PhoenixAHoMD

Pediatric Hematology & Oncology • Seattle, WA

Pediatric Hematology & Oncology at Seattle Children's Hospital

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Office
4800 Sand Point Way NE
Seattle Children's Hospital
Seattle, WA 98105
Phone+1 206-987-2106

Fax+1 206-987-3946
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Education & Training

U Washington Affil Hosps2009
Yale-New Haven Medical CenterResidency, Pediatrics, 2003 - 2006
Yale-New Haven Medical CenterInternship, Pediatrics, 2003 - 2004
Northeast Ohio Medical UniversityClass of 2003

Certifications & Licensure

WA State Medical License 2006 - 2025
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Biomarkers in Samples From Young Patients With Acute Myeloid Leukemia Start of enrollment: 2013 Feb 01
Completed
Everolimus With Multiagent Re-Induction Chemotherapy in Pediatric Patients With ALL Start of enrollment: 2011 Nov 01
Completed
Phase 1
A Safety Study of SGN-CD33A in AML Patients Start of enrollment: 2013 Jul 01
Completed
Phase 1
Safety Study of SEA-CD40 in Cancer Patients Start of enrollment: 2015 Feb 28
Terminated
Phase 1
Study of Vadastuximab Talirine (SGN-CD33A; 33A) in Combination With Azacitidine in Patients With Previously Untreated Higher Risk MDS Start of enrollment: 2016 Feb 01
Terminated
Phase 1, Phase 2
Vadastuximab Talirine (SGN-CD33A; 33A) Combined With Azacitidine or Decitabine in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2016 May 01
Terminated
Phase 3
A Safety Study of SGN-CD123A in Patients With Acute Myeloid Leukemia Start of enrollment: 2016 Aug 01
Terminated
Phase 1
A Safety Study of SGN-CD352A for Patients With Relapsed/Refractory Multiple Myeloma Start of enrollment: 2016 Dec 01
Terminated
Phase 1
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Publications & Presentations

PubMed

11 citations
A phase I study of panobinostat in children with relapsed and refractory hematologic malignancies
John Goldberg, Maria Luisa Sulis, Julia Glade Bender, Sima Jeha, Rebecca Gardner, Jessica A. Pollard, Victor M. Aquino, Theodore W. Laetsch, Naomi J. Winick, Cecilia F...> ;Pediatric Hematology and Oncology. 2020 Apr 27
21 citations
A phase 1/2, open-label, dose-escalation study of midostaurin in children with relapsed or refractory acute leukaemia
C. Michel Zwaan, Stefan Söderhäll, Benoit Brethon, Matteo Luciani, Carmelo Rizzari, Ronald W. Stam, Emmanuelle Besse, Catherine Dutreix, Franca Fagioli, Phoenix A. Ho,...> ;British Journal of Haematology. 2019 May 1
47 citations
A phase 1 trial of vadastuximab talirine combined with hypomethylating agents in patients with CD33-positive AML
Amir T. Fathi, Harry P. Erba, Jeffrey E. Lancet, Eytan M. Stein, Farhad Ravandi, Stefan Faderl, Roland B. Walter, Anjali S. Advani, Daniel J. DeAngelo, Tibor Kovacsovi...> ;Blood. 2018 Sep 13
112 citations
A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia
Eytan M. Stein, Roland B. Walter, Harry P. Erba, Amir T. Fathi, Anjali S. Advani, Jeffrey E. Lancet, Farhad Ravandi, Tibor Kovacsovics, Daniel J. DeAngelo, Dale L. Bix...> ;Blood. 2018 Jan 25
97 citations
Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients
Sioban Keel, Angela Scott, Marilyn Sanchez-Bonilla, Phoenix A. Ho, Suleyman Gulsuner, Colin C. Pritchard, Janis L. Abkowitz, Mary Claire King, Tom Walsh, Akiko Shimamura> ;Haematologica. 2016 Nov 1
27 citations
FAM111B Mutation Is Associated With Inherited Exocrine Pancreatic Dysfunction.
Aaron Seo, Tom Walsh, Ming K. Lee, Phoenix A. Ho, Evelyn K. Hsu, Robert Sidbury, Mary-Claire King, Akiko Shimamura> ;Pancreas. 2016 Jul 1
49 citations
Sorafenib treatment following hematopoietic stem cell transplant in pediatric FLT3/ITD acute myeloid leukemia
Katherine Tarlock, Bill H. Chang, Todd M. Cooper, Thomas G. Gross, Sumit Gupta, Steven Neudorf, Kathleen Adlard, Phoenix A. Ho, Suzanne M. McGoldrick, Tanya C. Watt, T...> ;Pediatric Blood & Cancer. 2015 Jun 1
17 citations
The prognostic effect of high diagnostic WT1 gene expression in pediatric AML depends on WT1 SNP rs16754 status: report from the Children's Oncology Group.
Phoenix A. Ho, Todd A. Alonzo, Robert B. Gerbing, Julia Kuhn, Jessica A. Pollard, Betsy A. Hirsch, Susana C. Raimondi, Alan S. Gamis, Soheil Meshinchi> ;Pediatric Blood & Cancer. 2014 Jan 1
31 citations
High EVI1 expression is associated with MLL rearrangements and predicts decreased survival in paediatric acute myeloid leukaemia: a report from the children's oncology...
Phoenix A. Ho, Todd A. Alonzo, Robert B. Gerbing, Jessica A. Pollard, Betsy A. Hirsch, Susana C. Raimondi, Todd Cooper, Alan S. Gamis, Soheil Meshinchi> ;British Journal of Haematology. 2013 Sep 1
45 citations
Mutations in the DNMT3A exon 23 independently predict poor outcome in older patients with acute myeloid leukemia: a SWOG report.
Fabiana Ostronoff, Megan Othus, Phoenix A. Ho, Matthew A. Kutny, Daniel E. Geraghty, Stephen H. Petersdorf, John E. Godwin, Cheryl L. Willman, Jerald P. Radich, Freder...> ;Leukemia. 2013 Jan 1
208 citations
Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: a report from Children's Onco...
Michael R. Loken, Todd A. Alonzo, Laura Pardo, Robert B. Gerbing, Susana C. Raimondi, Betsy A. Hirsch, Phoenix A. Ho, Janet Franklin, Todd Cooper, Alan S. Gamis, Sohei...> ;Blood. 2012 Aug 23
37 citations
Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric and adult AML: a report from the Children's Oncology Group and SWOG
Phoenix A. Ho, Kenneth J. Kopecky, Todd A. Alonzo, Robert B. Gerbing, Kristen L. Miller, Julia Kuhn, Rong Zeng, Rhonda E. Ries, Susana C. Raimondi, Betsy A. Hirsch, Vi...> ;Blood. 2011 Oct 27
91 citations
Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: A report from the Children's Oncology Group†
Phoenix A. Ho, Matthew A. Kutny, Todd A. Alonzo, Robert B. Gerbing, Jason Joaquin, Susana C. Raimondi, Alan S. Gamis, Soheil Meshinchi> ;Pediatric Blood & Cancer. 2011 Aug 1
24 citations
Prevalence and clinical implications of NRAS mutations in childhood AML: a report from the Children's Oncology Group
Jason N. Berman, Robert B. Gerbing, Todd A. Alonzo, Phoenix A. Ho, Kristen L. Miller, Craig A. Hurwitz, Nyla A. Heerema, Betsy A. Hirsch, Susana C. Raimondi, Beverly J...> ;Leukemia. 2011 Jun 1
54 citations
WT1 Synonymous Single Nucleotide Polymorphism rs16754 Correlates With Higher mRNA Expression and Predicts Significantly Improved Outcome in Favorable-Risk Pediatric Ac...
Phoenix A. Ho, Julia Kuhn, Robert B. Gerbing, Jessica A. Pollard, Rong Zeng, Kristen L. Miller, Nyla A. Heerema, Susana C. Raimondi, Betsy A. Hirsch, Janet Franklin, B...> ;Journal of Clinical Oncology. 2011 Feb 20
100 citations
C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations
John Anto Pulikkan, Philomina S. Peramangalam, Viola Dengler, Phoenix A. Ho, Claude Preudhomme, Soheil Meshinchi, Maximilian Christopeit, Oliver Nibourel, Carsten Müll...> ;Blood. 2010 Dec 16
139 citations
Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML)
Phoenix A. Ho, Rong Zeng, Todd A. Alonzo, Robert B. Gerbing, Kristen L. Miller, Jessica A. Pollard, Derek L. Stirewalt, Nyla A. Heerema, Susana C. Raimondi, Betsy A. H...> ;Blood. 2010 Aug 5
31 citations
High Expression of the Very Late Antigen-4 Integrin Independently Predicts Reduced Risk of Relapse and Improved Outcome in Pediatric Acute Myeloid Leukemia: A Report F...
Roland B. Walter, Todd A. Alonzo, Robert B. Gerbing, Phoenix A. Ho, Franklin O. Smith, Susana C. Raimondi, Betsy A. Hirsch, Alan S. Gamis, Janet Franklin, Craig A. Hur...> ;Journal of Clinical Oncology. 2010 Jun 10
80 citations
Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study.
Phoenix A. Ho, Todd A. Alonzo, Kenneth J. Kopecky, Kristen L. Miller, Julia Kuhn, Rong Zeng, Robert B. Gerbing, Susana C. Raimondi, Betsy A. Hirsch, Vivian G. Oehler, ...> ;Leukemia. 2010 Apr 8
132 citations
Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML
Jessica A. Pollard, Todd A. Alonzo, Robert B. Gerbing, Phoenix A. Ho, Rong Zeng, Yaddanapudi Ravindranath, Gary V. Dahl, Norman J. Lacayo, David L. Becton, Myron Chang...> ;Blood. 2010 Mar 25
22 citations
Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group.
Phoenix A Ho, Todd A Alonzo, Robert B Gerbing, Jessica Pollard, Derek L Stirewalt, Craig Hurwitz, Nyla A Heerema, Betsy Hirsch, Susana C Raimondi, Beverly Lange, Janet...> ;Blood. 2009 Jun 25
81 citations
Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML
Jessica A. Pollard, Todd A. Alonzo, Michael R. Loken, Robert B. Gerbing, Phoenix A. Ho, Irwin D. Bernstein, Susana C. Raimondi, Betsy A. Hirsch, Janet Franklin, Roland...> ;Blood. 2008 Nov 16
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Journal Articles

A Phase 1 Trial of Vadastuximab Talirine Combined with Hypomethylating Agents in Patients with CD33 Positive AML
Eytan M Stein, Anand Jillella, Anthony S Stein, Amir T Fathi, Roland B Walter, Jeffrey E Lancet, Tibor J Kovacsovics, Anjali S Advani, Phoenix A Ho, Dale Bixby, Blood

Grant Support

Exploiting WT1 Alterations in Pediatric AMLSt. Baldrick's Foundation2012–2014
Exploiting WT1 Genomic Alterations for Target Identification and Minimal Residual Disease Monitoring in Pediatric AMLAlex's Lemonade Stand Foundation2012–2013
Implications of s-SHIP Expression and SHIP Alterations in AMLNICHD2009–2012
SHIP and WT1 Alterations as Markers of PI3K/Akt Activation in Pediatric AMLMary Claire Satterly Foundation2011
Implications of s-SHIP Expression and SHIP Alterations in AMLAmerican Society of Clinical Oncology2009–2010