), long-term follow-up: a report from the Children's Oncology Group.
Peter G. Steinherz, Nita L. Seibel, Harland Sather, Lingyun Ji, Xinxin Xu, Meenakshi Devidas, Paul S. Gaynon> ;Leukemia. 2019 Feb 28
55 citations
Myeloid lineage switch following chimeric antigen receptor T‐cell therapy in a patient with TCF3‐ZNF384 fusion‐positive B‐lymphoblastic leukemia
Matthew J. Oberley, Paul S. Gaynon, Deepa Bhojwani, Michael A. Pulsipher, Rebecca Gardner, Matthew C. Hiemenz, Jianling Ji, Jennifer Han, Maurice R.G. O'Gorman, Alan S...> ;Pediatric Blood & Cancer. 2018 Sep 1
127 citations
Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate Randomiza...
Stuart S. Winter, Kimberly P. Dunsmore, Meenakshi Devidas, Brent L. Wood, Natia Esiashvili, Zhiguo Chen, Nancy Eisenberg, Nikki Briegel, Robert J. Hayashi, Julie M. Ga...> ;Journal of Clinical Oncology. 2018 Aug 23
40 citations
First pediatric experience of SL-401, a CD123-targeted therapy, in patients with blastic plasmacytoid dendritic cell neoplasm: report of three cases.
Weili Sun, Huaying Liu, Young L. Kim, Nicole Karras, Anna B. Pawlowska, Debbie Toomey, Wade Kyono, Paul S. Gaynon, Joseph Rosenthal, Anthony S. Stein> ;Journal of Hematology & Oncology. 2018 May 2
80 citations
Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study.
Weili Sun, Jemily Malvar, Richard Sposto, Anupam Verma, Jennifer J. Wilkes, Robyn M. Dennis, Kenneth Heym, Theodore W. Laetsch, Melissa Widener, Susan R. Rheingold, Ja...> ;Leukemia. 2018 Mar 15
40 citations
A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium
Weili Sun, Timothy J. Triche, Jemily Malvar, Paul S. Gaynon, Richard Sposto, Xiaojing Yang, Henrique Bittencourt, Andrew E. Place, Yoav Messinger, Chris Fraser, Lucian...> ;Blood. 2018 Mar 8
1 citations
Remission is good - relapse is bad.
Paul S. Gaynon> ;Haematologica. 2018 Jan 1
5 citations
Redefining treatment failure for pediatric acute leukemia in the era of minimal residual disease testing.
Van Huynh, Theodore W. Laetsch, Reuven J. Schore, Paul S. Gaynon, Maureen M. O'Brien> ;Pediatric Hematology and Oncology. 2017 Nov 30
3 citations
Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL): Overview and introduction to the proceedings of the 2016 TACL investigator meeting.
Alan S. Wayne, Erika Shin-Kashiyama, Richard Sposto, Paul S. Gaynon> ;Pediatric Hematology and Oncology. 2017 Nov 9
5 citations
A neoplasm with FIP1L1-PDGFRA fusion presenting as pediatric T-cell lymphoblastic leukemia/lymphoma without eosinophilia.
Matthew J. Oberley, Christopher C Denton, Jianling Ji, Matthew C. Hiemenz, Deepa Bhojwani, Dejerianne Ostrow, Samuel Wu, Paul S. Gaynon, Gordana Raca> ;Cancer Genetics. 2017 Oct 1
1 citations
Mercaptopurine in childhood acute lymphoblastic leukaemia
Paul S. Gaynon> ;The Lancet. Oncology. 2017 Apr 1
Historical Controls?
Paul S Gaynon> ;Haematologica. 2017 Mar 1
The Second Time is Sweeter After All
Paul S. Gaynon> ;British Journal of Haematology. 2017 Feb 1
50 citations
A Phase I Study of Quizartinib Combined With Chemotherapy in Relapsed Childhood Leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study
Todd M. Cooper, Jeannette Cassar, Elena Eckroth, Jemily Malvar, Richard Sposto, Paul S. Gaynon, Bill H. Chang, Lia Gore, Keith J. August, Jessica A. Pollard, Steven G....> ;Clinical Cancer Research. 2016 Aug 15
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Grant Support

Clinical Trial: ABT-751 Combined With Dexamethasone, Peg-Asparaginase, And DoxorNational Center For Research Resources2009
Childrens Cancer GroupNational Cancer Institute1998–2002
Childrens Cancer GroupNational Cancer Institute1997
Childrens CancerNational Cancer Institute1994–1996
Children'S Cancer Study GroupNational Cancer Institute1989–1993

Hospital Affiliations

Children's Hospital Los AngelesLos Angeles, California

PaulSamuelGaynonMD

Dr. Gaynon is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Clinical Trials

Publications & Presentations

Grant Support

Hospital Affiliations

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