Petros Constantine Karakousis MD

Professor of Medicine, Johns Hopkins University School of Medicine

1800 Orleans StreetBaltimore, MD 21287
Phone+1 410-955-5000
Fax+1 410-955-5001

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Education & Training

Johns Hopkins UniversityFellowship, Infectious Disease, 2002 - 2005
University of Pennsylvania Health SystemResidency, Internal Medicine, 1998 - 2001
WashU MedicineClass of 1998
Johns Hopkins UniversityB.A., Summa Cum Laude, 1994

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Certifications & Licensure

MD State Medical License 2005 - 2026
PA State Medical License 1999 - 2002
American Board of Internal Medicine Infectious Disease

Awards, Honors, & Recognition

Member American Society of Clinical Investigation, 2021
American Society of Clinical Investigation 2021
CMS Meaningful Use Stage 1 Certification Beacon Oncology 2014 Certified Module, Epic Systems Corporation, 2016

Clinical Trials

Statin Adjunctive Therapy for TB Start of enrollment: 2020 Mar 09
Completed
Phase 2
StAT-TB (Statin Adjunctive Therapy for TB): A Phase 2b Dose-finding Study of Pravastatin in Adults With Tuberculosis Start of enrollment: 2020 Feb 21
Completed
Phase 2

Publications & Presentations

PubMed

A copper uptake ABC transport system is essential forvirulence.
Zhihong Xu, Huang Tang, Meiyi Yan, Haifeng Li, Aiping Zhou
Emerging Microbes & Infections. 2026-12-01
Immunotherapy targeting drug-tolerant Mycobacterium tuberculosis persisters accelerates tuberculosis cure in preclinical models.
Styliani Karanika, Tianyin Wang, Addis Yilma, Jennie Ruelas Castillo, James T Gordy
The Journal of Clinical Investigation. 2026-04-01
1 citations
Cholesterol efflux in HIV-associated atherosclerosis: mechanisms and targets.
Emily Lu, Vignesh Chidambaram, Amudha Kumar, Hannah G Cotto Aparicio, Yasmeen Golzar
Trends in Molecular Medicine. 2026-02-01

Journal Articles

Genome analysis of Mycobacterium avium subspecies hominissuis strain 109
Matern WM, Bader JS, Karakousis PC, Sci Data, 1/1/2018
Unprecedented in Vitro Antitubercular Activitiy of Manganese(II) Complexes Containing 1, 10-Phenanthroline and Dicarboxylate Ligands: Increased Activity, Superior Sele...
McCarron P, McCann M, Devereux M, Kavanagh K, Skerry C, Karakousis PC, Aor AC, Mello TP, Santos ALS, Campos DL, Pavan FR, Front Microbiol, 1/1/2018
Gene enrichment analysis reveals major regulators of Mycobacterium tuberculosis gene expression in two models of antibiotic tolerance
Matern WM, Rifat D, Bader J, Karakousis PC, Front Microbiol, 1/1/2018

Books/Book Chapters

Handbook of Tuberculosis
Chapter: Clinical Features and Diagnosis of Tuberculosis: Primary Infection and Progressive Pulmonary Tuberculosis
Page 17 - 34Karakousis PC, Dutta NK, Manabe YCEditors: Grosset JH, Chaisson RE.Springer International Publishing, Switzerland2017
Tuberculosis, Leprosy and Mycobacterial Diseases of Man and Animals: The Many Hosts of Mycobacteria
Chapter: Rabbit Model of Mycobacterial Diseases
Page 402 - 418Subbian S, Karakousis PC, Kaplan GEditors: Mukundan H, et al.CAB International2015
Mycobacterium Tuberculosis/Book 2
Chapter: Old and New TB Drugs: Mechanisms of Action and Resistance
Kolyva A, Karakousis PCEditors: Cardona P-J.InTech2011

Lectures

"Overview of Tuberculosis"
1/1/2019
"Animal models of TB infection."
1/1/2019
"Tuberculosis and Antimicrobials"
JHUSOM (Johns Hopkins University School of Medicine), 2012-2019 - 1/1/2019

Other

"XDR-TB Scare"
Karakousis PC, Fox National News (11:00 AM, Thursday)
1/31/2007
Greetings from sunny (most of the time) San Diego: Highlights from the 41st Annual Meeting of the Infectious Diseases Society of America.
Karakousis PC, Page KR, Bishai WR, JHU (Johns Hopkins University)Antibiotic Guide Website
http://hopkins-abxguide.org
1/1/2003
Synopsis of key presentations at the 40th Annual Meeting of IDSA (October 24-27, 2002, Chicago).
Karakousis PC, Bishai WR, JHU (Johns Hopkins University)Antibiotic Guide Website
http://hopkins-abxguide.org
1/1/2002

Press Mentions

Why You Should Get Vaccinated Against COVID-19 if You Take StatinsNovember 2nd, 2021
Statins Not Beneficial for Preventing COVID-19 MortalityNovember 2nd, 2021
Do Cholesterol Drugs Reduce COVID Risks? Study Findings Are Conflicting. Here’s WhyOctober 27th, 2021

Grant Support

Advancing Apoptosis-Inducing Agents as Host-Directed Therapy for TBJOHNS HOPKINS UNIVERSITY2025–2029
JHU TRAC: Training and Supporting the Next Generation of TB ResearchersJOHNS HOPKINS UNIVERSITY2022–2027
Characterizing CaeA-mediated rifampin tolerance in MTBJOHNS HOPKINS UNIVERSITY2022–2025
Therapeutic vaccination to augment stringent response-specific T-cell immunity to MTB persistersJOHNS HOPKINS UNIVERSITY2020–2025
Mentoring in Immunometabolic Dysregulation in TB and TB/HIVJOHNS HOPKINS UNIVERSITY2019–2025