PetrosConstantineKarakousisMD

PubMed

• Preprints: Are they precedents or expedient substitutes for peer-reviewed journal publications?
  Emily Lu, Marie Gilbert Majella, Harinivas Shanmugavel Geetha, Alyssa Zimmerman, Amudha Kumar, Vignesh Chidambaram, Petros C Karakousis> ;The American Journal of the Medical Sciences. 2024 Mar 21
• A SARS-CoV-2 RBD vaccine fused to the chemokine MIP-3α elicits sustained murine antibody responses over 12 months and enhanced lung T-cell responses.
  James Tristan Gordy, Yinan Hui, Courtney Schill, Tianyin Wang, Fengyixin Chen, Kaitlyn Fessler, Jacob Meza, Yangchen Li, Alannah D Taylor, Rowan E Bates, Petros C Kara...> ;Frontiers in Immunology. 2024 Jan 1
• The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine mo...
  Ruelas Castillo, J., Neupane, P., Krug, S., Quijada, D., Garcia, A., Yilma, A., Costa, D., Sher, A., Fotouhi, N., Serbina, N., Karanika, S., Ayeh, S., Karakousis, P.> ;Antimicrobial Agents and Chemotherapy. 2024 Feb 7
• HIV/Tuberculosis Coinfection in Pregnancy and the Postpartum Period.
  Addis Yilma, Hannah Bailey, Petros C Karakousis, Styliani Karanika> ;Journal of Clinical Medicine. 2023 Sep 29
• Functional Whole Genome Screen of Nutrient-StarvedIdentifies Genes Involved in Rifampin Tolerance.
  William M Matern, Harley T Harris, Carina Danchik, Marissa McDonald, Gopi Patel, Aashish Srivastava, Thomas R Ioerger, Joel S Bader, Petros C Karakousis> ;Microorganisms. 2023 Sep 9
• Combination of a MIP3α-antigen fusion therapeutic DNA vaccine with treatments of IFNα and 5-Aza-2'Deoxycytidine enhances activated effector CD8+ T cells expressing CD1...
  Kaitlyn Fessler, James T Gordy, Avinaash K Sandhu, Yinan Hui, Aakanksha R Kapoor, Samuel K Ayeh, Styliani Karanika, Petros C Karakousis, Richard B Markham> ;Research Square. 2023 Aug 14
• The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine mo...
  Jennie Ruelas Castillo, Pranita Neupane, Styliani Karanika, Stefanie Krug, Darla Quijada, Andrew Garcia, Samuel Ayeh, Addis Yilma, Diego L Costa, Alan Sher, Nader Foto...> ;Biorxiv. 2023 Nov 13
• 2 citations
  Metabolic switching and cell wall remodelling of Mycobacterium tuberculosis during bone tuberculosis.
  Khushpreet Kaur, Sumedha Sharma, Sudhanshu Abhishek, Prabhdeep Kaur, Uttam Chand Saini, Mandeep Singh Dhillon, Petros C Karakousis, Indu Verma> ;The Journal of Infection. 2023 Feb 1
• 8 citations
  HDL cholesterol levels and susceptibility to COVID-19.
  Vignesh Chidambaram, Amudha Kumar, Marie Gilbert Majella, Bhavna Seth, Ranjith Kumar Sivakumar, Dinesh Voruganti, Mahesh Bavineni, Ahmad Baghal, Kim Gates, Subhi J Al'...> ;Ebiomedicine. 2022 Aug 1
• 17 citations
  Association of Lipid Levels With COVID-19 Infection, Disease Severity and Mortality: A Systematic Review and Meta-Analysis.
  Vignesh Chidambaram, Harinivaas Shanmugavel Geetha, Amudha Kumar, Marie Gilbert Majella, Ranjith Kumar Sivakumar, Dinesh Voruganti, Jawahar L Mehta, Petros C Karakousis> ;Frontiers in Cardiovascular Medicine. 2022 Jan 1
• 1 citations
  An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis.
  Styliani Karanika, James T Gordy, Pranita Neupane, Theodoros Karantanos, Jennie Ruelas Castillo, Darla Quijada, Kaitlyn Comstock, Avinaash K Sandhu, Aakanksha R Kapoor...> ;Frontiers in Immunology. 2022 Jan 1
• 5 citations
  IFNα and 5-Aza-2'-deoxycytidine combined with a dendritic-cell targeting DNA vaccine alter tumor immune cell infiltration in the B16F10 melanoma model.
  James T Gordy, Avinaash K Sandhu, Kaitlyn Fessler, Kun Luo, Aakanksha R Kapoor, Samuel K Ayeh, Yinan Hui, Courtney Schill, Fengyixin Chen, Tianyin Wang, Styliani Karan...> ;Frontiers in Immunology. 2022 Jan 1
• 17 citations
  Progression and Resolution of SARS-CoV-2 Infection in Golden Syrian Hamsters.
  Kathleen R. Mulka, Sarah E. Beck, Clarisse V. Solis, Andrew L. Johanson, Suzanne E. Queen, Megan E. McCarron, Morgan R. Richardson, Ruifeng Zhou, Paula Marinho, Anne E...> ;The American Journal of Pathology. 2021 Nov 9
• 6 citations
  Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment.
  Carina Danchik, Siqing Wang, Petros C. Karakousis> ;Frontiers in Microbiology. 2021 Oct 7
• 4 citations
  The Global Health Security Index is not predictive of vaccine rollout responses among OECD countries.
  Banda A. A. Khalifa, Enoch J. Abbey, Samuel K. Ayeh, Hasiya E. Yusuf, Richard D. Nudotor, Ngozi Osuji, Samiha Khan, Esosa Nosakhare, Modupe O. Oduwole, Emmanuella L. S...> ;International Journal of Infectious Diseases. 2021 Sep 20
• 4 citations
  Genetic Determinants of Intrinsic Antibiotic Tolerance in Mycobacterium avium.
  William M. Matern, Harley Parker, Carina Danchik, Leah Hoover, Joel S. Bader, Petros C. Karakousis> ;Microbiology Spectrum. 2021 Sep 15
• 36 citations
  Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model.
  Santosh Dhakal, Camilo A. Ruiz-Bedoya, Ruifeng Zhou, Patrick S. Creisher, Jason S Villano, Kirsten Littlefield, Jennie Ruelas Castillo, Paula Marinho, Anne E. Jedlicka...> ;Mbio. 2021 Jul 13
• 9 citations
  Higher Serum Cholesterol Levels Are Associated With Reduced Systemic Inflammation and Mortality During Tuberculosis Treatment Independent of Body Mass Index
  Vignesh Chidambaram, Lucas Zhou, Jennie Ruelas Castillo, Amudha Kumar, Samuel K. Ayeh, Akshay Gupte, Jann-Yuan Wang, Petros C. Karakousis> ;Frontiers in Cardiovascular Medicine. 2021 Jun 22
• 12 citations
  Male Sex Is Associated With Worse Microbiological and Clinical Outcomes Following Tuberculosis Treatment: A Retrospective Cohort Study, a Systematic Review of the Lite...
  Vignesh Chidambaram, Nyan Lynn Tun, Marie Gilbert Majella, Jennie Ruelas Castillo, Samuel K. Ayeh, Amudha Kumar, Pranita Neupane, Ranjith Kumar Sivakumar, Ei Phyo Win,...> ;Clinical Infectious Diseases. 2021 Nov 2
• 69 citations
  Modes of transmission of SARS-CoV-2 and evidence for preventive behavioral interventions
  Lucas Zhou, Samuel K. Ayeh, Vignesh Chidambaram, Petros C. Karakousis> ;BMC Infectious Diseases. 2021 May 28
• 8 citations
  The Association of Atherosclerotic Cardiovascular Disease and Statin Use With Inflammation and Treatment Outcomes in Tuberculosis
  Vignesh Chidambaram, Jennie Ruelas Castillo, Amudha Kumar, Justin Wei, Siqing Wang, Marie Gilbert Majella, Akshay Gupte, Jann-Yuan Wang, Petros C. Karakousis> ;Scientific Reports. 2021 Jul 27
• 36 citations
  Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model
  Santosh Dhakal, Camilo A. Ruiz-Bedoya, Ruifeng Zhou, Patrick S. Creisher, Jason S Villano, Kirsten Littlefield, Jennie Ruelas Castillo, Paula Marinho, Anne E. Jedlicka...> ;Biorxiv. 2021 Apr 4
• 1 citations
  Reply to Lai et al.
  Vignesh Chidambaram, Petros C. Karakousis> ;The Journal of Infectious Diseases. 2021 Oct 13
• 8 citations
  The New Frontier of Host-Directed Therapies for Mycobacterium avium Complex.
  Nathan P. Crilly, Samuel K. Ayeh, Petros C. Karakousis> ;Frontiers in Immunology. 2021 Jan 22
• 12 citations
  Key Macrophage Responses to Infection With Mycobacterium tuberculosis Are Co-Regulated by microRNAs and DNA Methylation.
  Monika M Looney, Rachel Lorenc, Marc K. Halushka, Petros C. Karakousis> ;Frontiers in Immunology. 2021 Jun 1
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Journal Articles

• Metformin use reverses the increased mortality associated with diabetes mellitus during tuberculosis treatment  
  Degner NR, Wang J-Y, Golub JE, Karakousis PC, Clin Infect Dis, 1/1/2018
• Intranasal immunization with DnaK protein induces protective mucosal immunity against tuberculosis in CD4-depleted mice  
  Chuang Y-M, Pinn ML, Karakousis PC, Hung C-F, Front Cell Infect Microbiol, 1/1/2018
• Altered Mycobacterium tuberculosis cell wall metabolism and physiology associated with RpoB mutation H526D  
  Campodonico VL, Rifat D, Chuang Y-M, Ioerger TR, Karakousis PC, Front Microbiol, 1/1/2018
• Gene enrichment analysis reveals major regulators of Mycobacterium tuberculosis gene expression in two models of antibiotic tolerance  
  Matern WM, Rifat D, Bader J, Karakousis PC, Front Microbiol, 1/1/2018
• Unprecedented in Vitro Antitubercular Activitiy of Manganese(II) Complexes Containing 1, 10-Phenanthroline and Dicarboxylate Ligands: Increased Activity, Superior Sele...  
  McCarron P, McCann M, Devereux M, Kavanagh K, Skerry C, Karakousis PC, Aor AC, Mello TP, Santos ALS, Campos DL, Pavan FR, Front Microbiol, 1/1/2018
• Genome analysis of Mycobacterium avium subspecies hominissuis strain 109  
  Matern WM, Bader JS, Karakousis PC, Sci Data, 1/1/2018
• In vitro and in vivo fitness costs associated with Mycobacterium tuberculosis RpoB mutation H526D  
  Rifat D, Campodonico VL, Tao J, Miller JA, Alp A, Yao Y, Karakousis PC, Antimicrob Agents Chemother, 1/1/2017
• Development of a novel lead that targets M tuberculosis polyketide synthase 13  
  Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha, R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion..., Cell, 1/1/2017
• Statin adjunctive therapy shortens the duration of TB treatment in mice  
  Dutta NK, Bruiners N, Pinn ML, Zimmerman MD, Prideaux B, Dartois V, Gennaro ML, Karakousis PC, J Antimicrob Chemother, 1/1/2016
• Identification of a transcription factor that regulates host cell exit and virulence of Mycobacterium tuberculosis  
  Srinivasan L, Gurses SA, Hurley BE, Miller JL, Karakousis PC, Briken V, PLoS Pathog, 1/1/2016
• First evaluation of GenoType MTBDRPlus 20 performed directly on respiratory specimens in Central America  
  Lanzas F, Ioerger TR, Shah H, Acosta W, Karakousis PC, J Clin Microbiol, 1/1/2016
• Mycobacterial protein tyrosine phosphatases A and B inhibitors augment the bactericidal activity of standard anti-TB regimen  
  Dutta NK, He R, Pinn ML, He Y, Burrows F, Zhang Z-Y, Karakousis PC, ACS Infect Dis, 1/1/2016
• The stringent response factors PPX1 and PPK2 play an important role in Mycobacterium tuberculosis metabolism, biofilm formation, and sensitivity to isoniazid in vivo  
  Chuang Y-M, Dutta NK, Hung CF, Wu TC, Rubin H, Karakousis PC, Antimicrob Agents Chemother, 1/1/2016
• Pleuropulmonary Kaposi Sarcoma in the Setting of Immune Reactivation  
  Suresh K, Semaan R, Arias S, Karakousis P, Lee H, J Pulm Respir Med, 1/1/2016
• Empirical Antifungal Therapy in Critically Ill Patients With Sepsis: Another Case of Less Is More in the ICU  
  Siddharthan T, Karakousis PC, Checkley W, JAMA (Journal of the American Medical Association), 1/1/2016
• Metabolomics specificity of tuberculosis plasma revealed by (1)H NMR spectroscopy  
  Zhou A, Ni J, Xu Z, Wang Y, Zhang H, Wu W, Lu S, Karakousis PC, Yao Y-F, Tuberculosis (Edinb), 1/1/2015
• Differential expression of miRNAs and their relation to active tuberculosis  
  Xu Z, Zhou A, Ni J, Wang Y, Lu J, Karakousis PC, Lu S, Yao Y, Tuberculosis (Edinb), 1/1/2015
• Host-mediated bioactivation of pyrazinamide: implications for efficacy, resistance and therapeutic alternatives  
  Via L, Savic R, Weiner D, Zimmerman M, Prideaux B, Irwin S, O'Brien P, Gopal P, Eum S, Lee M, Lanoix J-P, Lyon E, Dutta NK, Shim T, Cho JS, Kim W, Karakousis PC, Lenae..., ACS Infect Dis, 1/1/2015
• Can the duration of tuberculosis treatment be shortened with higher dosages of rifampicin?  
  Dutta NK, Karakousis PC, Front Microbiol, 1/1/2015
• A Tuberculosis Ontology for Host Systems Biology  
  Levine DM, Dutta NK, Eckels J, Scanga C, Stein C, Mehra S, Kaushal D, Karakousis PC, Salamon H, Tuberculosis (Edinb), 1/1/2015
• Replication of Mycobacterium tuberculosis in Retinal Pigment Epithelium  
  Nazari H, Karakousis PC, Rao NA, JAMA Ophthalmol, 1/1/2014
• Characterization of a novel necrotic granuloma model of latent tuberculosis infection and reactivation in mice  
  Dutta NK, Illei P, Jain S, Karakousis PC, Am J Pathol, 1/1/2014
• Differential regulation of the two-component regulatory system senX3-regX3 in Mycobacterium tuberculosis  
  Rifat D, Karakousis PC, Microbiology, 1/1/2014
• Reduced emergence of isoniazid resistance with concurrent use of thioridazine against acute murine tuberculosis  
  Dutta NK, Pinn ML, Karakousis PC, Antimicrob Agents Chemother, 1/1/2014
• Deficiency of double strand DNA break repair does not impair M tuberculosis virulence in multiple animal models of infection  
  Heaton B, Barkan D, Bongiorno P, Karakousis PC, Glickman MS, Infect Immun, 1/1/2014
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Books/Book Chapters

• Handbook of Tuberculosis 
  Chapter: Clinical Features and Diagnosis of Tuberculosis: Primary Infection and Progressive Pulmonary Tuberculosis 
  Page 17 - 34Karakousis PC, Dutta NK, Manabe YCEditors: Grosset JH, Chaisson RE.Springer International Publishing, Switzerland2017
• Tuberculosis, Leprosy and Mycobacterial Diseases of Man and Animals: The Many Hosts of Mycobacteria 
  Chapter: Rabbit Model of Mycobacterial Diseases 
  Page 402 - 418Subbian S, Karakousis PC, Kaplan GEditors: Mukundan H, et al.CAB International2015
• Mycobacterium Tuberculosis/Book 2 
  Chapter: Old and New TB Drugs: Mechanisms of Action and Resistance 
  Kolyva A, Karakousis PCEditors: Cardona P-J.InTech2011
• Antimicrobial Drug Resistance 
  Chapter: Mechanisms of Action and Resistance of the Antimycobacterial Agents 
  Page 271 - 291Karakousis PCEditors: Mayers D,.Humana Press, New York2009
• Fishman's Pulmonary Diseases and Disorders 
  Chapter: Mycobacterial infections and HIV infection. 
  Page 2487 - 2497Karakousis PC, Chaisson REEditors: Fishman AP, Elias JA, Fishman JA, Grippi MA, Senior RM, Pack AI.McGraw Hill, New YorkEdition 4th,2008
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Lectures

• "Overview of Tuberculosis" 
  1/1/2019
• "Animal models of TB infection." 
  1/1/2019
• "Tuberculosis and Antimicrobials" 
  JHUSOM (Johns Hopkins University School of Medicine), 2012-2019 - 1/1/2019
• "Classic Papers on Tuberculosis" 
  1/1/2019
• "Tuberculosis-Clinical Considerations" 
  1/1/2019
• "Advancing Host-Directed Therapies for Tuberculosis" 
  The Hague, Netherlands - 1/25/2018
• "Statins for TB: Can we harness the host?" 
  Newark, NJ - 1/20/2018
• "Inhibiting the Mtb Stringent Response: The Krotalon for Rousing Persisters?" 
  Baltimore, MD - 1/15/2018
• "What can 'omics tell us about TB reactivation risk in HIV-infected and uninfected adults and children?" 
  Rockville, MD - 1/2/2018
• "Novel strategies to detect and target Mtb persisters." 
  Silver Spring, MD - 1/28/2017
• "Strategic Discussion on Repurposing Drugs for TB" 
  Lucca, Italy - 1/27/2017
• "Tuberculosis Disease: Host Response and Diagnostics" 
  Washington, DC - 1/21/2017
• "Statins as Adjunctive, Host-Directed Therapy for Tuberculosis" 
  Athens, Greece - 1/21/2016
• "Tuberculosis: Susceptibility and Immune Response" 
  San Francisco, CA - 1/16/2016
• "Updates on Tuberculosis from CROI 2016" 
  Florence, Italy - 1/15/2016
• "Lessons Learned from the NHLBI-Sponsored Tuberculosis Systems Biology Program" 
  San Francisco, CA - 1/15/2016
• "Novel Approaches to Understanding and Combating Latent TB Infection" 
  San Francisco, CA - 1/15/2016
• "Novel Paradigms to Treat TB." 
  Baltimore, MD - 1/10/2016
• "Genetic and chemical validation of RelMtb as a target for M. tuberculosis persisters." 
  New York, NY - 1/28/2015
• "Mycobacterium tuberculosis: Molecular Basis of Persistence" 
  New Delhi, India - 1/23/2015
• "A Novel 'Shock and Kill' Strategy for Targeting Mtb Persisters." 
  Rockville, MD - 1/16/2015
• "Novel approaches to target Mycobacterium tuberculosis persisters." 
  Rockville, MD - 1/16/2015
• "Host directed therapies and biomarkers for TB." 
  Pune, India - 1/5/2015
• "Clinical Mycology" 
  1/1/2015
• "Latent TB Infection: Myths, Models, and Molecular Mechanisms" 
  Baltimore, MD - 1/31/2014
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Other

• "XDR-TB Scare" 
  Karakousis PC, Fox National News (11:00 AM, Thursday)
  1/31/2007
• Greetings from sunny (most of the time) San Diego: Highlights from the 41st Annual Meeting of the Infectious Diseases Society of America. 
  Karakousis PC, Page KR, Bishai WR, JHU (Johns Hopkins University)Antibiotic Guide Website
  http://hopkins-abxguide.org
  1/1/2003
• Synopsis of key presentations at the 40th Annual Meeting of IDSA (October 24-27, 2002, Chicago). 
  Karakousis PC, Bishai WR, JHU (Johns Hopkins University)Antibiotic Guide Website
  http://hopkins-abxguide.org
  1/1/2002