PhilipPConnellMD

Radiation Oncology • Chicago, IL

Associate Professor of Radiation and Cellular Oncology, University of Chicago Medicine

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Office
5841 S. MARYLAND AVE.
M/C 9006
Chicago, IL 60637
Phone+1 773-834-8119

Fax+1 773-834-7340
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Education & Training

University of Chicago/University of Illinois College of Medicine at ChicagoResidency, Radiation Oncology, 1996 - 2000
Westchester Medical CenterInternship, Internal Medicine, 1995 - 1996
New York Medical CollegeClass of 1995

Certifications & Licensure

IL State Medical License 1996 - 2026
IN State Medical License 2023 - 2025
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013

Publications & Presentations

PubMed

Inactivation Predicts Rapid Recurrence in Inoperable Early-Stage Non-Small-Cell Lung Cancer.
Rohan R Katipally, Liam F Spurr, Stanley I Gutiontov, William Tyler Turchan, Philip Connell, Aditya Juloori, Renuka Malik, Michael S Binkley, Alice L Jiang, Sherin J R...> ;JCO Precision Oncology. 2023 Jan 1
3 citations
A proliferative subtype of colorectal liver metastases exhibits hypersensitivity to cytotoxic chemotherapy.
Liam F Spurr, Carlos A Martinez, Rohan R Katipally, Soumya C Iyer, Sian A Pugh, John A Bridgewater, John N Primrose, Enric Domingo, Timothy S Maughan, Michael I D'Ange...> ;NPJ Precision Oncology. 2022 Oct 14
4 citations
Noncanonical NF-κB factor p100/p52 regulates homologous recombination and modulates sensitivity to DNA-damaging therapy.
Brian Budke, Alison Zhong, Katherine Sullivan, Chanyoung Park, David I Gittin, Timothy S Kountz, Philip P Connell> ;Nucleic Acids Research. 2022 Jun 24
Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination.
Jingfei Xu, Lingyun Zhao, Sijia Peng, Huiying Chu, Rui Liang, Meng Tian, Philip P Connell, Guohui Li, Chunlai Chen, Hong-Wei Wang> ;Nucleic Acids Research. 2021 Dec 16
5 citations
qRT-PCR-based DNA homologous recombination-associated 4-gene score predicts pathologic complete response to platinum-based neoadjuvant chemotherapy in triple-negative ...
Ke Zuo, Xiaoying Yuan, Xizi Liang, Xiangjie Sun, Shujin Liu, Philip P. Connell, Xingmin Li, Wentao Yang> ;Breast Cancer Research and Treatment. 2021 Nov 19
45 citations
CDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer.
Stanley I. Gutiontov, William Tyler Turchan, Liam F. Spurr, Sherin J. Rouhani, Carolina Soto Chervin, George Steinhardt, Angela M. Lager, Pankhuri Wanjari, Renuka Mali...> ;Scientific Reports. 2021 Oct 8
6 citations
Radiation-Induced Sarcoma After Heterotopic Ossification Prophylaxis: A Case Report.
David M. Rosenberg, Benjamin E. Onderdonk, Nasma K Majeed, Grace Guzman, Yasser R. Farid, Philip P. Connell, Christina H. Son> ;JBJS Case Connector. 2019 Dec 1
1 citations
Elevated Radiation Therapy Toxicity in the Setting of Germline PTEN Mutation.
Ken Tatebe, Steven J. Chmura, Philip P. Connell> ;Practical Radiation Oncology. 2019 Jun 8
4 citations
Heart V5 predicts cardiac events in unresectable lung cancer patients undergoing chemoradiation.
Lisa Ni, Philip P. Connell, Sean P. Pitroda, Daniel W. Golden, Hania A. Al-Hallaq, Greg Hubert, Greg Kauffman, Anne R. McCall, Renuka Malik> ;Journal of Thoracic Disease. 2019 Jun 1
7 citations
Optimization of Drug Candidates That Inhibit the D-Loop Activity of RAD51.
Brian Budke, Werner Tueckmantel, Kelsey Miles, Alan P. Kozikowski, Philip P. Connell> ;Chemmedchem. 2019 May 17
18 citations
Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma
Alexandre Chlenski, Chanyoung Park, Marija Dobratic, Helen R. Salwen, Brian Budke, Jae-Hyun Park, Ryan Miller, Mark A. Applebaum, Emma Wilkinson, Yusuke Nakamura, Phil...> ;Molecular Cancer Therapeutics. 2019 Mar 1
Retuning the Radio in Radiobiology.
Steven J. Chmura, Philip P. Connell, Ralph R. Weichselbaum> ;Journal of the National Cancer Institute. 2018 Apr 1
9 citations
A pilot study of the role of the claustrum in attention and seizures in rats.
Arezou Bayat, Sweta Joshi, Phillip Connell, Komei Tsuchiya, David Chau, Tanvir U. Syed, Patrick A. Forcelli, Mohamad Z. Koubeissi> ;Epilepsy Research. 2018 Feb 1
3 citations
Effect of Endoscopic Bronchial Ultrasound on Outcomes for Stage I Non–Small-Cell Lung Cancer Patients Receiving Hypofractionated Radiotherapy
Adil S. Akthar, Mark K. Ferguson, Septimiu Murgu, D. Kyle Hogarth, Daniel W. Golden, Philip P. Connell, Erik M. Davies, Eric H. Kowalski, Renuka Malik> ;Clinical Lung Cancer. 2017 Aug 31
17 citations
Effects of low-frequency electrical stimulation of the anterior piriform cortex on kainate-induced seizures in rats.
Arezou Bayat, Mark D. Skopin, Sweta Joshi, Mithilesh Siddu, Loulwah Mukharesh, Sahar Jahan, Phillip Connell, Naji Younes, Mohamad Z. Koubeissi> ;Epilepsy & Behavior. 2017 Jul 1
13 citations
Low Recombination Proficiency Score (RPS) predicts heightened sensitivity to DNA-damaging chemotherapy in breast cancer
Sean P. Pitroda, Riyue Bao, Jorge Andrade, Ralph R. Weichselbaum, Philip P. Connell> ;Clinical Cancer Research. 2017 Mar 24
14 citations
Acute and spontaneous seizure onset zones in the intraperitoneal kainic acid model
Phillip Connell, Arezou Bayat, Sweta Joshi, Mohamad Z. Koubeissi> ;Epilepsy & Behavior. 2017 Mar 1
7 citations
Angiographic features and disease outcomes of symptomatic retinal arterial macroaneurysms.
Emily Hughes, Ian J. Dooley, Kevin Patrick Kennelly, Fergus G. Doyle, W. F. Siah, Philip P. Connell> ;Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. 2016 May 25
33 citations
Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?
Brian Budke, Wei Lv, Alan P. Kozikowski, Philip P. Connell> ;Chemmedchem. 2016 Nov 21
29 citations
Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51
Wei Lv, Brian Budke, Michal Pawlowski, Philip P. Connell, Alan P. Kozikowski> ;Journal of Medicinal Chemistry. 2016 Apr 21
2 citations
Strategies to Overcome Late Complications from Radiotherapy for Childhood Head and Neck Cancers.
Michael T. Spiotto, Philip P. Connell> ;Oral and Maxillofacial Surgery Clinics of North America. 2016 Feb 1
8 citations
Dual and Opposite Effects of hRAD51 Chemical Modulation on HIV-1 Integration
Sylvain Thierry, Mohamed Salah Benleulmi, Ludivine Sinzelle, Eloïse Thierry, Christina Calmels, Stéphane Chaignepain, Pierre Waffo-Teguo, Jean-Michel Mérillon, Brian B...> ;Chemistry & Biology. 2015 Jun 18
52 citations
RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells
Jennifer M. Mason, Kritika Dusad, William Douglass Wright, Jennifer Grubb, Brian Budke, Wolf Dietrich Heyer, Philip P. Connell, Ralph R. Weichselbaum, Douglas K. Bishop> ;Nucleic Acids Research. 2015 Mar 31
35 citations
The RAD51-Stimulatory Compound RS-1 Can Exploit the RAD51 Overexpression That Exists in Cancer Cells and Tumors
Jennifer M. Mason, Hillary L. Logan, Brian Budke, Megan Wu, Michal Pawlowski, Ralph R. Weichselbaum, Alan P. Kozikowski, Douglas K. Bishop, Philip P. Connell> ;Cancer Research. 2014 Jul 1
74 citations
DNA Repair Pathway Gene Expression Score Correlates with Repair Proficiency and Tumor Sensitivity to Chemotherapy
Sean P. Pitroda, Itai Pashtan, Hillary L. Logan, Brian Budke, Thomas E. Darga, Ralph R. Weichselbaum, Philip P. Connell> ;Science Translational Medicine. 2014 Mar 26
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Grant Support

RAD51 Inhibitors For Chemotherapy And Radiation TherapyNational Cancer Institute2010–2012
Inhibition Of Recombination DNA Repair In Pancreatic Cancer CellsNational Cancer Institute2007–2008